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Volumn 7, Issue 2, 2011, Pages 492-504

Gel structure has an impact on pericellular and extracellular matrix deposition, which subsequently alters metabolic activities in chondrocyte-laden PEG hydrogels

Author keywords

Cartilage; Chondrocytes; Extracellular matrix; Hydrogels; Pericellular matrix

Indexed keywords

BLOOD VESSELS; CARTILAGE; COLLAGEN; DEGRADATION; DEPOSITION; ENZYME ACTIVITY; GELS; GENE EXPRESSION; GLYCOPROTEINS; POLYETHYLENE GLYCOLS;

EID: 78650725647     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.08.021     Document Type: Article
Times cited : (86)

References (62)
  • 1
    • 0026203776 scopus 로고
    • A triphasic theory for the swelling and deformation behaviors of articular-cartilage
    • W.M. Lai, J.S. Hou, and V.C. Mow A triphasic theory for the swelling and deformation behaviors of articular-cartilage J Biomech Eng - Trans ASME 113 1991 245 258
    • (1991) J Biomech Eng - Trans ASME , vol.113 , pp. 245-258
    • Lai, W.M.1    Hou, J.S.2    Mow, V.C.3
  • 2
    • 0017290857 scopus 로고
    • Balance between swelling pressure and collagen tension in normal and degenerate cartilage
    • A. Maroudas Balance between swelling pressure and collagen tension in normal and degenerate cartilage Nature 260 1976 808 809
    • (1976) Nature , vol.260 , pp. 808-809
    • Maroudas, A.1
  • 3
    • 68749115617 scopus 로고    scopus 로고
    • Proteoglycans and glycosaminoglycans
    • T.E. Hardingham Proteoglycans and glycosaminoglycans M.J. Seibel, S.P. Robins, J.P. Bilezikian, Dynamics of bone and cartilage metabolism 2nd ed. 2006 Elsevier Burlington, MA 85 98
    • (2006) Dynamics of Bone and Cartilage Metabolism , pp. 85-98
    • Hardingham, T.E.1
  • 4
    • 33744724912 scopus 로고    scopus 로고
    • The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage
    • F. Guilak, L.G. Alexopoulos, M.L. Upton, I. Youn, J.B. Choi, and L. Cao The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage Ann NY Acad Sci 1068 2006 498 512
    • (2006) Ann NY Acad Sci , vol.1068 , pp. 498-512
    • Guilak, F.1    Alexopoulos, L.G.2    Upton, M.L.3    Youn, I.4    Choi, J.B.5    Cao, L.6
  • 5
    • 0030979705 scopus 로고    scopus 로고
    • Articular cartilage chondrons: Form, function and failure
    • C.A. Poole Articular cartilage chondrons: form, function and failure J Anat 191 1997 1 13
    • (1997) J Anat , vol.191 , pp. 1-13
    • Poole, C.A.1
  • 6
    • 0022539753 scopus 로고
    • Molecular assembly, secretion, and matrix deposition of type-VI collagen
    • E. Engvall, H. Hessle, and G. Klier Molecular assembly, secretion, and matrix deposition of type-VI collagen J Cell Biol 102 1986 703 710
    • (1986) J Cell Biol , vol.102 , pp. 703-710
    • Engvall, E.1    Hessle, H.2    Klier, G.3
  • 7
    • 0023639253 scopus 로고
    • Chondrons in cartilage - Ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages
    • C.A. Poole, M.H. Flint, and B.W. Beaumont Chondrons in cartilage - ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages J Orthop Res 5 1987 509 522
    • (1987) J Orthop Res , vol.5 , pp. 509-522
    • Poole, C.A.1    Flint, M.H.2    Beaumont, B.W.3
  • 10
    • 0141621124 scopus 로고    scopus 로고
    • Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan
    • C. Wiberg, A.R. Klatt, R. Wagener, M. Paulsson, J.F. Bateman, and D. Heinegard Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan J Biol Chem 278 2003 37698 37704
    • (2003) J Biol Chem , vol.278 , pp. 37698-37704
    • Wiberg, C.1    Klatt, A.R.2    Wagener, R.3    Paulsson, M.4    Bateman, J.F.5    Heinegard, D.6
  • 11
    • 0036068237 scopus 로고    scopus 로고
    • Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production
    • C.M. Larson, S.S. Kelley, A.D. Blackwood, A.J. Banes, and G.M. Lee Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production Matrix Biol 21 2002 349 359
    • (2002) Matrix Biol , vol.21 , pp. 349-359
