-
1
-
-
0033824138
-
International union of pharmacology. XXIII. The angiotensin II receptors
-
de Gasparo M, Catt KJ, Inagami T, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52:415-72.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 415-472
-
-
De Gasparo, M.1
Catt, K.J.2
Inagami, T.3
-
2
-
-
0037160968
-
Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
-
LIFE Study Group
-
Dahlöf B, Devereux RB, Kjeldsen SE, et al.; LIFE Study Group. Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002;359:995-1003.
-
(2002)
Lancet
, vol.359
, pp. 995-1003
-
-
Dahlöf, B.1
Devereux, R.B.2
Kjeldsen, S.E.3
-
3
-
-
2942635317
-
Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: The VALUE randomised trial
-
VALUE trial group
-
Julius S, Kjeldsen SE, Weber M, et al.; VALUE trial group. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004;363:2022-31.
-
(2004)
Lancet
, vol.363
, pp. 2022-2031
-
-
Julius, S.1
Kjeldsen, S.E.2
Weber, M.3
-
4
-
-
34249950165
-
Effect of telmisartan on cholesterol levels in patients with hypertension-Saga Telmisartan Aggressive Research (STAR)
-
Inoue T, Morooka T, Moroe K, et al. Effect of telmisartan on cholesterol levels in patients with hypertension-Saga Telmisartan Aggressive Research (STAR). Horm Metab Res 2007;39:372-6.
-
(2007)
Horm Metab Res
, vol.39
, pp. 372-376
-
-
Inoue, T.1
Morooka, T.2
Moroe, K.3
-
5
-
-
34247881925
-
Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes
-
Mori Y, Itoh Y, Tajima N. Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes. Adv Ther 2007;24: 146-53.
-
(2007)
Adv Ther
, vol.24
, pp. 146-153
-
-
Mori, Y.1
Itoh, Y.2
Tajima, N.3
-
6
-
-
4344569280
-
Effects of telmisartan compared with eprosartan on blood pressure control, glucose metabolism and lipid profile in hypertensive, type 2 diabetic patients: A randomized, double-blind, placebo-controlled 12-month study
-
Derosa G, Ragonesi PD, Mugellini A, et al. Effects of telmisartan compared with eprosartan on blood pressure control, glucose metabolism and lipid profile in hypertensive, type 2 diabetic patients: a randomized, double-blind, placebo-controlled 12-month study. Hypertens Res 2004;27:457-64.
-
(2004)
Hypertens Res
, vol.27
, pp. 457-464
-
-
Derosa, G.1
Ragonesi, P.D.2
Mugellini, A.3
-
7
-
-
1542547460
-
Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
-
Benson SC, Pershadsingh HA, Ho CI, et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension 2004;43: 993-1002.
-
(2004)
Hypertension
, vol.43
, pp. 993-1002
-
-
Benson, S.C.1
Pershadsingh, H.A.2
Ho, C.I.3
-
8
-
-
33644672013
-
Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity
-
Schupp M, Clemenz M, Gineste R, et al. Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity. Diabetes 2005;54:3442-52.
-
(2005)
Diabetes
, vol.54
, pp. 3442-3452
-
-
Schupp, M.1
Clemenz, M.2
Gineste, R.3
-
9
-
-
2442451618
-
Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
-
Schupp M, Janke J, Clasen R, et al. Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation 2004;109:2054-7.
-
(2004)
Circulation
, vol.109
, pp. 2054-2057
-
-
Schupp, M.1
Janke, J.2
Clasen, R.3
-
10
-
-
84898492947
-
Angiotensin type II receptor antagonist activates PPARgamma
-
Jing DQ, Yin SN, Mu YM. Angiotensin type II receptor antagonist activates PPARgamma. Chinese J Diabetes 2008;16:375-8.
-
(2008)
Chinese J Diabetes
, vol.16
, pp. 375-378
-
-
Jing, D.Q.1
Yin, S.N.2
Mu, Y.M.3
-
11
-
-
0036399805
-
PPAR(gamma) and glucose homeostasis
-
Picard F, Auwerx J. PPAR(gamma) and glucose homeostasis. Annu Rev Nutr 2002;22:167-97.
