A novel multifunctional poly(amidoamine) dendrimeric delivery system with superior encapsulation capacity for targeted delivery of the chemotherapy drug 10-hydroxycamptothecin

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 378-387

  Kong, Xiuqi ^a   Yu, Kui ^b   Yu, Min ^a   Feng, Yupeng ^a   Wang, Jin ^a   Li, Mingjie ^a   Chen, Zeming ^a   He, Minghao ^a   Guo, Rui ^a   Tian, Ruisong ^b   Li, Yuxi ^b   Wu, Wenjie ^b   Hong, Zhangyong ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

10 Hydroxycamptothecin; Encapsulation; Integrin; Multifunctional dendrimers; Targeted cancer therapy

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ARGINYLGLYCYLASPARTIC ACID; ARGINYLGLYCYLASPARTYLPHENYLALANYLLYSINE; CYCLOPEPTIDE; DENDRIMER; DRUG CARRIER; INTEGRIN RECEPTOR; LIGAND; MACROGOL; POLYAMIDOAMINE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; 10-HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CYCLIC (ARGINYL-GLYCYL-ASPARTYL-PHENYLALANYL-LYSYL); PAMAM STARBURST; POLYAMINE; FLUORESCEIN ISOTHIOCYANATE; RHODAMINE; WATER;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL; CARCINOMA CELL; CELL STRAIN MCF 7; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROPHOBICITY; IC 50; IN VITRO STUDY; INTERNALIZATION; MOLECULARLY TARGETED THERAPY; MOLECULE; MTT ASSAY; NANOENCAPSULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; TARGET CELL; ANALOGS AND DERIVATIVES; BREAST TUMOR; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG FORMULATION; IC50; KINETICS; MALE; MCF 7 CELL LINE; MEDICINAL CHEMISTRY; METABOLISM; PATHOLOGY; PHARMACEUTICS; PROCEDURES; PROSTATE TUMOR; SOLUBILITY; SURFACE PROPERTY; CELL VIABILITY; CYTOTOXICITY; DIALYSIS; ENCAPSULATION; FLUORESCENCE MICROSCOPY; FREEZE DRYING; GENE OVEREXPRESSION; HELA CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY; WATER SOLUBILITY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CAMPTOTHECIN; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DENDRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; ENDOCYTOSIS; FEMALE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHAVBETA3; KINETICS; MALE; MCF-7 CELLS; PEPTIDES, CYCLIC; POLYAMINES; PROSTATIC NEOPLASMS; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 84898599864     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.022     Document Type: Article

References (35)

