메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages

Diagnostic and prognostic utility of a DNA hypermethylated gene signature in prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; GENOMIC DNA; HORMONE;

EID: 84898733307     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091666     Document Type: Article
Times cited : (10)

References (65)
  • 1
    • 79958043675 scopus 로고    scopus 로고
    • National Cancer Institute. Bethesda, MD, based on November 2012 SEER data submission, posted to the SEER web site on April Available: Accessed: 2013 December 15
    • Howlader N NA, Krapcho M, Garshell J, Neyman N, et al. SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, based on November 2012 SEER data submission, posted to the SEER web site on April 2013, Available: 〈http://seer.cancer.gov/csr/1975-2010/〉, Accessed: 2013 December 15.
    • (2013) SEER Cancer Statistics Review, 1975-2010
    • Howlader, N.N.A.1    Krapcho, M.2    Garshell, J.3    Neyman, N.4
  • 2
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, C.5
  • 3
    • 0013886401 scopus 로고
    • Survival rates of patients with prostatic cancer, tumor stage, and differentiation-preliminary report
    • Bailar JC, 3rd, Mellinger GT, Gleason DF (1966) Survival rates of patients with prostatic cancer, tumor stage, and differentiation-preliminary report. Cancer Chemother Rep 50: 129-136.
    • (1966) Cancer Chemother Rep , vol.50 , pp. 129-136
    • Bailar III, J.C.1    Mellinger, G.T.2    Gleason, D.F.3
  • 4
    • 17844402699 scopus 로고    scopus 로고
    • 20-Year outcomes following conservative management of clinically localized prostate cancer
    • DOI 10.1001/jama.293.17.2095
    • Albertsen PC, Hanley JA, Fine J (2005) 20-year outcomes following conservative management of clinically localized prostate cancer. JAMA 293: 2095-2101. (Pubitemid 40617061)
    • (2005) Journal of the American Medical Association , vol.293 , Issue.17 , pp. 2095-2101
    • Albertsen, P.C.1    Hanley, J.A.2    Fine, J.3
  • 5
    • 0030855912 scopus 로고    scopus 로고
    • Interobserver variation in prostate cancer Gleason scoring: Are there implications for the design of clinical trials and treatment strategies?
    • DOI 10.1016/S0936-6555(97)80005-2
    • McLean M, Srigley J, Banerjee D, Warde P, Hao Y (1997) Interobserver variation in prostate cancer Gleason scoring: are there implications for the design of clinical trials and treatment strategies? Clin Oncol (R Coll Radiol) 9: 222-225. (Pubitemid 27450096)
    • (1997) Clinical Oncology , vol.9 , Issue.4 , pp. 222-225
    • McLean, M.1    Srigley, J.2    Banerjee, D.3    Warde, P.4    Hao, Y.5
  • 6
    • 0028795910 scopus 로고
    • The role of increasing detection in the rising incidence of prostate cancer
    • Potosky AL, Miller BA, Albertsen PC, Kramer BS (1995) The role of increasing detection in the rising incidence of prostate cancer. JAMA 273: 548-552.
    • (1995) JAMA , vol.273 , pp. 548-552
    • Potosky, A.L.1    Miller, B.A.2    Albertsen, P.C.3    Kramer, B.S.4
  • 8
    • 1442329376 scopus 로고    scopus 로고
    • The Prognostic Significance of Tertiary Gleason Pattern 5 in Radical Prostatectomy Specimens
    • DOI 10.1097/00000478-200403000-00014
    • Mosse CA, Magi-Galluzzi C, Tsuzuki T, Epstein JI (2004) The prognostic significance of tertiary Gleason pattern 5 in radical prostatectomy specimens. Am J Surg Pathol 28: 394-398. (Pubitemid 38269575)
    • (2004) American Journal of Surgical Pathology , vol.28 , Issue.3 , pp. 394-398
    • Mosse, C.A.1    Magi-Galluzzi, C.2    Tsuzuki, T.3    Epstein, J.I.4
  • 9
    • 79956372563 scopus 로고    scopus 로고
    • Predictive models for newly diagnosed prostate cancer patients
    • Lowrance WT, Scardino PT (2009) Predictive models for newly diagnosed prostate cancer patients. Rev Urol 11: 117-126.
