Determination of paclitaxel in hyaluronic acid polymeric micelles in rat blood by protein precipitation-micelle breaking method: Application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 935, Issue , 2013, Pages 10-15

  Liu, Yanhua ^a,b   Sun, Jin ^a   Lian, He ^a   Li, Xin ^a   Cao, Wen ^a   Bai, Liming ^a   Wang, Yongjun ^a   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

HA C18 polymeric micelles; Paclitaxel; Pharmacokinetic study; Protein precipitation micelle breaking method; UPLC MS MS method

Indexed keywords

MULTIPLE-REACTION MONITORING MODES; PACLITAXEL; PHARMACOKINETIC STUDIES; POLYMERIC MICELLE; POSITIVE ELECTROSPRAY IONIZATION; RELATIVE STANDARD DEVIATIONS; TRIPLE-QUADRUPOLE MASS SPECTROMETRY; UPLC-MS/MS;

BLOOD; ELECTROSPRAY IONIZATION; EXTRACTION; HYALURONIC ACID; METHANOL; ORGANIC ACIDS; ORGANIC SOLVENTS; POLYMERS; PRECIPITATION (CHEMICAL); PROTEINS; RATS;

MICELLES;

HYALURONIC ACID; METHANOL; PACLITAXEL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HALF LIFE; ELECTROSPRAY; ELUTION; FEMALE; IONIZATION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MICELLE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; POLYMERIZATION; PRECIPITATION; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; SINGLE DRUG DOSE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84881513045     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.07.008     Document Type: Article

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