Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex

Journal of Biological Chemistry

Volumn 289, Issue 14, 2014, Pages 9651-9661

  Chen, Cuicui ^a   Shi, Zhubing ^a,b   Zhang, Wenqing ^a   Chen, Min ^a   He, Feng ^a   Zhang, Zhenzhen ^a   Wang, Yicui ^a   Feng, Miao ^a   Wang, Wenjia ^a   Zhao, Yun ^a   Brown, Jerry H ^c   Jiao, Shi ^a   Zhou, Zhaocai ^a,b  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b TONGJI UNIVERSITY   (China)

^c BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; SELENIUM COMPOUNDS;

ACTIVATION MECHANISMS; BIOLOGICAL FUNCTIONS; BIOPHYSICAL ANALYSIS; COILED-COIL DOMAINS; PROTEIN PHOSPHATASE 2A; REGULATORY SUBUNITS; STRUCTURAL INSIGHTS; SUPRAMOLECULAR COMPLEXES;

PHOSPHATASES;

PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE; SCAFFOLD PROTEIN; SELENOMETHIONINE; STRIATIN 3; STRIATIN INTERACTING PHOSPHATASE AND KINASE COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; BIOPHYSICS; CELL STRAIN HEK293; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; FLOW CYTOMETRY; HUMAN; IMMUNOPRECIPITATION; LEUKEMIA CELL LINE; LIGHT SCATTERING; MOLECULAR CLONING; MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; STOICHIOMETRY;

APOPTOSIS; COILED COIL; PARALLEL DIMER; PHOSPHATASE; PP2A; PROTEIN COMPLEXES; PROTEIN KINASES; PROTEIN STRUCTURE; STRIATIN; STRIPAK COMPLEX;

AUTOANTIGENS; CALMODULIN-BINDING PROTEINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; JURKAT CELLS; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; PROTEIN PHOSPHATASE 2; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES;

EID: 84898070194     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.529297     Document Type: Article

References (54)