    • (2009) Rev Urol , vol.11 , pp. 117-126
    • Lowrance, W.T.1    Scardino, P.T.2
  • 10
    • 33746864553 scopus 로고    scopus 로고
    • Watching the face of Janus-active surveillance as a strategy to reduce overtreatment for localised prostate cancer
    • Bratt O (2006) Watching the face of Janus-active surveillance as a strategy to reduce overtreatment for localised prostate cancer. Eur Urol 50: 410-412.
    • (2006) Eur Urol , vol.50 , pp. 410-412
    • Bratt, O.1
  • 11
    • 75449105857 scopus 로고    scopus 로고
    • Blood and tissue biomarkers in prostate cancer: State of the art
    • Fiorentino M, Capizzi E, Loda M (2010) Blood and tissue biomarkers in prostate cancer: state of the art. Urol Clin North Am 37: 131-141.
    • (2010) Urol Clin North Am , vol.37 , pp. 131-141
    • Fiorentino, M.1    Capizzi, E.2    Loda, M.3
  • 12
    • 33847065486 scopus 로고    scopus 로고
    • The Epigenomics of Cancer
    • DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
    • Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128: 683-692. (Pubitemid 46273572)
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 13
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428. (Pubitemid 34587077)
    • (2002) Nature Reviews Genetics , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 14
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - Biological and translational implications
    • Baylin SB, Jones PA (2011) A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer 11: 726-734.
    • (2011) Nat Rev Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 15
    • 80053945736 scopus 로고    scopus 로고
    • Predicting prostate biopsy result in men with prostate specific antigen 2.0 to 10.0 ng/ml using an investigational prostate cancer methylation assay
    • Baden J, Adams S, Astacio T, Jones J, Markiewicz J, et al. (2011) Predicting prostate biopsy result in men with prostate specific antigen 2.0 to 10.0 ng/ml using an investigational prostate cancer methylation assay. J Urol 186: 2101-2106.
    • (2011) J Urol , vol.186 , pp. 2101-2106
    • Baden, J.1    Adams, S.2    Astacio, T.3    Jones, J.4    Markiewicz, J.5
  • 18
    • 80053458910 scopus 로고    scopus 로고
    • A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer
    • Schwartzman J, Mongoue-Tchokote S, Gibbs A, Gao L, Corless CL, et al. (2011) A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer. Epigenetics 6: 1248-1256.
    • (2011) Epigenetics , vol.6 , pp. 1248-1256
    • Schwartzman, J.1    Mongoue-Tchokote, S.2    Gibbs, A.3    Gao, L.4    Corless, C.L.5
  • 19
    • 63049098369 scopus 로고    scopus 로고
    • Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays
    • Kron K, Pethe V, Briollais L, Sadikovic B, Ozcelik H, et al. (2009) Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays. PLoS ONE 4: e4830.
    • (2009) PLoS ONE , vol.4
    • Kron, K.1    Pethe, V.2    Briollais, L.3    Sadikovic, B.4    Ozcelik, H.5
  • 20
    • 79960320144 scopus 로고    scopus 로고
    • EFEMP1 as a novel DNA methylation marker for prostate cancer: Array-based DNA methylation and expression profiling
    • Kim YJ, Yoon HY, Kim SK, Kim YW, Kim EJ, et al. (2011) EFEMP1 as a novel DNA methylation marker for prostate cancer: array-based DNA methylation and expression profiling. Clin Cancer Res 17: 4523-4530.
