Effect of Carthamus tinctorius (Safflower) on fasting blood glucose and insulin levels in alloxan induced diabetic rabbits

Pakistan Journal of Pharmaceutical Sciences

Volumn 27, Issue 2, 2014, Pages 377-380

  Qazi, Nasreen ^a   Khan, Rafeeq Alam ^b   Rizwani, Ghazala H ^c   Feroz, Zeeshan ^d  

^a LIAQUAT UNIVERSITY OF MEDICAL AND HEALTH SCIENCES   (Pakistan)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^c UNIVERSITY OF KARACHI   (Pakistan)

^d KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

Author keywords

Carthamus tinctorius (CT); Fasting blood glucose (FBS); Type 2 diabetes mellitus (type 2 DM)

Indexed keywords

ALLOXAN; GLIBENCLAMIDE; GLUCOSE; INSULIN; SAFFLOWER EXTRACT;

ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FASTING BLOOD GLUCOSE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RABBIT; SAFFLOWER;

ANIMALS; BLOOD GLUCOSE; CARTHAMUS TINCTORIUS; DIABETES MELLITUS, EXPERIMENTAL; FLOWERS; GLYBURIDE; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PLANT EXTRACTS; RABBITS;

EID: 84898004755     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ahmad LA and Crandall JP (2010). Type 2 Diabetes Prevention: A Review Clinical Diabetes, 28: 53-60.
2. Alam K and Mahpara S (2003). Role of diet nutrients, spices and natural products in diabetes mellitus. Pak. J. Nutr., 2: 1-12.
3. Bhattaram VA, Graefe U, Kohlert C, Veit M and Derendorf H (2002). Pharmacokinetics and bioavailability of herbal medicinal products. Phytomedicine, 9(3): 1-33. (Pubitemid 41623448)
4. 2 induced dysfunction and oxidative damage in osteoblastic Mc 3T3-E1 cells. Phyother. Res., 24: 1037-1044.
5. Derek Le Roith (2001). Current therapeutic algorithms for type 2 diabetes. Clinical Corner Stone, 4(2): 38-49.
6. Earl MA (2005). Emerging therapies in the treatment of type 2 Diabetes. Pharmacotherapy update. Newsletter, 8 (1): Jan- Feb.
7. Edwin E, Sheeja E, Gupta VB and Jain DC (2006). Fight Diabetes the herbal way. Express Pharma Review, 1: 41-42.
8. Ernst E (2000). Prevalence of use of Complementary and Alternative Medicine: a systematic review. Bulletin of the World Health Organization, 78(2): 252-257.
9. Gupta V, Jadhav JK, Masirkar VJ and Deshmukh VN (2009). Antihyperglycemic effect of Diospyros melanoxylon (Roxb.) bark against Alloxan induced diabetic rats. International Journal of Pharm. Tech. Research, 1(2): 196-200.
10. Han SY, Li Hx, Bai CC, Wang L and TUPF (2010). Component analysis and free radical scavenging potential of Panax notoginseng and Cathramus tinctorius extracts. Chem. Biodivers, 7: 383-389.
11. Hayat AS and Shaikh N (2010). Barriers and myths to initiate insulin therapy for type II diabetes mellitus at primary health care centers of Hyderabad district. World Applied Sci., 8(1): 66-72.
12. Hou Z, Zhang Z and Hong W (2005). Effect of Sanguies draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats. Diabetes Res. & Clin. Pract., 68: 3-11. (Pubitemid 40461881)
13. Huang TH, Kota BP, Razmovski V and Roufoqalis BD (2005). Herbal or natural medicines as modulators of peroxisome proliferater - activated receptors and related nuclear receptors for therapy of metabolic syndrome. Basic Clin. Pharmacol. Toxicol., 96(1): 3-14. (Pubitemid 40260842)
