Chinese Yam Extracts Containing β-Sitosterol and Ethyl Linoleate Protect against Atherosclerosis in Apolipoprotein E-Deficient Mice and Inhibit Muscular Expression of VCAM-1 In Vitro

Journal of Food Science

Volumn 79, Issue 4, 2014, Pages

  Koo, Hyun Jung ^a   Park, Hye Jin ^a   Byeon, Hye Eun ^a   Kwak, Jong Hwan ^a   Um, Sung Hee ^b   Kwon, Soon Tae ^c   Rhee, Dong Kwon ^a   Pyo, Suhkneung ^a  

^a Sungkyunkwan University   (South Korea)

^b Samsung Medical Center   (South Korea)

^c Andong National University   (South Korea)

Author keywords

Anti atherogenic effect; dioscorea batatas decne; Ethyl linoleate; VCAM 1; sitosterol

Indexed keywords

DIOSCOREA; DIOSCOREA ALATA; DIOSCOREA POLYSTACHYA; MUS;

APOLIPOPROTEIN E; AUTACOID; C REACTIVE PROTEIN; CARDIOVASCULAR AGENT; GAMMA-SITOSTEROL; LINOLEIC ACID; LINOLEIC ACID ETHYL ESTER; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SITOSTEROL DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL; AORTA; ATHEROSCLEROSIS; C57BL MOUSE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; IN VITRO STUDY; MACROPHAGE; MALE; METABOLISM; MONOCYTE; MOUSE; PATHOLOGY; PHYTOTHERAPY; VASCULAR SMOOTH MUSCLE; YAM;

ANIMALS; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; C-REACTIVE PROTEIN; CARDIOVASCULAR AGENTS; DIOSCOREA; IN VITRO TECHNIQUES; INFLAMMATION MEDIATORS; LINOLEIC ACIDS; LIPOPROTEINS, LDL; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; MUSCLE, SMOOTH, VASCULAR; PHYTOTHERAPY; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; SITOSTEROLS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84897981255     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.12401     Document Type: Article

References (32)