    • (2011) Clin Cancer Res , vol.17 , pp. 4523-4530
    • Kim, Y.J.1    Yoon, H.Y.2    Kim, S.K.3    Kim, Y.W.4    Kim, E.J.5
  • 21
    • 79959875910 scopus 로고    scopus 로고
    • DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer
    • Kobayashi Y, Absher DM, Gulzar ZG, Young SR, McKenney JK, et al. (2011) DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer. Genome Res 21: 1017-1027.
    • (2011) Genome Res , vol.21 , pp. 1017-1027
    • Kobayashi, Y.1    Absher, D.M.2    Gulzar, Z.G.3    Young, S.R.4    McKenney, J.K.5
  • 22
    • 13844254856 scopus 로고    scopus 로고
    • High throughput screening of methylation status of genes in prostate cancer using an oligonucleotide methylation array
    • DOI 10.1093/carcin/bgh310
    • Yu YP, Paranjpe S, Nelson J, Finkelstein S, Ren B, et al. (2005) High throughput screening of methylation status of genes in prostate cancer using an oligonucleotide methylation array. Carcinogenesis 26: 471-479. (Pubitemid 40246570)
    • (2005) Carcinogenesis , vol.26 , Issue.2 , pp. 471-479
    • Yu, Y.P.1    Paranjpe, S.2    Nelson, J.3    Finkelstein, S.4    Ren, B.5    Kokkinakis, D.6    Michalopoulos, G.7    Luo, J.-H.8
  • 23
    • 78349241800 scopus 로고    scopus 로고
    • Differential gene expression in benign prostate epithelium of men with and without prostate cancer: Evidence for a prostate cancer field effect
    • Risk MC, Knudsen BS, Coleman I, Dumpit RF, Kristal AR, et al. (2010) Differential gene expression in benign prostate epithelium of men with and without prostate cancer: evidence for a prostate cancer field effect. Clin Cancer Res 16: 5414-5423.
    • (2010) Clin Cancer Res , vol.16 , pp. 5414-5423
    • Risk, M.C.1    Knudsen, B.S.2    Coleman, I.3    Dumpit, R.F.4    Kristal, A.R.5
  • 24
    • 77952449085 scopus 로고    scopus 로고
    • Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features
    • Ang PW, Loh M, Liem N, Lim PL, Grieu F, et al. (2010) Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features. BMC Cancer 10: 227.
    • (2010) BMC Cancer , vol.10 , pp. 227
    • Ang, P.W.1    Loh, M.2    Liem, N.3    Lim, P.L.4    Grieu, F.5
  • 26
    • 28044455863 scopus 로고    scopus 로고
    • An integrated feature selection and classification method to select minimum number of variables on the case study of gene expression data
    • DOI 10.1142/S0219720005001533, PII S0219720005001533
    • Goh L, Kasabov N (2005) An integrated feature selection and classification method to select minimum number of variables on the case study of gene expression data. J Bioinform Comput Biol 3: 1107-1136. (Pubitemid 41683432)
    • (2005) Journal of Bioinformatics and Computational Biology , vol.3 , Issue.5 , pp. 1107-1136
    • Goh, L.1    Kasabov, N.2
  • 27
    • 33847266422 scopus 로고    scopus 로고
    • Genomic sweeping for hypermethylated genes
    • DOI 10.1093/bioinformatics/btl620
    • Goh L, Murphy SK, Muhkerjee S, Furey TS (2007) Genomic sweeping for hypermethylated genes. Bioinformatics 23: 281-288. (Pubitemid 46323149)
    • (2007) Bioinformatics , vol.23 , Issue.3 , pp. 281-288
    • Goh, L.1    Murphy, S.K.2    Muhkerjee, S.3    Furey, T.S.4
  • 28
    • 1542609551 scopus 로고    scopus 로고
    • Support vector machine classification on the web
    • DOI 10.1093/bioinformatics/btg461
    • Pavlidis P, Wapinski I, Noble WS (2004) Support vector machine classification on the web. Bioinformatics 20: 586-587. (Pubitemid 38344342)
    • (2004) Bioinformatics , vol.20 , Issue.4 , pp. 586-587
    • Pavlidis, P.1    Wapinski, I.2    Noble, W.S.3
  • 29
    • 84880458786 scopus 로고    scopus 로고
    • Design and analysis of classifier learning experiments in bioinformatics: Survey and case studies
    • Irsoy O, Yildiz OT, Alpaydin E (2012) Design and analysis of classifier learning experiments in bioinformatics: survey and case studies. IEEE/ACM Trans Comput Biol Bioinform 9: 1663-1675.
