TGFβ-mediated downregulation of thrombopoietin is associated with platelet decline in asymptomatic SIV infection

Journal of Acquired Immune Deficiency Syndromes

Volumn 65, Issue 5, 2014, Pages 510-516

  Pate, Kelly A Metcalf ^a   Lyons, Claire E ^a   Dorsey, Jamie L ^a   Queen, Suzanne E ^a   Adams, Robert J ^a   Morrell, Craig N ^b   Mankowski, Joseph L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

HIV; Platelet; SIV; TGF ; Thrombocytopenia; Thrombopoietin

Indexed keywords

INTEGRASE INHIBITOR; L 870812; MESSENGER RNA; SAQUINAVIR; TENOFOVIR; THROMBOCYTE FACTOR 4; THROMBOPOIETIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ASYMPTOMATIC INFECTION; CELL DENSITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE RESPONSE; DOWN REGULATION; GENETIC TRANSCRIPTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACAQUE MODEL; MALE; MEGAKARYOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; THROMBOCYTE COUNT; THROMBOCYTE VOLUME; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; VIRUS REPLICATION;

ANIMALS; ANTI-RETROVIRAL AGENTS; ASYMPTOMATIC DISEASES; DOWN-REGULATION; GENE EXPRESSION PROFILING; LIVER; MACACA NEMESTRINA; MALE; MEGAKARYOCYTES; PLATELET COUNT; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; THROMBOCYTOPENIA; THROMBOPOIESIS; THROMBOPOIETIN; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 84897976281     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000048     Document Type: Conference Paper

References (40)

