Tumor necrosis factor alpha induces a serotonin dependent early increase in ciliary beat frequency and epithelial transport velocity in murine tracheae

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Weiterer, Sebastian ^a   Schulte, Dagmar ^a   Müller, Sabrina ^a   Kohlen, Thomas ^a   Uhle, Florian ^a   Weigand, Markus A ^a   Henrich, Michael ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; CYPROHEPTADINE; METHYSERGIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SEROTONIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; NITRIC OXIDE; SEROTONIN 2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CILIARY MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; TRACHEA MUCOSA; UPREGULATION; ANIMAL; CILIARY BODY; EPITHELIUM; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOPHYSIOLOGY; TRACHEA;

ANIMALS; CILIARY BODY; EPITHELIUM; INFLAMMATION; MICE; MICE, KNOCKOUT; NITRIC OXIDE; ORGAN CULTURE TECHNIQUES; RECEPTORS, SEROTONIN, 5-HT2; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SEROTONIN; TRACHEA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84897968849     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091705     Document Type: Article

References (44)

1. Knowles MR, Boucher RC (2002) Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 109: 571-577. (Pubitemid 34204834)
2. Lee TW, Southern KW (2012) Topical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease. Cochrane Database Syst Rev 10: CD005599.
3. Salathe M (2007) Regulation of mammalian ciliary beating. Annu Rev Physiol 69: 401-422.
4. Wyatt TA, Spurzem JR, May K, Sisson JH (1998) Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells. Am J Physiol 275: L827-835.
5. Konig P, Krain B, Krasteva G, Kummer W (2009) Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea. PLoS One 4: e4938.
6. Martin TR, Galli SJ, Katona IM, Drazen JM (1989) Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. J Clin Invest 83: 1375-1383. (Pubitemid 19113055)
7. Klein MK, Haberberger RV, Hartmann P, Faulhammer P, Lips KS, et al. (2009) Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development. Eur Respir J 33: 1113-1121.
8. Wanner A, Salathe M, O'Riordan TG (1996) Mucociliary clearance in the airways. Am J Respir Crit Care Med 154: 1868-1902. (Pubitemid 26424963)
9. Wyatt TA, Sisson JH, Von Essen SG, Poole JA, Romberger DJ (2008) Exposure to hog barn dust alters airway epithelial ciliary beating. Eur Respir J 31: 1249-1255.
10. Horiuchi T, Mitoma H, Harashima S, Tsukamoto H, Shimoda T (2010) Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents. Rheumatology (Oxford) 49: 1215-1228.
11. Pfeffer K, Matsuyama T, Kundig TM, Wakeham A, Kishihara K, et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-467. (Pubitemid 23143346)
12. Sangaletti S, Tripodo C, Ratti C, Piconese S, Porcasi R, et al. (2010) Oncogenedriven intrinsic inflammation induces leukocyte production of tumor necrosis factor that critically contributes to mammary carcinogenesis. Cancer Res 70: 7764-7775.
13. Morse DM, Smullen JL, Davis CW (2001) Differential effects of UTP, ATP, and adenosine on ciliary activity of human nasal epithelial cells. Am J Physiol Cell Physiol 280: C1485-1497.
14. Schmid A, Clunes LA, Salathe M, Verdugo P, Dietl P, et al. (2011) Nucleotidemediated airway clearance. Subcell Biochem 55: 95-138.
15. Schmid A, Sutto Z, Schmid N, Novak L, Ivonnet P, et al. (2010) Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation. J Biol Chem 285: 29998-30007.
16. Schmid A, Sutto Z, Nlend MC, Horvath G, Schmid N, et al. (2007) Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol 130: 99-109. (Pubitemid 47001074)
17. Kummer W, Lips KS, Pfeil U (2008) The epithelial cholinergic system of the airways. Histochem Cell Biol 130: 219-234.
18. Fry DE (2012) Sepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues. Am Surg 78: 1-8.
19. Arisoy O, Bes C, Cifci C, Sercan M, Soy M (2013) The effect of TNF-alpha blockers on psychometric measures in ankylosing spondylitis patients: a preliminary observation. Rheumatol Int.
20. Zhang Q, Cui F, Fang L, Hong J, Zheng B, et al. (2013) TNF-alpha impairs differentiation and function of TGF-beta-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway. J Mol Cell Biol.
