Identification of predictive biomarkers of disease state in transition dairy cows

Journal of Dairy Science

Volumn 97, Issue 5, 2014, Pages 2680-2693

  Hailemariam, D ^a   Mandal, R ^b   Saleem, F ^b   Dunn, S M ^a   Wishart, D S ^b   Ametaj, B N ^a  

^a Department of Agricultural Food and Nutritional Science ^*  (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Dairy cow; Periparturient disease; Plasma metabolite; Predictive biomarker

Indexed keywords

BIOLOGICAL MARKER; CARNITINE; LYSOPHOSPHATIDYLCHOLINE; PROPIONYLCARNITINE;

ANALOGS AND DERIVATIVES; ANIMAL; BIRTH; BLOOD; BOVINE; CATTLE DISEASE; CROSS-SECTIONAL STUDY; FEMALE; LACTATION; LONGITUDINAL STUDY; PUERPERAL DISORDER; PUERPERIUM; VETERINARY;

ANIMALS; BIOMARKERS; CARNITINE; CATTLE; CATTLE DISEASES; CROSS-SECTIONAL STUDIES; FEMALE; LACTATION; LONGITUDINAL STUDIES; LYSOPHOSPHATIDYLCHOLINES; PARTURITION; POSTPARTUM PERIOD; PUERPERAL DISORDERS;

EID: 84898833441     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2013-6803     Document Type: Article

References (38)