1. Goudreault, M., D'Ambrosio, L. M., Kean, M. J., Mullin, M. J., Larsen, B. G., Sanchez, A., Chaudhry, S., Chen, G. I., Sicheri, F., Nesvizhskii, A. I., Aebersold, R., Raught, B., and Gingras, A. C. (2009) A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol. Cell. Proteomics 8, 157-171
2. Glatter, T., Wepf, A., Aebersold, R., and Gstaiger, M. (2009) An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Mol. Syst. Biol. 5, 237
3. Sugden, P. H., McGuffin, L. J., and Clerk, A. (2013) SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. Biochem. J. 454, 13-30
4. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell 139, 468-484
5. 2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res. 23, 931-946
6. Castermans, D., Somers, I., Kriel, J., Louwet, W., Wera, S., Versele, M., Janssens, V., and Thevelein, J. M. (2012) Glucose-induced posttransla-tional activation of protein phosphatases PP2A and PP1 in yeast. Cell Res. 22, 1058-1077
7. Moreno, C. S., Park, S., Nelson, K., Ashby, D., Hubalek, F., Lane, W. S., and Pallas, D. C. (2000) WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J. Biol. Chem. 275, 5257-5263
8. Tan, B., Long, X., Nakshatri, H., Nephew, K. P., and Bigsby, R. M. (2008) Striatin-37 inhibits estrogen receptor activity by recruiting a protein phosphatase. J. Mol. Endocrinol. 40, 199-210
9. Kean, M. J., Ceccarelli, D. F., Goudreault, M., Sanches, M., Tate, S., Larsen, B., Gibson, L. C., Derry, W. B., Scott, I. C., Pelletier, L., Baillie, G. S., Sicheri, F., and Gingras, A. C. (2011) Structure-function analysis of coreSTRIPAK proteins: a signaling complex implicated in Golgi polarization. J. Biol. Chem. 286, 25065-25075
10. Gordon, J., Hwang, J., Carrier, K. J., Jones, C. A., Kern, Q. L., Moreno, C. S., Karas, R. H., and Pallas, D. C (2011) Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-like kinase Mst3. BMC Biochem. 12, 54
11. Moreno, C. S., Lane, W. S., and Pallas, D.C. (2001) A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. J. Biol. Chem. 276, 24253-24260
12. Ribeiro, P. S., Josué, F., Wepf, A., Wehr, M. C, Rinner, O., Kelly, G., Tapon, N., and Gstaiger, M. (2010) Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol. Cell 39, 521-534
13. Hyodo, T., Ito, S., Hasegawa, H, Asano, E., Maeda, M., Urano, T., Taka-hashi, M., Hamaguchi, M., and Senga, T. (2012) Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. J. Biol. Chem. 287, 25019-25029
14. Yu, F. X., and Guan, K. L. (2013) The Hippo pathway: regulators and regulations. Genes Dev. 27, 355-371
15. ten Klooster, J. P., Jansen, M., Yuan, J., Oorschot, V., Begthel, H, Di Gia-como, V., Colland, F., de Koning, J., Maurice, M. M., Hornbeck, P., and Clevers, H. (2009) Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev. Cell 16, 551-562
16. 2 cells. Exp. Cell Res. 212, 255-261
17. 2 phase cells. Biochem. Biophys. Res. Commun. 207, 1029-1037
18. Benoist, M., Gaillard, S., and Castets, F. (2006) The striatin family: a new signaling platform in dendritic spines. J. Physiol. Paris 99, 146-153
19. Castets, F., Rakitina, T., Gaillard, S., Moqrich, A., Mattei, M. G., and Mon-neron, A. (2000) Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. J. Biol. Chem. 275, 19970-19977
20. Gaillard, S., Bartoli, M., Castets, F., and Monneron, A. (2001) Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1. FEBSLett. 508, 49-52
21. Feng, X., Gaeta, M. L., Madge, L. A., Yang, J. H., Bradley, J. R., and Pober, J. S. (2001) Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors. J. Biol. Chem. 276, 8341-8349
22. Li, H, and Nord, E. P. (2004) Functional caveolae are a prerequisite for CD40 signaling in human renal proximal tubule cells. Am. J. Physiol. Renal Physiol. 286, F711-719
23. q family of G proteins. J. CellSci. 121, 1363-1372
24. Gaillard, S., Bailly, Y., Benoist, M., Rakitina, T., Kessler, J. P., Fronzaroli-Molinières, L., Dargent, B., and Castets, F. (2006) Targeting of proteins of the striatin family to dendritic spines: role of the coiled-coil domain. Traffic 7, 74-84
25. Castets, F., Bartoli, M., Barnier, J. V., Baillat, G., Salin, P., Moqrich, A., Bourgeois, J. P., Denizot, F., Rougon, G., Calothy, G., and Monneron, A. (1996) A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons. J. Cell Biol. 134, 1051-1062
26. Bartoli, M., Monneron, A., and Ladant, D. (1998) Interaction of calmodulin with striatin, a WD-repeat protein present in neuronal dendritic spines. J. Biol. Chem. 273, 22248-22253
27. Breitman, M., Zilberberg, A., Caspi, M., and Rosin-Arbesfeld, R. (2008) The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Biochim. Biophys. Acta 1783, 1792-1802
