A BSL-4 high-throughput screen identifies sulfonamide inhibitors of Nipah virus

Assay and Drug Development Technologies

Volumn 12, Issue 3, 2014, Pages 155-161

  Tigabu, Bersabeh ^a   Rasmussen, Lynn ^b   White, E Lucile ^b   Tower, Nichole ^b   Saeed, Mohammad ^b   Bukreyev, Alexander ^a   Rockx, Barry ^a   Leduc, James W ^a   Noah, James W ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AB 00991123; AB 00992391; AB 00993210; ANTIVIRUS AGENT; SULFONAMIDE; SULFONAMIDE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOTOXICITY; DRUG EFFICACY; HIGH THROUGHPUT SCREENING; NIPAH VIRUS; NONHUMAN; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHLOROCEBUS AETHIOPS; DEVICE FAILURE ANALYSIS; DEVICES; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; EQUIPMENT DESIGN; HAZARDOUS WASTE; PHYSIOLOGY; ROBOTICS; VERO CELL LINE;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CONTAINMENT OF BIOHAZARDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HIGH-THROUGHPUT SCREENING ASSAYS; NIPAH VIRUS; ROBOTICS; SULFONAMIDES; VERO CELLS; VIRUS REPLICATION;

EID: 84898854289     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2013.567     Document Type: Article

References (29)

1. Chua KB, Goh KJ, Wong KT, et al.: Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia. Lancet 1999;354:1257-1259. (Pubitemid 29469355)
2. Amal NM, Lye MS, Ksiazek TG, et al.: Risk factors for Nipah virus transmission, Port Dickson, Negeri Sembilan, Malaysia: results from a hospital-based casecontrol study. Southeast Asian J Trop Med Public Health 2000;31:301-306.
3. Chew MH, Arguin PM, Shay DK, et al.: Risk factors for Nipah virus infection among abattoir workers in Singapore. J Infect Dis 2000;181:1760-1763. (Pubitemid 30387772)
4. Chadha MS, Comer JA, Lowe L, et al.: Nipah virus-associated encephalitis outbreak, Siliguri, India. Emerg Infect Dis 2006;12:235-240.
5. Hsu VP, Hossain MJ, Parashar UD, et al.: Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis 2004;10:2082-2087. (Pubitemid 39587329)
6. Lo MK, Rota PA: The emergence of Nipah virus, a highly pathogenic paramyxovirus. J Clin Virol 2008;43:396-400.
7. Gurley ES, Montgomery JM, Hossain MJ, et al.: Person-to-person transmission of Nipah virus in a Bangladeshi community. Emerg Infect Dis 2007;13: 1031-1037. (Pubitemid 47048075)
8. Porotto M, Orefice G, Yokoyama CC, et al.: Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. J Virol 2009;83:5148-5155.
9. Aljofan M, Porotto M, Moscona A, Mungall BA: Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus. J Virol Methods 2008; 149:12-19.
10. Chung DH, Ardecky R, Ganji SR, et al.: A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus. Probe Reports from the NIH Molecular Libraries Program. Bethesda, MD, 2010.
11. Chung DH, Jonsson CB, Maddox C, et al.: HTS-driven discovery of new chemotypes with West Nile Virus inhibitory activity. Molecules 2010;15:1690-1704.
12. Chung DH, Moore BP, Matharu DS, et al.: A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus. Virol J. 2013;10:19.
13. Noah JW, Severson W, Noah DL, Rasmussen L, White EL, Jonsson CB: A cellbased luminescence assay is effective for high-throughput screening of potential influenza antivirals. Antiviral Res 2007;73:50-59. (Pubitemid 46080478)
14. Rasmussen L, Maddox C, Moore BP, Severson W, White EL: A high-throughput screening strategy to overcome virus instability. Assay Drug Dev Technol 2011; 9:184-190.
15. Severson WE, Shindo N, Sosa M, et al.: Development and validation of a highthroughput screen for inhibitors of SARS CoV and its application in screening of a 100,000-compound library. J Biomol Screen 2007;12:33-40. (Pubitemid 46224917)
16. Moore BP, Chung DH, Matharu DS, et al.: (S)-N-(2,5-Dimethylphenyl)-1- (quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. J Med Chem 2012; 55:8582-8587.
17. Noah JW, Severson W, Chung DH, et al.: A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV. Probe Reports from the NIH Molecular Libraries Program. Bethesda, MD, 2010.
18. Noah JW, Severson WE, Chung DH, et al.: Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus (hRSV) via a Cell-Based High Throughput Screen and Chemical Optimization. Probe Reports from the NIH Molecular Libraries Program. Bethesda, MD, 2010.
19. Seguin SP, Evans CW, Nebane-Akah M, et al.: High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. J Biomol Screen 2012;17:194-203.
20. Severson WE, McDowell M, Ananthan S, et al.: High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2). J Biomol Screen 2008;13:879-887.
21. Ghosh RN, DeBiasio R, Hudson CC, Ramer ER, Cowan CL, Oakley RH: Quantitative cell-based high-content screening for vasopressin receptor agonists using transfluor technology. J Biomol Screen 2005;10:476-484. (Pubitemid 41233226)
22. Zhang JH, Chung TD, Oldenburg KR: A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen. 1999;4:67-73. (Pubitemid 29278954)
23. Che P, Wang L, Li Q: The development, optimization and validation of an assay for high throughput antiviral drug screening against Dengue virus. Int J Clin Exp Med. 2009;2:363-373.
24. Niedermeier S, Singethan K, Rohrer SG, et al.: A small-molecule inhibitor of Nipah virus envelope protein-mediated membrane fusion. J Med Chem 2009; 52:4257-4265.
25. Bosio CM, Aman MJ, Grogan C, et al.: Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation. J Infect Dis 2003;188:1630-1638. (Pubitemid 38010672)
26. Bosio CM, Moore BD, Warfield KL, et al.: Ebola and Marburg virus-like particles activate human myeloid dendritic cells. Virology 2004;326:280-287. (Pubitemid 39078259)
27. Jasenosky LD, Neumann G, Kawaoka Y: Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription. Antimicrob Agents Chemother 2010;54:3007- 3010.
28. Compound Summary for: CID 17483530. National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=17483530 (Last accessed 4 January, 2014).
29. Compound Summary for: CID 25661567. National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=25661567 (Last accessed 4 January, 2014).