메뉴 건너뛰기




Volumn 133, Issue 5, 2014, Pages 855-862

The role of VLA-4 binding for experimental melanoma metastasis and its inhibition by heparin

Author keywords

Cell adhesion; Heparin; Melanoma cell metastasis; Selectins; VLA 4

Indexed keywords

HEPARIN; L SELECTIN; PADGEM PROTEIN; SHORT HAIRPIN RNA; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; TINZAPARIN; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4; ANTICOAGULANT AGENT; LOW MOLECULAR WEIGHT HEPARIN;

EID: 84898822355     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.02.020     Document Type: Article
Times cited : (38)

References (54)
  • 2
    • 0026562067 scopus 로고
    • Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells
    • N. Kojima, K. Handa, W. Newman, and S. Hakomori Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells Biochem Biophys Res Commun 182 1992 1288 1295
    • (1992) Biochem Biophys Res Commun , vol.182 , pp. 1288-1295
    • Kojima, N.1    Handa, K.2    Newman, W.3    Hakomori, S.4
  • 3
    • 0027249917 scopus 로고
    • P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer
    • J.P. Stone, and D.D. Wagner P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer J Clin Invest 92 1993 804 813
    • (1993) J Clin Invest , vol.92 , pp. 804-813
    • Stone, J.P.1    Wagner, D.D.2
  • 4
    • 0035853111 scopus 로고    scopus 로고
    • Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
    • L. Borsig, R. Wong, J. Feramisco, D.R. Nadeau, N.M. Varki, and A. Varki Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis Proc Natl Acad Sci U S A 98 2001 3352 3357
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3352-3357
    • Borsig, L.1    Wong, R.2    Feramisco, J.3    Nadeau, D.R.4    Varki, N.M.5    Varki, A.6
  • 5
    • 0033559946 scopus 로고    scopus 로고
    • Lysis of tumor cells by natural killer cells in mice is impeded by platelets
    • B. Nieswandt, M. Hafner, B. Echtenacher, and D.N. Männel Lysis of tumor cells by natural killer cells in mice is impeded by platelets Cancer Res 59 1999 1295 1300
    • (1999) Cancer Res , vol.59 , pp. 1295-1300
    • Nieswandt, B.1    Hafner, M.2    Echtenacher, B.3    Männel, D.N.4
  • 6
    • 32944476784 scopus 로고    scopus 로고
    • L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest
    • H. Läubli, J.L. Stevenson, A. Varki, N.M. Varki, and L. Borsig L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest Cancer Res 66 2006 1536 1542
    • (2006) Cancer Res , vol.66 , pp. 1536-1542
    • Läubli, H.1    Stevenson, J.L.2    Varki, A.3    Varki, N.M.4    Borsig, L.5
  • 7
    • 0037133173 scopus 로고    scopus 로고
    • Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis
    • L. Borsig, R. Wong, R.O. Hynes, N.M. Varki, and A. Varki Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis Proc Natl Acad Sci U S A 99 2002 2193 2198
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2193-2198
    • Borsig, L.1    Wong, R.2    Hynes, R.O.3    Varki, N.M.4    Varki, A.5
  • 8
    • 0026165044 scopus 로고
    • Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: Demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1
    • D.B. Taichman, M.I. Cybulsky, I. Djaffar, B.M. Longenecker, J. Teixidó, and G.E. Rice et al. Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1 Cell Regul 2 1991 347 355
    • (1991) Cell Regul , vol.2 , pp. 347-355
    • Taichman, D.B.1    Cybulsky, M.I.2    Djaffar, I.3    Longenecker, B.M.4    Teixidó, J.5    Rice, G.E.6
  • 9
    • 0025798945 scopus 로고
    • Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression
    • I. Martìn-Padura, R. Mortarini, D. Lauri, S. Bernasconi, F. Sanchez-Madrid, and G. Parmiani et al. Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression Cancer Res 51 1991 2239 2241
    • (1991) Cancer Res , vol.51 , pp. 2239-2241
    • Martìn-Padura, I.1    Mortarini, R.2    Lauri, D.3    Bernasconi, S.4    Sanchez-Madrid, F.5    Parmiani, G.6
  • 10
    • 0026676656 scopus 로고
    • VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines
    • P. Mattila, M.L. Majuri, and R. Renkonen VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines Int J Cancer 52 1992 918 923
    • (1992) Int J Cancer , vol.52 , pp. 918-923
    • Mattila, P.1    Majuri, M.L.2    Renkonen, R.3
  • 11
    • 34347393710 scopus 로고    scopus 로고
    • High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers
    • M. Klemke, T. Weschenfelder, M.H. Konstandin, and Y. Samstag High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers J Cell Physiol 212 2007 368 374
    • (2007) J Cell Physiol , vol.212 , pp. 368-374
    • Klemke, M.1    Weschenfelder, T.2    Konstandin, M.H.3    Samstag, Y.4
  • 12
    • 0024815584 scopus 로고
    • An inducible endothelial cell surface glycoprotein mediates melanoma adhesion
    • G.E. Rice, and M.P. Bevilacqua An inducible endothelial cell surface glycoprotein mediates melanoma adhesion Science 246 1989 1303 1306
    • (1989) Science , vol.246 , pp. 1303-1306
    • Rice, G.E.1    Bevilacqua, M.P.2
  • 13
    • 0028887370 scopus 로고
    • Involvement of the very late antigen 4 integrin on melanoma in interleukin 1-augmented experimental metastases
    • A. Garofalo, R.G. Chirivi, C. Foglieni, R. Pigott, R. Mortarini, and I. Martin-Padura et al. Involvement of the very late antigen 4 integrin on melanoma in interleukin 1-augmented experimental metastases Cancer Res 55 1995 414 419
    • (1995) Cancer Res , vol.55 , pp. 414-419
    • Garofalo, A.1    Chirivi, R.G.2    Foglieni, C.3    Pigott, R.4    Mortarini, R.5    Martin-Padura, I.6
  • 14
    • 0029896973 scopus 로고    scopus 로고
    • Involvement of tumor necrosis factor alpha and very late activation antigen 4/vascular cell adhesion molecule 1 interaction in surgical-stress- enhanced experimental metastasis
    • A. Higashiyama, H. Watanabe, K. Okumura, and H. Yagita Involvement of tumor necrosis factor alpha and very late activation antigen 4/vascular cell adhesion molecule 1 interaction in surgical-stress-enhanced experimental metastasis Cancer Immunol Immunother 42 1996 231 236
    • (1996) Cancer Immunol Immunother , vol.42 , pp. 231-236
    • Higashiyama, A.1    Watanabe, H.2    Okumura, K.3    Yagita, H.4
  • 15
    • 0028179102 scopus 로고
    • Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor alpha enhancement of experimental metastasis
    • H. Okahara, H. Yagita, K. Miyake, and K. Okumura Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor alpha enhancement of experimental metastasis Cancer Res 54 1994 3233 3236
    • (1994) Cancer Res , vol.54 , pp. 3233-3236
    • Okahara, H.1    Yagita, H.2    Miyake, K.3    Okumura, K.4
  • 16
    • 0028904388 scopus 로고
    • Association with clinical outcome of expression of VLA-4 in primary cutaneous malignant melanoma as well as P-selectin and E-selectin on intratumoral vessels
    • D. Schadendorf, J. Heidel, C. Gawlik, L. Suter, and B.M. Czarnetzki Association with clinical outcome of expression of VLA-4 in primary cutaneous malignant melanoma as well as P-selectin and E-selectin on intratumoral vessels J Natl Cancer Inst 87 1995 366 371
