High levels of antibodies to multiple domains and strains of VAR2CSA correlate with the absence of placental malaria in cameroonian women living in an area of high Plasmodium falciparum transmission

Infection and Immunity

Volumn 80, Issue 4, 2012, Pages 1479-1490

  Tutterrow, Yeung L ^a   Avril, Marion ^b   Singh, Kavita ^c   Long, Carole A ^d   Leke, Robert J ^e   Sama, Grace ^e   Salanti, Ali ^f,g   Smith, Joseph D ^b   Leke, Rose G F ^e   Taylor, Diane W ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c Research Technologies Branch   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN SULFATE; DUFFY BINDING PROTEIN; PARASITE ANTIGEN; PROTOZOON ANTIBODY; UNCLASSIFIED DRUG; VARIANT SURFACE ANTIGEN 2 CHONDROITIN SULFATE A; PROTOZOAL PROTEIN; VAR2CSA PROTEIN, PLASMODIUM FALCIPARUM;

ADULT; ALLELE; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CAMEROON; COHORT ANALYSIS; ERYTHROCYTE; FEMALE; FIRST TRIMESTER PREGNANCY; GENE FREQUENCY; GENETIC VARIABILITY; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; NUCLEOTIDE SEQUENCE; PARASITE TRANSMISSION; PLACENTA MALARIA; PLASMODIUM FALCIPARUM; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DOMAIN; SECOND TRIMESTER PREGNANCY; BLOOD; DISEASE TRANSMISSION; IMMUNOLOGY; PARASITOLOGY; PLACENTA; PLACENTA DISORDER; PREGNANCY; PREGNANCY COMPLICATION;

ADULT; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CAMEROON; FEMALE; HUMANS; MALARIA, FALCIPARUM; PLACENTA; PLACENTA DISEASES; PLASMODIUM FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PROTOZOAN PROTEINS; YOUNG ADULT;

EID: 84860797933     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00071-12     Document Type: Article

References (56)