    • (2012) IEEE/ACM Trans Comput Biol Bioinform , vol.9 , pp. 1663-1675
    • Irsoy, O.1    Yildiz, O.T.2    Alpaydin, E.3
  • 30
    • 84859516017 scopus 로고    scopus 로고
    • DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission
    • Nordlund J, Milani L, Lundmark A, Lonnerholm G, Syvanen AC (2012) DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission. PLoS One 7: e34513.
    • (2012) PLoS One , vol.7
    • Nordlund, J.1    Milani, L.2    Lundmark, A.3    Lonnerholm, G.4    Syvanen, A.C.5
  • 31
    • 79960927422 scopus 로고    scopus 로고
    • Increased methylation variation in epigenetic domains across cancer types
    • Hansen KD, Timp W, Bravo HC, Sabunciyan S, Langmead B, et al. (2011) Increased methylation variation in epigenetic domains across cancer types. Nat Genet 43: 768-775.
    • (2011) Nat Genet , vol.43 , pp. 768-775
    • Hansen, K.D.1    Timp, W.2    Bravo, H.C.3    Sabunciyan, S.4    Langmead, B.5
  • 32
    • 84887835489 scopus 로고    scopus 로고
    • Molecular Pathways in Prostate Cancer
    • Mazaris E, Tsiotras A (2013) Molecular Pathways in Prostate Cancer. Nephrourol Mon 5: 792-800.
    • (2013) Nephrourol Mon , vol.5 , pp. 792-800
    • Mazaris, E.1    Tsiotras, A.2
  • 33
    • 84869096283 scopus 로고    scopus 로고
    • Ligand-independent activation of EphA2 by arachidonic acid induces metastasis-like behaviour in prostate cancer cells
    • Tawadros T, Brown MD, Hart CA, Clarke NW (2012) Ligand-independent activation of EphA2 by arachidonic acid induces metastasis-like behaviour in prostate cancer cells. Br J Cancer 107: 1737-1744.
    • (2012) Br J Cancer , vol.107 , pp. 1737-1744
    • Tawadros, T.1    Brown, M.D.2    Hart, C.A.3    Clarke, N.W.4
  • 34
    • 84884475135 scopus 로고    scopus 로고
    • Loss of CDKN1B/p27Kip1 expression is associated with ERG fusion-negative prostate cancer, but is unrelated to patient prognosis
    • Sirma H, Broemel M, Stumm L, Tsourlakis T, Steurer S, et al. (2013) Loss of CDKN1B/p27Kip1 expression is associated with ERG fusion-negative prostate cancer, but is unrelated to patient prognosis. Oncol Lett 6: 1245-1252.
    • (2013) Oncol Lett , vol.6 , pp. 1245-1252
    • Sirma, H.1    Broemel, M.2    Stumm, L.3    Tsourlakis, T.4    Steurer, S.5
  • 35
    • 84884526271 scopus 로고    scopus 로고
    • Impact of Glutathione-S-Transferases (GST) Polymorphisms and Hypermethylation of Relevant Genes on Risk of Prostate Cancer Biochemical Recurrence: A Meta-Analysis
    • Chen R, Ren S, Meng T, Aguilar J, Sun Y (2013) Impact of Glutathione-S-Transferases (GST) Polymorphisms and Hypermethylation of Relevant Genes on Risk of Prostate Cancer Biochemical Recurrence: A Meta-Analysis. PLoS One 8: e74775.