1. Araghiniknam M, Chung S, Nelson-White T, Eskelson C, Watson RR. 1996. Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci 59:147-57.
2. Blake GJ, Ridker PM. 2003. C-reactive protein and other inflammatory risk markers in acute coronary syndromes. Am J Med 114:485-94.
3. Blankenberg S, Barbaux S, Tiret L. 2003. Adhesion molecules and atherosclerosis. Atherosclerosis 170:191-203.
4. Breslow J. 1996. Mouse models of atherosclerosis. Science 272:685-8.
5. Budijanto S, Ito M, Hida Y, Morimatsu F, Furukawa Y, Kimura S. 1993. Dietary Fatty acid ethyl esters and lecithin-cholesterol acyltransferase activity in rats. J Clin Biochem Nutr 14:183-93.
6. Cho SJ, Kang NS, Park SY, Kim BO, Rhee DK, Pyo S. 2003. Induction of apoptosis and expression of apoptosis related genes in human epithelial carcinoma cells by Helicobacter pylori VacA toxin. Toxicon 42:601-11.
7. Choi KW, Park HJ, Jung DH, Kim TW, Park YM, Kim BO, Sohn EH, Moon EY, Um SH, Rhee DK, Pyo S. 2010. Inhibition of TNF-α-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-κB signaling pathways. Vascul Pharmacol 53:273-80.
8. Choi KW, Um SH, Kwak JH, Park HJ, Kim KH, Moon EY, Kwon ST, Pyo S. 2012. Suppression of adhesion molecule expression by phenanthrene-containing extract of bulbils of Chinese Yam in vascular smooth muscle cells through inhibition of MAPK, Akt and NF-κB. Food Chem Toxicol 50:2792-804.
9. Dansky HM, Barlow CB, Lominska C, Sikes JL, Kao C, Weinsaft J, Cybulsky MI, Smith JD. 2001. Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage. Arterioscler Thromb Vasc Biol 21:1662-7.
10. Hou WC, Lee MH, Chen HJ, Liang WL, Han CH, Liu YW, Lin YH. 2001. Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber. J Agr Food Chem 49:4956-60.
11. Hsu JH, Wu YC, Liu IM, Cheng JT. 2007. Dioscorea as the principal herb of Die-Huang-Wan, a widely used herbal mixture in China, for improvement of insulin resistance in fructose-rich chow-fed rats. J Ethnopharmacol 112:577-84.
12. Huo Y, Ley K. 2001.Adhesion molecules and atherogenesis. Acta Physiol Scand 173:35-43.
13. Kato R, Mori C, Kitazato K, Arata S, Obama T, Mori M, Takahashi K, Aiuchi T, Takano T, Itabe H. 2009. Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 29:33-9.
14. Kim JY, Kwon O. 2011. Culinary plants and their potential impact on metabolic overload. Ann NY Acad Sci 1229:133-9.
15. Lusis AJ. 2000. Atherosclerosis. Nature 407:233-41.
16. Matsuoka K, Nakazawa T, Nakamura A, Honda C, Endo K, Tsukada M. 2008. Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles. Chem Phys Lipids 154:87-93.
17. Meir KS, Leitersdorf E. 2004. Atherosclerosis in the apolipoprotein-E-deficient mouse: a decade of progress. Arterioscler Thromb Vasc Biol 24:1006-14.
18. Moore KJ, Tabas I. 2011. Macrophages in the pathogenesis of atherosclerosis. Cell 145:341-55.
19. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. 1994. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb Vasc Biol 14:133-40.
20. Nashed B, Yeganeh B, HayGlass KT, Moghadasian MH. 2005. Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in Apo E-KO mice. J Nutr 135:2438-44.
21. Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasiela WJ, Tsai J, Orazem J, Magorien R D, O'Shaughnessy C, Ganz P. 2005. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med 352:29-38.
22. Niu CS, Chen W, Wu HT, Cheng KC, Wen YJ, Lin KC, Cheng JT. 2010. Decrease of plasma glucose by allantoin, an active principle of yam (Dioscorea spp.), in streptozotocin-induced diabetic rats. J Agric Food Chem 58:12031-5.
23. Nofer JR, Bot M, Brodde M, Taylor PJ, Salm P, Brinkmann V, van Berkel T, Assmann G, Biessen EA. 2007. FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 115:501-8.
24. Pepys MB, Hirschfield GM. 2003. C-reactive protein: a critical update. J Clin Invest 111:1805-12.
25. Pritchard PH, Li M, Zamfir C, Lukic T, Novak E, Moghadasian MH. 2003. Comparison of cholesterol-lowering efficacy and anti-atherogenic properties of hydrogenated versus non-hydrogenated (Phytrol) tall oil-derived phytosterols in apo E-deficient mice. Cardiovasc Drugs Ther 17:443-9.
26. Reissig D, Rassoul F, Salvetter J, Wagner O, Richter V. 2003. Effect of fatty acids on expression of endothelial leukocyte adhesion molecules. Eur J Nutr 42:224-7.
27. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. 2002. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 347:1557-65.
28. Rousselle A, Qadri F, Leuke Ll, Yilmaz R, Fontaine JF, Sihn G, Bader M, Ahluwalia A, Duchene J. 2013. CXCL5 limits macrophage foam cell formation in atherosclerosis. J Clin Invest 123:1343-7.
29. Scalbert A, Andres-Lacueva C, Arita M, Kroon P, Manach C, Urpi-Sarda M, Wishart D. 2011. Databases on food phytochemicals and their health-promoting effects. J Agric Food Chem 59:4331-48.
30. Shriram V, Jahagirdar S, Latha C, Kumar V, Puranik V, Rojatkar S, Dhakephalkar PK, Shitole MG. 2008. A potential plasmid-curing agent, 8-epidiosbulbin E acetate from Dioscorea bulbifera L. against multidrug-resistant bacteria. Int J Antimicrob Agents 32:405-10.
31. Verhoeven BA, Moll FL, Koekkoek JA, van der Wal AC, de Kleijn DP, de Vries JP, Verheijen JH, Velema E, Busser E, Schoneveld A, Virmani R, Pasterkamp G. 2006. Statin treatment is not associated with consistent alterations in inflammatory status of carotid atherosclerotic plaques: a retrospective study in 378 patients undergoing carotid endarterectomy. Stroke 37:2054-60.
32. Yamashita H, Ehara S, Yoshiyama M, Naruko T, Haze K, Shirai N, Sugama Y, Ikura Y, Ohsawa M, Itabe H, Kataoka T, Kobayashi Y, Becker AE, Yoshikawa J, Ueda M. 2007. Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients. Circ J 71:681-7.