Malaria in infants aged less than six months - Is it an area of unmet medical need?

Malaria Journal

Volumn 11, Issue , 2012, Pages

  D'Alessandro, Umberto ^a,b   Ubben, David ^c   Hamed, Kamal ^d   Ceesay, Serign Jawo ^a   Okebe, Joseph ^a   Taal, Makie ^e   Lama, Eugene Kaman ^f   Keita, Moussa ^f   Koivogui, Lamine ^f   Nahum, Alain ^g   Bojang, Kalifa ^a   Sonko, Aja Adam Jagne ^e   Lalya, Honorat Francis ^h   Brabin, Bernard ⁱ  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^c Switzerland   (Switzerland)

^d NOVARTIS PHARMA AG   (Switzerland)

^e MINISTRY OF HEALTH AND SOCIAL WELFARE   (Gambia)

^f Ministry of Health   (Equatorial Guinea)

^g Centre de Recherches Entomologiques de Cotonou (CREC)   (Benin)

^h Centre National Hospitalier Universitaire Hubert K Maga   (Benin)

ⁱ LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Artemisinin based combination therapy; Congenital; Malaria; Neonate; Parasitaemia; Prevalence

Indexed keywords

ANTIMALARIAL AGENT;

ANEMIA; CONVULSION; CYANOSIS; DIARRHEA; DISEASE TRANSMISSION; DROWSINESS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG METABOLISM; FEEDING DISORDER; FEVER; HEPATOMEGALY; HUMAN; IMMUNIZATION; INCIDENCE; INFECTION PREVENTION; JAUNDICE; MALARIA; PALLOR; PLACENTA; PREVALENCE; RESPIRATORY DISTRESS; RESTLESSNESS; REVIEW; RISK REDUCTION; SPLENOMEGALY; SYSTEMATIC REVIEW (TOPIC); THIRD TRIMESTER PREGNANCY; UMBILICAL CORD BLOOD; UNSPECIFIED SIDE EFFECT; VOMITING;

ANTIMALARIALS; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MALARIA; PREVALENCE;

EID: 84870225441     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-400     Document Type: Review

References (73)

