Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice

FASEB Journal

Volumn 24, Issue 8, 2010, Pages 2904-2915

  Xu, Jiqing ^a   Sato, Shinji ^a   Okuyama, Satoshi ^a   Swan, Russell J ^a   Jacobsen, Michael T ^a   Strunk, Elena ^a   Ikezu, Tsuneya ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cyclin dependent kinase 5; Frontotemporal dementia; Neurodegeneartion; Protein kinase; Tauopathy; Transgenic mouse model

Indexed keywords

CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3BETA; LYSINE; MEMBRANE PROTEIN; OLIGOMER; PAIRED HELICAL FILAMENT 1 PROTEIN; PROLINE; PROTEIN; PROTEIN P25; PROTEIN P35; PROTEIN PY216; SARKOSYL SOLUBLE PROTEIN; SUCROSE; TAU PROTEIN; TAU TUBULIN KINASE 1; TUBULIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; BRAIN CELL; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; FRAGMENTATION REACTION; GENE OVEREXPRESSION; GRIP STRENGTH; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOREACTIVITY; IN VIVO STUDY; LOCOMOTION; MOTONEURON; MOTOR DYSFUNCTION; MOTOR NEURON DISEASE; MOUSE; MUTANT; NERVE CELL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; ROTAROD TEST; SPINAL CORD; SUCROSE DENSITY GRADIENT CENTRIFUGATION; TAUOPATHY;

ANIMALS; MICE; MICE, MUTANT STRAINS; MOTOR SKILLS DISORDERS; MUTATION; NERVE DEGENERATION; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN-SERINE-THREONINE KINASES; TAU PROTEINS; TAUOPATHIES; UP-REGULATION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 77955780870     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-150144     Document Type: Article

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