    • (2013) PLoS One , vol.8
    • Chen, R.1    Ren, S.2    Meng, T.3    Aguilar, J.4    Sun, Y.5
  • 36
    • 77956281456 scopus 로고    scopus 로고
    • Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival
    • Hagglof C, Hammarsten P, Josefsson A, Stattin P, Paulsson J, et al. (2010) Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival. PLoS One 5: e10747.
    • (2010) PLoS One , vol.5
    • Hagglof, C.1    Hammarsten, P.2    Josefsson, A.3    Stattin, P.4    Paulsson, J.5
  • 37
    • 84888198328 scopus 로고    scopus 로고
    • Epigenetic biomarkers in urological tumors: A systematic review
    • Jeronimo C, Henrique R (2014) Epigenetic biomarkers in urological tumors: A systematic review. Cancer Lett 342: 264-274.
    • (2014) Cancer Lett , vol.342 , pp. 264-274
    • Jeronimo, C.1    Henrique, R.2
  • 39
    • 84888200099 scopus 로고    scopus 로고
    • Epigenetic biomarkers in prostate cancer: Current and future uses
    • Chiam K, Ricciardelli C, Bianco-Miotto T (2014) Epigenetic biomarkers in prostate cancer: Current and future uses. Cancer Lett 342: 248-256.
    • (2014) Cancer Lett , vol.342 , pp. 248-256
    • Chiam, K.1    Ricciardelli, C.2    Bianco-Miotto, T.3
  • 40
    • 84055184656 scopus 로고    scopus 로고
    • Biomarkers in prostate cancer epidemiology
    • Basel
    • Verma M, Patel P, Verma M (2011) Biomarkers in prostate cancer epidemiology. Cancers (Basel) 3: 3773-3798.
    • (2011) Cancers , vol.3 , pp. 3773-3798
    • Verma, M.1    Patel, P.2    Verma, M.3
  • 41
    • 84878856021 scopus 로고    scopus 로고
    • Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
    • Basel
    • Gupta A, Zhou CQ, Chellaiah MA (2013) Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells. Cancers (Basel) 5: 617-638.
    • (2013) Cancers , vol.5 , pp. 617-638
    • Gupta, A.1    Zhou, C.Q.2    Chellaiah, M.A.3
  • 42
    • 41749122372 scopus 로고    scopus 로고
    • Tertiary Gleason pattern 5 in Gleason 7 prostate cancer predicts pathological stage and biochemical recurrence
    • Sim HG, Telesca D, Culp SH, Ellis WJ, Lange PH, et al. (2008) Tertiary Gleason pattern 5 in Gleason 7 prostate cancer predicts pathological stage and biochemical recurrence. J Urol 179: 1775-1779.
    • (2008) J Urol , vol.179 , pp. 1775-1779
    • Sim, H.G.1    Telesca, D.2    Culp, S.H.3    Ellis, W.J.4    Lange, P.H.5
  • 43
    • 50449101737 scopus 로고    scopus 로고
    • Correlation between prostate needle biopsies and radical prostatectomy specimens: Can we predict pathological outcome?
    • Zam NA, Tan PH, Sim HG, Lau WK, Yip SK, et al. (2008) Correlation between prostate needle biopsies and radical prostatectomy specimens: can we predict pathological outcome? Pathology 40: 586-591.
    • (2008) Pathology , vol.40 , pp. 586-591
    • Zam, N.A.1    Tan, P.H.2    Sim, H.G.3    Lau, W.K.4    Yip, S.K.5
  • 44
    • 33749864510 scopus 로고    scopus 로고
    • Genomics and the impact of new technologies on the management of colorectal cancer
    • Harkin DP (2006) Genomics and the impact of new technologies on the management of colorectal cancer. Oncologist 11: 988-991.
    • (2006) Oncologist , vol.11 , pp. 988-991
    • Harkin, D.P.1
  • 46
    • 84872732113 scopus 로고    scopus 로고
    • DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases
    • Aryee MJ, Liu W, Engelmann JC, Nuhn P, Gurel M, et al. (2013) DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Sci Transl Med 5: 169ra110.
