Biochemical and structural characterization of neocartilage formed by mesenchymal stem cells in alginate hydrogels

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Olderøy, Magnus Ø ^a   Lilledahl, Magnus B ^b   Beckwith, Marianne Sandvold ^b   Melvik, Jan Egil ^c   Reinholt, Finn ^d   Sikorski, Pawel ^b   Brinchmann, Jan E ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c NovaMatrix/FMC Biopolymer AS   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; ADAM PROTEIN; ADAMTS3 PROTEIN, HUMAN; COLLAGEN; GLUCURONIC ACID; HEXURONIC ACID; HYDROGEL; PROCOLLAGEN N PROTEINASE;

ARTICLE; CARTILAGE; CELL DENSITY; CELL DIFFERENTIATION; CELL EXPANSION; CELL ISOLATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEL; IMMOBILIZED CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MESENCHYMAL STEM CELL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; TRANSMISSION ELECTRON MICROSCOPY; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL CULTURE TECHNIQUE; CHEMISTRY; CHONDROGENESIS; CYTOLOGY; GENE EXPRESSION REGULATION; IMAGE PROCESSING; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; PROCEDURES; THEORETICAL MODEL; THREE DIMENSIONAL IMAGING;

ADAM PROTEINS; ALGINATES; CARTILAGE; CARTILAGE, ARTICULAR; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CHONDROCYTES; CHONDROGENESIS; COLLAGEN; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYDROGELS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STROMAL CELLS; MODELS, THEORETICAL; PROCOLLAGEN N-ENDOPEPTIDASE; TISSUE ENGINEERING;

EID: 84898011854     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091662     Document Type: Article

References (33)

