Thrombocytopenia is strongly associated with simian AIDS in pigtail macaques

Journal of Acquired Immune Deficiency Syndromes

Volumn 51, Issue 4, 2009, Pages 374-379

  Alcantara, Sheilajen ^a   Reece, Jeanette ^a   Amarasena, Thakshila ^a   De Rose, Robert ^a   Manitta, Joe ^b   Amin, Janiki ^c   Kent, Stephen J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b VICTORIAN INFECTIOUS DISEASES REFERENCE LABORATORY   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

AIDS; Macaque; Platelets; SIV

Indexed keywords

CD14 ANTIGEN; EMTRICITABINE; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; TENOFOVIR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE ASSOCIATION; MACACA; MEMORY T LYMPHOCYTE; MONKEY DISEASE; NONHUMAN; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; SURVIVAL RATE; T CELL DEPLETION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; VIRUS LOAD;

ANIMALS; ANTIGENS, CD14; CD4 LYMPHOCYTE COUNT; MACACA NEMESTRINA; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; THROMBOCYTOPENIA; VIRAL LOAD;

EID: 68049137678     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181a9cbcf     Document Type: Article

References (21)

1. Watkins DI, Burton DR, Kallas EG, et al. Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans. Nat Med. 2008;14:617-621.
2. Smith MZ, Kent SJ. Genetic influences on HIV infection: implications for vaccine development. Sex Health. 2005;2:53-62.
3. Martin MP, Dean M, Smith MW, et al. Genetic acceleration of AIDS progression by a promoter variant of CCR5. Science. 1998;282:1907-1911. (Pubitemid 28555273)
4. Mothe BR, Weinfurter J, Wang C, et al. Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication. J Virol. 2003;77:2736-2740. (Pubitemid 36222798)
5. Fernandez CS, Stratov I, De Rose R, et al. Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost. J Virol. 2005;79:5721-5731. (Pubitemid 40548241)
6. Mellors JW, Rinaldo CJ, Gupta P, et al. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science. 1996;272:1167-1170. (Pubitemid 26001148)
7. Picker LJ, Hagen SI, Lum R, et al. Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med. 2004;200:1299-1314. (Pubitemid 39552571)
8. Letvin NL, Mascola JR, Sun Y, et al. Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science. 2006;312:1530-1533.
9. Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-1371.
10. Koefoed K, Ditzel HJ. Identification of talin head domain as an immunodominant epitope of the antiplatelet antibody response in patients with HIV-1-associated thrombocytopenia. Blood. 2004;104:4054-4062. (Pubitemid 39620156)
11. Dittmer U, Coulibaly C, Sauermann U, et al. Autoantibody-mediated platelet phagocytosis in SIV-infected macaques. Aids. 1994;8:1509. (Pubitemid 24296817)
12. Song RJ, Chenine AL, Rasmussen RA, et al. Molecularly cloned SHIV-1157ipd3N4: a highly replication-competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C Env. J Virol. 2006;80:8729-8738.
13. Hofmann-Lehmann R, Vlasak J, Williams AL, et al. Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation. Aids. 2003;17:157-166. (Pubitemid 36183040)
14. Wachtman LM, Tarwater PM, Queen SE, et al. Platelet decline: an early predictive hematologic marker of simian immunodeficiency virus central nervous system disease. J Neurovirol. 2006;12:25-33.
15. De Rose R, Fernandez CS, Smith MZ, et al. Control of viremia following immunotherapy of SIV-infected macaques with peptide pulsed blood. Plos Pathog. 2008;4:e1000055. (Pubitemid 351811535)
16. Kent SJ, et al. Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques. Virology. 2008;347:538-1534
17. Batten CJ, et al. Comparative evaluation of simian, simian-human, and human immunodeficiency virus infections in the pigtail macaque (Macaca nemestrina) model. AIDS Res Hum Retroviruses. 2006;22:580-588.
18. De Rose R, et al. Comparative efficacy of subtype AE simian-human immunodeficiency virus priming and boosting vaccines in pigtail macaques. J Virol. 2007;81:292-300. (Pubitemid 44975169)
19. Pal R, Venzon D, Santra S, et al. Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels. J Virol. 2006;80:3732-3742.
20. Mattapallil JJ, et al. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature. 2005;434:1093-1097.
21. Mason RD, et al. Inactivated simian immunodeficiency virus-pulsed autologous fresh blood cells as an immunotherapy strategy. J Virol. 2009; 83:1501-1510.