Folate and CD44 receptors dual-targeting hydrophobized hyaluronic acid paclitaxel-loaded polymeric micelles for overcoming multidrug resistance and improving tumor distribution

Journal of Pharmaceutical Sciences

Volumn 103, Issue 5, 2014, Pages 1538-1547

  Liu, Yanhua ^a,b   Sun, Jin ^a   Lian, He ^a   Cao, Wen ^a   Wang, Yongjun ^a   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

cancer chemotherapy; multidrug resistance; nanotechnology; polymeric drug delivery systems; PTX; targeted drug delivery; tumor targeting

Indexed keywords

CD44 RECEPTOR; COPOLYMER; DRUG RECEPTOR; FOLATE RECEPTOR; HYALURONIC ACID; PACLITAXEL; POLYMER; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DRUG CARRIER; FOLIC ACID; HERMES ANTIGEN; MICELLE; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG TARGETING; DRUG TUMOR LEVEL; ENDOCYTOSIS; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; INTERNALIZATION; MICELLE; MOUSE; MULTIDRUG RESISTANCE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; MALE; MCF 7 CELL LINE; MEDICINAL CHEMISTRY; METABOLISM; PROCEDURES; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; ANTIGENS, CD44; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FOLIC ACID; HUMANS; HYALURONIC ACID; MALE; MCF-7 CELLS; MICE; MICELLES; P-GLYCOPROTEIN; PACLITAXEL; RATS, WISTAR;

EID: 84897969099     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23934     Document Type: Article

References (28)

1. Gillet JP, Gottesman MM,. 2010. Mechanisms of multidrug resistance in cancer. Methods Mol Biol 596: 47-75.
2. Gao ZB, Zhang LN, Sun YJ,. 2012. Nanotechnology applied to overcome tumor drug resistance. J Control Release 162: 45-55.
3. Dong XW, Mumper RJ,. 2010. Nanomedicinal strategies to treat multidrug-resistant tumors: Current progress. Nanomedicine 5: 597-615.
4. Shapira A, Livney YD, Broxterman HJ, Assaraf YG,. 2011. Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance. Drug Resist Updat 14: 150-163.
5. Wang J, Tao X, Zhang Y, Wei D, Ren Y,. 2010. Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles. Biomaterials 31: 4426-4433.
6. Wu J, Lu Y, Lee A, Pan X, Yang X, Zhao X, Lee RJ,. 2007. Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil. J Pharm Sci 10: 350-357.
7. Li R, Wu R, Zhao L, Wu M, Yang L, Zou H,. 2010. P-glycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cell. ACS Nano 4: 1399-1408.
8. Sun J, Luo C, Wang YJ, He ZG,. 2013. The holistic 3M modality of drug delivery nanosystems for cancer therapy. Nanoscale 5: 845-859.
9. Jabr-Milane LS, van Vlerken LE, Yadav S,. 2008. Multi-functional nanocarriers to overcome tumor drug resistance. Cancer Treat Rev 34: 592-602.
10. Zhang X, Guo S, Fan R, Yu M, Li F, Zhu C, Gan Y,. 2012. Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells. Biomaterials 33: 7103-7114.
11. Michael JH, Patrick SS, Neil D,. 2008. Protein nanoparticles as drug carrier in clinical medicine. Adv Drug Deliv Rev 60: 876-885.
12. Liu YH, Sun J, Cao W, Yang JH, Lian H, Li X, Sun YH, Wang YJ, Wang SL, He ZG,. 2011. Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery. Int J Pharm 421: 160-169.
13. Liu YH, Sun J, Zhang P, He ZG,. 2011. Amphiphilic polysaccharide- hydrophobicized graft polymeric micelles for drug delivery nanosystems. Curr Med Chem 18: 2638-2648.
14. Lee H, Lee K, Park TG,. 2008. Hyaluronic acid-paclitaxel conjugate micelles: Synthesis, characterization, and antitumor activity. Bioconjug Chem 19: 1319-1325.
15. Lee ES, Na K, Bae YH,. 2003. Polymeric micelle for tumor pH and folate-mediated targeting. J Control Release 91: 103-113.
16. Liu YH, Sun J, Lian H, Li X, Cao W, Bai LM, Wang YJ, He ZG,. 2013. Determination of paclitaxel in hyaluronic acid polymeric micelles in rat blood by protein precipitation-micelle breaking method: Application to a pharmacokinetic study. J Chromato B 935: 10-15.
17. Xiao L, Xiong XQ, Sun XH, Zhu YH, Yang H, Chen HB, Gan L, Xu HB, Yang XL,. 2011. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials 32: 5148-5157.
18. Du YZ, Wang L, Yuan H, Hu FQ,. 2011. Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. Int J Biol Macromol 48: 215-222.
19. Du YZ, Weng Q, Yuan H, Hu FQ,. 2010. Synthesis and anticancer activity of stearate-g-dextran micelles for intracellular doxorubicin delivery. ACS Nano 4: 6894-6902.
20. Tran PH, Tran TT, Vo TV, Vo CL, Lee BJ,. 2013. Novel multifunctional biocompatible gelatin-oleic acid conjugate: Self-assembled nanoparticles for drug delivery. J Biomed Nanotechnol 9: 1416-1431.
21. Yang XQ, Deng WJ, Fu LW, Blanco E, Gao JM, Quan DP, Shuai XT,. 2008. Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326. J Biomed Mater Res A 86: 50-60.
22. Wang JQ, Tao XY, Zhang YF, Wei DZ, Ren YH,. 2010. Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles. Biomaterials 31: 4426-4433.
23. Fan L, Li F, Zhang H, Wang Y, Cheng C, Li X, Gu CH, Yang Q, Wu H, Zhang S,. 2010. Co-delivery of PDTC and doxorubicin by multifunctional micellar nanoparticles to achieve active targeted drug delivery and overcome multidrug resistance. Biomaterials 31: 5634-5642.
24. Pan LM, Liu JN, He QJ, Wang LJ, Shi JL,. 2013. Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles. Biomaterials 34: 2719-2730.
25. Choi KY, Min KH, Na JH, Choi KW, Kim K, Park JH, Kwon IC, Jeong SY,. 2009. Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: Synthesis, characterization, and in vivo biodistribution. J Mater Chem 19: 4102-4107.
26. Yadav AK, Mishra P, Jain S, Mishra P, Mishra AK, Agrawal GP,. 2008. Preparation and characterization of HA-PEG-PCL intelligent core-corona nanoparticles for delivery of doxorubicin. J Drug Target 16: 464-478.
27. Choi KY, Chung H, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Jeong SY,. 2010. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials 31: 106-114.
28. Zhou B, Weigel JA, Fauss L, Weigel PH,. 2000. Identification of the hyaluronan receptor for endocytosis (HARE). J Biol Chem 275: 37733-37741.