Pediatric non-alcoholic steatohepatitis: The first report on the ultrastructure of hepatocyte mitochondria

World Journal of Gastroenterology

Volumn 20, Issue 15, 2014, Pages 4335-4340

  Lotowska, Joanna M ^a   Sobaniec Lotowska, Maria E ^a   Bockowska, Sylwia B ^b   Lebensztejn, Dariusz M ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b Maria Sk odowska Curie Memorial Bialystok Oncology Center   (Poland)

Author keywords

Foamy cytoplasm of hepatocytes; Hepatocyte ultrastructure; Megamitochondria with crystalline inclusions; Pediatric non alcoholic steatohepatitis

Indexed keywords

ALANINE AMINOTRANSFERASE; LEAD; ORGANOMETALLIC COMPOUND; URANYL ACETATE;

ADOLESCENT; ARTICLE; AUTOIMMUNE HEPATITIS; CELIAC DISEASE; CHILD; CLINICAL ARTICLE; ERYTHROPHAGOCYTOSIS; FEMALE; FIBROSIS; HUMAN; HUMAN TISSUE; INFLAMMATION; LIVER BIOPSY; MALE; MITOCHONDRION; NECROSIS; NONALCOHOLIC FATTY LIVER; STEATOSIS; TRANSMISSION ELECTRON MICROSCOPY; ULTRASOUND; ULTRASTRUCTURE; BIOPSY; CHEMISTRY; CRYSTALLIZATION; CYTOLOGY; CYTOPLASM; LIVER CELL; LIVER DISEASE; LIVER MITOCHONDRION; METABOLISM; PATHOPHYSIOLOGY; PRESCHOOL CHILD;

ADOLESCENT; BIOPSY; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; CRYSTALLIZATION; CYTOPLASM; FEMALE; HEPATITIS, AUTOIMMUNE; HEPATOCYTES; HUMANS; INFLAMMATION; LEAD; LIVER DISEASES; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA, LIVER; NON-ALCOHOLIC FATTY LIVER DISEASE; ORGANOMETALLIC COMPOUNDS;

EID: 84898846491     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i15.4335     Document Type: Article

References (31)