14. Juliana CN, Chan MBChB, Vasanti M, Weiping Jia, Takashi K, Chittaranjan S, Yajnik, Kun-Ho Y, Frank B. Hu (2009). Diabetes in Asia; Epidemiology, Risk Factors, and Pathophysiology. JAMA, 301 (20): 2129-2140.
15. Kaleem M, Medha P, Ahmed QU, Asif M and Bano B (2008). Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med. J., 49(10): 800-804.
16. Kaur R, Afzal M, Kazmi I, Ahmed I, Ahmed Z. Ali B, Ahmed S and Anwar F(2012). Polypharmacy (herbal and synthetic drug combination): A novel approach in the treatment of type-2 diabetes and its complications in rats. J Nat Med, Doi.10.1007/s11418-012-0720-5
17. Lyra RM, Oliveria D, Lins and Cavalcanti N (2006). Prevention of type 2 diabetes mellitus Arq Bras. Endocronol metabolism, 50: 239-249.
18. Machewad GM, Ghatge P, Chappalwar V, Jadhav B and Chappalwar A (2012). Studies on extraction of safflower pigments and its utilization in ice cream. J. Food Process Technol., 3(8): doi.org.10.4172/2157-7110.1000172.
19. Mahomed IM and Ojewole JA (2003). Hypoglycemic effect of Hypoxis hemerocallidea corm (African potato) aqueous extract in rats. Methods Find. Exp. Clin. Pharmacol., 25(8): 617-623. (Pubitemid 37448677)
20. Mandade R (2012). Protective effect of Carthamus tinctorius on streptozotocin induced Diabetic complications in rats and the possible morphological changes in the liver and kidney. IJSID, 2(5): 502-510.
21. Moller DE (2001). New drug targets for type 2 diabetes and the metabolic syndrome. Nature, 414: 821-827. (Pubitemid 34000786)
22. Nimbkar N (2002). Safflower rediscovered. Times Agric., 2: 32-36.
23. Parisa Z, Jinous A and Mehrnaz K (2012). The essential oil composition of Carthamus tinctorius L. flower growing in Iran. African J. of Biotech., 11(65): 12921-12924.
24. Sedigheh A, Parivash R, Mahzoni P and Hossein M (2012). Antidiabetic effect of hydro alcoholic extract of carthamus tinctorius L in alloxan-induced diabetic rats. J. Res. Med. Sci., 17(4): 386-392.
25. Shaw JE, Sicree RA, and Zimmet PZ (2010). Global estimates o the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 87(1): 4-14.
26. Shukla R, Sharma SB, Puri D, Prabhu KM and Murthy PS (2000). Medicinal plants for treatment of diabetes mellitus. Indian J. Clinical Biochem., 15: 169-177.
27. Venkatesh S, Reddy GD, Reddy BM, Ramesh M and Rao AV (2003). Antihyperglycemic activity of Caralluma attenuata. Fitoterapia, 74(3): 274-279. (Pubitemid 36511414)
28. Wang CC, Choy CS, Liu YH, Cheah KP, Li JS, Wang JT, Yu WY, Lin CW, Cheng HW and Hu CM (2011). Protective effect of dried safflower petal aqueous extract and its main constituent carthamus yellow, against lipopolysaccharide induced inflammation in RAW264.7 macrophage. J. Sci. Food Agric., 91(2); 218-225.
29. Wang CY, Zhang DL, Li GS, Liu JT, Tian JW and Fu FH et al (2007). Neuroprotective effects of safflor yellow B on brain ischemic injury. Exp. Brain Res., 177: 533-539.
30. Weiss EA (1971). Castrol oil, sesame and safflower. Barnes and noble. Inc. New York, pp.529-744.
31. Weiss EA (1983). Oil seed crops. Chapter 6. Safflower Longman Group Limited. Longman House, London, UK, pp.216-281.
32. Wild S, Roglic G, Green A, Sicree R and King H. (2004). Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care, 27(5): 1047-1053. (Pubitemid 38579764)
33. Zimmet P, K.G.M.M, Alberti and Jonathan S (2001). Global and societal implications of the diabetes epidemic. Nature, 414: 782-787. (Pubitemid 34000780)