Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy

Journal of Virology

Volumn 83, Issue 10, 2009, Pages 5148-5155

  Porotto, Matteo ^a   Orefice, Gianmarco ^a   Yokoyama, Christine C ^a   Mungall, Bruce A ^b   Realubit, Ronald ^d   Sganga, Michael L ^a   Aljofan, Mohamad ^b   Whitt, Michael ^c   Glickman, Fraser ^d   Moscona, Anne ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b CSIRO   (Australia)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CATHEPSIN L; CHLOROQUINE; GLYCOPROTEIN; VIRUS ENVELOPE PROTEIN; VIRUS FUSION PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BIOSAFETY; CONTROLLED STUDY; HENIPAVIRUS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIFE CYCLE; MALARIA; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; VIRION; VIRUS INFECTION; VIRUS REPLICATION; ANIMAL; CERCOPITHECUS; DRUG DEVELOPMENT; DRUG EFFECT; HENDRA VIRUS; HENIPAVIRUS INFECTION; METABOLISM; METHODOLOGY; NIPAH VIRUS; PHYSIOLOGY; VALIDATION STUDY; VERO CELL;

HENDRA VIRUS; HENIPAVIRUS;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CHLOROQUINE; DRUG DISCOVERY; HENDRA VIRUS; HENIPAVIRUS INFECTIONS; HUMANS; NIPAH VIRUS; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

EID: 65349165096     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00164-09     Document Type: Article

References (32)