1. Liebman HA, Stasi R. Secondary immune thrombocytopenic purpura. Curr Opin Hematol. 2007;14:557-573
2. Landonio G, Nosari A, Spinelli F, et al. HIV-related thrombocytopenia: Four different clinical subsets. Haematologica. 1992;77:398-401
3. Zucker-Franklin D, Termin CS, Cooper MC. Structural changes in the megakaryocytes of patients infected with the human immune deficiency virus (HIV-1). Am J Pathol. 1989;134:1295-1303
4. Koenig C, Sidhu GS, Schoentag RA. The platelet volume-number relationship in patients infected with the human immunodeficiency virus. Am J Clin Pathol. 1991;96:500-503
5. Abgrall JF, el Kassar N, Berthou C, et al. HIV-associated thrombocytopenia: In vitro megakaryocyte colony formation in 10 patients. Ann Med Interne (Paris). 1992;143:104-106
6. Ragin A, DSouza G, Reynolds S, et al. Platelet decline as a predictor of brain injury in HIV infection. J Neurovirol. 2011;17:487-495
7. Stoffel R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood. 1996;87:567-573
8. Young G, Loechelt BJ, Rakusan TA, et al. Thrombopoietin levels in HIVassociated thrombocytopenia in children. J Pediatr. 1998;133:765-769
9. Gatanaga H, Hoshikawa N, Tahara T, et al. Serum thrombopoietin levels correlate with disease progression of AIDS. AIDS. 1999;13: 1590-1591
10. Qian S, Fu F, Li W, et al. Primary role of the liver in thrombopoietin production shown by tissue-specific knockout. Blood. 1998;92: 2189-2191
11. Wolber EM, Ganschow R, Burdelski M, et al. Hepatic thrombopoietin mRNA levels in acute and chronic liver failure of childhood. Hepatology. 1999;29:1739-1742
12. Sungaran R, Chisholm OT, Markovic B, et al. The role of platelet alphagranular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. Blood. 2000;95:3094-3101
13. Sakamaki S, Hirayama Y, Matsunaga T, et al. Transforming growth factor-beta1 (TGF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity. Blood. 1999;94:1961-1970
14. Wolber EM, Fandrey J, Frackowski U, et al. Hepatic thrombopoietin mRNA is increased in acute inflammation. Thromb Haemost. 2001;86: 1421-1424
15. Lotz M, Seth P. TGF beta and HIV infection. Ann N Y Acad Sci. 1993; 685:501-511
16. Schwartzkopff F, Grimm TA, Lankford CS, et al. Platelet factor 4 (CXCL4) facilitates human macrophage infection with HIV-1 and potentiates virus replication. Innate Immun. 2009;15:368-379
17. Kaser A, Brandacher G, Steurer W, et al. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: Role in inflammatory thrombocytosis. Blood. 2001;98:2720-2725
18. Marks KM, Clarke RM, Bussel JB, et al. Risk factors for thrombocytopenia in HIV-infected persons in the era of potent antiretroviral therapy. J Acquir Immune Defic Syndr. 2009;52:595-599
19. Neunert C, Lim W, Crowther M, et al. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011;117:4190-4207
20. Voulgaropoulou F, Pontow SE, Ratner L. Productive infection of CD34+-cell-derived megakaryocytes by X4 and R5 HIV-1 isolates. Virology. 2000;269:78-85
21. Gibellini D, Vitone F, Buzzi M, et al. HIV-1 negatively affects the survival/maturation of cord blood CD34(+) hematopoietic progenitor cells differentiated towards megakaryocytic lineage by HIV-1 gp120/CD4 membrane interaction. J Cell Physiol. 2007;210:315-324
22. Metcalf Pate KA, Lyons CE, Dorsey JL, et al. Platelet activation and platelet-monocyte aggregate formation contribute to platelet decline during acute SIV infection in pigtailed macaques. J Infect Dis. 2013;208: 874-883
23. Clements JE, Mankowski JL, Gama L, et al. The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: From mechanism to treatment. J Neurovirol. 2008;14:309-317
24. Dinoso JB, Rabi SA, Blankson JN, et al. A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy. J Virol. 2009;83:9247-9257
25. Tacke F, Trautwein C, Zhao S, et al. Quantification of hepatic thrombopoietin mRNA transcripts in patients with chronic liver diseases shows maintained gene expression in different etiologies of liver cirrhosis. Liver. 2002;22:205-212
26. Kelly K, Tarwater P, Karper J, et al. Diastolic dysfunction is associated with myocardial viral load in simian immunodeficiency virus-infected macaques. AIDS. 2012;26:815-823
27. McDonald T, Odell TT, Gosslee DG. Platelet size in relation to platelet age. Proc Soc Exp Biol Med. 1964;115:684-689
28. de Graaf CA, Metcalf D. Thrombopoietin and hematopoietic stem cells. Cell Cycle. 2011;10:1582-1589
29. Nagata Y, Muro Y, Todokoro K. Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis. J Cell Biol. 1997;139:449-457
30. Alcantara S, Reece J, Amarasena T, et al. Thrombocytopenia is strongly associated with simian AIDS in pigtail macaques. J Acquir Immune Defic Syndr. 2009;51:374-379
31. Wachtman LM, Skolasky RL, Tarwater PM, et al. Platelet decline: An avenue for investigation into the pathogenesis of human immunodeficiency virus-associated dementia. Arch Neurol. 2007;64:1264-1272
32. Wachtman LM, Tarwater PM, Queen SE, et al. Platelet decline: An early predictive hematologic marker of simian immunodeficiency virus central nervous system disease. J Neurovirol. 2006;12:25-33
33. Kekow J, Wachsman W, McCutchan JA, et al. Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc Natl Acad Sci U S A. 1990;87:8321-8325
34. Costantini A, Giuliodoro S, Mancini S, et al. Impaired in-vitro growth of megakaryocytic colonies derived from CD34 cells of HIV-1-infected patients with active viral replication. AIDS. 2006;20:1713-1720
35. Rinder HM, Bonan JL, Rinder CS, et al. Dynamics of leukocyte-platelet adhesion in whole blood. Blood. 1991;78:1730-1737
36. Metcalf Pate K, Mankowski J. HIV and SIV associated thrombocytopenia: An expanding role for platelets in the pathogenesis of HIV. Drug Discovery Today Dis Mech. 2011;8:e25-e32
37. Wierci-nska-Drapalo A, Flisiak R, Jaroszewicz J, et al. Increased plasma transforming growth factor-beta1 is associated with disease progression in HIV-1-infected patients. Viral Immunol. 2004;17:109-113
38. Bettaccini AA, Baj A, Accolla RS, et al. Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: Expression profile of pathogenetically relevant genes. BMC Microbiol. 2005;5:20
39. Boasso A, Vaccari M, Fuchs D, et al. Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques. J Immunol. 2009;182:4313-4320
40. Montaner JS, Le T, Fanning M, et al. The effect of zidovudine on platelet count in HIV-infected individuals. J Acquir Immune Defic Syndr. 1990;3:565-570