Thromboxane receptor α mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells

Lung Cancer

Volumn 69, Issue 1, 2010, Pages 26-32

  Wei, Jingyan ^a,b   Yan, Weili ^a   Li, Xiuling ^a   Ding, Yunfei ^a   Tai, Hsin Hsiung ^a  

^a University of Kentucky   (United States)

^b JILIN UNIVERSITY   (China)

Author keywords

Angiogenesis; Lung cancer; Signal transduction; Thromboxane receptor; Vascular endothelial growth factor

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; THROMBOXANE A2; THROMBOXANE RECEPTOR; THROMBOXANE RECEPTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; 7-(3-(3-HYDROXY-4-(4'-IODOPHENOXY)-1-BUTENYL)-7-OXABICYCLO(2.2.1)HEPTAN-2-YL)-5-HEPTENOIC ACID; FUSED HETEROCYCLIC RINGS; UNSATURATED FATTY ACID; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VASCULARIZATION; ADENOCARCINOMA; ANIMAL; BIOSYNTHESIS; CANCER TRANSPLANTATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; MOLECULAR CLONING; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PATHOLOGY; TRANSGENE; TUMOR CELL LINE; TUMOR VOLUME;

ADENOCARCINOMA; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TUMOR; CLONING, MOLECULAR; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, THROMBOXANE; SIGNAL TRANSDUCTION; TRANSGENES; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77953362012     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2009.09.009     Document Type: Article

References (40)

1. Folkman J., Shing Y. Angiogenesis. J Biol Chem 1992, 267:10931-10934.
2. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000, 6:389-395.
3. Ferrara N., Gerber H.P., LeCouter J. The biology of VEGF and its receptors. Nat Med 2003, 9:669-676.
4. Pertovaara L., Kaipainen A., Mustonen T., Orpana A., Ferrara N., Saksela D., et al. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem 1994, 269:6271-6274.
5. Tuder R., Flook B., Voelkel N. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. J Clin Invest 1995, 95:1798-1807.
6. Boussat S., Eddahibi S., Coste A., Fataccioli V., Gouge M., Housset B., et al. Expression and regulation of vascular endothelial growth factor in human pulmonary epithelial cells. Am J Physiol 2000, 279:L371-L378.
7. Bergers G., Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003, 3:401-410.
8. Hoper M.M., Voelkel N.F., Betes T.O., Allard J.D., Horan M., Shepherd D., et al. Prostaglandins induce vascular endothelial growth factor in a human monocytic cell line and rat lungs via cAMP. Am J Respir Cell Mol Biol 1997, 17:748-756.
9. 1 in osteoblasts. J Clin Invest 1994, 93:2490-2496.
10. Nie D., Krishnamoorthy S., Jin R., Tang K., Chen Y., Qiao Y., et al. Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. J Biol Chem 2006, 281:18601-18609.
11. Fujino H., Regan J.W. Prostanoid receptors and phosphatidyl inositol 3-kinase: a pathway to cancer?. Trends Pharmacol Sci 2003, 24:335-340.
12. Majima M., Amano H., Hayashi I. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends Pharmacol Sci 2003, 24:524-529.
13. Raychowdhury M.K., Yukawa M., Collins L.J., McGray S.H., Kent K.C., Ware J.A. Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane receptor. J Biol Chem 1994, 269:19256-19261.
14. Chen G.G., Lee T.W., Yip J.H.Y., Xu H., Lee I.K.Y., Mok T.S.K., et al. Increased thromboxane B2 levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma. Cancer Lett 2006, 234:193-198.
15. 2 receptor, TBXA2R, in human breast cancer. Int Semin Surg Oncol 2005, 2:23-30.
16. Moussa O., Yordy J.S., Abol-Enein H., Sinha D., Bissada N.K., Halushka P.V., et al. Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer. Cancer Res 2005, 65:11581-11587.
17. 2 synthase antithetically altered tumor angiogenesis and tumor growth. Cancer Res 2002, 62:63-66.
18. Yan W., Tai H.H. Glycogen synthase kinase-3 phosphorylation, T-cell factor signaling activation and cell morphology change following stimulation of thromboxane receptor α. J Pharmacol Exp Ther 2006, 317:267-274.
19. Wei J., Yan W., Li X., Chang W.C., Tai H.H. Activation of thromboxane receptor α induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cell. Biochem Pharmacol 2007, 74:787-800.
20. Zhou H.P., Yan F.X., Tai H.H. PhosphorylatIon and desensitization of the human thromboxane receptor by G protein-coupled receptor kinases. J Pharmacol Exp Ther 2001, 298:1243-1251.
21. Anderson P.H., Loughlin P.D.O., May B.K., Morris H.A. Quantitation of mRNA for vitamin D metabolic enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real time reverse transcriptase-polymerase chain reaction. J Mol Endocrinol 2003, 31:123-132.
22. +-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer. Carcinogenesis 2005, 26:65-72.
23. Morinelli T.A., Oatis J.E., Okwu A.K., Mais D.E., Mayeux P.R., Masuda A., et al. Characterization of a 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist. J Pharmacol Exp Ther 1989, 251:557-562.
24. 2 receptor. Mol Pharmacol 2002, 61:817-831.
25. Davies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000, 351:95-105.
26. Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst 1996, 82:4-6.
27. Takahashi Y., Tucker S.L., Kitadai Y., Koura A.N., Bucana C.D., Cleary K.R., et al. Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. Arch Surg 1997, 132:541-546.
28. Tsujii M., Kawano S., Tsujii S., Sawaoka H., Hori H., DuBois R.N. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998, 93:705-716.
29. 2-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med 2003, 197:221-231.
30. 2 is mediated by hypoxia-inducible factor 1. Cancer Res 2003, 63:2330-2334.
31. 2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. Cancer Res 1999, 59:4574-4577.
32. 2 regulation of endothelial cell migration, angiogenesis and tumor metastasis. Biochem Biophys Res Commun 2000, 267:245-251.
33. Arisato T., Hashiguchi T., Sarker K.P., Arimura K., Asano M., Matsuo K., et al. Highly accumulated platelet vascular endothelial growth factor in coagulant thrombotic region. J Thromb Haemost 2003, 1:2589-2593.
34. Rhee J.S., Black M., Achubert U., Fisher S., Morgenstern E., Hamms H.P., et al. The functional role of blood platelet components in angiogenesis. Thromb Haemost 2004, 92:394-402.
35. Amano H., Ando K., Minamida S., Hayashi I., Ogino M., Yamashima S., et al. Adenylate cyclase/protein kinase A signaling pathway enhances angiogenesis through induction of vascular endothelial growth factor in vivo. Jpn J Pharmacol 2001, 87:181-188.
36. Regan J.W. EP2 and EP4 prostanoid receptor signaling. Life Sci 2003, 74:143-153.
37. Nambe T., Sugimoto Y., Negishi M., Irie A., Ushikubi F., Kakizuka A., et al. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature 1993, 315:166-170.
38. 60 to leu mutation. J Clin Invest 1996, 97:949-956.
39. 2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cells differentiation and migration. Circ Res 2004, 95:372-379.
40. 2 activates mitogen-activated protein kinase/ERK pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Cancer Res 2005, 65:6275-6281.