Low antibody levels to pregnancy-specific malaria antigens and heightened cytokine responses associated with severe malaria in pregnancy

Journal of Infectious Diseases

Volumn 209, Issue 9, 2014, Pages 1408-1417

  Chandrasiri, Upeksha P ^a   Randall, Louise M ^a   Saad, Alfarazdeg A ^b   Bashir, Ahmed M ^b   Rogerson, Stephen J ^a   Adam, Ishag ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF KHARTOUM   (Sudan)

Author keywords

cerebral malaria; cytokines; parasitaemia; Plasmodium falciparum infection; pregnancy specific malaria antigens; severe anaemia; Severe malaria; Sudan; VAR2CSA DBL5; variant surface antigens

Indexed keywords

CEREBRAL MALARIA; CYTOKINES; PARASITAEMIA; PLASMODIUM FALCIPARUM INFECTION; PREGNANCY-SPECIFIC MALARIA ANTIGENS; SEVERE ANAEMIA; SEVERE MALARIA; SUDAN; VAR2CSA-DBL5; VARIANT SURFACE ANTIGENS;

ADULT; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; COHORT STUDIES; CYTOKINES; FEMALE; HEMOGLOBINS; HUMANS; MALARIA, FALCIPARUM; PARASITEMIA; PLASMODIUM FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; SUDAN; YOUNG ADULT;

EID: 84898838705     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jit646     Document Type: Article

References (36)

