SCOPUS 정보 검색 플랫폼

Volumn 9, Issue 4, 2014, Pages 693-698

Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: Opening avenues towards the first SV2A positron emission tomography (PET) ligands

(16) Mercier, Joël a Archen, Laurence a Bollu, Véronique a Carré, Stéphane a Evrard, Yves a Jnoff, Eric a Kenda, Benoît a Lallemand, Bénédicte a Michel, Philippe a Montel, Florian a Moureau, Florence a Price, Nathalie a Quesnel, Yannick a Sauvage, Xavier b,c Valade, Anne a Provins, Laurent a

a UCB PHARMA (Belgium)

b UNIVERSITY OF LIÈGE (Belgium)

c Stem Cell Sciences UK Ltd (United Kingdom)

Author keywords

epilepsy; imaging agents; levetiracetam; positron emission tomography (PET); synaptic vesicle proteins; tracers

Indexed keywords

BRAIN PROTEIN; ETIRACETAM; HETEROCYCLIC COMPOUND; SYNAPTIC VESICLE PROTEIN 2A; TRACER; UCB A; UCB H; UCB J; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; LIGAND; MEMBRANE PROTEIN; NERVE PROTEIN; SV2A PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EPILEPSY; HUMAN; LIGAND BINDING; PHARMACOPHORE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DIAGNOSTIC USE; DRUG DEVELOPMENT; MALE; METABOLISM; RAT; SYNTHESIS; WISTAR RAT;

ACETAMIDES; ANIMALS; DRUG DISCOVERY; HETEROCYCLIC COMPOUNDS; HUMANS; LIGANDS; MALE; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RATS; RATS, WISTAR;

EID: 84898016857 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300482 Document Type: Article

Times cited : (63)

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