Effects of safranal, a constituent of saffron, and vitamin e on nerve functions and histopathology following crush injury of sciatic nerve in rats

Phytomedicine

Volumn 21, Issue 5, 2014, Pages 717-723

  Tamaddonfard, Esmaeal ^a   Farshid, Amir Abbas ^a   Maroufi, Shirin ^a   Kazemi Shojaei, Sharare ^a   Erfanparast, Amir ^a   Asri Rezaei, Siamak ^a   Taati, Mina ^a   Dabbaghi, Milad ^a   Escort, Mona ^a  

^a URMIA UNIVERSITY   (Iran)

Author keywords

Oxidative stress; Rats; Safranal; Sciatic nerve function; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; MALONALDEHYDE; NATURAL PRODUCT; SAFRANAL; UNCLASSIFIED DRUG; ANTIOXIDANT; CYCLOHEXENE DERIVATIVE; PLANT EXTRACT; TERPENE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CROCUS SATIVUS; CRUSH TRAUMA; DISEASE SEVERITY; GASTROCNEMIUS MUSCLE; HISTOPATHOLOGY; MALE; MICROSCOPY; MUSCLE ATROPHY; NERVE FUNCTION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE INJURY; WALLERIAN DEGENERATION; ANIMAL; CROCUS; DRUG SCREENING; PHYTOTHERAPY; SCIATIC NERVE; SCIATIC NEUROPATHY; WISTAR RAT;

RATTUS; WALLERIA;

ANIMALS; ANTIOXIDANTS; CROCUS; CYCLOHEXENES; DRUG EVALUATION, PRECLINICAL; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS, WISTAR; SCIATIC NERVE; SCIATIC NEUROPATHY; TERPENES; VITAMIN E;

EID: 84898059195     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.10.031     Document Type: Article

References (40)