21. Jain B, Rubinstein I, Robbins RA, Sisson JH (1995) TNF-alpha and IL-1 beta upregulate nitric oxide-dependent ciliary motility in bovine airway epithelium. Am J Physiol 268: L911-917.
22. Schliemann M, Bullinger E, Borchers S, Allgower F, Findeisen R, et al. (2011) Heterogeneity reduces sensitivity of cell death for TNF-stimuli. BMC Syst Biol 5: 204.
23. Aparicio CL, Berthiaume F, Chang CC, Yarmush ML (1996) Tumor necrosis factor-alpha (TNF-alpha) induces a reversible, time- and dose-dependent adhesion of progenitor T cells to endothelial cells. Mol Immunol 33: 671-680. (Pubitemid 26326300)
24. Suter PM, Suter S, Girardin E, Roux-Lombard P, Grau GE, et al. (1992) High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am Rev Respir Dis 145: 1016-1022.
25. Schulman CI, Wright JK, Nwariaku F, Sarosi G, Turnage RH (2002) The effect of tumor necrosis factor-alpha on microvascular permeability in an isolated, perfused lung. Shock 18: 75-81.
26. Benyo DF, Pate JL (1992) Tumor necrosis factor-alpha alters bovine luteal cell synthetic capacity and viability. Endocrinology 130: 854-860.
27. McFarlane SM, Jupp OJ, Cobban HJ, Hunter I, Anderson HM, et al. (2001) Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle. Biochem Pharmacol 61: 749-759. (Pubitemid 32239429)
28. Amrani Y, Aubier M, Bronner C (1996) [Interaction between tumor necrosis factor-alpha and the smooth muscle cells of the airway: implication in the physiopathology of asthma]. Rev Mal Respir 13: 539-546.
29. Amrani Y, Lazaar AL, Hoffman R, Amin K, Ousmer S, et al. (2000) Activation of p55 tumor necrosis factor-alpha receptor-1 coupled to tumor necrosis factor receptor-associated factor 2 stimulates intercellular adhesion molecule-1 expression by modulating a thapsigargin-sensitive pathway in human tracheal smooth muscle cells. Mol Pharmacol 58: 237-245. (Pubitemid 30452547)
30. Moffatt JD, Cocks TM, Page CP (2004) Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea. Br J Pharmacol 141: 1159-1166. (Pubitemid 38582253)
31. König P, Krain B, Krasteva G, Kummer W (2009) Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea. PLoS One 4: e4938.
32. 2+ regulates the phosphorylation and the dephosphorylation of ciliary proteins via the NO pathway. J Gen Physiol 124: 527-540.
33. Sisson JH, May K, Wyatt TA (1999) Nitric oxide-dependent ethanol stimulation of ciliary motility is linked to cAMP-dependent protein kinase (PKA) activation in bovine bronchial epithelium. Alcohol Clin Exp Res 23: 1528-1533. (Pubitemid 29468451)
34. 2+]i enhances ciliary activity in rabbit trachea. J Physiol 516 (Pt 1): 179-190.
35. Berger M, Gray JA, Roth BL (2009) The expanded biology of serotonin. Annu Rev Med 60: 355-366.
36. Esteve JM, Launay JM, Kellermann O, Maroteaux L (2007) Functions of serotonin in hypoxic pulmonary vascular remodeling. Cell Biochem Biophys 47: 33-44.
37. Kereveur A, Callebert J, Humbert M, Herve P, Simonneau G, et al. (2000) High plasma serotonin levels in primary pulmonary hypertension. Effect of long-term epoprostenol (prostacyclin) therapy. Arterioscler Thromb Vasc Biol 20: 2233-2239.
38. Shimoda LA, Laurie SS (2013) Vascular remodeling in pulmonary hypertension. J Mol Med (Berl) 91: 297-309.
39. Maclean MR, Dempsie Y (2010) The serotonin hypothesis of pulmonary hypertension revisited. Adv Exp Med Biol 661: 309-322.
40. Eddahibi S, Fabre V, Boni C, Martres MP, Raffestin B, et al. (1999) Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circ Res 84: 329-336. (Pubitemid 29095574)
41. Ni W, Watts SW (2006) 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT). Clin Exp Pharmacol Physiol 33: 575-583. (Pubitemid 43894017)
42. Carneiro AM, Cook EH, Murphy DL, Blakely RD (2008) Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest 118: 1544-1552. (Pubitemid 351500447)
43. Brzezinska-Blaszczyk E, Pietrzak A, Misiak-Tloczek AH (2007) Tumor necrosis factor (TNF) is a potent rat mast cell chemoattractant. J Interferon Cytokine Res 27: 911-919. (Pubitemid 350223111)
44. Weigand LA, Myers AC, Meeker S, Undem BJ (2009) Mast cell-cholinergic nerve interaction in mouse airways. J Physiol 587: 3355-3362.