28. Salin, P., Kachidian, P., Bartoli, M., and Castets, F. (1998) Distribution of striatin, a newly identified calmodulin-binding protein in the rat brain: an in situ hybridization and immunocytochemical study. J. Comp. Neurol. 397, 41-59
29. Moqrich, A., Mattei, M. G., Bartoli, M., Rakitina, T., Baillat, G., Monneron, A., and Castets, F. (1998) Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. Genomics 51, 136-139
30. Bartoli, M., Ternaux, J.P., Forni, C, Portalier, P., Salin, P., Amalric, M., and Monneron, A. (1999) Down-regulation of striatin, a neuronal calmodulin-binding protein, impairs rat locomotor activity. J. Neurobiol. 40, 234-243
31. Chen, Y. K., Chen, C. Y., Hu, H. T., and Hsueh, Y. P. (2012) CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex. Mol. Biol. Cell 23, 4383-4392
32. Zhang, H., Ma, X., Deng, X., Chen, Y., Mo, X., Zhang, Y., Zhao, H, and Ma, D. (2012) PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress. Front. Biosci. 17, 2295-2305
33. Lu, Q., Pallas, D. C, Surks, H. K., Baur, W. E., Mendelsohn, M. E., and Karas, R. H. (2004) Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor a. Proc. Natl. Acad. Sci. U.S.A. 101, 17126-17131
34. Bernelot Moens, S. J., Schnitzler, G. R., Nickerson, M., Guo, H., Ueda, K., Lu, Q., Aronovitz, M. J., Nickerson, H., Baur, W. E., Hansen, U., Iyer, L. K., and Karas, R. H. (2012) Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation 126, 1993-2004
35. Bailly, Y. J., and Castets, F. (2007) Phocein: a potential actor in vesicular trafficking at Purkinje cell dendritic spines. Cerebellum 1-9
36. Shi, Z., Jiao, S., Zhang, Z., Ma, M., Zhang, Z., Chen, C, Wang, K., Wang, H, Wang, W., Zhang, L., Zhao, Y., and Zhou, Z. (2013) Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure 21, 449-461
37. Zhang, M., Dong, L., Shi, Z., Jiao, S., Zhang, Z., Zhang, W., Liu, G., Chen, C., Feng, M., Hao, Q., Wang, W., Yin, M., Zhao, Y., Zhang, L., and Zhou, Z. (2013) Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure 21, 680-688
38. Otwinowski, Z., and Minor, W. (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326
39. Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L. W., Kapral, G. J., Grosse-Kunstleve, R. W., McCoy, A. J., Moriarty, N. W., Oeffner, R., Read, R. J., Richardson, D. C, Richardson, J. S., Terwilliger, T. C, and Zwart, P. H. (2010) PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213-221
40. Emsley, P., Lohkamp, B., Scott, W. G., and Cowtan, K. (2010) Features and development of Coot. Acta Crystallogr. D. Biol. Crystallogr. 66, 486-501
41. McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Sto-roni, L. C, and Read, R. J. (2007) Phaser crystallographic software. J. Appl. Crystallogr. 40, 658-674
42. Brown, J. H. (2010) How sequence directs bending in tropomyosin and other two-stranded a-helical coiled coils. Protein Sci. 19, 1366-1375
43. Aurora, R., and Rose, G. D. (1998) Helix capping. Protein Sci. 7, 21-38
44. Xu, Y., Chen, Y., Zhang, P., Jeffrey, P. D., and Shi, Y. (2008) Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau de-phosphorylation. Mol. Cell 31, 873-885
45. Xu, Z., Cetin, B., Anger, M., Cho, U. S., Helmhart, W., Nasmyth, K., and Xu, W. (2009) Structure and function of the PP2A-shugoshin interaction. Mol. Cell 35, 426-441
46. Huang, C. Y., Wu, Y. M., Hsu, C. Y., Lee, W. S., Lai, M. D., Lu, T. J., Huang, C. L., Leu, T. H, Shih, H. M., Fang, H. I., Robinson, D. R., Kung, H. J., and Yuan, C. J. (2002) Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. J. Biol. Chem. 277, 34367-34374
47. Wu, H. Y., Lin, C. Y., Lin, T. Y., Chen, T. C., and Yuan, C. J. (2008) Mammalian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery. Apoptosis 13, 283-294
48. Lin, C. Y., Wu, H. Y., Wang, P. L., and Yuan, C. J. (2010) Mammalian Ste20-like protein kinase3 inducesacaspase-independent apoptotic pathway. Int. J. Biochem. Cell Biol. 42, 98-105
49. Lechward, K., Awotunde, O. S., Swiatek, W., and Muszyńska, G. (2001) Protein phosphatase 2A: variety of forms and diversity of functions. Acta Biochim. Pol. 48, 921-933
50. Sontag, E. (2001) Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cell. Signal. 13, 7-16
51. Janssens, V., and Goris, J. (2001) Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417-439
52. Perrotti, D., and Neviani, P. (2013) Protein phosphatase 2A: a target for anticancer therapy. Lancet Oncol. 14, e229-238
53. Renatus, M., Stennicke, H. R., Scott, F. L., Liddington, R. C., and Salvesen, G. S. (2001) Dimer formation drives the activation of the cell death protease caspase 9. Proc. Natl. Acad. Sci. U.S.A. 98, 14250-14255
54. Brown, J. H. (2006) Breaking symmetry in protein dimers: designs and functions. Protein Sci. 15, 1-13