4-methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2/ARE-mediated defense mechanism in A549 lung cancer cells

Molecules and Cells

Volumn 36, Issue 4, 2013, Pages 340-346

  Lim, Juhee ^a   Lee, Sung Ho ^b   Cho, Sera ^b   Lee, Ik Soo ^b   Kang, Bok Yun ^b   Choi, Hyun Jin ^a  

^a CHA University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

4 methoxychalcone; A549; chemosensitivity; cisplatin; Nrf2

Indexed keywords

4 METHOXYCHALCONE; CHALCONE DERIVATIVE; CISPLATIN; HESPERIDIN METHYLCHALCONE; NEOHESPERIDIN DIHYDROCHALCONE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DEFENSE MECHANISM; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG CANCER; OXIDATIVE STRESS; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONES; CISPLATIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84888427700     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-013-0123-9     Document Type: Article

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