-
(2002)
Annu Rev Nutr
, vol.22
, pp. 167-197
-
-
Picard, F.1
Auwerx, J.2
-
12
-
-
21544466158
-
A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
-
GLAI Study Investigators
-
Goldberg RB, Kendall DM, Deeg MA, et al.; GLAI Study Investigators. A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care 2005;28:1547-54.
-
(2005)
Diabetes Care
, vol.28
, pp. 1547-1554
-
-
Goldberg, R.B.1
Kendall, D.M.2
Deeg, M.A.3
-
13
-
-
0034735992
-
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone
-
Sakamoto J, Kimura H, Moriyama S, et al. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem Biophys Res Commun 2000;278:704-11.
-
(2000)
Biochem Biophys Res Commun
, vol.278
, pp. 704-711
-
-
Sakamoto, J.1
Kimura, H.2
Moriyama, S.3
-
14
-
-
23644456172
-
Therapeutic roles of peroxisome proliferator-activated receptor agonists
-
Staels B, Fruchart JC. Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 2005;54:2460-70.
-
(2005)
Diabetes
, vol.54
, pp. 2460-2470
-
-
Staels, B.1
Fruchart, J.C.2
-
15
-
-
0032506273
-
Mechanism of action of fibrates on lipid and lipoprotein metabolism
-
Staels B, Dallongeville J, Auwerx J, et al. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998;98: 2088-93.
-
(1998)
Circulation
, vol.98
, pp. 2088-2093
-
-
Staels, B.1
Dallongeville, J.2
Auwerx, J.3
-
16
-
-
0030952937
-
Hypolipidemic drugs, polyunsat-urated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
-
Forman BM, Chen J, Evans RM. Hypolipidemic drugs, polyunsat-urated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci USA 1997;94:4312-7.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4312-4317
-
-
Forman, B.M.1
Chen, J.2
Evans, R.M.3
-
17
-
-
0029791412
-
PPARalpha and PPARgamma activators direct a distinct tissue-specific tran-scriptional response via a PPRE in the lipoprotein lipase gene
-
Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific tran-scriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996;15:5336-48.
-
(1996)
EMBO J
, vol.15
, pp. 5336-5348
-
-
Schoonjans, K.1
Peinado-Onsurbe, J.2
Lefebvre, A.M.3
-
18
-
-
0035875376
-
Inhibition of peroxisome-proliferator-activated receptor (PPAR)a by MK886
-
Kehrer JP, Biswal SS, La E, et al. Inhibition of peroxisome-proliferator- activated receptor (PPAR)a by MK886. Biochem J 2001;356:899-906.
-
(2001)
Biochem J
, vol.356
, pp. 899-906
-
-
Kehrer, J.P.1
Biswal La, S.S.E.2
-
19
-
-
84898462866
-
Angiotensin type 1 receptor blockers telmisartan and irbesartan activate PPARa Chinese
-
Jing DQ, Yin SM, Mu YM. Angiotensin type 1 receptor blockers telmisartan and irbesartan activate PPARa Chinese. J Endocrinol Metabol 2009;25:70-4.
-
(2009)
J Endocrinol Metabol
, vol.25
, pp. 70-74
-
-
Jing, D.Q.1
Yin, S.M.2
Mu, Y.M.3
-
20
-
-
0031458144
-
Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors
-
Johnson TE, Holloway MK, Vogel R, et al. Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors. J Steroid Biochem Mol Biol 1997;63:1-8.
-
(1997)
J Steroid Biochem Mol Biol
, vol.63
, pp. 1-8
-
-
Johnson, T.E.1
Holloway, M.K.2
Vogel, R.3
-
21
-
-
0032079712
-
Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis
-
Nagao Y, French BA, Cai Y, et al. Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis. J Cell Biochem 1998;69:189-200.