1. WHO, World malaria report World Health Organization, Geneva 2011
2. The analysis of malaria parasite rates in infants. Macdonald G, Trop Dis Bull 1950 47 915 938 14798657
3. Application of malariometric data obtained from longitudinal studies on infants in northern Nigeria. Foll CV, Bull World Health Organ 1968 38 255 265 5302301
4. Malaria in nyasaland: (section of tropical diseases and parasitology). Thomson JG, Proc R Soc Med 1935 28 391 404 19990138
5. An analysis of malaria parasite rates in infants: 40 years after Macdonald. Brabin B, Trop Dis Bull 1990 87 1 21
6. The serological response to primary malaria infection in urban Ghanaian infants. Biggar RJ, Collins WE, Campbell CC, AmJTrop Med Hyg 1980 29 720 724
7. A seroepidemiological study to evaluate the role of passive maternal immunity to malaria in infants. Sehgal VM, Siddjiqui WA, Alpers MP, Trans R Soc Trop Med Hyg 1989 83 Suppl 105 106 2696154 (Pubitemid 20003639)
8. Malaria and newborns. Fischer PR, J Trop Pediatr 2003 49 132 134 10.1093/tropej/49.3.132 12848200 (Pubitemid 36789798)
9. Malaria in the first 6 months of life in urban African infants with anemia. Afolabi BM, Salako LA, Mafe AG, Ovwigho UB, Rabiu KA, Sanyaolu NO, Ibrahim MM, AmJTrop Med Hyg 2001 65 822 827 (Pubitemid 34049478)
10. Do maternally acquired antibodies protect infants from malaria infection? Riley EM, Wagner GE, Akanmori BD, Koram KA, Parasite Immunol 2001 23 51 59 10.1046/j.1365-3024.2001.00364.x 11240896 (Pubitemid 32231907)
11. Lack of association between maternal antibody and protection of African infants from malaria infection. Riley EM, Wagner GE, Ofori MF, Wheeler JG, Akanmori BD, Tetteh K, McGuinness D, Bennett S, Nkrumah FK, Anders RF, Koram KA, Infect Immun 2000 68 5856 5863 10.1128/IAI.68.10.5856-5863.2000 10992495
12. Acquired immunity to malaria. Doolan DL, Dobano C, Baird JK, Clin Microbiol Rev 2009 22 13 36 Table 10.1128/CMR.00025-08 19136431
13. Inhibitory factors in breastmilk, maternal and infant sera against in vitro growth of Plasmodium falciparum malaria parasite. Kassim OO, Ako-Anai KA, Torimiro SE, Hollowell GP, Okoye VC, Martin SK, J Trop Pediatr 2000 46 92 96 10.1093/tropej/46.2.92 10822935 (Pubitemid 30232544)
14. Malaria in pregnancy: clinical, therapeutic and prophylactic considerations. Gitau GM, Eldred JM, Obstet Gynaecol 2005 7 5 11 10.1576/toag.7.1.005.27036
15. A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. Amaratunga C, Lopera-Mesa TM, Brittain NJ, Cholera R, Arie T, Fujioka H, Keefer JR, Fairhurst RM, PLoS One 2011 6 14798 10.1371/journal.pone.0014798 21532754
16. Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Gwamaka M, Kurtis JD, Sorensen BE, Holte S, Morrison R, Mutabingwa TK, Fried M, Duffy PE, Clin Infect Dis 2012 54 1137 1144 10.1093/cid/cis010 22354919
17. Impact of malaria at the end of pregnancy on infant mortality and morbidity. Bardaji A, Sigauque B, Sanz S, Maixenchs M, Ordi J, Aponte JJ, Mabunda S, Alonso PL, Menéndez C, J Infect Dis 2011 203 691 699 10.1093/infdis/jiq049 21199881
18. Placental malaria increases malaria risk in the first 30 months of life. Schwarz NG, Adegnika AA, Breitling LP, Gabor J, Agnandji ST, Newman RD, Lell B, Issifou S, Yazdanbakhsh M, Luty AJ, Kremsner PG, Grobusch MP, Clin Infect Dis 2008 47 1017 1025 10.1086/591968 18781874
19. Can prenatal malaria exposure produce an immune tolerant phenotype? A prospective birth cohort study in Kenya. Malhotra I, Dent A, Mungai P, Wamachi A, Ouma JH, Narum DL, Muchiri E, Tisch DJ, King CL, PLoS Med 2009 6 1000116 10.1371/journal.pmed.1000116 19636353
20. Epidemiology of congenital malaria in Nigeria: a multi-centre study. Falade C, Mokuolu O, Okafor H, Orogade A, Falade A, Adedoyin O, Oguonu T, Aisha M, Hamer DH, Callahan MV, Trop Med Int Health 2007 12 1279 1287 10.1111/j.1365-3156.2007.01931.x 17956542 (Pubitemid 350191140)
21. The growing incidence of neonatal malaria-a situational review in developing countries. Mukhtar M, Niger J Med 2007 16 25 30 17563964
22. Congenital malaria in twins. Fischer PR, Nyirjesy P, Toko RM, West J Med 1995 163 395 396 7483614
