Controlling cartilaginous matrix evolution in hydrogels with degradation triggered by exogenous addition of an enzyme

Tissue Engineering

Volumn 13, Issue 4, 2007, Pages 683-691

  Rice, Mark A ^a   Anseth, Kristi S ^a,b  

^a UCB 450   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; ENZYME KINETICS; GROWTH KINETICS; HYDROGELS; POLYETHYLENE GLYCOLS; STIFFNESS;

CAPROLACTONE; CARTILAGE REGENERATION; CULTURE MEDIA; ENZYMATIC DEGRADATION; LIPASE;

CARTILAGE;

COLLAGEN TYPE 2; LACTONE DERIVATIVE; MACROGOL; TRIACYLGLYCEROL LIPASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL ENCAPSULATION; CONTROLLED STUDY; CULTURE MEDIUM; HYDROGEL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; TISSUE REGENERATION;

ABSORBABLE IMPLANTS; ANIMALS; BIOCOMPATIBLE MATERIALS; CARTILAGE, ARTICULAR; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHONDROCYTES; COMPRESSIVE STRENGTH; EXTRACELLULAR MATRIX; HYDROGELS; LIPASE; MATERIALS TESTING; POLYESTERS; SHEEP; TISSUE ENGINEERING;

EID: 34247502714     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2006.0142     Document Type: Article

References (26)

1. Anseth, K.S., Metters, A.T., Bryant, S.J., Martens, P.J., Elisseeff, J.H., Bowman, C.N. In situ forming degradable networks and their application in tissue engineering and drug delivery. J Control Release 78, 199, 2002.
2. Fragonas, E., Valente, M., Pozzi-Mucelli, M., Toffanin, R., Rizzo, R., Silvestri, F., Vittur, F. Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate. Biomaterials 21, 795, 2000.
3. Smeds, K.A., Pfister-Serres, A., Miki, D., Dastgheib, K., Inoue, M., Hatchell, D.L., Grinstaff, M.W. Photo crosslinkable polysaccharides for in situ hydrogel formation. J Biomed Mater Res 54, 115, 2001.
4. Bryant, S.J., Nuttelman, C.R., Anseth, K.S. Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro. J Biomater Sci Polym Ed 11, 439, 2000.
5. Bryant, S.J., Anseth, K.S. Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels. J Biomed Mater Res 59, 63, 2002.
6. Bryant, S.J., Chowdhury, T.T., Lee, D.A., Bader, D.L., Anseth, K.S. Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked polyx(ethylene glycol) hydrogels. Ann Biomed Eng 32, 407, 2004.
7. Sawhney, A.S., Pathak, C.P., Hubbell, J.A. Bioerodible Hydrogels Based on Photopolymerized Poly(Ethylene Glycol)-Co-Poly(Alpha-Hydroxy Acid) Diacrylate Macromers. Macromolecules 26, 581, 1993.
8. Metters, A.T., Anseth, K.S., Bowman, C.N. Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel. Polymer 41, 3993, 2000.
9. Bryant, S.J., Anseth, K.S. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J Biomed Mater Res A 64A, 70, 2003.
10. Rice, M.A., Anseth, K.S. Encapsulating chondrocytes in copolymer gels: bimodal degradation kinetics influence cell phenotype and extracellular matrix development. J Biomed Mater Res 70A, 560, 2004.
11. Metters, A.T., Bowman, C.N., Anseth, K.S. A statistical kinetic model for the bulk degradation of PLA-b- PEG-b-PLA hydrogel networks. J Phys Chem B 104, 7043, 2000.
12. Bryant, S.J., Bender, R.J., Durand, K.L., Anseth, K.S. Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production. Biotechnol Bioeng 86, 747, 2004.
13. West, J.L., Hubbell, J.A. Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules 32, 241, 1999.
14. Zhu, A.P., Chan-Park, M.B., Gao, J.X. Foldable micropatterned hydrogel film made from biocompatible PCL-b-PEG-b-PCL diacrylate by UV embossing. J Biomed Mater Res B 76B, 76, 2006.
15. Rice, M.A., Anseth, K.S. Exogenously triggered, enzymatic degradation of photopolymerized hydrogels with polycaprolactone subunits: experimental observation and modeling of mass loss behavior. Biomacromolecules 7, 1968, 2006.
16. Zhao, Y., Hu, T.J., Lv, Z., Wang, S.G., Wu, C. Laser light-scattering studies of poly(caprolactone-b-ethylene oxide-b-caprolactone) nanoparticles and their enzymatic biodegradation. J Polym Sci, Part B: Polym Phys 37, 3288, 1999.
17. Nie, T., Zhao, Y., Xie, Z.W., Wu, C. Micellar formation of poly(caprolactone-block-ethylene oxide-block-caprolactone) and its enzymatic biodegradation in aqueous dispersion. Macromolecules 36, 8825, 2003.
18. Farndale, R.W., Buttle, D.J., Barrett, A.J. Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 883, 173, 1986.
19. Woessner, J.F. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 93, 440, 1961.
20. Hollander, A.P., Heathfield, T.F., Webber, C., Iwata, Y., Bourne, R., Rorabeck, C., Poole, A.R. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J Clin Invest 93, 1722, 1994.
21. Kim, Y.J., Sah, R.L.Y., Doong, J.Y.H., Grodzinsky, A.J. Fluorometric assay of DNA in cartilage explants using Hoechst-33258. Anal Biochem 174, 168, 1988.
22. Pei, M., Seidel, J., Vunjak-Novakovic, G., Freed, L.E. Growth factors for sequential cellular de- and re-differentiation in tissue engineering. Biochem Biophys Res Commun 294, 149, 2002.
23. Blunk, T., Sieminski, A.L., Gooch, K.J., Courter, D.L., Hollander, A.P., Nahir, M., Langer, R., Vunjak-Novakovic, G., Freed, J.E. Differential effects of growth factors on tissue-engineered cartilage. Tissue Eng 8, 73, 2002.
24. Metters, A.T., Anseth, K.S., Bowman, C.N. A statistical kinetic model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks: incorporating network non-idealities. J Phys Chem B 105, 8069, 2001.
25. Pencreach, G., Leullier, M., Baratti, J.C. Properties of free and immobilized lipase from Pseudomonas cepacia. Biotechnol Bioeng 56, 181, 1997.
26. Bryant, S.J., Durand, K.L., Anseth, K.S. Manipulations in hydrogel chemistry control photoencapsulated chondrocyte behavior and their extracellular matrix production. J Biomed Mater Res A 67A, 1430, 2003.