1. Ametaj B.N., Zebeli Q., Iqbal S., Dunn S.M. Meeting the challenges of improving health in periparturient dairy cows. Adv. Dairy Technol 2012, 24:287-317.
2. Ametaj B.N., Zebeli Q., Saleem F., Psychogios N., Lewis M.J., Dunn S.M., Xia J., Wishart D.S. Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows. Metabolomics 2010, 6:583-594.
3. Bahado-Singh R.O., Akolekar R., Mandal R., Dong E., Xia J., Kruger M., Wishart D.S., Nicolaides K. Metabolomics and first-trimester prediction of early-onset preeclampsia. J. Matern. Fetal Neonatal Med 2012, 25:1840-1847.
4. Bahado-Singh R.O., Akolekar R., Mandal R., Dong E., Xia J., Kruger M., Wishart D.S., Nicolaides K. Metabolomic analysis for first-trimester Down syndrome prediction. Am. J. Obstet. Gynecol 2013, 208:371.
5. Bigras-Poulin M., Meek A.H., Martin S.W. Interrelationships among health problems and milk production from consecutive lactations in selected Ontario Holstein cows. Prev. Vet. Med 1990, 8:15-24.
6. Buch L.H., Sørensen A.C., Lassen J., Berg P., Eriksson J.Å., Jakobsen J.H., Sørensen M.K. Hygiene-related and feed-related hoof diseases show different patterns of genetic correlations to clinical mastitis and female fertility. J. Dairy Sci 2011, 94:1540-1551.
7. Guide to the Care and Use of Experimental Animals 1993, 1. Canadian Council on Animal Care, Canadian Council on Animal Care, Ottawa, ON, Canada.
8. Correa M.T., Erb H.N., Scarlett J. Path analysis for seven postpartum disorders of Holstein cows. J. Dairy Sci 1993, 76:1305-1312.
9. Curtis C.R., Erb H.N., Sniffen C.J., Smith R.D., Powers P.A., Smith M.C., White M.E., Hillman R.B., Pearson E.J. Association of parturient hypocalcemia with eight periparturient disorders in Holstein cows. J. Am. Vet. Med. Assoc 1983, 183:559-561.
10. Duan L., Gan H., Arm J., Remold H.G. Cytosolic phospholipase A2 participates with TNF-alpha in the induction of apoptosis of human macrophages infected with Mycobacterium tuberculosis H37Ra. J. Immunol 2001, 166:7469-7476.
11. Enjalbert F., Nicot M.C., Bayourthe C., Moncoulon R. Ketone bodies in milk and blood of dairy cows: Relationship between concentrations and utilization for detection of subclinical ketosis. J. Dairy Sci 2001, 84:583-589.
12. Frye R.E., Melnyk S., Macfabe D.F. Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Transl. Psychiatry 2013, 3:e220.
13. Guo Y., Wang X., Qiu L., Qin X., Liu H., Wang Y., Li F., Chen G., Song G., Guo S., Li Z. Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry. Clin. Chim. Acta 2012, 414:135-141.
14. Iuliano L., Pratico D., Ferro D., Pittoni V., Valesini G., Lawson J., FitzGerald G.A., Violi F. Enhanced lipid peroxidation in patients positive for antiphospholipid antibodies. Blood 1997, 90:3931-3935.
15. Jing Q., Xin S.M., Zhang W.B., Wang P., Qin Y.W., Pei G. Lysophosphatidylcholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis. Circ. Res 2000, 87:52-59.
16. Kabarowski J.H., Xu Y., Witte O.N. Lysophosphatidylcholine as a ligand for immunoregulation. Biochem. Pharmacol 2002, 64:161-167.
17. Klein M.S., Buttchereit N., Miemczyk S.P., Immervoll A.K., Louis C., Wiedemann S., Junge W., Thaller G., Oefner P.J., Gronwald W. NMR metabolomic analysis of dairy cows reveals milk glycerophosphocholine to phosphocholine ratio as prognostic biomarker for risk of ketosis. J. Proteome Res 2012, 11:1373-1381.
18. Kloosterman P. Laminitis-Prevention, diagnosis and treatment. Adv. Dairy Technol. 2007, 19:157-166.
19. Koh J.S., Wang Z., Levine J.S. Cytokine dysregulation induced by apoptotic cells is a shared characteristic of murine lupus. J. Immunol 2000, 165:4190-4201.
20. LeBlanc S. Monitoring metabolic health of dairy cattle in the transition period. J. Reprod. Dev 2010, 56(Suppl):S29-S35.
21. McKean M.L., Smith J.B., Silver M.J. Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid. J. Biol. Chem 1981, 256:1522-1524.
22. Ospina P.A., Nydam D.V., Stokol T., Overton T.R. Evaluation of nonesterified fatty acids and beta-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases. J. Dairy Sci 2010, 93:546-554.
23. Piechotta M., Sander A., Kastelic J., Wilde R., Heppelmann M., Rudolphi B., Schuberth H., Bollwein H., Kaske M. Short communication: Prepartum plasma insulin-like growth factor-I concentrations based on day of insemination are lower in cows developing postpartum diseases. J. Dairy Sci 2012, 95:1367-1370.
24. Roe D.S., Roe C.R., Brivet M., Sweetman L. Evidence for a short-chain carnitine-acylcarnitine translocase in mitochondria specifically related to the metabolism of branched-chain amino acids. Mol. Genet. Metab 2000, 69:69-75.
25. Romero F.I., Khamashta M.A., Hughes G.R. Lipoprotein(a) oxidation and autoantibodies: A new path in atherothrombosis. Lupus 2000, 9:206-209.
26. Saleem F., Ametaj B.N., Bouatra S., Mandal R., Zebeli Q., Dunn S.M., Wishart D.S. A metabolomics approach to uncover the effects of grain diets on rumen health in dairy cows. J. Dairy Sci 2012, 95:6606-6623.
27. Sampey B.P., Freemerman A.J., Zhang J., Kuan P.F., Galanko J.A., O'Connell T.M., Ilkayeva O.R., Muehlbauer M.J., Stevens R.D., Newgard C.B., Brauer H.A., Troester M.A., Makowski L. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS ONE 2012, 7:e38812.
28. Sheldon I.M., Lewis G.S., LeBlanc S., Gilbert R.O. Defining postpartum uterine disease in cattle. Theriogenology 2006, 65:1516-1530.
29. Stanley C.A., Hale D.E., Berry G.T., Deleeuw S., Boxer J., Bonnefont J.P. Brief report: A deficiency of carnitine-acylcarnitine translocase in the inner mitochondrial membrane. N. Engl. J. Med 1992, 327:19-23.
30. Sundekilde U.K., Frederiksen P.D., Clausen M.R., Larsen L.B., Bertram H.C. Relationship between the metabolite profile and technological properties of bovine milk from two dairy breeds elucidated by NMR-based metabolomics. J. Agric. Food Chem 2011, 59:7360-7367.
31. Sundekilde U.K., Poulsen N., Larsen L.B., Bertram H.C. Nuclear magnetic resonance metabonomics reveals strong association between milk metabolites and somatic cell count in bovine milk. J. Dairy Sci 2013, 96:290-299.
32. van der Kloet F.M., Tempels F.W., Ismail N., van der Heijden R., Kasper P.T., Rojas-Cherto M., van Doorn R., Spijksma G., Koek M., van der Greef J., Makinen V.P., Forsblom C., Holthofer H., Groop P.H., Reijmers T.H., Hankemeier T. Discovery of early stage biomarkers for diabetic kidney disease using ms-based metabolomics. Metabolomics 2012, 8:109-119.
33. Wishart D.S. Computational approaches to metabolomics. Methods Mol. Biol 2010, 593:283-313.
34. Xia J., Broadhurst D.I., Wilson M., Wishart D.S. Translational biomarker discovery in clinical metabolomics: An introductory tutorial. Metabolomics 2013, 9:280-299.
35. Xia J., Psychogios N., Young N., Wishart D.S. MetaboAnalyst: A web server for metabolomic data analysis and interpretation. Nucleic Acids Res 2009, 37:W652-W660.
36. 3-binding protein (group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages. J. Immunol 1991, 147:273-280.
37. Zadoks R.N., Middleton J.R., McDougall S., Katholm J., Schukken Y.H. Molecular epidemiology of mastitis pathogens of dairy cattle and comparative relevance to humans. J. Mammary Gland Biol. Neoplasia 2011, 16:357-372.
38. Zebeli Q., Dunn S.M., Ametaj B.N. Perturbations of plasma metabolites correlated with the rise of rumen endotoxin in dairy cows fed diets rich in easily degradable carbohydrates. J. Dairy Sci 2011, 94:2374-2382.