23. Congenital malaria: an African survey. Fischer PR, Clin Pediatr (Phila) 1997 36 411 413 10.1177/000992289703600706 (Pubitemid 27297595)
24. Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants. Kamwendo DD, Dzinjalamala FK, Snounou G, Kanjala MC, Mhango CG, Molyneux ME, Rogerson SJ, Trans R Soc Trop Med Hyg 2002 96 145 149 10.1016/S0035-9203(02)90284-1 12055802 (Pubitemid 34846556)
25. Congenital and neonatal malaria in a rural Kenyan district hospital: an eight-year analysis. Mwaniki MK, Talbert AW, Mturi FN, Berkley JA, Kager P, Marsh K, Newton CR, Malar J 2010 9 313 10.1186/1475-2875-9-313 21054891
26. [Congenital and neonatal malaria in sub-sahara Africa, a scarce event?]. Dicko-Traoré F, Syla M, Djimde AA, Diakité AA, Diawara M, Togo B, Togo P, Dara A, Dama S, Traoré K, Traoré S, Sissoko S, Poudiougo B, Sidibé T, Keita MM, Doumbo O, J Pediatr Pueric 2011 24 57 61
27. Malaria and asymptomatic parasitaemia in Gabonese infants under the age of 3 months. Klein Klouwenberg PM, Oyakhirome S, Schwarz NG, Glaser B, Issifou S, Kiessling G, Klöpfer A, Kremsner PG, Längin M, Lassmann B, Necek M, Pötschke M, Ritz A, Grobusch MP, Acta Trop 2005 95 81 85 10.1016/j.actatropica.2005.05.003 15950165 (Pubitemid 40943357)
28. Malaria in infants below six months of age: retrospective surveillance of hospital admission records in Blantyre. Malawi. Larru B, Molyneux E, ter Kuile FO, Taylor T, Molyneux M, Terlouw DJ, Malar J 2009 8 310 10.1186/1475-2875-8-310 20038299
29. Malaria parasitaemia among infants and its association with breastfeeding peer counselling and vitamin A supplementation: a secondary analysis of a cluster randomized trial. Nankabirwa V, Tylleskar T, Nankunda J, Engebretsen IM, Sommerfelt H, Tumwine JK, PLoS One 2011 6 21862 10.1371/journal.pone.0021862 21760916
30. Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital. Kenya. Pedro R, Akech S, Fegan G, Maitland K, Malar J 2010 9 307 10.1186/1475-2875-9-307 21034494
31. Neonatal malaria in Nigeria-a 2 year review. Runsewe-Abiodun IT, Ogunfowora OB, Fetuga BM, BMC Pediatr 2006 6 19 10.1186/1471-2431-6-19 16768801 (Pubitemid 44151453)
32. HIV, malaria, and infant anemia as risk factors for postneonatal infant mortality among HIV-seropositive women in Kisumu. Kenya. van Eijk AM, Ayisi JG, ter Kuile FO, Slutsker L, Shi YP, Udhayakumar V, Otieno JA, Kager PA, Lal RB, Steketee RW, Nahlen BL, J Infect Dis 2007 196 30 37 10.1086/518441 17538880 (Pubitemid 46982734)
33. Severe malaria in neonates masquerading as septicaemia. Ojukwu JU, Ezeonu CT, Ogbu CN, Nigerian J Paediatr 2004 31 48 55
34. Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa. Abdullah S, Adazu K, Masanja H, Diallo D, Hodgson A, Ilboudo-Sanogo E, Nhacolo A, Owusu-Agyei S, Thompson R, Smith T, Binka FN, AmJTrop Med Hyg 2007 77 99 105
35. Newborn splenic volumes vary under different malaria endemic conditions. Corkill JA, Brabin BJ, MacGregor DF, Alpers MP, Milner RD, Arch Dis Child 1989 64 541 545 10.1136/adc.64.4.541 2665658 (Pubitemid 19104113)
36. Malaria in rural Mozambique. Part I: children attending the outpatient clinic. Guinovart C, Bassat Q, Sigauque B, Aide P, Sacarlal J, Nhampossa T, Bardají A, Nhacolo A, Macete E, Mandomando I, Aponte JJ, Menéndez C, Alonso PL, Malar J 2008 7 36 10.1186/1475-2875-7-36 18302770 (Pubitemid 351417046)
37. [Epidemiological study of the malaria at the neonatal period in the teaching hospital of Yopougon-Republic of Cote d'Ivoire] (in French). Adja EA, Dick FA, N'guessan R, Mali Med 2009 24 36 39 20093219
38. The prevalence of congenital malaria among neonates with suspected sepsis in Calabar. Nigeria. Ekanem AD, Anah MU, Udo JJ, Trop Doct 2008 38 73 76 10.1258/td.2007.005274 18453488
39. Clinical characteristics of neonatal malaria. Ibhanesebhor SE, J Trop Pediatr 1995 41 330 333 10.1093/tropej/41.6.330 8606438 (Pubitemid 26020161)
40. Clinical presentation of congenital malaria at the Lagos university teaching hospital. Lesi FE, Mukhtar MY, Iroha EU, Egri-Okwaji MT, Niger J Clin Pract 2010 13 134 138 20499743