1. Alexander J, Torbenson M, Wu TT, Yeh MM. Non-alcoholic fatty liver disease contributes to hepatocarcinogenesis in non-cirrhotic liver: a clinical and pathological study. J Gastroenterol Hepatol 2013; 28: 848-854 [PMID: 23302015 DOI: 10.1111/jgh.12116]
2. Basaranoglu M, Basaranoglu G, Sentürk H. From fatty liver to fibrosis: a tale of "second hit". World J Gastroenterol 2013; 19: 1158-1165 [PMID: 23483818 DOI: 10.3748/wjg.v19.i8.1158]
3. Caldwell SH, Lee VD, Kleiner DE, Al-Osaimi AM, Argo CK, Northup PG, Berg CL. NASH and cryptogenic cirrhosis: a histological analysis. Ann Hepatol 2009; 8: 346-352 [PMID: 20009134]
4. Brunt EM, Tiniakos DG. Histopathology of nonalcoholic fatty liver disease. World J Gastroenterol 2010; 16: 5286-5296 [PMID: 21072891]
5. Jeen YM, Jin SY. [Pathology of nonalcoholic steatohepatitis]. Korean J Hepatol 2009; 15: 122-130 [PMID: 19581764 DOI: 10.3350/kjhep.2009.15.2.122]
6. Farrell GC, Teoh NC, McCuskey RS. Hepatic microcirculation in fatty liver disease. Anat Rec (Hoboken) 2008; 291: 684-692 [PMID: 18484615 DOI: 10.1002/ar.20715]
7. Takahashi Y, Fukusato T. Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology. World J Gastroenterol 2010; 16: 5280-5285 [PMID: 21072890 DOI: 10.3748/ wjg.v16.i42.5280]
8. Basaranoglu M, Turhan N, Sonsuz A, Basaranoglu G. Mallory-Denk Bodies in chronic hepatitis. World J Gastroenterol 2011; 17: 2172-2177 [PMID: 21633525 DOI: 10.3748/wjg.v17. i17.2172]
9. Fromenty B, Robin MA, Igoudjil A, Mansouri A, Pessayre D. The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab 2004; 30: 121-138 [PMID: 15223984]
10. Henkel J, Frede K, Schanze N, Vogel H, Schürmann A, Spruss A, Bergheim I, Püschel GP. Stimulation of fat accumulation in hepatocytes by PGE2-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis. Lab Invest 2012; 92: 1597-1606 [PMID: 22964849 DOI: 10.1038/labinvest.2012.128]
11. Jiang Y, Zhao M, An W. Increased hepatic apoptosis in highfat diet-induced NASH in rats may be associated with downregulation of hepatic stimulator substance. J Mol Med (Berl) 2011; 89: 1207-1217 [PMID: 21814826 DOI: 10.1007/s00109-011-0790-y]
12. Pessayre D. Role of mitochondria in non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2007; 22 Suppl 1: S20-S27 [PMID: 17567459]
13. Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic Biol Med 2012; 52: 59-69 [PMID: 22064361 DOI: 10.1016/j.free radbiomed.2011.10.003]
14. Thomas A, Klein MS, Stevens AP, Reinders Y, Hellerbrand C, Dettmer K, Gronwald W, Oefner PJ, Reinders J. Changes in the hepatic mitochondrial and membrane proteome in mice fed a non-alcoholic steatohepatitis inducing diet. J Proteomics 2013; 80C: 107-122 [PMID: 23313215 DOI: 10.1016/j.jprot.2012.12.027]
15. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94: 2467-2474 [PMID: 10484010 DOI: 10.1111/ j.1572-0241.1999.01377.x]
16. Tandra S, Yeh MM, Brunt EM, Vuppalanchi R, Cummings OW, Unalp-Arida A, Wilson LA, Chalasani N. Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease. J Hepatol 2011; 55: 654-659 [PMID: 21172393 DOI: 10.1016/j.jhep.2010.11.021]
17. Tiniakos DG. Liver biopsy in alcoholic and non-alcoholic steatohepatitis patients. Gastroenterol Clin Biol 2009; 33: 930-939 [PMID: 19646834 DOI: 10.1016/j.gcb.2009.05.009]
18. Lotowska JM, Sobaniec-Lotowska ME, Lebensztejn DM. The role of Kupffer cells in the morphogenesis of nonalcoholic steatohepatitis-ultrastructural findings. The first report in pediatric patients. Scand J Gastroenterol 2013; 48: 352-357 [PMID: 23268566 DOI: 10.3109/00365521.2012.746390]
19. Rombouts K, Marra F. Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis. Dig Dis 2010; 28: 229-235 [PMID: 20460917 DOI: 10.1159/000282094]
20. Ahishali E, Demir K, Ahishali B, Akyuz F, Pinarbasi B, Poturoglu S, Ibrisim D, Gulluoglu M, Ozdil S, Besisik F, Kaymakoglu S, Boztas G, Cakaloglu Y, Mungan Z, Canberk Y, Okten A. Electron microscopic findings in non-alcoholic fatty liver disease: is there a difference between hepatosteatosis and steatohepatitis? J Gastroenterol Hepatol 2010; 25: 619-626 [PMID: 20370732 DOI: 10.1111/j.1440-1746.2009.06142.x]
21. Caldwell SH, Swerdlow RH, Khan EM, Iezzoni JC, Hespenheide EE, Parks JK, Parker WD. Mitochondrial abnormalities in non-alcoholic steatohepatitis. J Hepatol 1999; 31: 430-434 [PMID: 10488700 DOI: 10.1016/S0168-8278(99)80033-6]
22. Le TH, Caldwell SH, Redick JA, Sheppard BL, Davis CA, Arseneau KO, Iezzoni JC, Hespenheide EE, Al-Osaimi A, Peterson TC. The zonal distribution of megamitochondria with crystalline inclusions in nonalcoholic steatohepatitis. Hepatology 2004; 39: 1423-1429 [PMID: 15122772 DOI: 10.1002/ hep.20202]
23. Park KS, Jang BK, Chung WJ, Cho KB, Hwang JS, Ahn SH, Kang YN, Hwang JB, Keum DY. [Abnormal electron microscopic findings of nonalcoholic steatohepatitis and related factors]. Korean J Gastroenterol 2005; 45: 417-424 [PMID: 15973076]
24. Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-1192 [PMID: 11266382 DOI: 10.1053/gast.2001.23256]
25. Sobaniec-Lotowska ME, Lebensztejn DM. Ultrastructure of hepatocyte mitochondria in nonalcoholic steatohepatitis in pediatric patients: usefulness of electron microscopy in the diagnosis of the disease. Am J Gastroenterol 2003; 98: 1664-1665 [PMID: 12873608 DOI: 10.1111/j.1572-0241.2003.07561.x]
26. Sobaniec-Łotowska ME, Lebensztejn DM, Lotowska JM, Kańczuga-Koda L, Sulkowski S. Ultrastructure of liver progenitor/ oval cells in children with nonalcoholic steatohepatitis. Adv Med Sci 2011; 56: 172-179 [PMID: 21940261 DOI: 10.2478/v10039-011-0037-8]
27. Lotowska JM, Sobaniec-Lotowska ME, Sulkowska U, Lebensztejn DM. Mitochondrial abnormalities in nonalcoholic steatohepatitis in pediatric patients. Falk Symposium 186. Challenges of Liver Cirrhosis and Tumors: Prevent it, Treat it, Manage Consequences; October 5-6, 2012, Mainz, Germany, 46. Available from: URL: http://www.drfalkpharma. de/uploads/tx_tocfpshoperw/FS186_Program.pdf
28. Sobaniec-Lotowska ME, Lotowska JM, Bockowska SB, Lebensztejn DM. The role of Kupffer cells in the pathogenesis of non-alcoholic steatohepatitis: immunohistochemical and ultrastructural findings in pediatric patients. Falk Symposium 181. Innate Immunity in Gastrointestinal Disorders: Basic and Therapeutic Concepts; February 8-9, 2012, Munich, Germany, 28. Available from: URL: http://www.drfalkpharma. de/uploads/tx_tocfpshoperw/FS181_Program.pdf
29. Chedid A, Mendenhall CL, Tosch T, Chen T, Rabin L, Garcia-Pont P, Goldberg SJ, Kiernan T, Seeff LB, Sorrell M. Significance of megamitochondria in alcoholic liver disease. Gastroenterology 1986; 90: 1858-1864 [PMID: 3699404]
30. Phillips MJ, Poucell S, Patterson J, Valencia P. The Liver: An Atlas and Text of Ultrastructural Pathology. New York: Raven Press, 1987: 239-446
31. Kirsch R, Clarkson V, Shephard EG, Marais DA, Jaffer MA, Woodburne VE, Kirsch RE, Hall Pde L. Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies. J Gastroenterol Hepatol 2003; 18: 1272-1282 [PMID: 14535984]