Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Sijwali, Puran Singh ^a   Rosenthal, Philip J ^b  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; ERYTHROCYTE MEMBRANE PROTEIN 1; KNOB ASSOCIATED HISTIDINE RICH PROTEIN; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; KNOB PROTEIN, PLASMODIUM FALCIPARUM; PEPTIDE; PROTOZOAL PROTEIN; SIGNAL PEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; MOUSE; NONHUMAN; NUCLEAR EXPORT SIGNAL; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTEIN TRANSPORT; ANIMAL; CELL VACUOLE; CHEMISTRY; METABOLISM; PARASITOLOGY; PROTEIN MOTIF;

PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RODENTIA;

AMINO ACID MOTIFS; ANIMALS; ERYTHROCYTES; GREEN FLUORESCENT PROTEINS; PEPTIDES; PLASMODIUM BERGHEI; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; VACUOLES;

EID: 77956308656     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010227     Document Type: Article

References (36)

1. Maier AG, Cooke BM, Cowman AF, Tilley L (2009) Malaria parasite proteins that remodel the host erythrocyte. Nat Rev Microbiol 7: 341-354.
2. Rowe JA, Claessens A, Corrigan RA, Arman M (2009) Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. Expert Rev Mol Med 11: e16.
3. Pasternak ND, Dzikowski R (2009) PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum. Int J Biochem Cell Biol 41: 1463-1466.
4. Fernandez V, Hommel M, Chen Q, Hagblom P, Wahlgren M (1999) Small, clonally variant antigens expressed on the surface of the Plasmodium falciparuminfected erythrocyte are encoded by the rif gene family and are the target of human immune responses. J Exp Med 190: 1393-1404.
5. Cheng Q, Cloonan N, Fischer K, Thompson J, Waine G, et al. (1998) stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol Biochem Parasitol 97: 161-176.
6. Niang M, Yan Yam X, Preiser PR (2009) The Plasmodium falciparum STEVOR multigene family mediates antigenic variation of the infected erythrocyte. PLoS Pathog 5: e1000307.
7. Blisnick T, Morales Betoulle ME, Barale JC, Uzureau P, Berry L, et al. (2000) Pfsbp1, a Maurer's cleft Plasmodium falciparum protein, is associated with the erythrocyte skeleton. Mol Biochem Parasitol 111: 107-121.
8. Haase S, Herrmann S, Gruring C, Heiber A, Jansen PW, et al. (2009) Sequence requirements for the export of the Plasmodium falciparum Maurer's clefts protein REX2. Mol Microbiol 71: 1003-1017.
9. Winter G, Kawai S, Haeggstrom M, Kaneko O, von Euler A, et al. (2005) SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytes. J Exp Med 201: 1853-1863.
10. Cooke BM, Buckingham DW, Glenister FK, Fernandez KM, Bannister LH, et al. (2006) A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells. J Cell Biol 172: 899-908.
11. Maier AG, Rug M, O'Neill MT, Beeson JG, Marti M, et al. (2007) Skeletonbinding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface. Blood 109: 1289-1297.
12. Janssen CS, Barrett MP, Turner CM, Phillips RS (2002) A large gene family for putative variant antigens shared by human and rodent malaria parasites. Proc Biol Sci 269: 431-436.
13. Marti M, Good RT, Rug M, Knuepfer E, Cowman AF (2004) Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science 306: 1930-1933.
14. Hiller NL, Bhattacharjee S, van Ooij C, Liolios K, Harrison T, et al. (2004) A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science 306: 1934-1937.
15. Sargeant TJ, Marti M, Caler E, Carlton JM, Simpson K, et al. (2006) Lineagespecific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol 7: R12.
16. Chang HH, Falick AM, Carlton PM, Sedat JW, DeRisi JL, et al. (2008) Nterminal processing of proteins exported by malaria parasites. Mol Biochem Parasitol 160: 107-115.
17. Boddey JA, Moritz RL, Simpson RJ, Cowman AF (2009) Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic 10: 285-299.
18. Boddey JA, Hodder AN, Gunther S, Gilson PR, Patsiouras H, et al. (2010) An aspartyl protease directs malaria effector proteins to the host cell. Nature 463: 627-631.
19. Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, et al. (2010) Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature 463: 632-636.
20. de Koning-Ward TF, Gilson PR, Boddey JA, Rug M, Smith BJ, et al. (2009) A newly discovered protein export machine in malaria parasites. Nature 459: 945-949.
21. Templeton TJ, Deitsch KW (2005) Targeting malaria parasite proteins to the erythrocyte. Trends Parasitol 21: 399-402.
22. Saridaki T, Frohlich KS, Braun-Breton C, Lanzer M (2009) Export of PfSBP1 to the Plasmodium falciparum Maurer's clefts. Traffic 10: 137-152.
23. Knuepfer E, Rug M, Klonis N, Tilley L, Cowman AF (2005) Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytes. Blood 105: 4078-4087.
24. Spielmann T, Gilberger TW(2010) Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways? Trends Parasitol 26: 6-10.
25. Janse CJ, Franke-Fayard B, Mair GR, Ramesar J, Thiel C, et al. (2006) High efficiency transfection of Plasmodium berghei facilitates novel selection procedures. Mol Biochem Parasitol 145: 60-70.
26. Jongco AM, Ting LM, Thathy V, Mota MM, Kim K (2006) Improved transfection and new selectable markers for the rodent malaria parasite Plasmodium yoelii. Mol Biochem Parasitol 146: 242-250.
27. MacKenzie JJ, Gomez ND, Bhattacharjee S, Mann S, Haldar K (2008) A Plasmodium falciparum host-targeting motif functions in export during blood stage infection of the rodent malarial parasite Plasmodium berghei. PLoS One 3: e2405.
28. Scherf A, Lopez-Rubio JJ, Riviere L (2008) Antigenic variation in Plasmodium falciparum. Annu Rev Microbiol 62: 445-470.
29. Gardner MJ, Hall N, Fung E, White O, Berriman M, et al. (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419: 498-511.
30. Jensen AT, Magistrado P, Sharp S, Joergensen L, Lavstsen T, et al. (2004) Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes. J Exp Med 199: 1179-1190.
31. Petter M, Haeggstrom M, Khattab A, Fernandez V, Klinkert MQ, et al. (2007) Variant proteins of the Plasmodium falciparum RIFIN family show distinct subcellular localization and developmental expression patterns. Mol Biochem Parasitol 156: 51-61.
32. Joannin N, Abhiman S, Sonnhammer EL, Wahlgren M (2008) Sub-grouping and sub-functionalization of the RIFIN multi-copy protein family. BMC Genomics 9: 19.
33. Sato S, Rangachari K, Wilson RJ (2003) Targeting GFP to the malarial mitochondrion. Mol Biochem Parasitol 130: 155-158.
34. Duraisingh MT, Triglia T, Cowman AF (2002) Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol 32: 81-89.
35. Trager W, Jensen JB (1976) Human malaria parasites in continuous culture. Science 193: 673-675.
36. Janse CJ, Ramesar J, Waters AP (2006) High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei. Nat Protoc 1: 346-356.