The p53 tumor suppressor-like protein nvp63 mediates selective germ cell death in the sea anemone Nematostella vectensis

PLoS ONE

Volumn 2, Issue 9, 2007, Pages

  Pankow, Sandra ^a   Bamberger, Casimir ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN P63;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; DNA BINDING; GENE ACTIVATION; GENETIC TRANSCRIPTION; GERM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; RNA INTERFERENCE; SEA ANEMONE; ULTRAVIOLET IRRADIATION; ANIMAL; CHEMISTRY; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; MOLECULAR GENETICS; PHYLOGENY; PHYSIOLOGY; RADIATION EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; ULTRAVIOLET RADIATION;

ACTINIARIA; ANIMALIA; BILATERIA; CNIDARIA; NEMATOSTELLA VECTENSIS; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GERM CELLS; MOLECULAR SEQUENCE DATA; PHYLOGENY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEA ANEMONES; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 41149140262     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000782     Document Type: Article

References (51)

1. Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908.
2. Baum JS, St George JP, McCall K (2005) programmed cell death in the germline. Semin Cell Dev Biol 16: 245-259.
3. Soussi T, Lozano G (2005) p53 mutation heterogeneity in cancer. Biochem Biophys Res Common 331: 834-842.
4. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
5. Pozniak CD, Radinovic S, Yang A, McKeon F, Kapla DR, et al. (2000) An anti-apoptotic role for the p53 family member, p73 dating developmental neuron death. Science 289: 304-306.
6. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, et al. (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404: 99-103.
7. Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, et al. (2005) p63 is an essential proapaptotic protein during neural development. Neuron 48: 743-756.
8. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, et al. (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398: 714-718.
9. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, et al. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398: 708-713.
10. Suh EK, Yang A, Kettenbach A, Bamberger C, Michaelis AH, et al. (2006) p63 protects the female germ line during meiotic arrest. Nature 444: 624-628.
11. Ollmann M, Young LM, Di Como CJ, Karim F, Belvin M, et al. (2000) Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 101: 91-101.
12. Derry WB, Putzkc AP, Rothman JH (2001) Cacnorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science 294: 591-595.
13. Nordstrom W, Abrams JM (2000) Guardian ancestry: fly p53 and damage-inducible apoptosis. Cell Death Differ 7: 1035-1038.
14. Brodsky MH, Nordstrom W, Tsang G, Kwan E, Rubin GM, et al. (2000) Drosoplida p53 binds a damage response element at the reaper locu, Cell 101: 103-113.
15. Dunn SR, Phillips WS, Spatafora JW, Green DR, Weis VM (2006) Highly conserved caspase and Bcl-2 homologues from the sea arremone Aiptasia pallida: lower metazoans as models for the study of apoptosis evolution. J Mol Evol 63: 95-107.
16. Kuznetsov SG, Bosch TC (2003) Self/nonself recognition in Cnidaria: contact to allogeneic tissue does not result in elimination of nonself cells in Hydra vulgaris. Zoology (Jena) 106: 109-116.
17. Rentzsch F, Hobmayer B, Holstein TW (2005) Glycogen synthase kinase 3 has a proapoptotic function in Hydra gametogenesis. Dev Biol 278: 1-12.
18. Technau U, Miller MA, Bridge D, Steele RE (2003) Arrested apoptosis of nurse cells during Hydra oogenesis and embryogenesis, Dev Biol 260: 191-206.
19. Cikala M, Wilm B, Hobmayer E, Bottger A, David CN (1999) Identification of caspases and apoptosis in the simple metazoan Hydra. Curr Biol 9: 959-962.
20. Kuznetsov SG, Anton-Erxleben F, Bosch TC (2002) Epithelial interactions in Hydra: apoptosis in interspecies grafts is induced by detachment from the extracellular matrix. J Exp Biol 205: 3809-3817.
21. Bottger A, Alexandrova O (2007) Programmed cell death in Hydra. Semin Cancer Biol 17: 134-146.
22. Stephenson TA (1935) The British Sea Anemones. London: The Ray Society. pp xxii+426, 415-433.
23. Finnerty JR, Martindale MQ (1999) Ancient origins of axial patterning genes: Hox genes and Para Hox genes in the Cnidaria. Evol Dev 1: 16-23.