1. K.P. Anil, M. Andrzej, B. James, P.T. Thommey, H.B. Neil, and R.B. James Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapy Bioconjugate Chemistry 15 2004 1174 1181
2. D. Chandrasekar, R. Sistla, F.J. Ahmad, R.K. Khar, and P.V. Diwan The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats Biomaterials 28 2007 504 512 (Pubitemid 44602223)
3. Y.Y. Cheng, L.B. Zhao, Y.W. Li, and T.W. Xu Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives Chemical Society Reviews 40 2011 2673 2703
4. E.O. Donald, and A.P. Nicholas Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles International Journal of Pharmaceutics 307 2006 93 102
5. M.R. Dreher, W. Liu, C.R. Michelich, M.W. Dewhirst, F. Yuan, and A. Chilkoti Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers Journal of the National Cancer Institute 98 2006 335 344 (Pubitemid 43338213)
6. R. Duncan The dawning era of polymer therapeutics Nature Reviews Drug Discovery 2 2003 347 360 (Pubitemid 37361705)
7. A. Gabizon, R. Catane, B. Uziely, B. Kaufman, T. Safra, R. Cohen, F.A.H. Martin, and Y. Barenholz Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes Cancer Research 54 1994 987 992 (Pubitemid 24085451)
8. R. Garcia-Carbonero, and J.G. Supko Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins Clinical Cancer Research 8 2002 641 661 (Pubitemid 34742090)
9. U. Gupta, H.B. Agashe, A. Asthana, and N.K. Jain Dendrimers: novel polymeric nanoarchitectures for solubility enhancement Biomacromolecules 7 2006 649 658
10. A. Hatefi, and B. Amsden Camptothecin delivery methods Pharmaceutical Research 19 2002 1389 1399 (Pubitemid 35266542)
11. M. Hong, S. Zhu, Y. Jiang, G. Tang, and Y. Pei Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin Journal of Controlled Release 133 2009 96 102
12. J. Hu, Y. Su, H. Zhang, T. Xu, and Y. Cheng Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery Biomaterials 32 2011 9950 9959
13. J.M. István, M. Andrzej, T. Thommey, B.M. Chandan, and R.B. James PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality Biomacromolecules 7 2006 572 579
14. N. Kamaly, Z. Xiao, P.M. Valencia, A.F. Radovic-Moreno, and O.C. Farokhzad Targeted polymeric therapeutic nanoparticles: design, development and clinical translation Chemical Society Reviews 41 2012 2971
15. T.Y. Kim, D.W. Kim, J.Y. Chung, S.G. Shin, S.C. Kim, D.S. Heo, N.K. Kim, and Y.J. Bang Phase I and pharmacokinetic study of Genexol-PM, a cremophor free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies Clinical Cancer Research 10 2004 3708 3716 (Pubitemid 38697604)
16. K. Kono, C. Kojima, N. Hayashi, E. Nishisaka, K. Kiura, S. Watarai, and A. Harada Preparation and cytotoxic activity of poly(ethylene glycol)-modified poly(amidoamine) dendrimers bearing adriamycin Biomaterials 29 2008 1664 1675
17. Y.E. Kurtoglu, R.S. Navath, B. Wang, S. Kannan, R. Romero, and R.M. Kannan Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery Biomaterials 30 2009 2112 2121
18. N. Larson, and H. Ghandehari Polymeric conjugates for drug delivery Chemistry of Materials 24 2012 840 853
19. A.R. Menjoge, R.M. Kannan, and D.A. Tomalia Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications Drug Discovery Today 15 2010 171 185
20. S.M. Moghimi, A.C. Hunter, and J.C. Murray Nanomedicine: current status and future prospects FASEB Journal 19 2005 311 330 (Pubitemid 40316520)
21. M.T. Morgan, Y. Nakanishi, D.J. Kroll, A.P. Griset, M.A. Carnahan, M. Wathier, N.H. Oberlies, G. Manikumar, M.C. Wani, and M.W. Grinstaff Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro Cancer Research 66 2006 11913 11921 (Pubitemid 46094204)
22. D. Neri, and R. Bicknell Tumour vascular targeting Nature Reviews Cancer 5 2005 436 446 (Pubitemid 40791486)
23. J. Nicolas, S. Mura, D. Brambilla, N. Mackiewicz, and P. Couvreur Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery Chemical Society Reviews 42 2013 1147
24. A.K. Patri, J.F. Kukowska-Latallo, and J.R. Baker Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex Advanced Drug Delivery Reviews 57 2005 2203 2214 (Pubitemid 41759393)
25. D. Peer, J.M. Karp, S. Hong, O.C. FarokHzad, R. Margalit, and R. Langer Nanocarriers as an emerging platform for cancer therapy Nature Nanotechnology 2 2007 751 760 (Pubitemid 350223348)
26. R. Plummer, R.H. Wilson, H. Calvert, A.V. Boddy, M. Griffin, J. Sludden, M.J. Tilby, M. Eatock, D.G. Pearson, C.J. Ottley, Y. Matsumura, K. Kataoka, and T. Nishiya A phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours British Journal of Cancer 104 2011 593 598
27. E. Ruoslahti, S.N. Bhatia, and M.J. Sailor Targeting of drugs and nanoparticles to tumors Journal of Cell Biology 188 2010 759 768
28. S. Svenson Dendrimers as versatile platform in drug delivery applications European Journal of Pharmaceutics and Biopharmaceutics 71 2009 445 462
29. P.A. Vasey, S.B. Kaye, R. Morrison, C. Twelves, P. Wilson, R. Duncan, A.H. Thomson, L.S. Murray, T.E. Hilditch, T. Murray, S. Burtles, D. Fraier, E. Frigerio, and J. Cassidy Phase I clinical and pharmacokinetic study of PK1 [N-(2-Hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents - drug-polymer conjugates Clinical Cancer Research 5 1999 83 94 (Pubitemid 29045181)
30. C.L. Waite, and C.M. Roth PAMAM-RGD conjugates enhance siRNA delivery through a multicellular spheroid model of malignant glioma Bioconjugate Chemistry 20 2009 1908 1916
31. Y. Wang, R. Guo, X. Cao, M. Shen, and X. Shi Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy Biomaterials 32 2011 3322 3329
32. W. Wijagkanalan, S. Kawakami, and M. Hashida Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations Pharmaceutical Research 28 2010 1500 1519
33. X.B. Xiong, Y. Huang, W.L. Lu, X. Zhang, H. Zhang, T. Nagai, and Q. Zhang Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic Journal of Controlled Release 107 2005 262 275 (Pubitemid 41316289)
34. Y.F. Zhang, J.C. Wang, D.Y. Bian, X. Zhang, and Q. Zhang Targeted delivery of RGD-modified liposomes encapsulating both combretastatin A-4 and doxorubicin for tumor therapy: in vitro and in vivo studies European Journal of Pharmaceutics and Biopharmaceutics 74 2010 467 473
35. S. Zhu, M. Hong, L. Zhang, G. Tang, Y. Jiang, and Y. Pei PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation and in vivo tumor accumulation Pharmaceutical Research 27 2010 161 174