Inhibitors of the p53-Mdm2 interaction increase programmed cell death and produce abnormal phenotypes in the placozoon Trichoplax adhaerens (F.E. Schulze)

Development Genes and Evolution

Volumn 224, Issue 2, 2014, Pages 79-85

  Von Der Chevallerie, Karolin ^a   Rolfes, Sarah ^a   Schierwater, Bernd ^a,b  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b YALE UNIVERSITY   (United States)

Author keywords

Mdm2; Nutlin 3; p53; Placozoa; Roscovitine

Indexed keywords

BROXURIDINE; DIMETHYL SULFOXIDE; NUTLIN 3; PROTEIN MDM2; PROTEIN P53; ROSCOVITINE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL PROLIFERATION; CONTROLLED STUDY; MICROSCOPY; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SURVIVAL; TRICHOPLAX; TRICHOPLAX ADHAERENS;

ANIMALIA; METAZOA; PLACOZOA; TRICHOPLAX ADHAERENS;

ANIMALS; APOPTOSIS; BROMODEOXYURIDINE; CELL PROLIFERATION; HUMANS; IMIDAZOLES; IN SITU NICK-END LABELING; PHENOTYPE; PIPERAZINES; PLACOZOA; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; PURINES; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84898038459     PISSN: 0949944X     EISSN: 1432041X     Source Type: Journal    
DOI: 10.1007/s00427-014-0465-0     Document Type: Article

References (28)

1. Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP (2009) Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer 9(12):862-873. doi: 10.1038/nrc2763
2. de Jong D, Eitel M, Jakob W, Osigus HJ, Hadrys H, DeSalle R, Schierwater B (2009) Multiple dicer genes in the early-diverging metazoa. Mol Biol Evol 26(6):1333-1340. doi: 10.1093/molbev/msp042
3. Derry WB, Putzke AP, Rothman JH (2001) Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science 294(5542):591-595. doi: 10.1126/science.1065486
4. Eitel M, Osigus HJ, DeSalle R, Schierwater B (2013) Global diversity of the Placozoa. PLoS One 8(4):e57131. doi: 10.1371/journal.pone.0057131
5. Jakob W, Sagasser S, Dellaporta S, Holland P, Kuhn K, Schierwater B (2004) The Trox-2 Hox/ParaHox gene of Trichoplax (Placozoa) marks an epithelial boundary. Dev Genes Evol 214(4):170-175. doi: 10.1007/s00427-004-0390-8
6. Jessen-Eller K, Kreiling JA, Begley GS, Steele ME, Walker CW, Stephens RE, Reinisch CL (2002) A new invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls. Environ Health Perspect 110(4):377-385
7. Jin S, Martinek S, Joo WS, Wortman JR, Mirkovic N, Sali A, Yandell MD, Pavletich NP, Young MW, Levine AJ (2000) Identification and characterization of a p53 homologue in Drosophila melanogaster. Proc Natl Acad Sci U S A 97(13):7301-7306
8. Joerger AC, Fersht AR (2007) Structure-function-rescue: The diverse nature of common p53 cancer mutants. Oncogene 26(15):2226-2242. doi: 10.1038/sj.onc.1210291
9. Lane DP, Verma C (2012) Mdm2 in evolution. Genes Cancer 3(3-4):320-324. doi: 10.1177/1947601912458285
10. Lane DP, Cheok CF, Brown C, Madhumalar A, Ghadessy FJ, Verma C (2010) Mdm2 and p53 are highly conserved from placozoans to man. Cell Cycle 9(3):540-547
11. Levine AJ, Oren M (2009) The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9(10):749-758. doi: 10.1038/nrc2723
12. Lu W, Chen L, Peng Y, Chen J (2001) Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 20(25):3206-3216. doi: 10.1038/sj.onc.1204412
13. Manfredi JJ (2010) The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev 24(15):1580-1589. doi: 10.1101/gad.1941710
14. Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP (1997) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 243(1-2):527-536
15. Momand J, Villegas A, Belyi VA (2011) The evolution of MDM2 family genes. Gene 486(1-2):23-30. doi: 10.1016/j.gene.2011.06.030
16. Muttray AF, O'Toole TF, Morrill W, Van Beneden RJ, Baldwin SA (2010) An invertebrate mdm homolog interacts with p53 and is differentially expressed together with p53 and ras in neoplastic Mytilus trossulus haemocytes. Comp Biochem Physiol B Biochem Mol Biol 156(4):298-308. doi: 10.1016/j.cbpb.2010.04. 008
17. Osigus HJ, Eitel M, Schierwater B (2013) Chasing the urmetazoon: striking a blow for quality data? Mol Phylogenet Evol 66(2):551-557. doi: 10.1016/j.ympev.2012.05.028
18. Pankow S, Bamberger C (2007) The p53 tumor suppressor-like protein nvp63 mediates selective germ cell death in the sea anemone Nematostella vectensis. PLoS One 2(9):e782. doi: 10.1371/journal.pone.0000782
19. Pearson BJ, Sanchez Alvarado A (2010) A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development 137(2):213-221. doi: 10.1242/dev.044297
20. Ringrose JH, van den Toorn HW, Eitel M, Post H, Neerincx P, Schierwater B, Maarten Altelaar AF, Heck AJ (2013) Deep proteome profiling of Trichoplax adhaerens reveals remarkable features at the origin of metazoan multicellularity. Nat Commun 4:1408. doi: 10.1038/ncomms2424
21. Schierwater B (2005) My favorite animal, Trichoplax adhaerens. Bioessays 27(12):1294-1302. doi: 10.1002/bies.20320
22. Schierwater B, Kuhn K (1998) Homology of Hox genes and the zootype concept in early metazoan evolution. Mol Phylogenet Evol 9(3):375-381. doi: 10.1006/mpev.1998.0489
23. Schierwater B, de Jong D, Desalle R (2009a) Placozoa and the evolution of Metazoa and intrasomatic cell differentiation. Int J Biochem Cell Biol 41(2):370-379. doi: 10.1016/j.biocel.2008.09.023
24. Schierwater B, Eitel M, Jakob W, Osigus HJ, Hadrys H, Dellaporta SL, Kolokotronis SO, DeSalle R (2009b) Concatenated analysis sheds light on early metazoan evolution and fuels a modern "Urmetazoon" hypothesis. Plos Biol 7(1):36-44. doi: 10.1371/journal.pbio.1000020
25. Schwartz V (1984) The radial polar pattern of differentiation in Trichoplax adhaerens F.E. Schulze (Placozoa). Z Naturforsch 39:818-832
26. Srivastava M, Begovic E, Chapman J, Putnam NH, Hellsten U, Kawashima T, Kuo A, Mitros T, Salamov A, Carpenter ML, Signorovitch AY, Moreno MA, Kamm K, Grimwood J, Schmutz J, Shapiro H, Grigoriev IV, Buss LW, Schierwater B, Dellaporta SL, Rokhsar DS (2008) The Trichoplax genome and the nature of placozoans. Nature 454(7207):955-960. doi: 10.1038/nature07191
27. Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303(5659):844-848. doi: 10.1126/science.1092472
28. Vousden KH, Prives C (2009) Blinded by the light: The growing complexity of p53. Cell 137(3):413-431. doi: 10.1016/j.cell.2009.04.037