1. K. Al Moutaery, M. Arshaduddin, M. Tarig, and S. Al Deeb Functional recovery and vitamin E level following sciatic nerve crush injury in normal and diabetic rats Int. J. Neurosci. 96 1998 245 254
2. B. Amin, and H. Hosseinzadeh Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats Fitoterapia 83 2012 888 895
3. A.N. Assimopolou, Z. Sinakos, and V.P. Papageorgiou Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents Phytother. Res. 19 2005 997 1000
4. C. Bagdatoglu, A. Sarray, H.S. Surucu, H. Ozturk, and L. Tamer Effect of trapidil in ischemia/reperfusion injury of peripheral nerves Neurosurgery 51 2002 212 220
5. J.R. Bain, S.E. Mackinnon, and D.A. Hunter Functional evaluation of complete sciatic, peroneal and posterior tibial nerve lesions in the rat Plast. Reconstr. Surg. 83 1989 129 138
6. M.H. Boskabady, A. Tabatabaee, and G. Byrami The effect of the extract of Crocus sativus and its constituent safranal, on lung inflammation of ovalbumin sensitized guinea-pigs Phytomedicine 19 2012 904 911
7. M.G. Burnett, and E.L. Zager Pathophysiology of peripheral nerve injury: brief review Neurosurg. Focus 16 2004 161 167
8. C.R. Camara-Lemarroy, F.J. Guzmán-de la Garza, and N.E. Fernández-Garza Molecular inflammatory mediators in peripheral nerve degeneration and regeneration Neuroimmunomodulation 17 2010 314 324
9. T. Cecchini, R. Cuppini, S. Ciaroni, and P. Del Grande Effect of vitamin E-deficiency on regeneration of the sciatic nerve Arch. Ital. Anat. Embriol. 95 1990 155 165
10. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, and T.L. Yaksh Quantitative assessment of tactile allodynia in the rat paw J. Neurosci. Methods 53 1994 55 63
11. Y. Choi, Y.M. Yoon, H.S. Na, S.H. Kim, and J.M. Chung Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain Pain 59 1994 369 376
12. S. Demiryurek, and A. Babul Effects of vitamin E and electrical stimulation on the denervated rat gastrocnemius muscle malodialdehyde and glutathione levels Int. J. Neurosci. 114 2004 45 54
13. P. Dubovy Wallerian degeneration and peripheral nerve condition for both axon regeneration and neuropathic pain induction Ann. Anat. 193 2011 267 275
14. J. Escribano, G.L. Alonso, M. Coca-Prados, and J.A. Fernandez Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro Cancer Lett. 100 1996 23 30
15. S. Hall The response to injury in the peripheral nervous system J. Bone Joint Surg. [Br] 87-B 2005 1309 1319
16. H. Hosseinzadeh, M.H. Modaghegh, and Z. Saffari Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle eCAM 6 2009 343 350
17. H. Hosseinzadeh, and H.R. Sadeghnia Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus J. Pharm. Pharm. Sci. 22 2005 394 399
18. H. Hosseinzadeh, and T. Ziaei Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine-induced learning deficits in rats performing the Morris water maze task J. Med. Plants 5 2006 40 50
19. W. Kallenborn-Gerhardt, K. Schroder, G. Geisslinger, and A. Schmidtko NOXious signaling in pain processing Pharmacol. Ther. 137 2013 309 317
20. A. Kamal-Eldin, and L.A. Appelqvist The chemistry and antioxidant properties of tocopherols and tocotrienols Lipids 31 1996 671 701
21. S. Kianbakht, and K. Mozaffari Effects of saffron and its active constituents, crocin and safranal, on prevention of indomethacin induced gastric ulcers in diabetic and nondiabetic rats J. Med. Plants 5 2009 30 38
22. M.P. Lancellota, R.N. Sheth, R.A. Meyer, A.J. Belzberg, J.W. Griffin, and J.N. Campbell Severity and duration of hyperalgesia in rats varies with types of nerve lesion Neurosurgery 53 2003 1200 1208
23. M. Liu, D. Zhang, C. Shao, J. Liu, F. Ding, and X. Gu Expression pattern of myostatin in gastrocnemius muscle of rats after sciatic nerve crush injury Muscle Nerve 35 2007 649 656
24. G. Moalem, and D.J. Tracey Immune and inflammatory mechanisms in neuropathic pain Brain Res. Rev. 51 2006 240 264
25. A.S. Morani, and S.L. Bodhankar Early co-administration of vitamin E acetate and methylcobalamin improves thermal hyperalgesia and motor nerve conduction velocity following sciatic nerve crush injury in rats Pharmacol. Rep. 62 2010 405 409
26. F.L. Muller, W. Song, Y.C. Jang, Y. Liu, M. Sabia, A. Richardson, and H.V. Remmen Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 2007 R1159 R1168
27. H. Ohkawa, N. Ohishi, and N. Yagi Assay for lipid peroxides in animal tissues by tiobarbituric acid reaction Anal. Biochem. 95 1979 351 358
28. S.A. Panthan, S.M.A. Zaidi, G.K. Jain, D. Vohora, F.J. Ahmed, and P.K. Khar Anticonvulsant evaluation of safranal in pentylenetetrazole-induced status epilepticus in mice Int. Essential Oil Therapeut. 3 2009 106 108
29. R. Rezaee, and H. Hosseinzadeh Safranal: from an aromatic natural product to a rewarding pharmacological agent Iran. J. Basic Med. Sci. 16 2013 12 26
30. J.L. Rios, M.C. Recio, R.M. Ginger, and S. Manz An update review of saffron and its active constituents Phytother. Res. 10 1996 189 193
31. M. Schmidt, G. Betti, and A. Hensen Saffron in phytotherapy: pharmacology and clinical uses Wien. Med. Wochenschr. 157 2007 315 319
32. M. Senoglu, V. Nacitarhan, E.B. Kurutas, N. Senoglu, I. Altun, Y. Atli, and D. Ozbag Intraperitoneal alpha-lipoic acid to prevent neural damage after crush injury to the rat sciatic nerve Brachial Plex. Peripher. Nerve Inj. 4 2009 22
33. R. Srivastava, H. Ahmed, R. Dixit, and S.A. Saraf Crocus sativus L.: a comprehensive review Pharmacogn. Rev. 4 2010 200 208
34. E. Tamaddonfard, A.A. Farshid, E. Ahmadian, and A. Hamidhoseyni Crocin enhanced functional recovery after sciatic nerve crush injury in rats Iran. J. Basic Med. Sci. 16 2013 83 90
35. E. Tamaddonfard, A.A. Farshid, K. Eghdami, F. Samadi, and E. Erfanparast Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats Pharmacol. Rep. 65 2013 1272 1280 (Accepted for publication)
36. 12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats Vet. Res. Forum 4 2013 19 24
37. A. Vanotti, M. Osio, E. Mailland, C. Nascimbene, E. Capiluppi, and C. Mariani Overview on pathophysiology and newer approaches to treatment of peripheral neuropathies CNS Drugs 21 Suppl. 1 2007 3 12
38. A.S. Varejao, M.F. Meek, A.J. Ferreira, J.A. Patricia, and A.M. Cabrita Functional evaluation of peripheral nerve regeneration in rats: walking track analysis J. Neurosci. Methods 108 2001 1 9
39. R.M. Vigueras-Villasenor, I. Ojeda, O. Gutierrez-Perez, M. Chavez-Saldana, O. Cuevas, D.S. Maria, and J.C. Roja-Castaneda Protective effect of α-tocopherol on damage to rat tests by experimental cryptorchidism Int. J. Exp. Pathol. 92 2011 131 139
40. D. Zhang, M. Liu, F. Ding, and X. Gu Expression of myostatin RNA transcript and protein in gastrocnemius muscle of rats after sciatic nerve resection J. Muscle Res. Cell Motil. 27 2006 37 44