Stress, giucocorticoids and the susceptibility to develop autoimmune disorders of the central nervous system

Neurological Sciences

Volumn 22, Issue 2, 2001, Pages 159-162

  Morale, C ^a   Brouwer, J ^a   Testa, N ^a   Tirolo, C ^b   Barden, N ^b   Dijkstra, C D ^b   Amor, S ^c   Marchetti, B ^c  

^a Institute for Research and Care on Mental Retardation and Brain   (Italy)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

EAE; Glucocorticoid receptor; Hpa axis; Mogs; Mrna; Stress; Transgenic

Indexed keywords

COMPLEMENTARY RNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MYELIN ASSOCIATED GLYCOPROTEIN; OLIGODENDROCYTE MYELIN GLYCOPROTEIN; OLIGODENDROCYTE-MYELIN GLYCOPROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL; ARTICLE; DEMYELINATING DISEASE; FEEDBACK SYSTEM; FEMALE; GENETIC PREDISPOSITION; GENETICS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOLOGY; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION; STRESS; TRANSGENIC MOUSE;

ANIMALS; DEMYELINATING AUTOIMMUNE DISEASES, CNS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEEDBACK; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUCOCORTICOIDS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MICE; MICE, TRANSGENIC; MYELIN-ASSOCIATED GLYCOPROTEIN; RECEPTORS, GLUCOCORTICOID; RNA, ANTISENSE; STRESS;

EID: 0035319958     PISSN: 15901874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100720170016     Document Type: Article

References (5)

1. Marchetti B, Gallo F, Tirolo C et al (1997) Developmental consequence of hypothalamic-pituitary-adrenocortical system disruption: impact on thymus gland maturation and the susceptibility to develop neuroimmune diseases. Devel Brain Dysf 10:503-527
2. Marchetti B, Morale M, Gallo F et al (2001 ) The hypothalamic-hypophyseal gonadal axis and the immune system. In: Ader R, Feiten DL, Cohen N (eds) Psychoneuroimmunology, vol. l, 3rd edn. Academic Press, New York, pp 363-389
3. Morale M, Batticane, N, Gallo, F et al (1995) Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type glucocorticoid receptor antisense ribonucleic acid permanently impairs T-cell functions: effects on T-cell trafficking and T-cell responsiveness during postnatal maturation. Endocrinology 136:3949-3960
4. Chrousos G ( 1995) The hypothalamic-pituitary-adrenal axis and immune-related inflammation. N Engl J Med 332:1351-1362
5. Sacedön R, Vicente A, Varas A et al (1999) Partial blockade of T-cell differentiation during ontogeny and marked alterations of the thymic microenvironment in transgenic mice with impaired glucocorticoid receptor function. J Neuroimmunol 98:157-167