24. Kusserow A, Pang K, Sturm C, Hrouda M, Lentfer J, et al. (2005) Unexpected complexity of the Wnt gene family in a sea anemone. Nature 433: 156-160.
25. Putnam NH, Srivastava M, Hellsten U, Dicks B. Chapman J, et al. (2007) Sea anemone genome reveals ancestral cumctazoan gene repertoire and genomic organization. Science 317: 86-94.
26. Brusca RB, GJ (2002) Invertebrates. SunderlandMA: Sinauer Associates, Inc.
27. Larkman A (1980) Utrastructural Aspects of Gametogensis in Aclimia equina L.; Tardent P, Tardent R, eds. Amsterdam: Elsevier/ North-Holland Biomedical Press. pp 61-66.
28. Saccone C, Caggese C, D'Erchia AM, Lanave C, Oliva M, et al. (2003) Molecular dock and gene function. J Mol Evol 57 Suppl 1: S277-285.
29. el-Deiry WS, Kern SE, Pictenpol JA, Kinzler KW, Vogelstein B (1992) Definition of a consensus binding site for p53. Nat Genet 1: 45-49.
30. Extavour CG, Pang K, Matus DQ, Martindale MQ (2005) vasa and nanos expression patterns in a sea anemone and the evolution of bilaterian germ cell specification mechanisms. Evol Dev 7: 201-215.
31. Serber Z, Lai HC, Yang A, Ou HD, Sigal MS, et al. (2002) A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Mol Cell Biol 22: 8601-8611.
32. Bamberger C, Schmale H (2001) Identification and tissue distribution of novel KET/p63 splice variants. FEBS Lett 501: 121-176.
33. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, et al. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2: 305-316.
34. Hainaut P, Hernandez T, Robinson A, Rodriguez-Tome P, Flores T, et al. (1998) IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res 26: 205-213.
35. Celli J, Duijf P, Hamel BC, Bamshad M, Kramer B, et al. (1999) Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell 99: 143-153.
36. Chang CC, Dearden P, Akam M (2002) Germ line development in the grasshopper Schistocerca gregaria: vasa as a marker. Dev Biol 252: 100-118.
37. Fire A, Xu S, Montgomery MY, Kostas SA, Driver SE, et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.
38. Schumacher B, Hanazawa M, Lee MH, Nayak S, Volkmann K, et al. (2005) Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced poptosis. Cell 120: 357-368.
39. Intergovernmental Panel On Climate Change (2007) Fourth Assessment report "Climate Change 2007".
40. Metz B, Kuijpers E, Solomon S, Andersen SO, Davidson O, et al. (2001) Special Report on Safeguarding the Ozone Layer and the Global Climate System: Issues Related to Hydrofluorocarbons and Perfluorocarbons.
41. Malloy KD, Holman MA, Mitchell D, Devich HW 3rd (1997) Sol. UVB-induced. DNA damage and photoenzymatic DNA repair in antarctic zooplankton. Proc Natl Acad Sci U S A 94: 1258-1263.
42. Lesser MP (2007) Coral reef bleaching and global climate change: Can corals survive the next century? Proc Natl Acad Sci U S A 104: 5259-5260.
43. Donner SD, Knutson TR, Oppenheimer M (2007) From the Cover: Model-based assessment of the role of human-induced climate change in the 2005 Caribbean coral bleaching event. Proc Natl Acad Sci U S A 104: 5483-5488.
44. Wilhelm SW, Jeffrey WH, Suttle CA, Mitchell DL (2002) Estimation of biologically damaging UV levels in marine surface waters with DNA and viral dosimeters. Photochem Photobiol 76: 268-273.
45. Schroder HC, Di Bella G, Janipour N, Bonaventura R, Russo R, et al. (2005) DNA damage and developmental defects after exposure to UV and heavy metals in sea urchin cells and embryos compared to other invertebrates. Prog Mol Subcell Biol 39: 111-137.
46. Hand C, Uhlinger KR (1992) The Culture, Sexual and Asexual Reproduction, and Growth of the Sea Anemone Nematostella vectensis. The Biological Bulletin 182: 169-176.
47. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
48. Sullivan JC, Ryan JF, Watson JA, Webb J, Mullikin JC, et al. (2006) StellaBase: the Nematostella vectensis Genomics Database. Nucleic Acids Res 34: D495-499.
49. Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680.
50. Traven A, Heierhorst J (2005) SQ/TQ cluster domains: concentrated ATM/ ATR kinase phosphorylation site regions in DNA-damage-response proteins. Bioessays 27: 397-407.
51. Shiloh Y (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3: 155-168.