    • Larson, C.M.1    Kelley, S.S.2    Blackwood, A.D.3    Banes, A.J.4    Lee, G.M.5
  • 12
    • 0024599190 scopus 로고
    • Acquisition of hyaluronate-binding affinity in vivo by newly synthesized cartilage proteoglycans
    • J.D. Sandy, J.R. O'Neill, and L.C. Ratzlaff Acquisition of hyaluronate-binding affinity in vivo by newly synthesized cartilage proteoglycans Biochem J 258 1989 875 880
    • (1989) Biochem J , vol.258 , pp. 875-880
    • Sandy, J.D.1    O'Neill, J.R.2    Ratzlaff, L.C.3
  • 13
    • 0026080765 scopus 로고
    • Proteoglycans as modulators of growth-factor activities
    • E. Ruoslahti, and Y. Yamaguchi Proteoglycans as modulators of growth-factor activities Cell 64 1991 867 869
    • (1991) Cell , vol.64 , pp. 867-869
    • Ruoslahti, E.1    Yamaguchi, Y.2
  • 14
    • 33749557616 scopus 로고    scopus 로고
    • Rational design of hydrogels for tissue engineering: Impact of physical factors on cell behavior
    • F. Brandl, F. Sommer, and A. Goepferich Rational design of hydrogels for tissue engineering: impact of physical factors on cell behavior Biomaterials 28 2007 134 146
    • (2007) Biomaterials , vol.28 , pp. 134-146
    • Brandl, F.1    Sommer, F.2    Goepferich, A.3
  • 16
    • 45249104205 scopus 로고    scopus 로고
    • Cell encapsulation in biodegradable hydrogels for tissue engineering applications
    • G.D. Nicodemus, and S.J. Bryant Cell encapsulation in biodegradable hydrogels for tissue engineering applications Tissue Eng B - Rev 14 2008 149 165
    • (2008) Tissue Eng B - Rev , vol.14 , pp. 149-165
    • Nicodemus, G.D.1    Bryant, S.J.2
  • 18
    • 49149094136 scopus 로고    scopus 로고
    • Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs
    • J.T. Connelly, C.G. Wilson, and M.E. Levenston Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs Osteoarthritis Cartilage 16 2008 1092 1100
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1092-1100
    • Connelly, J.T.1    Wilson, C.G.2    Levenston, M.E.3
  • 19
    • 0028969166 scopus 로고
    • Mechanical compression modulates matrix biosynthesis in chondrocyte agarose culture
    • M.D. Buschmann, Y.A. Gluzband, A.J. Grodzinsky, and E.B. Hunziker Mechanical compression modulates matrix biosynthesis in chondrocyte agarose culture J Cell Sci 108 1995 1497 1508
    • (1995) J Cell Sci , vol.108 , pp. 1497-1508
    • Buschmann, M.D.1    Gluzband, Y.A.2    Grodzinsky, A.J.3    Hunziker, E.B.4
  • 20
    • 0036311836 scopus 로고    scopus 로고
    • Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage
    • T. Davisson, S. Kunig, A. Chen, R. Sah, and A. Ratcliffe Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage J Orthop Res 20 2002 842 848
    • (2002) J Orthop Res , vol.20 , pp. 842-848
    • Davisson, T.1    Kunig, S.2    Chen, A.3    Sah, R.4    Ratcliffe, A.5
  • 21
    • 0042360401 scopus 로고    scopus 로고
    • Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering
    • R.L. Mauck, S.B. Nicoll, S.L. Seyhan, G.A. Ateshian, and C.T. Hung Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering Tissue Eng 9 2003 597 611
    • (2003) Tissue Eng , vol.9 , pp. 597-611
    • Mauck, R.L.1    Nicoll, S.B.2    Seyhan, S.L.3    Ateshian, G.A.4    Hung, C.T.5
  • 22
    • 0344825353 scopus 로고    scopus 로고
    • The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading
    • R.L. Mauck, C.C.B. Wang, E.S. Oswald, G.A. Ateshian, and C.T. Hung The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading Osteoarthritis Cartilage 11 2003 879 890
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 879-890
    • Mauck, R.L.1    Wang, C.C.B.2    Oswald, E.S.3    Ateshian, G.A.4    Hung, C.T.5
  • 23
    • 2942564346 scopus 로고    scopus 로고
    • A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading
    • C.T. Hung, R.L. Mauck, C.C.B. Wang, E.G. Lima, and G.A. Ateshian A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading Ann Biomed Eng 32 2004 35 49
    • (2004) Ann Biomed Eng , vol.32 , pp. 35-49