    • (1995) J Natl Cancer Inst , vol.87 , pp. 366-371
    • Schadendorf, D.1    Heidel, J.2    Gawlik, C.3    Suter, L.4    Czarnetzki, B.M.5
  • 17
    • 0029810285 scopus 로고    scopus 로고
    • Beta 1 integrin expression: A marker of lymphatic metastases in cutaneous malignant melanoma
    • T.J. Hieken, S.G. Ronan, M. Farolan, A.L. Shilkaitis, and T.K. Das Gupta Beta 1 integrin expression: a marker of lymphatic metastases in cutaneous malignant melanoma Anticancer Res 16 1996 2321 2324
    • (1996) Anticancer Res , vol.16 , pp. 2321-2324
    • Hieken, T.J.1    Ronan, S.G.2    Farolan, M.3    Shilkaitis, A.L.4    Das Gupta, T.K.5
  • 18
    • 0028970691 scopus 로고
    • Beta 1 integrin expression in malignant melanoma predicts occult lymph node metastases
    • [discussion 673-675]
    • T.J. Hieken, S.G. Ronan, M. Farolan, A.L. Shilkaitis, D.K. Kim, and T.K. Das Gupta Beta 1 integrin expression in malignant melanoma predicts occult lymph node metastases Surgery 118 1995 669 673 [discussion 673-675]
    • (1995) Surgery , vol.118 , pp. 669-673
    • Hieken, T.J.1    Ronan, S.G.2    Farolan, M.3    Shilkaitis, A.L.4    Kim, D.K.5    Das Gupta, T.K.6
  • 19
    • 44349130354 scopus 로고    scopus 로고
    • ANTI-ADHESION evolves to a promising therapeutic concept in oncology
    • R. Schmidmaier, and P. Baumann ANTI-ADHESION evolves to a promising therapeutic concept in oncology Curr Med Chem 15 2008 978 990
    • (2008) Curr Med Chem , vol.15 , pp. 978-990
    • Schmidmaier, R.1    Baumann, P.2
  • 20
    • 70349398317 scopus 로고    scopus 로고
    • Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: A randomised, placebo-controlled, double-blind study
    • G. Agnelli, G. Gussoni, C. Bianchini, M. Verso, M. Mandalà, and L. Cavanna et al. Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double-blind study Lancet Oncol 10 2009 943 949
    • (2009) Lancet Oncol , vol.10 , pp. 943-949
    • Agnelli, G.1    Gussoni, G.2    Bianchini, C.3    Verso, M.4    Mandalà, M.5    Cavanna, L.6
  • 21
    • 12844289104 scopus 로고    scopus 로고
    • A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer
    • M. Altinbas, H.S. Coskun, O. Er, M. Ozkan, B. Eser, and A. Unal et al. A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer J Thromb Haemost 2 2004 1266 1271
    • (2004) J Thromb Haemost , vol.2 , pp. 1266-1271
    • Altinbas, M.1    Coskun, H.S.2    Er, O.3    Ozkan, M.4    Eser, B.5    Unal, A.6
  • 22
    • 3042704507 scopus 로고    scopus 로고
    • Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: The fragmin advanced malignancy outcome study (FAMOUS)
    • A.K. Kakkar, M.N. Levine, Z. Kadziola, N.R. Lemoine, V. Low, and H.K. Patel et al. Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS) J Clin Oncol 22 2004 1944 1948
    • (2004) J Clin Oncol , vol.22 , pp. 1944-1948
    • Kakkar, A.K.1    Levine, M.N.2    Kadziola, Z.3    Lemoine, N.R.4    Low, V.5    Patel, H.K.6
  • 23
    • 17144385138 scopus 로고    scopus 로고
    • Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism
    • A.Y.Y. Lee, F.R. Rickles, J.A. Julian, M. Gent, R.I. Baker, and C. Bowden et al. Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism J Clin Oncol 23 2005 2123 2129
    • (2005) J Clin Oncol , vol.23 , pp. 2123-2129
    • Lee, A.Y.Y.1    Rickles, F.R.2    Julian, J.A.3    Gent, M.4    Baker, R.I.5    Bowden, C.6
  • 25
    • 67449085403 scopus 로고    scopus 로고
    • Heparins attenuate cancer metastasis: Are selectins the link?
