Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates

Journal of Controlled Release

Volumn 183, Issue 1, 2014, Pages 124-137

  Barrett, Stephanie E ^a   Burke, Rob S ^a   Abrams, Marc T ^a   Bason, Carol ^a   Busuek, Marina ^a   Carlini, Edward ^a   Carr, Brian A ^a   Crocker, Louis S ^a   Fan, Haihong ^a   Garbaccio, Robert M ^a   Guidry, Erin N ^a   Heo, Jun H ^a   Howell, Bonnie J ^a   Kemp, Eric A ^a   Kowtoniuk, Robert A ^a   Latham, Andrew H ^a   Leone, Anthony M ^a   Lyman, Michael ^a   Parmar, Rubina G ^a   Patel, Mihir ^a   Pechenov, Sergey Y ^a   Pei, Tao ^a   Pudvah, Nicole T ^a   Raab, Conrad ^a   Riley, Sean ^a   Sepp Lorenzino, Laura ^a   Smith, Sheri ^a   Soli, Eric D ^a   Staskiewicz, Steven ^a   Stern, Melissa ^a   Truong, Quang ^a   Vavrek, Marissa ^a   Waldman, Jacob H ^a   Walsh, Eileen S ^a   Williams, J Michael ^a   Young, Stephanie ^a   Colletti, Steven L ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Biodegradable; Delivery vehicle; Gene delivery; Polypeptide

Indexed keywords

AMIDES; AUTOMOBILE BODIES; BIODEGRADABLE POLYMERS; GENE TRANSFER; POLYPEPTIDES; RNA;

BIODEGRADABLE; BIODISTRIBUTIONS; DELIVERY VEHICLE; GENE DELIVERY; POLYMER CONJUGATE; POLYMER PLATFORM; SIRNA DELIVERY; STRUCTURE ACTIVITY RELATIONSHIPS;

FUNCTIONAL POLYMERS;

DRUG CARRIER; MESSENGER RNA; POLYAMIDE; RADIOISOTOPE; SMALL INTERFERING RNA; BIOMATERIAL; NYLON; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONJUGATE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STABILITY; FEMALE; GENE SILENCING; GENE TARGETING; ISOTOPE LABELING; LIVER; LIVER CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RAT; ANIMAL; AUTORADIOGRAPHY; CHEMISTRY; DRUG DESIGN; GENETICS; HEPG2 CELL LINE; HUMAN; METABOLISM; RHESUS MONKEY; SCINTISCANNING; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TISSUE DISTRIBUTION; TOXICITY;

ANIMALS; AUTORADIOGRAPHY; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; DRUG DESIGN; DRUG STABILITY; FEMALE; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; MACACA MULATTA; NYLONS; PEPTIDES; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 84898667367     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.03.028     Document Type: Article

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