High-affinity RNA targeting by oligonucleotides displaying aromatic stacking and amino groups in the major groove. Comparison of triazoles and phenyl substituents

Journal of Organic Chemistry

Volumn 79, Issue 7, 2014, Pages 2854-2863

  Kumar, Pawan ^a   Hornum, Mick ^a   Nielsen, Lise J ^a   Enderlin, Gérald ^b   Andersen, Nicolai Krog ^a   Len, Christophe ^b   Hervé, Gwénaëlle ^b   Sartori, Guillaume ^b   Nielsen, Poul ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b Centre de Recherche de Royallieu   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR DICHROISM SPECTROSCOPY; OLIGONUCLEOTIDES; RNA;

CD SPECTROSCOPY; DUPLEX STABILITY; HIGH THERMAL STABILITY; MD SIMULATION; NEGATIVE CHARGE; PARTIAL NEUTRALIZATION; PHENYL SUBSTITUENTS; STACKING INTERACTION;

MONOMERS;

DNA; MONOMER; OLIGONUCLEOTIDE; PHENYL GROUP; RNA; TRIAZOLE DERIVATIVE; 5-(1-PHENYL-1,2,3-TRIAZOL-4-YL)-2'-DEOXYURIDINE; 5-PHENYLTHIO-2'-DEOXYURIDINE; AMINE; DEOXYURIDINE;

ARTICLE; CIRCULAR DICHROISM; MOLECULAR DYNAMICS; SIMULATION; SPECTROSCOPY; THERMOSTABILITY; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION;

AMINES; DEOXYURIDINE; DNA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; RNA; TRIAZOLES;

EID: 84898070514     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo4025896     Document Type: Article

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