    • H. Laubli, and L. Borsig Heparins attenuate cancer metastasis: are selectins the link? Cancer Invest 27 2009 474 481
    • (2009) Cancer Invest , vol.27 , pp. 474-481
    • Laubli, H.1    Borsig, L.2
  • 27
    • 4544370585 scopus 로고    scopus 로고
    • Inhibition of endothelial cell tube formation by the low molecular weight heparin, tinzaparin, is mediated by tissue factor pathway inhibitor
    • S.A. Mousa, and S. Mohamed Inhibition of endothelial cell tube formation by the low molecular weight heparin, tinzaparin, is mediated by tissue factor pathway inhibitor Thromb Haemost 92 2004 627 633
    • (2004) Thromb Haemost , vol.92 , pp. 627-633
    • Mousa, S.A.1    Mohamed, S.2
  • 28
    • 0031032234 scopus 로고    scopus 로고
    • Heparin oligosaccharides: Inhibitors of the biological activity of bFGF on Caco-2 cells
    • G.C. Jayson, and J.T. Gallagher Heparin oligosaccharides: inhibitors of the biological activity of bFGF on Caco-2 cells Br J Cancer 75 1997 9 16
    • (1997) Br J Cancer , vol.75 , pp. 9-16
    • Jayson, G.C.1    Gallagher, J.T.2
  • 29
    • 35948980396 scopus 로고    scopus 로고
    • P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins
    • N. Hostettler, A. Naggi, G. Torri, R. Ishai-Michaeli, B. Casu, and I. Vlodavsky et al. P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins FASEB J 21 2007 3562 3572
    • (2007) FASEB J , vol.21 , pp. 3562-3572
    • Hostettler, N.1    Naggi, A.2    Torri, G.3    Ishai-Michaeli, R.4    Casu, B.5    Vlodavsky, I.6
  • 30
    • 84871888502 scopus 로고    scopus 로고
    • Are low molecular weight heparins able to sensitize chemoresistant tumor cells?
    • D.P. Stölting, U. Jaehde, M. Wiese, and G. Bendas Are low molecular weight heparins able to sensitize chemoresistant tumor cells? Int J Clin Pharmacol Ther 51 2013 70 73
    • (2013) Int J Clin Pharmacol Ther , vol.51 , pp. 70-73
    • Stölting, D.P.1    Jaehde, U.2    Wiese, M.3    Bendas, G.4
  • 31
    • 79952144802 scopus 로고    scopus 로고
    • Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and migration
    • G. Chalkiadaki, D. Nikitovic, A. Berdiaki, P. Katonis, N.K. Karamanos, and G.N. Tzanakakis Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and migration IUBMB Life 63 2011 109 119
    • (2011) IUBMB Life , vol.63 , pp. 109-119
    • Chalkiadaki, G.1    Nikitovic, D.2    Berdiaki, A.3    Katonis, P.4    Karamanos, N.K.5    Tzanakakis, G.N.6
  • 32
    • 80053934330 scopus 로고    scopus 로고
    • Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes
    • G. Chalkiadaki, D. Nikitovic, P. Katonis, A. Berdiaki, A. Tsatsakis, and I. Kotsikogianni et al. Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes Cancer Lett 312 2011 235 244
    • (2011) Cancer Lett , vol.312 , pp. 235-244
    • Chalkiadaki, G.1    Nikitovic, D.2    Katonis, P.3    Berdiaki, A.4    Tsatsakis, A.5    Kotsikogianni, I.6
  • 33
    • 84860448186 scopus 로고    scopus 로고
    • The inhibition of the integrin VLA-4 in MV3 melanoma cell binding by non-anticoagulant heparin derivatives
    • M. Schlesinger, P. Schmitz, R. Zeisig, A. Naggi, G. Torri, and B. Casu et al. The inhibition of the integrin VLA-4 in MV3 melanoma cell binding by non-anticoagulant heparin derivatives Thromb Res 129 2012 603 610
    • (2012) Thromb Res , vol.129 , pp. 603-610
    • Schlesinger, M.1    Schmitz, P.2    Zeisig, R.3    Naggi, A.4    Torri, G.5    Casu, B.6
  • 34
    • 20144388264 scopus 로고    scopus 로고
    • Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting
    • A. Naggi, B. Casu, M. Perez, G. Torri, G. Cassinelli, and S. Penco et al. Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting J Biol Chem 280 2005 12103 12113
    • (2005) J Biol Chem , vol.280 , pp. 12103-12113
    • Naggi, A.1    Casu, B.2    Perez, M.3    Torri, G.4    Cassinelli, G.5    Penco, S.6
  • 35
    • 57349172005 scopus 로고    scopus 로고
    • Melanoma cell adhesion can be blocked by heparin in vitro: Suggestion of VLA-4 as a novel target for antimetastatic approaches
    • J. Fritzsche, D. Simonis, and G. Bendas Melanoma cell adhesion can be blocked by heparin in vitro: suggestion of VLA-4 as a novel target for antimetastatic approaches Thromb Haemost 100 2008 1166 1175
    • (2008) Thromb Haemost , vol.100 , pp. 1166-1175
    • Fritzsche, J.1    Simonis, D.2    Bendas, G.3
  • 37
    • 0036665476 scopus 로고    scopus 로고
    • Effect of divalent cations on the affinity and selectivity of alpha4 integrins towards the integrin ligands vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1: Ca2 + activation of integrin alpha4beta1 confers a distinct ligand specificity
    • E.S. Day, L. Osborn, and A. Whitty Effect of divalent cations on the affinity and selectivity of alpha4 integrins towards the integrin ligands vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1: Ca2 + activation of integrin alpha4beta1 confers a distinct ligand specificity Cell Commun Adhes 9 2002 205 219
    • (2002) Cell Commun Adhes , vol.9 , pp. 205-219
    • Day, E.S.1    Osborn, L.2    Whitty, A.3
  • 40
    • 34347385401 scopus 로고    scopus 로고
    • Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms
    • J.S. Palumbo, K.E. Talmage, J.V. Massari, C.M. La Jeunesse, M.J. Flick, and K.W. Kombrinck et al. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms Blood 110 2007 133 141
    • (2007) Blood , vol.110 , pp. 133-141
    • Palumbo, J.S.1    Talmage, K.E.2    Massari, J.V.3    La Jeunesse, C.M.4    Flick, M.J.5    Kombrinck, K.W.6
  • 41
    • 84859305668 scopus 로고    scopus 로고
    • Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice
    • A.M. Gil-Bernabé, S. Ferjancic, M. Tlalka, L. Zhao, P.D. Allen, and J.H. Im et al. Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice Blood 119 2012 3164 3175
    • (2012) Blood , vol.119 , pp. 3164-3175
    • Gil-Bernabé, A.M.1    Ferjancic, S.2    Tlalka, M.3    Zhao, L.4    Allen, P.D.5    Im, J.H.6
  • 42
    • 26444566779 scopus 로고    scopus 로고
    • Differential metastasis inhibition by clinically relevant levels of heparins-correlation with selectin inhibition, not antithrombotic activity
    • J.L. Stevenson, S.H. Choi, and A. Varki Differential metastasis inhibition by clinically relevant levels of heparins-correlation with selectin inhibition, not antithrombotic activity Clin Cancer Res 11 2005 7003 7011
    • (2005) Clin Cancer Res , vol.11 , pp. 7003-7011
    • Stevenson, J.L.1    Choi, S.H.2    Varki, A.3
  • 43
    • 34748863572 scopus 로고    scopus 로고
    • Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    • G.H. Mahabeleshwar, W. Feng, K. Reddy, E.F. Plow, and T.V. Byzova Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis Circ Res 101 2007 570 580
    • (2007) Circ Res , vol.101 , pp. 570-580
    • Mahabeleshwar, G.H.1    Feng, W.2    Reddy, K.3    Plow, E.F.4    Byzova, T.V.5
  • 44
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • J.S. Desgrosellier, and D.A. Cheresh Integrins in cancer: biological implications and therapeutic opportunities Nat Rev Cancer 10 2010 9 22
    • (2010) Nat Rev Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 45