-
(1998)
J Cell Biochem
, vol.69
, pp. 189-200
-
-
Nagao, Y.1
French, B.A.2
Cai, Y.3
-
22
-
-
0032546929
-
Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism
-
Fan CY, Pan J, Usuda N, et al. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem 1998;273:15639-45.
-
(1998)
J Biol Chem
, vol.273
, pp. 15639-15645
-
-
Fan, C.Y.1
Pan, J.2
Usuda, N.3
-
23
-
-
0030766476
-
Alterations in lipoprotein metabolism in peroxisome proliferator- activated receptor alpha-deficient mice
-
Peters JM, Hennuyer N, Staels B, et al. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem 1997;272:27307-12.
-
(1997)
J Biol Chem
, vol.272
, pp. 27307-27312
-
-
Peters, J.M.1
Hennuyer, N.2
Staels, B.3
-
24
-
-
0032565868
-
Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators
-
Staels B, Koenig W, Habib A, et al. Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. Nature 1998;393:790-3.
-
(1998)
Nature
, vol.393
, pp. 790-793
-
-
Staels, B.1
Koenig, W.2
Habib, A.3
-
25
-
-
0030047806
-
Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha-beta, and-gamma in the adult rat
-
Braissant O, Foufelle F, Scotto C, et al. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha,-beta, and-gamma in the adult rat. Endocrinology 1996;137:354-66.
-
(1996)
Endocrinology
, vol.137
, pp. 354-366
-
-
Braissant, O.1
Foufelle, F.2
Scotto, C.3
-
26
-
-
0030747895
-
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: No alteration in adipose tissue of obese and NIDDM patients
-
Auboeuf D, Rieusset J, Fajas L, et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 1997;46:1319-27.
-
(1997)
Diabetes
, vol.46
, pp. 1319-1327
-
-
Auboeuf, D.1
Rieusset, J.2
Fajas, L.3
-
27
-
-
0034064359
-
Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: Relation to insulin action
-
Loviscach M, Rehman N, Carter L, et al. Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action. Diabetologia 2000;43:304-11.
-
(2000)
Diabetologia
, vol.43
, pp. 304-311
-
-
Loviscach, M.1
Rehman, N.2
Carter, L.3
-
28
-
-
0034801882
-
Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding
-
Escher P, Braissant O, Basu-Modak S, et al. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 2001;142:4195-202.
-
(2001)
Endocrinology
, vol.142
, pp. 4195-4202
-
-
Escher, P.1
Braissant, O.2
Basu-Modak, S.3
-
29
-
-
48449106424
-
Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan
-
Clemenz M, Frost N, Schupp M, et al. Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan. Diabetes 2008;57: 1405-13.
-
(2008)
Diabetes
, vol.57
, pp. 1405-1413
-
-
Clemenz, M.1
Frost, N.2
Schupp, M.3
-
30
-
-
0001433298
-
Pharmakokinetics of 14C-telmisartan: Absorption, distribution and protein binding of 14C-telmisartan after a single oral administration to rats
-
Shimasaki M, Yamashita K, Imanishi RK, et al. Pharmakokinetics of 14C-telmisartan: absorption, distribution and protein binding of 14C-telmisartan after a single oral administration to rats. Xenobio Metab Disp 1999;14:425-31.
-
(1999)
Xenobio Metab Disp
, vol.14
, pp. 425-431
-
-
Shimasaki, M.1
Yamashita, K.2
Imanishi, R.K.3
-
31
-
-
64549144327
-
Distribution of telmi-sartan in rat liver and binding to cytosol and cytosolic proteins
-
Abstract
-
Entzeroth M, Ebner TJS, Hadamovsky S. Distribution of telmi-sartan in rat liver and binding to cytosol and cytosolic proteins. J Hum Hypertens 1999;13:43 (Abstract).
-
(1999)
J Hum Hypertens
, vol.13
, pp. 43
-
-
Entzeroth, M.1
Tjs, E.2
Hadamovsky, S.3
-
32
-
-
77950490149
-
Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways
-
He H, Yang D, Ma L, et al. Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways. Hypertension 2010;55:869-79.