    • Hung, C.T.1    Mauck, R.L.2    Wang, C.C.B.3    Lima, E.G.4    Ateshian, G.A.5
  • 24
    • 33847401967 scopus 로고    scopus 로고
    • Nanomechanical properties of individual chondrocytes and their developing growth factor-stimulated pericellular matrix
    • L. Ng, H.H. Hung, A. Sprunt, S. Chubinskaya, C. Ortiz, and A. Grodzinsky Nanomechanical properties of individual chondrocytes and their developing growth factor-stimulated pericellular matrix J Biomech 40 2007 1011 1023
    • (2007) J Biomech , vol.40 , pp. 1011-1023
    • Ng, L.1    Hung, H.H.2    Sprunt, A.3    Chubinskaya, S.4    Ortiz, C.5    Grodzinsky, A.6
  • 25
    • 0037162463 scopus 로고    scopus 로고
    • Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: Implications for cartilage tissue repair
    • J. Kisiday, M. Jin, B. Kurz, H. Hung, C. Semino, and S. Zhang Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair Proc Natl Acad Sci USA 99 2002 9996 10001
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9996-10001
    • Kisiday, J.1    Jin, M.2    Kurz, B.3    Hung, H.4    Semino, C.5    Zhang, S.6
  • 26
    • 1842576576 scopus 로고    scopus 로고
    • Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds
    • J.D. Kisiday, M.S. Jin, M.A. DiMicco, B. Kurz, and A.J. Grodzinsky Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds J Biomech 37 2004 595 604
    • (2004) J Biomech , vol.37 , pp. 595-604
    • Kisiday, J.D.1    Jin, M.S.2    Dimicco, M.A.3    Kurz, B.4    Grodzinsky, A.J.5
  • 27
    • 0036132916 scopus 로고    scopus 로고
    • Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels
    • S.J. Bryant, and K.S. Anseth Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels J Biomed Mater Res 59 2002 63 72
    • (2002) J Biomed Mater Res , vol.59 , pp. 63-72
    • Bryant, S.J.1    Anseth, K.S.2
  • 28
    • 2942567997 scopus 로고    scopus 로고
    • Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels
    • S.J. Bryant, T.T. Chowdhury, D.A. Lee, D.L. Bader, and K.S. Anseth Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels Ann Biomed Eng 32 2004 407 417
    • (2004) Ann Biomed Eng , vol.32 , pp. 407-417
    • Bryant, S.J.1    Chowdhury, T.T.2    Lee, D.A.3    Bader, D.L.4    Anseth, K.S.5
  • 29
    • 0346123010 scopus 로고    scopus 로고
    • Manipulations in hydrogel chemistry control photoencapsulated chondrocyte behavior and their extracellular matrix production
    • S.J. Bryant, K.L. Durand, and K.S. Anseth Manipulations in hydrogel chemistry control photoencapsulated chondrocyte behavior and their extracellular matrix production J Biomed Mater Res Part A 67A 2003 1430 1436
    • (2003) J Biomed Mater Res Part A , vol.67 , pp. 1430-1436
    • Bryant, S.J.1    Durand, K.L.2    Anseth, K.S.3
  • 30
    • 60549100859 scopus 로고    scopus 로고
    • Cross-linking density alters early metabolic activities in chondrocytes encapsulated in poly(ethylene glycol) hydrogels and cultured in the rotating wall vessel
    • I. Villanueva, B.J. Klement, D. von Deutsch, and S.J. Bryant Cross-linking density alters early metabolic activities in chondrocytes encapsulated in poly(ethylene glycol) hydrogels and cultured in the rotating wall vessel Biotechnol Bioeng 102 2009 1242 1250
    • (2009) Biotechnol Bioeng , vol.102 , pp. 1242-1250
    • Villanueva, I.1    Klement, B.J.2    Von Deutsch, D.3    Bryant, S.J.4
  • 31
    • 56449084391 scopus 로고    scopus 로고
    • The differential effect of scaffold composition and architecture on chondrocyte response to mechanical stimulation
    • T.P. Appelman, J. Mizrahi, J.H. Elisseeff, and D. Seliktar The differential effect of scaffold composition and architecture on chondrocyte response to mechanical stimulation Biomaterials 30 2009 518 525
    • (2009) Biomaterials , vol.30 , pp. 518-525
    • Appelman, T.P.1    Mizrahi, J.2    Elisseeff, J.H.3    Seliktar, D.4
  • 32
    • 0038612869 scopus 로고    scopus 로고
    • Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage
    • S.J. Bryant, and K.S. Anseth Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage J Biomed Mater Res Part A 64A 2003 70 79
    • (2003) J Biomed Mater Res Part A , vol.64 , pp. 70-79
    • Bryant, S.J.1    Anseth, K.S.2
  • 33
    • 2942558681 scopus 로고    scopus 로고
    • Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: Engineering gel structural changes to facilitate cartilaginous tissue production
    • S.J. Bryant, R.J. Bender, K.L. Durand, and K.S. Anseth Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production Biotechnol Bioeng 86 2004 747 755
    • (2004) Biotechnol Bioeng , vol.86 , pp. 747-755
    • Bryant, S.J.1    Bender, R.J.2    Durand, K.L.3    Anseth, K.S.4
  • 34
    • 4344587250 scopus 로고    scopus 로고
    • Encapsulating chondrocytes in copolymer gels: Bimodal degradation kinetics influence cell phenotype and extracellular matrix development
    • M.A. Rice, and K.S. Anseth Encapsulating chondrocytes in copolymer gels: bimodal degradation kinetics influence cell phenotype and extracellular matrix development J Biomed Mater Res Part A 70A 2004 560 568
    • (2004) J Biomed Mater Res Part A , vol.70 , pp. 560-568
    • Rice, M.A.1    Anseth, K.S.2
  • 35
    • 34247502714 scopus 로고    scopus 로고
    • Controlling cartilaginous matrix evolution in hydrogels with degradation triggered by exogenous addition of an enzyme
    • M.A. Rice, and K.S. Anseth Controlling cartilaginous matrix evolution in hydrogels with degradation triggered by exogenous addition of an enzyme Tissue Eng 13 2007 683 691
    • (2007) Tissue Eng , vol.13 , pp. 683-691
    • Rice, M.A.1    Anseth, K.S.2
  • 36
    • 20444395813 scopus 로고    scopus 로고
    • The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells
    • F. Yang, C.G. Williams, D.A. Wang, H. Lee, P.N. Manson, and J. Elisseeff The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells Biomaterials 26 2005 5991 5998
    • (2005) Biomaterials , vol.26 , pp. 5991-5998
    • Yang, F.1    Williams, C.G.2    Wang, D.A.3    Lee, H.4    Manson, P.N.5    Elisseeff, J.6
  • 37
    • 33644806716 scopus 로고    scopus 로고
    • Incorporation of tissue-specific molecules alters chondrocyte metabolism and gene expression in photocrosslinked hydrogels
    • S.J. Bryant, J.A. Arthur, and K.S. Anseth Incorporation of tissue-specific molecules alters chondrocyte metabolism and gene expression in photocrosslinked hydrogels Acta Biomater 1 2005 243 252
    • (2005) Acta Biomater , vol.1 , pp. 243-252
    • Bryant, S.J.1    Arthur, J.A.2    Anseth, K.S.3
  • 38
  • 39
    • 33845403216 scopus 로고    scopus 로고
    • Immobilized fibrinogen in PEG hydrogels does not improve chondrocyte-mediated matrix deposition in response to mechanical stimulation
    • O. Schmidt, J. Mizrahi, J. Elisseeff, and D. Seliktar Immobilized fibrinogen in PEG hydrogels does not improve chondrocyte-mediated matrix deposition in response to mechanical stimulation Biotechnol Bioeng 95 2006 1061 1069
    • (2006) Biotechnol Bioeng , vol.95 , pp. 1061-1069
    • Schmidt, O.1    Mizrahi, J.2    Elisseeff, J.3    Seliktar, D.4
  • 40
    • 42749095720 scopus 로고    scopus 로고
    • Static and dynamic compressive strains influence nitric oxide production and chondrocyte bioactivity when encapsulated in PEG hydrogels of different crosslinking densities
    • 10.1016/j.joca.2007.12.003
    • I. Villanueva, D.S. Hauschulz, D. Mejic, and S.J. Bryant Static and dynamic compressive strains influence nitric oxide production and chondrocyte bioactivity when encapsulated in PEG hydrogels of different crosslinking densities Osteoarthritis Cartilage 2008 10.1016/j.joca.2007.12.003
    • (2008) Osteoarthritis Cartilage
    • Villanueva, I.1    Hauschulz, D.S.2    Mejic, D.3    Bryant, S.J.4
  • 41
    • 14644407431 scopus 로고    scopus 로고
    • Investigation of molecular transport and distributions in poly(ethylene glycol) hydrogels with confocal laser scanning microscopy