    • (2013) Sci Transl Med , vol.5
    • Aryee, M.J.1    Liu, W.2    Engelmann, J.C.3    Nuhn, P.4    Gurel, M.5
  • 49
    • 84866869795 scopus 로고    scopus 로고
    • DNA methylation analysis of ALOX12 and GSTM1 in acute myeloid leukaemia identifies prognostically significant groups
    • Ohgami RS, Ma L, Ren L, Weinberg OK, Seetharam M, et al. (2012) DNA methylation analysis of ALOX12 and GSTM1 in acute myeloid leukaemia identifies prognostically significant groups. Br J Haematol 159: 182-190.
    • (2012) Br J Haematol , vol.159 , pp. 182-190
    • Ohgami, R.S.1    Ma, L.2    Ren, L.3    Weinberg, O.K.4    Seetharam, M.5
  • 50
    • 34548840830 scopus 로고    scopus 로고
    • Methylation of tumor-related genes in neoadjuvant-treated gastric cancer: Relation to therapy response and clinicopathologic and molecular features
    • DOI 10.1158/1078-0432.CCR-07-0241
    • Napieralski R, Ott K, Kremer M, Becker K, Boulesteix AL, et al. (2007) Methylation of tumor-related genes in neoadjuvant-treated gastric cancer: relation to therapy response and clinicopathologic and molecular features. Clin Cancer Res 13: 5095-5102. (Pubitemid 47502076)
    • (2007) Clinical Cancer Research , vol.13 , Issue.17 , pp. 5095-5102
    • Napieralski, R.1    Ott, K.2    Kremer, M.3    Becker, K.4    Boulesteix, A.-L.5    Lordick, F.6    Siewert, J.R.7    Hofler, H.8    Keller, G.9
  • 51
    • 74949089956 scopus 로고    scopus 로고
    • Three DNA methylation epigenotypes in human colorectal cancer
    • Yagi K, Akagi K, Hayashi H, Nagae G, Tsuji S, et al. (2010) Three DNA methylation epigenotypes in human colorectal cancer. Clin Cancer Res 16: 21-33.
    • (2010) Clin Cancer Res , vol.16 , pp. 21-33
    • Yagi, K.1    Akagi, K.2    Hayashi, H.3    Nagae, G.4    Tsuji, S.5
  • 52
    • 84856100724 scopus 로고    scopus 로고
    • Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma
    • Ammerpohl O, Pratschke J, Schafmayer C, Haake A, Faber W, et al. (2012) Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma. Int J Cancer 130: 1319-1328.
    • (2012) Int J Cancer , vol.130 , pp. 1319-1328
    • Ammerpohl, O.1    Pratschke, J.2    Schafmayer, C.3    Haake, A.4    Faber, W.5
  • 54
    • 84855487228 scopus 로고    scopus 로고
    • Phase 2 clinical trial of 5-azacitidine, valproic acid, and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome
    • Raffoux E, Cras A, Recher C, Boelle PY, de Labarthe A, et al. (2010) Phase 2 clinical trial of 5-azacitidine, valproic acid, and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome. Oncotarget 1: 34-42.
    • (2010) Oncotarget , vol.1 , pp. 34-42
    • Raffoux, E.1    Cras, A.2    Recher, C.3    Boelle, P.Y.4    De Labarthe, A.5
  • 55
    • 77953230908 scopus 로고    scopus 로고
    • 12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells
    • Krishnamoorthy S, Jin R, Cai Y, Maddipati KR, Nie D, et al. (2010) 12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells. Exp Cell Res 316: 1706-1715.