1. Achur RN, Valiyaveettil M, Alkhalil A, Ockenhouse CF, Gowda DC. 2000. Characterization of proteoglycans of human placenta and identification of unique chondroitin sulfate proteoglycans of the intervillous spaces that mediate the adherence of Plasmodium falciparum-infected erythrocytes to the placenta. J. Biol. Chem. 275:40344-40356.
2. Agbor-Enoh ST, et al. 2003. Chondroitin sulfate proteoglycan expression and binding of Plasmodium falciparum-infected erythrocytes in the human placenta during pregnancy. Infect. Immun. 71:2455-2461.
3. Aitken EH, et al. 2010. Antibodies to chondroitin sulfate A-binding infected erythrocytes: dynamics and protection during pregnancy in women receiving intermittent preventive treatment. J. Infect. Dis. 201: 1316-1325.
4. Albiti AH, Adam I, Ghouth AS. 2010. Placental malaria, anaemia and low birthweight in Yemen. Trans. R. Soc. Trop. Med. Hyg. 104:191-194.
5. Andersen P, et al. 2008. Structural insight into epitopes in the pregnancyassociated malaria protein VAR2CSA. PLoS Pathog. 4:e42.
6. Aribodor DN, et al. 2009. Association of low birth weight and placental malarial infection in Nigeria. J. Infect. Dev. Ctries. 3:620-623.
7. Avril M, et al. 2010. Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes. Infect. Immun. 78:2248-2256.
8. Avril M, Cartwright MM, Hathaway MJ, Smith JD. 2011. Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins. Malar. J. 10:36.
9. Avril M, et al. 2009. Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris. Malar. J. 8:143.
10. Avril M, et al. 2008. Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA. Infect. Immun. 76:1791-1800.
11. Bardají A, et al. 2011. Impact of malaria at the end of pregnancy on infant mortality and morbidity. J. Infect. Dis. 203:691-699.
12. Barfod L, et al. 2007. Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA. Mol. Microbiol. 63:335-347.
13. Barfod L, et al. 2010. Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants. J. Immunol. 185:7553-7561.
14. Beeson JG, et al. 2007. Antibodies among men and children to placentalbinding Plasmodium falciparum-infected erythrocytes that express var2csa. Am. J. Trop. Med. Hyg. 77:22-28.
15. Beeson JG, et al. 2004. Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets. J. Infect. Dis. 189:540-551.
16. Black RE, et al. 2010. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 375:1969-1987.
17. Bockhorst J, et al. 2007. Structural polymorphism and diversifying selection on the pregnancy malaria vaccine candidate VAR2CSA. Mol. Biochem. Parasitol. 155:103-112.
18. Brabin BJ. 1983. An analysis of malaria in pregnancy in Africa. Bull. World Health Organ. 61:1005-1016.
19. Brabin BJ, et al. 2004. The sick placenta-the role of malaria. Placenta 25:359-378.
20. Duffy PE, Fried M. 2003. Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns. Infect. Immun. 71:6620-6623.
21. Fievet N, et al. 2006. Acquisition of antibodies to variant antigens on the surface of Plasmodium falciparum-infected erythrocytes during pregnancy. Infect. Genet. Evol. 6:459-463.
22. Fouda GG, et al. 2006. Multiplex assay for simultaneous measurement of antibodies to multiple Plasmodium falciparum antigens. Clin. Vaccine Immunol. 13:1307-1313.
23. Fried M, Nosten F, Brockman A, Brabin BJ, Duffy PE. 1998. Maternal antibodies block malaria. Nature 395:851-852.
24. Fried M, Domingo GJ, Gowda CD, Mutabingwa TK, Duffy PE. 2006. Plasmodium falciparum: chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta. Exp. Parasitol. 113: 36-42.
25. Guyatt HL, Snow RW. 2001. Malaria in pregnancy as an indirect cause of infant mortality in sub-Saharan Africa. Trans. R. Soc. Trop. Med. Hyg. 95:569-576.
26. Gysin J, Pouvelle B, Fievet N, Scherf A, Lépolard C. 1999. Ex vivo desequestration of Plasmodium falciparum-infected erythrocytes from human placenta by chondroitin sulfate A. Infect. Immun. 67:6596-6602.
27. Hartman TK, Rogerson SJ, Fischer PR. 2010. The impact of maternal malaria on newborns. Ann. Trop. Paediatr. 30:271-282.
28. Hayes B, Sharif F. 2009. Behavioural and emotional outcome of very low birth weight infants-literature review. J. Matern. Fetal. Neonatal. Med. 22:849-856.
29. Kalilani L, Mofolo I, Chaponda M, Rogerson SJ, Meshnick SR. 2010. The effect of timing and frequency of Plasmodium falciparum infection during pregnancy on the risk of low birth weight and maternal anemia. Trans. R. Soc. Trop. Med. Hyg. 104:416-422.
30. Kanaka-Gantenbein C. 2010. Fetal origins of adult diabetes. Ann. N. Y. Acad. Sci. 1205:99-105.
31. Khattab A, et al. 2004. Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolates. Malar. J. 3:21.
32. Kraemer SM, Smith JD. 2006. A family affair: var genes, PfEMP1 binding, and malaria disease. Curr. Opin. Microbiol. 9:374-380.
33. Leke RFG, et al. 2010. Longitudinal studies of Plasmodium falciparum malaria in pregnant women living in a rural Cameroonian village with high perennial transmission. Am. J. Trop. Med. Hyg. 83:996-1004.
34. Manga L, Robert V, Mess J, Desfontaine M, Carnevale P. 1992. Le paludisme urbain a Yaounde, Cameroon: l'etude entomologique dans duex quartiers centraux. Mem. Soc. R. Belg Entomol. 35:155-162.
35. Maubert B, Fievet N, Tami G, Boudin C, Deloron P. 2000. Cytoadherence of Plasmodium falciparum-infected erythrocytes in the human placenta. Parasite Immunol. 22:191-199.
36. McCormick MC. 1985. The contribution of low birth weight to infant mortality and childhood morbidity. N. Engl. J. Med. 312:82-90.
37. McGregor IA. 1984. Epidemiology, malaria and pregnancy. Am. J. Trop. Med. Hyg. 33:517-525.
38. McGregor IA, Wilson ME, Billewicz WZ. 1983. Malaria infection of the placenta in The Gambia, West Africa; its incidence and relationship to stillbirth, birthweight and placental weight. Trans. R. Soc. Trop. Med. Hyg. 77:232-244.
39. Mu J, et al. 2005. Recombination hotspots and population structure in Plasmodium falciparum. PLoS Biol. 3:e335.
40. Muthusamy A, et al. 2004. Plasmodium falciparum-infected erythrocytes adhere both in the intervillous space and on the villous surface of human placenta by binding to the low-sulfated chondroitin sulfate proteoglycan receptor. Am. J. Pathol. 164:2013-2025.
41. Nielsen MA, et al. 2009. Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSA. Infect. Immun. 77:2482-2487.
42. Nogueira PA, Wunderlich G, Pereira da Silva LH. 2001. Variant antigens of Plasmodium falciparum encoded by the var multigenic family are multifunctional macromolecules. Res. Microbiol. 152:141-147.
43. Nomura Y, et al. 2007. Low birth weight and risk of affective disorders and selected medical illness in offspring at high and low risk for depression. Compr. Psychiatry. 48:470-478.
44. O'Neil-Dunne I, et al. 2001. Gravidity-dependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancy. Infect. Immun. 69:7487-7492.
45. Salanti A, et al. 2004. Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. J. Exp. Med. 200:1197-1203.
46. Salanti A, et al. 2003. Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria. Mol. Microbiol. 49:179-191.
47. Sander AF, et al. 2011. Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women. J. Infect. Dis. 203:1679-1685.
48. Sartelet H, et al. 1999. Quantitative computer image analysis of chondroitin sulfate A expression in placentas infected with Plasmodium falciparum. J. Histochem. Cytochem. 47:751-756.
49. Schwarz NG, et al. 2008. Placental malaria increases malaria risk in the first 30 months of life. Clin. Infect. Dis. 47:1017-1025.
50. Singh K, et al. 2008. Structure of the DBL3x domain of pregnancyassociated malaria protein VAR2CSA complexed with chondroitin sulfate A. Nat. Struct. Mol. Biol. 15:932-938.
51. Staalsoe T, et al. 2004. Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria. Lancet 363:283-289.
52. Steketee RW, Campbell CC. 2010. Impact of national malaria control scale-up programmes in Africa: magnitude and attribution of effects. Malar. J. 9:299.
53. Trimnell AR, et al. 2006. Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria. Mol. Biochem. Parasitol. 148:169-180.
54. Tuikue Ndam NG, et al. 2006. Dynamics of anti-VAR2CSA immunoglobulin G response in a cohort of Senegalese pregnant women. J. Infect. Dis. 193:713-720.
55. Were FN, Bwibo NO. 2009. The contribution of very low birth weight deaths to infant mortality. East Afr. Med. J. 86:374-377.
56. World Health Organization. 2009. World Malaria Report 2009. World Health Organization, Geneva, Switzerland.