    • A.W. Watkins, and K.S. Anseth Investigation of molecular transport and distributions in poly(ethylene glycol) hydrogels with confocal laser scanning microscopy Macromolecules 38 2005 1326 1334
    • (2005) Macromolecules , vol.38 , pp. 1326-1334
    • Watkins, A.W.1    Anseth, K.S.2
  • 42
    • 70449118261 scopus 로고    scopus 로고
    • Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function
    • L.M. Weber, C.G. Lopez, and K.S. Anseth Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function J Biomed Mater Res Part A 90A 2009 720 729
    • (2009) J Biomed Mater Res Part A , vol.90 , pp. 720-729
    • Weber, L.M.1    Lopez, C.G.2    Anseth, K.S.3
  • 43
    • 4344699758 scopus 로고    scopus 로고
    • Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain
    • S.J. Bryant, K.S. Anseth, D.A. Lee, and D.L. Bader Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain J Orthop Res 22 2004 1143 1149
    • (2004) J Orthop Res , vol.22 , pp. 1143-1149
    • Bryant, S.J.1    Anseth, K.S.2    Lee, D.A.3    Bader, D.L.4
  • 44
    • 42749097645 scopus 로고    scopus 로고
    • The role of hydrogel structure and dynamic loading on chondrocyte gene expression and matrix formation
    • G.D. Nicodemus, and S.J. Bryant The role of hydrogel structure and dynamic loading on chondrocyte gene expression and matrix formation J Biomech 41 2008 1528 1536
    • (2008) J Biomech , vol.41 , pp. 1528-1536
    • Nicodemus, G.D.1    Bryant, S.J.2
  • 45
    • 51649083975 scopus 로고    scopus 로고
    • Designing 3D photopolymer hydrogels to regulate biomechanical cues and tissue growth for cartilage tissue engineering
    • S.J. Bryant, G.D. Nicodemus, and I. Villanueva Designing 3D photopolymer hydrogels to regulate biomechanical cues and tissue growth for cartilage tissue engineering Pharm Res 25 2008 2379 2386
    • (2008) Pharm Res , vol.25 , pp. 2379-2386
    • Bryant, S.J.1    Nicodemus, G.D.2    Villanueva, I.3
  • 46
    • 0034129774 scopus 로고    scopus 로고
    • Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks
    • J. Elisseeff, W. McIntosh, K. Anseth, S. Riley, P. Ragan, and R. Langer Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks J Biomed Mater Res 51 2000 164 171
    • (2000) J Biomed Mater Res , vol.51 , pp. 164-171
    • Elisseeff, J.1    McIntosh, W.2    Anseth, K.3    Riley, S.4    Ragan, P.5    Langer, R.6
  • 47
    • 0022552896 scopus 로고
    • Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene blue
    • R.W. Farndale, D.J. Buttle, and A.J. Barrett Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene blue Biochim Biophys Acta 883 1986 173 177
    • (1986) Biochim Biophys Acta , vol.883 , pp. 173-177
    • Farndale, R.W.1    Buttle, D.J.2    Barrett, A.J.3
  • 48
    • 72149105318 scopus 로고    scopus 로고
    • Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels
    • 10.1016/j.joca.2009.08.005
    • G.D. Nicodemus, and S.J. Bryant Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels Osteoarthritis Cartilage 2009 10.1016/j.joca.2009.08.005
    • (2009) Osteoarthritis Cartilage
    • Nicodemus, G.D.1    Bryant, S.J.2
  • 49
    • 84882564866 scopus 로고    scopus 로고
    • Structure, biosynthesis, and gene regulation of collagens in cartilage and bones
    • K.V.D. Mark Structure, biosynthesis, and gene regulation of collagens in cartilage and bones M.J. Seibel, S.P. Robins, J.P. Bilezikian, Dynamics of bone and cartilage metabolism 2nd ed. 2006 Elsevier Burlington, MA 3 40
    • (2006) Dynamics of Bone and Cartilage Metabolism , pp. 3-40
    • Mark, K.V.D.1
  • 50
    • 0026507880 scopus 로고
    • Proteoglycans: Many forms and many functions
    • T.E. Hardingham, and A.J. Fosang Proteoglycans: many forms and many functions FASEB J 6 1992 861 870
    • (1992) FASEB J , vol.6 , pp. 861-870
    • Hardingham, T.E.1    Fosang, A.J.2
  • 51
    • 0015510675 scopus 로고
    • The specific interaction of hyaluronic acid with cartilage proteoglycans