1. Dellicour S, Tatem AJ, Guerra CA, Snow RW, ter Kuile FO. Quantifying the Number of Pregnancies at Risk of Malaria in 2007: A Demographic Study. PLOS Med 2010; 7:e1000221
2. WHO. 2001-2010 United Nations Decade to Roll Back Malaria. Malaria in pregnancy fact sheet. Available at: Http://www.rbm.who.int/ cmc-upload/0/000/ 015/369/RBMInfosheet-4.htm. Accessed 09 December 2013
3. Desai M, Ter Kuile FO, Nosten F, et al. Epidemiology and burden in malaria in pregnancy. Lancet Infect Dis 2007; 7:93-104
4. Taylor WR, Hanson J, Turner GD, White NJ, Dondorp AM. Respiratory manifestations of malaria. Chest 2012; 142:492-505
5. Ali AA, Elhassan EM, Magzoub MM, Elbashir MI, Adam I. Hypoglycaemia and severe Plasmodium falciparum malaria among pregnant Sudanese women in an area characterized by unstable malaria transmission. Parasit Vectors 2011; 4:88
6. Adam I, Khamis AH, Elbashir MI. Prevalence and risk factors for Plasmodium falciparum malaria in pregnant women of eastern Sudan. Malar J 2005; 4:18
7. Rogerson SJ, Tembenu R, Dobano C, Plitt S, Taylor TE, Molyneux ME. Cytoadherence characteristics of Plasmodium falciparum-infected erythrocytes from Malawian children with severe and uncomplicated malaria. Am J Trop Med Hyg 1999; 61:467-72
8. Wassmer SC, Combes V, Grau GE. Pathophysiology of cerebral malaria: Role of host cells in the modulation of cytoadhesion. Ann N Y Acad Sci 2003; 992:30-8
9. Fried M, Duffy PE. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta. Science 1996; 272:1502-4
10. Salanti A, Dahlback M, Turner L, et al. Evidence for the involvement of VAR2CSA in pregnancy-Associated malaria. J Exp Med 2004; 200:1197-203
11. Mayor A, Rovira-Vallbona E, Machevo S, et al. Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy. Infect Immun 2011; 79:1654-9
12. Feng G, Aitken E, Yosaatmadja F, et al. Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes are associated with protection from treatment failure and the development of anemia in pregnancy. J Infect Dis 2009; 200:299-306
13. Duffy PE, Fried M. Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns. Infect Immun 2003; 71:6620-3
14. Angulo I, Fresno M. Cytokines in the pathogenesis of and protection against malaria. Clin Diagn Lab Immunol 2002; 9:1145-52
15. Othoro C, Lal AA, Nahlen B, Koech D, Orago AS, Udhayakumar V. A low interleukin-10 tumor necrosis factor-Alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya. J Infect Dis 1999; 179:279-82
16. WHO. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 2000; 94 (Suppl 1):S1-90
17. Aitken EH, Mbewe B, Luntamo M, et al. Antibodies to Chondroitin Sulfate A-Binding Infected Erythrocytes: Dynamics and Protection during Pregnancy in Women Receiving Intermittent Preventive Treatment. JID 2010; 201:1316-25
18. Ataíde R, HasangW, Wilson DW, et al. Using an Improved Phagocytosis Assay to Evaluate the Effect of HIV on Specific Antibodies to Pregnancy-Associated Malaria. PLoS one 2010; 5:e10807
19. Nosten F, Rogerson SJ, Beeson JG, McGready R, Mutabingwa TK, Brabin B. Malaria in pregnancy and the endemicity spectrum: What can we learn? Trends Parasitol 2004; 20:425-32
20. O'Neil-Dunne I, Achur RN, Agbor-Enoh ST, et al. Graviditydependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancy. Infect Immun 2001; 69:7487-92
21. Jaworowski A, Fernandes LA, Yosaatmadja F, et al. Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-Associated malaria. Clin Vaccine Immunol 2009; 16:312-9
22. Adam I, Ali DM, Elbashir MI. Manifestations of falciparum malaria in pregnant women of Eastern Sudan. Saudi Med J 2004; 25:1947-50
23. Fried M, Nosten F, Brockman A, Brabin BJ, Duffy PE. Maternal antibodies block malaria. Nature 1998; 395:851-852
24. Fernandez P, Petres S, Mecheri S, Gysin J, Scherf A. Strain-Transcendent immune response to recombinant Var2CSA DBL5-epsilon domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions. PLoS One 2010; 5:e12558
25. Brolin KJ, Persson KE, Wahlgren M, Rogerson SJ, Chen Q. Differential recognition of P. falciparum VAR2CSA domains by naturally acquired antibodies in pregnant women from a malaria endemic area. PLoS One 2010; 5:e9230
26. Tutterrow YL, Avril M, Singh K, et al. High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in Cameroonian women living in an area of high Plasmodium falciparum transmission. Infect Immun, 2012; 80:1479-90
27. Keen J, Serghides L, Ayi K, et al. HIV impairs opsonic phagocytic clearance of pregnancy-Associated malaria parasites. PLoSMed 2007; 4:e181
28. Tutterrow YL, Salanti A, Avril M, et al. High avidity antibodies to fulllength VAR2CSA correlate with absence of placental malaria. PLoS One 2012; 7:e40049
29. Oleinikov AV, Voronkova VV, Frye IT, et al. A plasma survey using 38 PfEMP1 domains reveals frequent recognition of the Plasmodium falciparum antigen VAR2CSA among young Tanzanian children. PLoS One 2012; 7:e31011
30. Dong C, Flavell RA. Th1 and Th2 cells. Curr Opin Hematol 2001; 8:47-51
31. Day NP, Hien TT, Schollaardt T, et al. The prognostic and pathophysiologic role of pro-And antiinflammatory cytokines in severe malaria. J Infect Dis 1999; 180:1288-97
32. Rovira-Vallbona E, Moncunill G, Bassat Q, et al. Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: A case-control study. Malar J 2012; 11:181
33. D'Alessandro U, Ubben D, Hamed K, et al. Malaria in infants aged less than six months-is it an area of unmet medical need? Malar J 2012; 11:400
34. DeWaal MR, Abrams J, Bennett B, Figdor CG, De Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 17:1209-20
35. Kabyemela ER, Muehlenbachs A, Fried M, Kurtis JD, Mutabingwa TK, Duffy PE. Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria. Malar J 2008; 7: 26
36. Staalsoe T, Shulman CE, Bulmer JN, Kawuondo K, Marsh K, Hviid L. Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-Associated Plasmodium falciparum malaria. Lancet 2004; 9405:283-9.