A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia

Biochemical Journal

Volumn 459, Issue 3, 2014, Pages 427-439

  Willemen, Hanneke L D M ^a   Campos, Pedro M ^b,g   Lucas, Elisa ^b,c   Morreale, Antonio ^d,h   GIL Redondo, Rubén ^d,i   Agut, Juan ^e   González, Florenci V ^e   Ramos, Paula ^b,c   Heijnen, Cobi ^a,f   Mayor Jr , Federico ^b,c   Kavelaars, Annemieke ^a,f   Murga, Cristina ^b,c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^c Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas   (Spain)

^d CSIC   (Spain)

^e UNIVERSITAT JAUME I   (Spain)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^g Allinky Biopharma Parque Científico de Madrid   (Spain)

^h REPSOL YPF   (Spain)

ⁱ UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Docking; Inflammatory hyperalgesia; P38 mitogen activated protein kinase (p38 mapk); Pain; Persistent pain

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; FGA 19; LIPOPOLYSACCHARIDE; METHYL GROUP; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N (5 CHLORO 2 METHYLPHENYL) 7 NITROBENZO[ C ][1,2,5]OXADIAZOL 4 AMINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING SITE; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYPERALGESIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY HYPERALGESIA; MAXIMUM PERMISSIBLE DOSE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; HYPERALGESIA; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MONOCYTES; OXADIAZOLES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; RANDOM ALLOCATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898618996     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130172     Document Type: Article

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