    • (2010) Exp Cell Res , vol.316 , pp. 1706-1715
    • Krishnamoorthy, S.1    Jin, R.2    Cai, Y.3    Maddipati, K.R.4    Nie, D.5
  • 56
    • 84873910693 scopus 로고    scopus 로고
    • SuperTAG methylation-specific digital karyotyping reveals uremia-induced epigenetic dysregulation of atherosclerosis-related genes
    • Zawada AM, Rogacev KS, Hummel B, Grun OS, Friedrich A, et al. (2012) SuperTAG methylation-specific digital karyotyping reveals uremia-induced epigenetic dysregulation of atherosclerosis-related genes. Circ Cardiovasc Genet 5: 611-620.
    • (2012) Circ Cardiovasc Genet , vol.5 , pp. 611-620
    • Zawada, A.M.1    Rogacev, K.S.2    Hummel, B.3    Grun, O.S.4    Friedrich, A.5
  • 57
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • DOI 10.1101/gad.1653708
    • Andrae J, Gallini R, Betsholtz C (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22: 1276-1312. (Pubitemid 351717519)
    • (2008) Genes and Development , vol.22 , Issue.10 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 58
    • 78649910284 scopus 로고    scopus 로고
    • A novel signaling axis of matriptase/PDGF-D/ss-PDGFR in human prostate cancer
    • Ustach CV, Huang W, Conley-LaComb MK, Lin CY, Che M, et al. (2010) A novel signaling axis of matriptase/PDGF-D/ss-PDGFR in human prostate cancer. Cancer Res 70: 9631-9640.
    • (2010) Cancer Res , vol.70 , pp. 9631-9640
    • Ustach, C.V.1    Huang, W.2    Conley-LaComb, M.K.3    Lin, C.Y.4    Che, M.5
  • 59
    • 83655182199 scopus 로고    scopus 로고
    • Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer
    • Gallick GE, Corn PG, Zurita AJ, Lin SH (2012) Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer. Future Med Chem 4: 107-119.
    • (2012) Future Med Chem , vol.4 , pp. 107-119
    • Gallick, G.E.1    Corn, P.G.2    Zurita, A.J.3    Lin, S.H.4
  • 60
    • 84862903434 scopus 로고    scopus 로고
    • PDGFRbeta expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation
    • Hewitt KJ, Shamis Y, Knight E, Smith A, Maione A, et al. (2012) PDGFRbeta expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation. J Cell Sci 125: 2276-2287.
    • (2012) J Cell Sci , vol.125 , pp. 2276-2287
    • Hewitt, K.J.1    Shamis, Y.2    Knight, E.3    Smith, A.4    Maione, A.5
  • 61
    • 33846821916 scopus 로고    scopus 로고
    • High TGFbeta-Smad Activity Confers Poor Prognosis in Glioma Patients and Promotes Cell Proliferation Depending on the Methylation of the PDGF-B Gene
    • DOI 10.1016/j.ccr.2006.11.023, PII S1535610806003813
    • Bruna A, Darken RS, Rojo F, Ocana A, Penuelas S, et al. (2007) High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11: 147-160. (Pubitemid 46209848)
    • (2007) Cancer Cell , vol.11 , Issue.2 , pp. 147-160
    • Bruna, A.1    Darken, R.S.2    Rojo, F.3    Ocana, A.4    Penuelas, S.5    Arias, A.6    Paris, R.7    Tortosa, A.8    Mora, J.9    Baselga, J.10    Seoane, J.11
  • 62
    • 33644867457 scopus 로고    scopus 로고
    • The stem cell factor receptor/c-Kit as a drug target in cancer
    • Lennartsson J, Ronnstrand L (2006) The stem cell factor receptor/c-Kit as a drug target in cancer. Curr Cancer Drug Targets 6: 65-75.
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 65-75
    • Lennartsson, J.1    Ronnstrand, L.2
  • 64
    • 79961171626 scopus 로고    scopus 로고
    • MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia
    • Gao XN, Lin J, Li YH, Gao L, Wang XR, et al. (2012) MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia. Oncogene 30: 3416-3428.
    • (2012) Oncogene , vol.30 , pp. 3416-3428
    • Gao, X.N.1    Lin, J.2    Li, Y.H.3    Gao, L.4    Wang, X.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.