A 7-dimethylallyl tryptophan synthase from a fungal Neosartorya sp.: Biochemical characterization and structural insight into the regioselective prenylation

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 8, 2014, Pages 2517-2528

  Miyamoto, Kengo ^a   Ishikawa, Fumihiro ^a   Nakamura, Shinya ^b   Hayashi, Yutaka ^a   Nakanishi, Isao ^b   Kakeya, Hideaki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KINKI UNIVERSITY   (Japan)

Author keywords

7 Dimethylallyl tryptophan synthase (7 DMATS); Neosartorya sp.; Prenylated indole derivatives; Regioselective prenylation; Three dimensional structural models

Indexed keywords

7 DIMETHYLALLYL TRYPTOPHAN SYNTHASE; GERANYLGERANYL PYROPHOSPHATE; TRYPTOPHAN SYNTHASE; UNCLASSIFIED DRUG; FUNGAL PROTEIN; RECOMBINANT PROTEIN; TRANSFERASE; TRYPTOPHAN; TRYPTOPHAN DIMETHYLALLYLTRANSFERASE;

ARTICLE; ASPERGILLUS FUMIGATUS; CATALYSIS; COCULTURE; CRYSTAL STRUCTURE; DMATS GENE; ELECTROSPRAY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; FUNGAL GENE; FUNGAL STRAIN; GENE OVEREXPRESSION; GENE PRODUCT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; MOLECULAR CLONING; MOLECULAR WEIGHT; NEOSARTORYA; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN PRENYLATION; STEREOCHEMISTRY; AMINO ACID SEQUENCE; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; KINETICS; METABOLISM; PRENYLATION; STEREOISOMERISM;

ASPERGILLUS FUMIGATUS; ESCHERICHIA COLI; NEOSARTORYA;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; ASPERGILLUS FUMIGATUS; CATALYTIC DOMAIN; ESCHERICHIA COLI; FUNGAL PROTEINS; KINETICS; NEOSARTORYA; PRENYLATION; RECOMBINANT PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TRYPTOPHAN;

EID: 84898008601     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.02.031     Document Type: Article

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