1. Huey DJ, Hu JC and Athanasiou KA (2012) Unlike bone, cartilage regeneration remains elusive. Science 338: 917-921.
2. Balakrishnan B and Banerjee R (2011) Biopolymer-based hydrogels for cartilage tissue engineering. Chem Rev 111: 4453-4474.
3. Erickson IE, Kestle SR, Zellars KH, Farrell MJ, Kim M, et al. (2012) High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties. Acta Biomater 8: 3027-3034.
4. Guo Y, Yuan T, Xiao Z, Tang P, Xiao Y, et al. (2012) Hydrogels of collagen/chondroitin sulfate/hyaluronan interpenetrating polymer network for cartilage tissue engineering. J Mater Sci: Mater Med 23: 2267-2279.
5. Nicodemus GD, Skaalure SC and Bryant SJ (2011) Gel structure has an impact on pericellular and extracellular matrix deposition, which subsequently alters metabolic activities in chondrocyte-laden PEG hydrogels. Acta Biomater 7: 492-504.
6. Roberts JJ, Nicodemus GD, Greenwald EC and Bryant SJ (2011) Degradation Improves Tissue Formation in (Un)Loaded Chondrocyte-laden Hydrogels. Clin Orthop 469: 2725-2734.
7. Chung C, Beecham M, Mauck RL and Burdick JA (2009) The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells. Biomaterials 30: 4287-4296.
8. Wong M, Siegrist M, Wang XH and Hunziker E (2001) Development of mechanically stable alginate/chondrocyte constructs: effects of guluronic acid content and matrix synthesis. J Orthop Res 19: 493-499. (Pubitemid 32472021)
9. Anderson SB, Lin C-C, Kuntzler DV and Anseth KS (2011) The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels. Biomaterials 32: 3564-3574.
10. Klein TJ, Rizzi SC, Schrobback K, Reichert JC, Jeon JE, et al. (2010) Long-term effects of hydrogel properties on human chondrocyte behavior. Soft Matter 6: 5175-5183.
11. Kundu J, Shim J-H, Jang J, Kim S-W and Cho D-W (2013) An additive manufacturing-based PCL-alginate-chondrocyte bioprinted scaffold for cartilage tissue engineering. J Tissue Eng Regen Med DOI: 10.1002/term.1682.
12. Canty EG and Kadler KE (2005) Procollagen trafficking, processing and fibrillogenesis. J Cell Sci 118: 1341-1353. (Pubitemid 40585115)
13. Prockop DJ, Sieron AL and Li SW (1998) Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling. Matrix Biol 16: 399-408. (Pubitemid 28069866)
14. Kalamajski S and Oldberg A (2010) The role of small leucine-rich proteoglycans in collagen fibrillogenesis. Matrix Biol 29: 248-253.
15. Eyre D (2002) Collagen of articular cartilage. Arthritis Res 4: 30-35.
16. Bouhadir KH, Lee KY, Alsberg E, Damm KL, Anderson KW, et al. (2001) Degradation of partially oxidized alginate and its potential application for tissue engineering. Biotechnol Prog 17: 945-950. (Pubitemid 32972660)
17. Rice MA and Anseth KS (2007) Controlling cartilaginous matrix evolution in hydrogels with degradation triggered by exogenous addition of an enzyme. Tissue Eng 13: 683-691. (Pubitemid 46651499)
18. Ashton RS, Banerjee A, Punyani S, Schaffer DV and Kane RS (2007) Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Biomaterials 28: 5518-5525. (Pubitemid 47599644)
19. Ng KW, Kugler LE, Doty SB, Ateshian GA and Hung CT (2009) Scaffold degradation elevates the collagen content and dynamic compressive modulus in engineered articular cartilage. Osteoarthritis Cartilage 17: 220-227.
20. Boontheekul T, Kong H-J and Mooney DJ (2005) Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials 26: 2455-2465. (Pubitemid 39600698)
21. Melvik JE, Bjornstad J and Svendsen T (2011) Delayed Self-Gelling Alginate Systems and Uses Thereof. US Patent Application 20110053886.
22. Knott G, Marchman H, Wall D and Lich B (2008) Serial section scanning electron microscopy of adult brain tissue using focused ion beam milling. J Neurosci 28: 2959-2964. (Pubitemid 351442268)
23. Bushby AJ, P'ng KMY, Young RD, Pinali C, Knupp C, et al. (2011) Imaging three-dimensional tissue architectures by focused ion beam scanning electron microscopy. Nat Protoc 6: 845-858.
24. Lee S, Solow-Cordero DE, Kessler E, Takahara K and Greenspan DS (1997) Transforming growth factor-beta regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes. J Biol Chem 272: 19059-19066. (Pubitemid 27318263)
25. Herlofsen SR, Kuechler AM, Melvik JE and Brinchmann JE (2011) Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in Self-Gelling Alginate Discs Reveals Novel Chondrogenic Signature Gene Clusters. Tissue Eng Part A 17: 1003-1013.
26. Fernandes AM, Herlofsen SR, Karlsen TA, Kuechler AM, Floisand Y, et al. (2013) Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage. PLoS One 8: e62994.
27. Mørch YA, Donati I, Strand BL and Skjåk-Bræk G (2006) Effect of Ca2+, Ba2+, and Sr2+ on alginate microbeads. Biomacromolecules 7: 1471-1480.
28. Smith AM, Hunt NC, Shelton RM, Birdi G and Grover LM (2012) Alginate Hydrogel Has a Negative Impact on in Vitro Collagen 1 Deposition by Fibroblasts. Biomacromolecules 13: 4032-4038.
29. Leal-Egana A, Braumann U-D, Diaz-Cuenca A, Nowicki M and Bader A (2011) Determination of pore size distribution at the cell-hydrogel interface. J Nanobiotechnology 9: 24.
30. Kadler KE, Holmes DF, Trotter JA and Chapman JA (1996) Collagen fibril formation. Biochem J 316: 1-11. (Pubitemid 26158194)
31. Trewenack AJ, Please CP and Landman KA (2009) A continuum model for the development of tissue-engineered cartilage around a chondrocyte. Math Med Biol 26: 241-262.
32. Friedmann A, Hoess A, Cismak A and Heilmann A (2011) Investigation of cell-substrate interactions by focused ion beam preparation and scanning electron microscopy. Acta Biomater 7: 2499-2507.
33. Zehbe R, Riesemeier H, Kirkpatrick CJ and Brochhausen C (2012) Imaging of articular cartilage - Data matching using X-ray tomography, SEM, FIB slicing and conventional histology. Micron 43: 1060-1067.