Targeted inhibition of cell-surface serine protease hepsin blocks prostate cancer bone metastasis

Oncotarget

Volumn 5, Issue 5, 2014, Pages 1352-1362

  Tang, Xi ^a   Mahajan, Sumit S ^a   Nguyen, Liem T ^a   Béliveau, François ^b   Leduc, Richard ^b   Simon, Julian A ^a   Vasioukhin, Valeri ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Bone metastasis; Cancer; Hepsin; Metastasis; Prostate cancer; Protease

Indexed keywords

HEPSIN; HEPSIN INHIBITOR 1; HEPSIN INHIBITOR 13; HEPSIN INHIBITOR 17; HEPSIN INHIBITOR 20; HEPSIN INHIBITOR 25; HEPSIN INHIBITOR 8; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; HEPIN-13; MEMBRANE PROTEIN; NAPHTHALENE DERIVATIVE; PYRIMIDINE DERIVATIVE; SERINE PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE METASTASIS; CANCER INHIBITION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG EXPOSURE; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; LUNG METASTASIS; MALE; METASTASIS INHIBITION; MOLECULAR DOCKING; MOUSE; MURINE MODEL; NONHUMAN; PROSTATE CANCER; TREATMENT DURATION; ADENOCARCINOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOAVAILABILITY; BONE NEOPLASMS; CHEMICAL STRUCTURE; HALF LIFE TIME; HEK293 CELL LINE; IC50; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PROSTATIC NEOPLASMS; SECONDARY;

ADENOCARCINOMA; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BONE NEOPLASMS; HALF-LIFE; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; NAPHTHALENES; PROSTATIC NEOPLASMS; PYRIMIDINES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS;

EID: 84898632762     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1817     Document Type: Article

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