Side chain hydrophobicity modulates therapeutic activity and membrane selectivity of antimicrobial peptide mastoparan-X

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Henriksen, Jonas R ^a   Etzerodt, Thomas ^a   Gjetting, Torben ^a   Andresen, Thomas L ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; MASTOPARAN X; MASTOPARAN X DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; UNNATURAL AMINO ACID; ANTIINFECTIVE AGENT; PEPTIDE;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; BACTERIUM; BIOPHYSICAL PARAMETERS; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG POTENCY; DRUG SELECTIVITY; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; NONHUMAN; PHYSICAL PARAMETERS; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; ALKYLATION; AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; METABOLISM; MOLECULAR GENETICS; STRUCTURE ACTIVITY RELATION;

ALKYLATION; AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; CELL MEMBRANE; HEMOLYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR SEQUENCE DATA; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84898011069     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091007     Document Type: Article

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