-
(2010)
Hypertension
, vol.55
, pp. 869-879
-
-
He, H.1
Yang, D.2
Ma, L.3
-
33
-
-
33644664433
-
Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: Comparison of activation of PPARalpha, PPARgamma, and their combination
-
Tsuchida A, Yamauchi T, Takekawa S, et al. Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 2005;54:3358-70.
-
(2005)
Diabetes
, vol.54
, pp. 3358-3370
-
-
Tsuchida, A.1
Yamauchi, T.2
Takekawa, S.3
-
34
-
-
33847021451
-
Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level
-
Hiuge A, Tenenbaum A, Maeda N, et al. Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level. Arterioscler Thromb Vasc Biol 2007;27: 635-41.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 635-641
-
-
Hiuge, A.1
Tenenbaum, A.2
Maeda, N.3
-
35
-
-
0041321275
-
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha
-
Fu J, Gaetani S, Oveisi F, et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 2003;425:90-3.
-
(2003)
Nature
, vol.425
, pp. 90-93
-
-
Fu, J.1
Gaetani, S.2
Oveisi, F.3
-
36
-
-
85047693466
-
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma
-
Li AC, Binder CJ, Gutierrez A, et al. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest 2004;114: 1564-76.
-
(2004)
J Clin Invest
, vol.114
, pp. 1564-1576
-
-
Li, A.C.1
Binder, C.J.2
Gutierrez, A.3
-
37
-
-
44649141518
-
Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue
-
Toyoda T, Kamei Y, Kato H, et al. Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue. Obesity 2008;16:1199-207.
-
(2008)
Obesity
, vol.16
, pp. 1199-1207
-
-
Toyoda, T.1
Kamei, Y.2
Kato, H.3
-
38
-
-
33646148948
-
Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis
-
Sugimoto K, Qi NR, Kazdová L, et al. Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis. Hypertension 2006;47:1003-9.
-
(2006)
Hypertension
, vol.47
, pp. 1003-1009
-
-
Sugimoto, K.1
Qi, N.R.2
Kazdová, L.3
-
39
-
-
0027099736
-
Lipoprotein lipase: Recent contributions from molecular biology
-
Auwerx J, Leroy P, Schoonjans K. Lipoprotein lipase: recent contributions from molecular biology. Crit Rev Clin Lab Sci 1992; 29:243-68.
-
(1992)
Crit Rev Clin Lab Sci
, vol.29
, pp. 243-268
-
-
Auwerx, J.1
Leroy, P.2
Schoonjans, K.3
-
40
-
-
48849086696
-
Effect of the angiotensin II receptor antagonist telmisartan on lipoprotein lipase mass in preheparin serum
-
Hitsumoto T, Takahashi M, Iizuka T, Shirai K. Effect of the angiotensin II receptor antagonist telmisartan on lipoprotein lipase mass in preheparin serum. J Atheroscler Thromb 2008;15:138-45.
-
(2008)
J Atheroscler Thromb
, vol.15
, pp. 138-145
-
-
Hitsumoto, T.1
Takahashi, M.2
Iizuka, T.3
Shirai, K.4
-
41
-
-
0035943681
-
Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expression
-
Lawrence JW, Li Y, Chen S, et al. Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expression. J Biol Chem 2001; 276:31521-7.
-
(2001)
J Biol Chem
, vol.276
, pp. 31521-31527
-
-
Lawrence, J.W.1
Li, Y.2
Chen, S.3
-
42
-
-
0035958960
-
Identification of per-oxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells
-
Hsu MH, Savas U, Griffin KJ, Johnson EF. Identification of per-oxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. J Biol Chem 2001;276:27950-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 27950-27958
-
-
Hsu, M.H.1
Savas, U.2
Griffin, K.J.3
Johnson, E.F.4
-
43
-
-
36248982581
-
Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling
-
Rakhshandehroo M, Sanderson LM, Matilainen M, et al. Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res 2007; 2007:26839-52.
-
(2007)
PPAR Res
, vol.2007
, pp. 26839-26852
-
-
Rakhshandehroo, M.1
Sanderson, L.M.2
Matilainen, M.3
|