Tocilizumab in adult-onset still's disease: The Israeli experience

Journal of Rheumatology

Volumn 41, Issue 2, 2014, Pages 244-247

  Elkayam, Ori ^a   Jiries, Nizar ^b   Dranitzki, Zvi ^c   Kivity, Shay ^d   Lidar, Merav ^d   Levy, Ofer ^e   Ablin, Jacob ^a,b   Abu Shakra, Mahmoud ^f   Savargyl Maman, Hagit ^a   Padova, Hagit ^a   Caspi, Dan ^a   Rosner, Itzhak ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b BNAI ZION MEDICAL CENTER   (Israel)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d SHEBA MEDICAL CENTER   (Israel)

^e ASSAF HAROFEH MEDICAL CENTER   (Israel)

^f BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Adult onset still's disease; Biologics; Cytokines; Disease modifying antirheumatic drugs; Inflammation

Indexed keywords

ADULT-ONSET STILL'S DISEASE; BIOLOGICS; CYTOKINES; DISEASE-MODIFYING ANTIRHEUMATIC DRUGS; INFLAMMATION;

ADULT; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIRHEUMATIC AGENTS; FEMALE; HUMANS; ISRAEL; MALE; MIDDLE AGED; PREDNISONE; STILL'S DISEASE, ADULT-ONSET; TREATMENT OUTCOME;

EID: 84893590547     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.130881     Document Type: Article

References (16)

1. Bywaters EGL. Still's disease in the adult. Ann Rheum Dis 1971;30:121-32.
2. Fautrel B. Adult-onset Still disease. Best Pract Res Clin Rheumatol 2008;22:773-92.
3. Dinarello C, Simon A, van der Meer JW. Treating inflammation by blocking IL-1 in a broad spectrum of diseases. Nat Rev Drug Discov 2012;11:633-52.
4. Fitzgerald AA, LeClercq AA, Yan A, Homik JE, Dinarello C. Rapid response to anakinra in patients with refractory adult-onset Still's disease. Arthritis Rheum 2005;52:1794-803.
5. Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet 2008;371:998-1006.
6. De Benedetti F, Brunner HI, Ruperto N, Kenwright A, Wright S, Calvo I, et al. Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis. N Engl J Med 2012;367:2385-95.
7. Puéchal X, de Bandt M, Berthelot JM, Breban M, Dubost JJ, Fain O, et al. Tocilizumab in refractory Still's disease. Arthritis Care Res 2011;63:155-9.
8. Suematsu R, Ohta A, Matsuura E, Takahashi H, Fujii T, Horiuchi T, et al. Therapeutic response of patients with adult Still's disease to biologic agents: multicenter results in Japan. Mod Rheumatol 2012;22:712-9.
9. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol 1992;19:424-30.
10. Boysson H, Fevrier J, Nicolle A, Auzary C, Geffray L. Tocilizumab in the treatment of the adult-onset Still's disease: current clinical evidence. Clin Rheumatol 2013;32:141-7.
11. Shimizu M, Nakagishi Y, Kasai K, Yamasaki Y, Miyoshi M, Takei S, et al. Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: the diagnostic significance of interleukin-18 and interleukin-6. Cytokine 2012;58:287-94.
12. Kessler EA, Vora SS, Verbsky JW. Risk of significant cytopenias after treatment with tocilizumab in systemic juvenile arthritis patients with a history of macrophage activation syndrome. Pediatr Rheumatol Online J 2012;10:30.
13. Bruck N, Suttorp M, Kabus M, Heubner G, Gahr M, Pessler F. Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroids. J Clin Rheumatol 2011;17:23-7.
14. Kishida D, Okuda Y, Onishi M, Takebayashi M, Matoba K, Jouyama K, et al. Successful tocilizumab treatment in a patient with adult-onset Still's disease complicated by chronic active hepatitis B and amyloid A amyloidosis. Mod Rheumatol 2011;21:215-8.
15. Okuda Y, Ohnishi M, Matoba K, Jouyama K, Yamada A, Sawada N, et al. Comparison of the clinical utility of tocilizumab and anti-TNF therapy in AA amyloidosis complicating rheumatic diseases. Mod Rheumatol 2014;24:137-43.
16. Pouchot J, Arlet JB. Biological treatment in adult-onset Still's disease. Best Pract Res Clin Rheumatol 2012;26:477-87.