41. Prevalence of congenital malaria among neonates at morogoro regional hospital, morogoro. Tanzania. Mosha TCE, Ntarukimana D, John M, Tanzania J Health Res 2010 12 1 10
42. Congenital malaria among inborn babies at a tertiary centre in Lagos. Nigeria. Mukhtar MY, Lesi FE, Iroha EU, Egri-Okwaji MT, Mafe AG, J Trop Pediatr 2006 52 19 23 10.1093/tropej/fmi044 15927946 (Pubitemid 43174772)
43. Congenital Plasmodium falciparum infection in neonates in Muheza District. Tanzania. Mwangoka GW, Kimera SI, Mboera LE, Malar J 2008 7 117 10.1186/1475-2875-7-117 18598342 (Pubitemid 352019982)
44. Prevalence of congenital malaria in Ile-ife. Nigeria. Obiajunwa PO, Owa JA, Adeodu OO, J Trop Pediatr 2005 51 219 222 10.1093/tropej/fmi003 15980030 (Pubitemid 41444440)
45. Congenital malaria in Calabar, Nigeria: the molecular perspective. Oduwole OA, Ejezie GC, Odey FA, Oringanje CM, Nwakanma D, Bello S, Oriero E, Okebe J, Alaribe AA, Etuk S, Meremikwu M, AmJTrop Med Hyg 2011 84 386 389 10.4269/ajtmh.2011.10-0253
46. Risk factors associated with congenital malaria in Enugu. South eastern Nigeria. Okafor UH, Oguonu T, Onah HE, J Obstet Gynaecol 2006 26 612 616 10.1080/09638280600902893 17071423 (Pubitemid 44663870)
47. Congenital malaria among newborns admitted for suspected neonatal sepsis in Abuja. Okechukwu AA, Olateju EK, Olutunde EO, Nigerian J Paediatr 2011 38 82 89
48. Prevalence of congenital malaria in Minna, north central Nigeria. Omalu IC, Mgbemena C, Mgbemena A, Ayanwale V, Olayemi IK, Lateef A, Chukwuemeka VI, J Trop Med 2012 201 2 274142
49. Clinical and laboratory features of congenital malaria in Nigeria. Orogade AA, Falade CO, Okafor HU, Mokuolu OA, Mamman AI, Ogbonu TA, Ogunkunle OO, Ernest KS, Callahan MV, Hamer DH, J Pediatr Infect Dis 2008 3 181 187
50. Congenital malaria in Uraba. Colombia. Pineros-Jimenez JG, Alvarez G, Tobon A, Arboleda M, Carrero S, Blair S, Malar J 2011 10 239 10.1186/1475-2875-10-239 21846373
51. Impact of asymptomatic maternal malaria parasitaemia at parturition on perinatal outcome. Sule-Odu AO, Ogunledun A, Olatunji AO, J Obstet Gynaecol 2002 22 25 28 10.1080/01443610120101664 12521723 (Pubitemid 34151263)
52. Congenital malaria in a hyperendemic area. Larkin GL, Thuma PE, AmJTrop Med Hyg 1991 45 587 592
53. Congenital malaria in a hyperendemic area: a preliminary study. Akindele JA, Sowunmi A, Abohweyere AE, Ann Trop Paediatr 1993 13 273 276 7505553 (Pubitemid 23293906)
54. High incidence of asymptomatic malara infections in a birth cohort of children less than one year of age in Ghana, detected by multicopy gene polymerase chain reaction. Wagner G, Koram K, McGuinness D, Bennett S, Nkrumah F, Riley E, AmJTrop Med Hyg 1998 59 115 123 (Pubitemid 28304807)
55. Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis. Carneiro I, Roca-Feltrer A, Griffin JT, Smith L, Tanner M, Schellenberg JA, Greenwood B, Schellenberg D, PLoS One 2010 5 8988 10.1371/journal.pone.0008988 20126547
56. Congenital malaria in a neonate. Hashemzadeh A, Heydarian F, Arch Iranian Med 2005 8 226 228 (Pubitemid 40903475)
57. Laboratory malaria diagnostic capacity in health facilities in five administrative zones of oromia regional state. Ethiopia. Hailegiorgis B, Girma S, Melaku Z, Teshi T, Demeke L, Gebresellasie S, Yadeta D, Tibesso G, Whitehurst N, Yamo E, Carter J, Reithinger R, Trop Med Int Health 2010 15 1449 1457 10.1111/j.1365-3156.2010.02646.x 21040254
58. The performance of health laboratories and the quality of malaria diagnosis in six districts of Tanzania. Ishengoma DR, Derua YA, Rwegoshora RT, Tenu F, Massaga JJ, Mboera LE, Magesa SM, Ann Trop Med Parasitol 2010 104 123 135 10.1179/136485910X12607012373993 20406579
59. Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence? Uneke CJ, Parasitol Res 2007 101 835 842 10.1007/s00436-007-0577-9 17549517 (Pubitemid 47228812)
60. 4 million neonatal deaths: when? Where? Why? Lawn JE, Cousens S, Zupan J, Lancet 2005 365 891 900 10.1016/S0140-6736(05)71048-5 15752534 (Pubitemid 40332168)