1. Aljofan, M., M. Porotto, A. Moscona, and B. A. Mungall. 2008. Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus. J. Virol. Methods 149:12-19.
2. Butler, D. 2004. Fatal fruit bat virus sparks epidemics in southern Asia. Nature 429:7.
3. Chua, K. B., W. J. Bellini, P. A. Rota, B. H. Harcourt, A. Tamin, S. K. Lam, T. G. Ksiazek, P. E. Rollin, S. R. Zaki, W. Shieh, C. S. Goldsmith, D. J. Gubler, J. T. Roehrig, B. Eaton, A. R. Gould, J. Olson, H. Field, P. Daniels, A. E. Ling, C. J. Peters, L. J. Anderson, and B. W. Mahy. 2000. Nipah virus: a recently emergent deadly paramyxovirus. Science 288:1432-1435.
4. Diederich, S., L. Thiel, and A. Maisner. 2008. Role of endocytosis and cathepsin-mediated activation in Nipah virus entry. Virology 375:391-400.
5. Enserink, M. 2004. Emerging infectious diseases. Nipah virus (or a cousin) strikes again. Science 303:1121.
6. Goulet, B., A. Baruch, N. S. Moon, M. Poirier, L. L. Sansregret, A. Erickson, M. Bogyo, and A. Nepveu. 2004. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol. Cell 14:207-219. (Pubitemid 38515648)
7. Harcourt, B. H., A. Tamin, T. G. Ksiazek, P. E. Rollin, L. J. Anderson, W. J. Bellini, and P. A. Rota. 2000. Molecular characterization of Nipah virus, a newly emergent paramyxovirus. Virology 271:334-349.
8. Hossain, M. J., E. S. Gurley, J. M. Montgomery, M. Bell, D. S. Carroll, V. P. Hsu, P. Formenty, A. Croisier, E. Bertherat, M. A. Faiz, A. K. Azad, R. Islam, M. A. Molla, T. G. Ksiazek, P. A. Rota, J. A. Comer, P. E. Rollin, S. P. Luby, and R. F. Breiman. 2008. Clinical presentation of nipah virus infection in Bangladesh. Clin. Infect. Dis. 46:977-984.
9. Inglese, J., R. L. Johnson, A. Simeonov, M. Xia, W. Zheng, C. P. Austin, and D. S. Auld. 2007. High-throughput screening assays for the identification of chemical probes. Nat. Chem. Biol. 3:466-479. (Pubitemid 47080373)
10. Kawaoka, Y. 2005. How Ebola virus infects cells. N. Engl. J. Med. 352:2645-2646. (Pubitemid 41007854)
11. Lee, B. 2007. Envelope-receptor interactions in Nipah virus pathobiology. Ann. N. Y. Acad. Sci. 1102:51-65. (Pubitemid 47084909)
12. Murray, K., P. Selleck, P. Hooper, A. Hyatt, A. Gould, L. Gleeson, H. Westbury, L. Hiley, L. Selvey, B. Rodwell, et al. 1995. A morbillivirus that caused fatal disease in horses and humans. Science 268:94-97.
13. O'Sullivan, J. D., A. M. Allworth, D. L. Paterson, T. M. Snow, R. Boots, L. J. Gleeson, A. R. Gould, A. D. Hyatt, and J. Bradfield. 1997. Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet 349:93-95.
14. Pager, C. T., W. W. Craft, Jr., J. Patch, and R. E. Dutch. 2006. A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L. Virology 346:251-257.
15. Pager, C. T., and R. E. Dutch. 2005. Cathepsin L is involved in proteolytic processing of the Hendra virus fusion protein. J. Virol. 79:12714-12720. (Pubitemid 41433191)
16. Pager, C. T., M. A. Wurth, and R. E. Dutch. 2004. Subcellular localization and calcium and pH requirements for proteolytic processing of the Hendra virus fusion protein. J. Virol. 78:9154-9163. (Pubitemid 39096526)
17. Park, M. S., M. L. Shaw, J. Munoz-Jordan, J. F. Cros, T. Nakaya, N. Bouvier, P. Palese, A. Garcia-Sastre, and C. F. Basler. 2003. Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins. J. Virol. 77:1501-1511. (Pubitemid 36055570)
18. Paton, N. I., J. Aboulhab, and F. Karim. 2002. Hydroxychloroquine, hydroxycarbamide, and didanosine as economic treatment for HIV-1. Lancet 359:1667-1668.
19. Porotto, M., P. Carta, Y. Deng, G. Kellogg, M. Whitt, M. Lu, B. Mungall, and A. Moscona. 2007. Molecular determinants of antiviral potency of paramyxovirus entry inhibitors. J. Virol. 81:10567-10574. (Pubitemid 47463330)
20. Porotto, M., L. Doctor, P. Carta, M. Fornabaio, O. Greengard, G. Kellogg, and A. Moscona. 2006. Inhibition of Hendra virus membrane fusion. J. Virol. 80:9837-9849. (Pubitemid 44435658)
21. Porotto, M., M. Murrell, O. Greengard, M. Lawrence, J. McKimm-Breschkin, and A. Moscona. 2004. Inhibition of parainfluenza type 3 and Newcastle disease virus hemagglutinin-neuraminidase receptor binding: Effect of receptor avidity and steric hindrance at the inhibitor binding sites. J. Virol. 78:13911-13919.
22. Porotto, M., M. Murrell, O. Greengard, and A. Moscona. 2003. Triggering of human parainfluenza virus 3 fusion protein(F) by the hemagglutinin- neuraminidase (HN): an HN mutation diminishing the rate of F activation and fusion. J. Virol. 77:3647-3654.
23. Rolain, J. M., P. Colson, and D. Raoult. 2007. Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century. Int. J. Antimicrob. Agents 30:297-308.
24. Schornberg, K., S. Matsuyama, K. Kabsch, S. Delos, A. Bouton, and J. White. 2006. Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein. J. Virol. 80:4174-4178.
25. Sejvar, J. J., J. Hossain, S. K. Saha, E. S. Gurley, S. Banu, J. D. Hamadani, M. A. Faiz, F. M. Siddiqui, Q. D. Mohammad, A. H. Mollah, R. Uddin, R. Alam, R. Rahman, C. T. Tan, W. Bellini, P. Rota, R. F. Breiman, and S. P. Luby. 2007. Long-term neurological and functional outcome in Nipah virus infection. Ann. Neurol. 62:235-242. (Pubitemid 47525399)
26. Shiryaev, S. A., A. G. Remacle, B. I. Ratnikov, N. A. Nelson, A. Y. Savinov, G. Wei, M. Bottini, M. F. Rega, A. Parent, R. Desjardins, M. Fugere, R. Day, M. Sabet, M. Pellecchia, R. C. Liddington, J. W. Smith, T. Mustelin, D. G. Guiney, M. Lebl, and A. Y. Strongin. 2007. Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J. Biol. Chem. 282:20847-20853. (Pubitemid 47099910)
27. Simmons, G., A. J. Rennekamp, and P. Bates. 2006. Proteolysis of SARS-associated coronavirus spike glycoprotein. Adv. Exp. Med. Biol. 581:235-240.
28. Takada, A., C. Robison, H. Goto, A. Sanchez, K. G. Murti, M. A. Whitt, and Y. Kawaoka. 1997. A system for functional analysis of Ebola virus glycoprotein. Proc. Natl. Acad. Sci. USA 94:14764-14769.
29. Vincent, M. J., E. Bergeron, S. Benjannet, B. R. Erickson, P. E. Rollin, T. G. Ksiazek, N. G. Seidah, and S. T. Nichol. 2005. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol. J. 2:69.
30. Wang, L., B. H. Harcourt, M. Yu, A. Tamin, P. A. Rota, W. J. Bellini, and B. T. Eaton. 2001. Molecular biology of Hendra and Nipah viruses. Microbes Infect. 3:279-287. (Pubitemid 32385777)
31. Yonezawa, A., M. Cavrois, and W. C. Greene. 2005. Studies of Ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha. J. Virol. 79:918-926.
32. Zhang, J. H., T. D. Chung, and K. R. Oldenburg. 1999. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4:67-73. (Pubitemid 29278954)