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • P.C. Brooks, R.A. Clark, and D.A. Cheresh Requirement of vascular integrin alpha v beta 3 for angiogenesis Science 264 1994 569 571
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 46
    • 33646422999 scopus 로고    scopus 로고
    • CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins
    • T. Engl, B. Relja, D. Marian, C. Blumenberg, I. Müller, and W.-D. Beecken et al. CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins Neoplasia 8 2006 290 301
    • (2006) Neoplasia , vol.8 , pp. 290-301
    • Engl, T.1    Relja, B.2    Marian, D.3    Blumenberg, C.4    Müller, I.5    Beecken, W.-D.6
  • 47
    • 34249779852 scopus 로고    scopus 로고
    • Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells
    • J.J. Grzesiak, K.C. Smith, D.W. Burton, L.J. Deftos, and M. Bouvet Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells Surgery 141 2007 804 814
    • (2007) Surgery , vol.141 , pp. 804-814
    • Grzesiak, J.J.1    Smith, K.C.2    Burton, D.W.3    Deftos, L.J.4    Bouvet, M.5
  • 48
    • 0030568857 scopus 로고    scopus 로고
    • Integrin beta 3 cDNA transfection into a highly metastatic alpha v beta 3-negative human melanoma cell line inhibits invasion and experimental metastasis
    • E.H. Danen, A.A. van Kraats, I.M. Cornelissen, D.J. Ruiter, and G.N. van Muijen Integrin beta 3 cDNA transfection into a highly metastatic alpha v beta 3-negative human melanoma cell line inhibits invasion and experimental metastasis Biochem Biophys Res Commun 226 1996 75 81
    • (1996) Biochem Biophys Res Commun , vol.226 , pp. 75-81
    • Danen, E.H.1    Van Kraats, A.A.2    Cornelissen, I.M.3    Ruiter, D.J.4    Van Muijen, G.N.5
  • 49
    • 9444251067 scopus 로고    scopus 로고
    • Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen
    • W. Bao, and S. Strömblad Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen J Cell Biol 167 2004 745 756
    • (2004) J Cell Biol , vol.167 , pp. 745-756
    • Bao, W.1    Strömblad, S.2
  • 51
    • 14844317695 scopus 로고    scopus 로고
    • Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal
    • H. Zhao, F.P. Ross, and S.L. Teitelbaum Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal Mol Endocrinol 19 2005 771 780
    • (2005) Mol Endocrinol , vol.19 , pp. 771-780
    • Zhao, H.1    Ross, F.P.2    Teitelbaum, S.L.3
  • 52
    • 80054725681 scopus 로고    scopus 로고
    • Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs
    • Q. Chen, X.H.-F. Zhang, and J. Massagué Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs Cancer Cell 20 2011 538 549
    • (2011) Cancer Cell , vol.20 , pp. 538-549
    • Chen, Q.1    Zhang, X.H.-F.2    Massagué, J.3
  • 53
    • 84867494076 scopus 로고    scopus 로고
    • Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis
    • Q. Chen, and J. Massagué Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis Clin Cancer Res 18 2012 5520 5525
    • (2012) Clin Cancer Res , vol.18 , pp. 5520-5525
    • Chen, Q.1    Massagué, J.2
  • 54
    • 84879177512 scopus 로고    scopus 로고
    • VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice
    • S. Ferjancic, A.M. Gil-Bernabé, S.A. Hill, P.D. Allen, P. Richardson, and T. Sparey et al. VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice Blood 121 2013 3289 3297
    • (2013) Blood , vol.121 , pp. 3289-3297
    • Ferjancic, S.1    Gil-Bernabé, A.M.2    Hill, S.A.3    Allen, P.D.4    Richardson, P.5    Sparey, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.