Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice

Neuroscience Letters

Volumn 528, Issue 2, 2012, Pages 190-195

  Okuyama, Satoshi ^a   Shimada, Naoko ^a   Kaji, Miki ^a   Morita, Mayu ^a   Miyoshi, Kazuhiro ^a   Minami, Sona ^a   Amakura, Yoshiaki ^a   Yoshimura, Morio ^a   Yoshida, Takashi ^a   Watanabe, Sono ^a   Nakajima, Mitsunari ^a   Furukawa, Yoshiko ^a  

^a MATSUYAMA UNIVERSITY   (Japan)

Author keywords

BDNF; CREB; ERK1 2; Global cerebral ischemia; Heptamethoxyflavone; Neurogenesis

Indexed keywords

3,5,6,7,3',4',5' HEPTAMETHOXYFLAVONE; BRAIN DERIVED NEUROTROPHIC FACTOR; DOUBLECORTIN; FLAVONOID; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPAL STRATUM LUCIDUM; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STRATUM RADIATUM;

ANIMALS; ASTROCYTES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FLAVONOIDS; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; MALE; MICE; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; NEUROPEPTIDES; PHOSPHORYLATION;

EID: 84867733887     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.08.079     Document Type: Article

References (28)

1. Al Rahim M., Nakajima A., Saigusa D., Tetsu N., Maruyama Y., Shibuya M., Yamakoshi H., Tomioka Y., Iwabuchi Y., Ohizumi Y., Yamakuni T. 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. Biochemistry 2009, 48:7713-7721.
2. Barde Y.A. Trophic factors and neuronal survival. Neuron 1989, 2:1525-1534.
3. Beck T., Lindholm D., Castrén E., Wree A. Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. Journal of Cerebral Blood Flow and Metabolism 1994, 14:689-692.
4. Béjot Y., Prigent-Tessier A., Cachia C., Giroud M., Mossiat C., Bertrand N., Garnier P., Marie C. Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats. Neurochemistry International 2011, 58:102-111.
5. Bobyn P.J., Corbett D., Saucier D.M., Noyan-Ashraf M.H., Juurlink B.H.J., Paterson P.G. Protein-energy malnutrition impairs functional outcome in global ischemia. Experimental Neurology 2005, 196:308-315.
6. Broughton B.R.S., Reutens D.C., Sobey C.G. Apoptotic mechanisms after cerebral ischemia. Stroke 2009, 40:331-339.
7. Furukawa Y., Okuyama S., Amakura Y., Watanabe S., Fukata T., Nakajima M., Yoshimura M., Yoshida T. Isolation and characterization of activators of ERK/MAPK from citrus plants. International Journal of Molecular Sciences 2012, 13:1832-1845.
8. Harukuni I., Bhardwaj A. Mechanisms of brain injury after global cerebral ischemia. Neurologic Clinics 2006, 24:1-21.
9. Kee N.J., Preston E., Wojtowicz J.M. Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat. Experimental Brain Research 2001, 136:313-320.
10. Kim D.H., Kim S., Jung W.Y., Park S.J., Park D.H., Kim J.M., Cheong J.H., Ryu J.H. The neuroprotective effects of the seeds of Cassia obtusifolia on transient cerebral global ischemia in mice. Food and Chemical Toxicology 2009, 47:1473-1479.
11. Kiyota T., Yamamoto M., Schroder B., Jacobsen M.T., Swan R.J., Lambert M.P., Klein W.L., Gendelman H.E., Ransohoff R.M., Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, β-amyloidosis, and learning impairment of APP/PS1 mice. Molecular Therapy 2009, 17:803-809.
12. Kokaia Z., Zhao Q., Kokaia M., Elmer E., Metsis M., Smith M.L., Siesjö B.K., Lindvall O. Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage. Experimental Neurology 1995, 136:73-88.
13. Lampe J.W., Becker L.B. State of the art in therapeutic hypothermia. Annual Review of Medicine 2011, 62:79-93.
14. Lichtenwalner R.J., Parent J.M. Adult neurogenesis and the ischemic forebrain. Journal of Cerebral Blood Flow and Metabolism 2005, 26:1-20.
15. Lindvall O., Ernfors P., Bengzon J., Kokaia Z., Smith M.L., Siesjö B.K., Persson H. Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proceedings of the National Academy of Sciences of the United States of America 1992, 89:648-652.
16. Liu J., Solway K., Messing R.O., Sharp F.R. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. Journal of Neuroscience 1998, 18:7768-7778.
17. Nakatomi H., Kuriu T., Okabe S., Yamamoto S., Hatano O., Kawahara N., Tamura A., Kirino T., Nakafuku M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002, 110:429-441.
18. Neves G., Cooke S.F., Bliss T.V. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nature Reviews Neuroscience 2008, 9:65-75.
19. Sato S., Xu J., Okuyama S., Martinez L.B., Walsh S.M., Jacobsen M.T., Swan R.J., Schlautman J.D., Ciborowski P., Ikezu T. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. Journal of Neuroscience 2008, 28:14511-14521.
20. Schäbitz W.R., Schwab S., Spranger M., Hacke W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. Journal of Cerebral Blood Flow and Metabolism 1997, 17:500-506.
21. Tonchev A.B. Brain ischemia, neurogenesis, and neurotrophic receptor expression in primates. Archives Italiennes de Biologie 2011, 149:225-231.
22. Tsukahara T., Iihara K., Hashimoto N., Taniguchi T. Increases in levels of brain-derived neurotrophic factor mRNA and its promoters after transient forebrain ischemia in the rat brain. Neurochemistry International 1998, 33:201-207.
23. Tsukahara T., Yonekawa Y., Tanaka K., Ohara O., Wantanabe S., Kimura T., Nishijima T., Taniguchi T. The role of brain-derived neurotrophic factor in transient forebrain ischemia in the rat brain. Neurosurgery 1994, 34:323-331.
24. Wang Z.F., Tang L.L., Yan H., Wang Y.J., Tang X.C. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice. Pharmacology Biochemistry and Behavior 2006, 83:603-611.
25. Wu D. Neuroprotection in experimental stroke with targeted neurotrophins. NeuroRx 2005, 2:120-128.
26. Yamamoto Y., Shioda N., Han F., Moriguchi S., Nakajima A., Yokosuka A., Mimaki Y., Sashida Y., Yamakuni T., Ohizumi Y., Fukunaga K. Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation. Brain Research 2009, 1295:218-229.
27. Yonekura I., Kawahara N., Nakatomi H., Furuya K., Kirino T. A model of global cerebral ischemia in C57 BL/6 mice. Journal of Cerebral Blood Flow and Metabolism 2004, 24:151-158.
28. Zhu X.H., Yan H.C., Zhang J., Qu H.D., Qiu X.S., Chen L., Li S.J., Cao X., Bean J.C., Chen L.H., Qin X.H., Liu J.H., Bai X.C., Mei L., Gao T.M. Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats. Journal of Neuroscience 2010, 30:12653-12663.