61. A 10 year study of the cause of death in children under 15 years in Manhica. Mozambique. Sacarlal J, Nhacolo AQ, Sigauque B, Nhalungo DA, Abacassamo F, Sacoor CN, Aide P, Machevo S, Nhampossa T, Macete EV, Bassat Q, David C, Bardají A, Letang E, Saúte F, Aponte JJ, Thompson R, Alonso PL, BMC Publ Health 2009 9 67 10.1186/1471-2458-9-67
62. Developmental pharmacology-drug disposition, action, and therapy in infants and children. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE, N Engl J Med 2003 349 1157 1167 10.1056/NEJMra035092 13679531 (Pubitemid 37122329)
63. WHO, Guidelines for the treatment of Malaria World Health Organization, Geneva, Switzerland Second 2010
64. Pharmacokinetics in the infant. Milsap RL, Jusko WJ, Environ Health Perspect 1994 102 Suppl 11 107 110 10.1289/ehp.94102s11107 7737034
65. Congenital malaria: the least known consequence of malaria in pregnancy. Menendez C, Mayor A, Semin Fetal Neonatal Med 2007 12 207 213 10.1016/j.siny.2007.01.018 17483042 (Pubitemid 46680526)
66. Analysis of the effects of malaria chemoprophylaxis in children on haematological responses, morbidity and mortality. Geerligs PD, Brabin BJ, Eggelte TA, Bull World Health Organ 2003 81 205 216 12764517 (Pubitemid 36372959)
67. Effects of heavy and repeated malarial infections on Gambian infants and children; effects of erythrocytic parasitization. McGregor IA, Gilles HM, Walters JH, Davies AH, Pearson FA, BMJ 1956 2 686 692 10.1136/bmj.2.4994.686 13356045
68. Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials. Aponte JJ, Schellenberg D, Egan A, Breckenridge A, Carneiro I, Critchley J, Danquah I, Dodoo A, Kobbe R, Lell B, May J, Premji Z, Sanz S, Sevene E, Soulaymani-Becheikh R, Winstanley P, Adjei S, Anemana S, Chandramohan D, Issifou S, Mockenhaupt F, Owusu-Agyei S, Greenwood B, Grobusch MP, Kremsner PG, Macete E, Mshinda H, Newman RD, Slutsker L, Tanner M, Alonso P, Menendez C, Lancet 2009 374 1533 1542 10.1016/S0140-6736(09)61258-7 19765816
69. WHO Global Malaria Programme, WHO Policy Recommendation: Seasonal Malaria Chemoprevention (SMC) for Plasmodium falciparum malaria control in highly seasonal transmission areas of the Sahel sub-region in Africa 2012 http://www.who.int/malaria/publications/atoz/smc-policy-recommendation-en- 032012.pdf
70. The role of antimalarial treatment in the elimination of malaria. Gosling RD, Okell L, Mosha J, Chandramohan D, Clin Microbiol Infect 2011 17 1617 1623 10.1111/j.1469-0691.2011.03660.x 21951597
71. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. The RTS,S Clinical Trials Partnership, N Engl J Med 2012 10.1056/NEJMoa1208394
72. Malaria vaccine trials-beyond efficacy end points. Daily JP, N Engl J Med 2012 10.1056/NEJMe1213392
73. RTS,S Clinical Trials Partnership: First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. Agnandji ST, Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, Conzelmann C, Methogo BG, Doucka Y, Flamen A, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Nhamuave A, Quelhas D, Bassat Q, Mandjate S, Macete E, Alonso P, Abdulla S, Salim N, Juma O, Shomari M, Shubis K, Machera F, Hamad AS, Minja R, Mtoro A, Sykes A, Ahmed S, Urassa AM, Ali AM, Mwangoka G, Tanner M, Tinto H, D'Alessandro U, Sorgho H, Valea I, Tahita MC, Kaboré W, Ouédraogo S, Sandrine Y, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Odero C, Oneko M, Otieno K, Awino N, Omoto J, Williamson J, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Nekoye O, Gondi S, Otieno A, Ogutu B, Wasuna R, Owira V, Jones D, Onyango AA, Njuguna P, Chilengi R, Akoo P, Kerubo C, Gitaka J, Maingi C, Lang T, Olotu A, Tsofa B, Bejon P, Peshu N, Marsh K, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Ayamba S, Kayan K, Owusu-Ofori R, Dosoo D, Asante I, Adjei G, Adjei G, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Kilavo H, Mahende C, Liheluka E, Lemnge M, Theander T, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Agyekum A, Owusu L, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Msika A, Jumbe A, Chome N, Nyakuipa D, Chintedza J, Ballou WR, Bruls M, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Vekemans J, Carter T, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P, N Engl J Med 2011 365 1863 1875 22007715