    • T.E. Hardingham, and H. Muir The specific interaction of hyaluronic acid with cartilage proteoglycans Biochim Biophys Acta 279 1972 401 405
    • (1972) Biochim Biophys Acta , vol.279 , pp. 401-405
    • Hardingham, T.E.1    Muir, H.2
  • 52
    • 0018383249 scopus 로고
    • The role of link-protein in the structure of cartilage proteoglycan aggregates
    • T.E. Hardingham The role of link-protein in the structure of cartilage proteoglycan aggregates Biochem J 177 1979 237 247
    • (1979) Biochem J , vol.177 , pp. 237-247
    • Hardingham, T.E.1
  • 53
    • 0031939945 scopus 로고    scopus 로고
    • Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family
    • A.P. Spicer, and J.A. McDonald Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family J Biol Chem 273 1998 1923 1932
    • (1998) J Biol Chem , vol.273 , pp. 1923-1932
    • Spicer, A.P.1    McDonald, J.A.2
  • 54
    • 33746836954 scopus 로고    scopus 로고
    • Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation
    • J.N.A. De Croos, S.S. Dhaliwal, M.D. Grynpas, R.M. Pilliar, and R.A. Kandel Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation Matrix Biol 25 2006 323 331
    • (2006) Matrix Biol , vol.25 , pp. 323-331
    • De Croos, J.N.A.1    Dhaliwal, S.S.2    Grynpas, M.D.3    Pilliar, R.M.4    Kandel, R.A.5
  • 55
    • 0028966138 scopus 로고
    • The structure of aggrecan and its turnover in cartilage
    • T.E. Hardingham, and A.J. Fosang The structure of aggrecan and its turnover in cartilage J Rheumatol Suppl 43 1995 86 90
    • (1995) J Rheumatol Suppl , vol.43 , pp. 86-90
    • Hardingham, T.E.1    Fosang, A.J.2
  • 57
    • 30544436016 scopus 로고    scopus 로고
    • Editorial - A contentious issue finds some clarity: On the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis
    • J.D. Sandy Editorial - a contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis Osteoarthritis Cartilage 14 2006 95 100
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 95-100
    • Sandy, J.D.1
  • 58
    • 34249815837 scopus 로고    scopus 로고
    • Mechanical regulation of matrix metalloproteinases
    • E.J. Blain Mechanical regulation of matrix metalloproteinases Front Biosci 12 2007 507 527
    • (2007) Front Biosci , vol.12 , pp. 507-527
    • Blain, E.J.1
  • 59
    • 0035580553 scopus 로고    scopus 로고
    • Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro
    • E.J. Blain, S.J. Gilbert, R.J. Wardale, S.J. Capper, D.J. Mason, and V.C. Duance Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro Arch Biochem Biophys 396 2001 49 55
    • (2001) Arch Biochem Biophys , vol.396 , pp. 49-55
    • Blain, E.J.1    Gilbert, S.J.2    Wardale, R.J.3    Capper, S.J.4    Mason, D.J.5    Duance, V.C.6
  • 60
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • A.J. Engler, S. Sen, H.L. Sweeney, and D.E. Discher Matrix elasticity directs stem cell lineage specification Cell 126 2006 677 689
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 61
    • 33745135423 scopus 로고    scopus 로고
    • Hydrogels in biology and medicine: From molecular principles to bionanotechnology
    • N.A. Peppas, J.Z. Hilt, A. Khademhosseini, and R. Langer Hydrogels in biology and medicine: from molecular principles to bionanotechnology Adv Mater 18 2006 1345 1360
    • (2006) Adv Mater , vol.18 , pp. 1345-1360
    • Peppas, N.A.1    Hilt, J.Z.2    Khademhosseini, A.3    Langer, R.4
  • 62
    • 33745622879 scopus 로고    scopus 로고
    • Exogenously triggered, enzymatic degradation of photopolymerized hydrogels with polycaprolactone subunits: Experimental observation and modeling of mass loss behavior
    • M.A. Rice, J. Sanchez-Adams, and K.S. Anseth Exogenously triggered, enzymatic degradation of photopolymerized hydrogels with polycaprolactone subunits: experimental observation and modeling of mass loss behavior Biomacromolecules 7 2006 1968 1975
    • (2006) Biomacromolecules , vol.7 , pp. 1968-1975
    • Rice, M.A.1    Sanchez-Adams, J.2    Anseth, K.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.