G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling

Molecular Medicine

Volumn 18, Issue 4, 2012, Pages 556-564

  Eijkelkamp, Niels ^a,b   Heijnen, Cobi J ^a   Carbajal, Anibal Garza ^a   Willemen, Hanneke L D M ^a   Wang, Huijing ^a   Minett, Michael S ^b   Wood, John N ^b   Schedlowski, Manfred ^c   Dantzer, Robert ^d   Kelley, Keith W ^d   Kavelaars, Annemieke ^a,d  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; CYTOKINE; G PROTEIN COUPLED RECEPTOR KINASE 6; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY PAIN; MOUSE; MOUSE STRAIN; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPINAL GANGLION; TEMPERATURE SENSITIVITY;

ANIMALS; CYTOKINES; DINOPROSTONE; DOPAMINERGIC NEURONS; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASES; GENE EXPRESSION REGULATION; HYPERALGESIA; INFLAMMATION; INTERLEUKIN-1BETA; MICE; MICE, KNOCKOUT; NEURALGIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862233533     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00398     Document Type: Article

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