(S)- N -(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2- carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection

Journal of Medicinal Chemistry

Volumn 55, Issue 20, 2012, Pages 8582-8587

  Moore, Blake P ^a   Chung, Dong Hoon ^a   Matharu, Daljit S ^c   Golden, Jennifer E ^c   Maddox, Clinton ^a   Rasmussen, Lynn ^a   Noah, James W ^a   Sosa, Melinda I ^a   Ananthan, Subramaniam ^a   Tower, Nichole A ^a   White, E Lucile ^a   Jia, Fuli ^a   Prisinzano, Thomas E ^c   Aubé, Jeffrey ^c   Jonsson, Colleen B ^b   Severson, William E ^b  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ANTIVIRUS AGENT; N(2,5 DIMETHYLPHENYL) 1 (QUINOLINE 8 YLSULFONYL)PYRROLIDINE 2 CARBOXAMIDE; RIBAVIRIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR PROBE; NONHUMAN; PROCESS OPTIMIZATION; RESPIRATORY SYNCYTIAL VIRUS INFECTION; VIRUS ENTRY;

ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOPATHOGENIC EFFECT, VIRAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PYRROLIDINES; QUINOLINES; RESPIRATORY SYNCYTIAL VIRUSES; RIBAVIRIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONES; VIRAL LOAD; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 84867769390     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300612z     Document Type: Article

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