Identification of a new export signal in Plasmodium yoelii: Identification of a new exportome

Cellular Microbiology

Volumn 16, Issue 5, 2014, Pages 673-686

  Siau, Anthony ^a   Huang, Ximei ^a   Yam, Xue Yan ^a   Bob, Ndeye Sakha ^a   Sun, Hequan ^b   Rajapakse, Jagath C ^b   Renia, Laurent ^c   Preiser, Peter R ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PROTOZOAL PROTEIN; SIGNAL PEPTIDE;

ARTICLE; NONHUMAN; NUCLEAR EXPORT SIGNAL; PLASMODIUM YOELII; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN CONFORMATION; SECRETION (PROCESS);

AMINO ACID SEQUENCE; PLASMODIUM YOELII; PROTEIN CONFORMATION; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; PROTOZOAN PROTEINS;

EID: 84898484806     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12293     Document Type: Article

References (30)

1. Acquaah-Mensah, G.K., Leach, S.M., and Guda, C. (2006) Predicting the subcellular localization of human proteins using machine learning and exploratory data analysis. Genomics Proteomics Bioinformatics 4: 120-133.
2. Bozdech, Z., Llinas, M., Pulliam, B.L., Wong, E.D., Zhu, J., and DeRisi, J.L. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 1: E5.
3. Bozdech, Z., Mok, S., Hu, G., Imwong, M., Jaidee, A., Russell, B., etal. (2008) The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites. Proc Natl Acad Sci USA 105: 16290-16295.
4. Carlton, J., Silva, J., and Hall, N. (2005) The genome of model malaria parasites, and comparative genomics. Curr Issues Mol Biol 7: 23-37.
5. Carlton, J.M., Angiuoli, S.V., Suh, B.B., Kooij, T.W., Pertea, M., Silva, J.C., etal. (2002) Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature 419: 512-519.
6. Cole, C., Barber, J.D., and Barton, G.J. (2008) The Jpred 3 secondary structure prediction server. Nucleic Acids Res 36 (Web Server issue): W197-W201.
7. Cunningham, D.A., Jarra, W., Koernig, S., Fonager, J., Fernandez-Reyes, D., Blythe, J.E., etal. (2005) Host immunity modulates transcriptional changes in a multigene family (yir) of rodent malaria. Mol Microbiol 58: 636-647.
8. Di Girolamo, F., Raggi, C., Birago, C., Pizzi, E., Lalle, M., Picci, L., etal. (2008) Plasmodium lipid rafts contain proteins implicated in vesicular trafficking and signalling as well as members of the PIR superfamily, potentially implicated in host immune system interactions. Proteomics 8: 2500-2513.
9. Franke-Fayard, B., Fonager, J., Braks, A., Khan, S.M., and Janse, C.J. (2010) Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria? PLoS Pathog 6: e1001032.
10. Gilchrist, A., Au, C.E., Hiding, J., Bell, A.W., Fernandez-Rodriguez, J., Lesimple, S., etal. (2006) Quantitative proteomics analysis of the secretory pathway. Cell 127: 1265-1281.
11. Gruring, C., Heiber, A., Kruse, F., Flemming, S., Franci, G., Colombo, S.F., etal. (2012) Uncovering common principles in protein export of malaria parasites. Cell Host Microbe 12: 717-729.
12. Heiber, A., Kruse, F., Pick, C., Gruring, C., Flemming, S., Oberli, A., etal. (2013) Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export. PLoS Pathog 9: e1003546.
13. Horton, P., and Nakai, K. (1997) Better prediction of protein cellular localization sites with the k nearest neighbors classifier. Proc Int Conf Intell Syst Mol Biol 5: 147-152.
14. Ingmundson, A., Nahar, C., Brinkmann, V., Lehmann, M.J., and Matuschewski, K. (2012) The exported Plasmodium berghei protein IBIS1 delineates membranous structures in infected red blood cells. Mol Microbiol 83: 1229-1243.
15. Janse, C.J., Ramesar, J., and Waters, A.P. (2006) High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei. Nat Protoc 1: 346-356.
16. Janssen, C.S., Phillips, R.S., Turner, C.M., and Barrett, M.P. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Res 32: 5712-5720.
17. Jemmely, N.Y., Niang, M., and Preiser, P.R. (2010) Small variant surface antigens and Plasmodium evasion of immunity. Future Microbiol 5: 663-682.
18. Lawton, J., Brugat, T., Yan, Y.X., Reid, A.J., Bohme, U., Otto, T.D., etal. (2012) Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS). BMC Genomics 13: 125.
19. Marti, M., Good, R.T., Rug, M., Knuepfer, E., and Cowman, A.F. (2004) Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science 306: 1930-1933.
20. Neafsey, D.E., Galinsky, K., Jiang, R.H., Young, L., Sykes, S.M., Saif, S., etal. (2012) The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nat Genet 44: 1046-1050.
21. van Ooij, C., Tamez, P., Bhattacharjee, S., Hiller, N.L., Harrison, T., Liolios, K., etal. (2008) The malaria secretome: from algorithms to essential function in blood stage infection. PLoS Pathog 4: e1000084.
22. Pasini, E.M., Braks, J.A., Fonager, J., Klop, O., Aime, E., Spaccapelo, R., etal. (2012) Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins. Mol Cell Proteomics 12: 426-448.
23. Pedelacq, J.D., Cabantous, S., Tran, T., Terwilliger, T.C., and Waldo, G.S. (2006) Engineering and characterization of a superfolder green fluorescent protein. Nat Biotechnol 24: 79-88.
24. Petersen, T.N., Brunak, S., von Heijne, G., and Nielsen, H. (2011) SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods 8: 785-786.
25. Petter, M., Haeggstrom, M., Khattab, A., Fernandez, V., Klinkert, M.Q., and Wahlgren, M. (2007) Variant proteins of the Plasmodium falciparum RIFIN family show distinct subcellular localization and developmental expression patterns. Mol Biochem Parasitol 156: 51-61.
26. del Portillo, H.A., Fernandez-Becerra, C., Bowman, S., Oliver, K., Preuss, M., Sanchez, C.P., etal. (2001) A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature 410: 839-842.
27. Quinlan, J.R. (1993) C4.5: Programs for Machine Learning. San Mateo: Morgan Kaufmann.
28. Sargeant, T.J., Marti, M., Caler, E., Carlton, J.M., Simpson, K., Speed, T.P., and Cowman, A.F. (2006) Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol 7: R12.
29. Sijwali, P.S., and Rosenthal, P.J. (2010) Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export. PLoS ONE 5: e10227.
30. Spielmann, T., and Gilberger, T.W. (2010) Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways? Trends Parasitol 26: 6-10.