Exposure to hog barn dust alters airway epithelial ciliary beating

European Respiratory Journal

Volumn 31, Issue 6, 2008, Pages 1249-1255

  Wyatt, T A ^a,b   Sisson, J H ^a   Von Essen, S G ^a   Poole, J A ^a   Romberger, D J ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

Author keywords

Airway epithelial cells; Cilia; Hog barn dust; Swine confinement

Indexed keywords

ENDOTOXIN; INTERLEUKIN 8; ISOPRENALINE; NITRIC OXIDE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; NITROGEN OXIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; CELL VIABILITY; CILIARY MOTILITY; CONTROLLED STUDY; DUST EXPOSURE; EPITHELIUM CELL; MUCOCILIARY CLEARANCE; NONHUMAN; PRIORITY JOURNAL; SWINE; AIR POLLUTANT; ANIMAL; ANIMAL HOUSING; ANIMAL HUSBANDRY; ANIMAL MODEL; CATTLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; DUST; EUKARYOTIC FLAGELLUM; HUMAN; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

ADRENERGIC BETA-AGONISTS; AIR POLLUTANTS, OCCUPATIONAL; ANIMAL HUSBANDRY; ANIMALS; CATTLE; CELLS, CULTURED; CILIA; DUST; EPITHELIAL CELLS; HOUSING, ANIMAL; HUMANS; INTERLEUKIN-8; ISOPROTERENOL; MODELS, ANIMAL; NITROGEN OXIDES; RESPIRATORY MUCOSA; SWINE;

EID: 49649115533     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00015007     Document Type: Article

References (31)

1. Cole D, Todd L, Wing S. Concentrated swine feeding operations and public health: a review of occupational and community health effects. Environ Health Perspect 2000; 108: 685-699.
2. Donham KJ, Reynolds SJ, Whitten P, Merchant JA, Burmeister L, Popendorf WJ. Respiratory dysfunction in swine production facility workers: dose-response relationships of environmental exposures and pulmonary function. Am J Ind Med 1995; 27: 405-418.
3. Zejda JE, Barber E, Dosman JA, et al. Respiratory health status in swine producers relates to endotoxin exposure in the presence of low dust levels. J Occup Med 1994; 36: 49-56.
4. Von Essen S, Donham K. Illness and injury in animal confinement workers. Occup Med 1999; 14: 337-350.
5. Preller L, Heederik D, Boleij JS, Vogelzang PF, Tielen MJ. Lung function and chronic respiratory symptoms of pig farmers: focus on exposure to endotoxins and ammonia and use of disinfectants. Occup Environ Med 1995; 52: 654-660.
6. Wang Z, Larsson K, Palmberg L, Malmberg P, Larsson P, Larsson L. Inhalation of swine dust induces cytokine release in the upper and lower airways. Eur Respir J 1997; 10: 381-387.
7. Cormier Y, Duchaine C, Israel-Assayag E, Bedard G, Laviolette M, Dosman J. Effects of repeated swine building exposures on normal naive subjects. Eur Respir J 1997; 10: 1516-1522.
8. Snyder MC, Leopold DA, Chiu BC, Von Essen SG, Liebentritt N. The relationship between agricultural environments and olfactory dysfunction. J Agric Saf Health 2003; 9: 211-219.
9. Wanner A, Salathé M, O'Riordan TG. Mucociliary clearance in the airways. Am J Respir Crit Care Med 1996; 154: 1868-1902.
10. Jain B, Rubinstein I, Robbins RA, Leise KL, Sisson JH. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun 1993; 191: 83-87.
11. Wyatt TA, Forget MA, Adams JM, Sisson JH. Both cAMP and cGMP are required for maximal ciliary beat stimulation in a cell-free model of bovine ciliary axonemes. Am J Physiol Lung Cell Mol Physiol 2005; 288: L546-L551.
12. Verdugo P, Johnson NT, Tam PY. β-Adrenergic stimulation of respiratory ciliary activity. J Appl Physiol 1980; 48: 868-871.
13. Wyatt TA, Sisson JH. Chronic ethanol downregulates PKA activation and ciliary beating in bovine bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2001; 281: L575-L581.
14. Allen-Gipson DS, Romberger DJ, Forget MA, May KL, Sisson JH, Wyatt TA. IL-8 inhibits isoproterenol-stimulated ciliary beat frequency in bovine bronchial epithelial cells. J Aerosol Med 2004; 17: 107-115.
15. Romberger DJ, Bodlak V, Von Essen SG, Mathisen T, Wyatt TA. Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation. J Appl Physiol 2002; 93: 289-296.
16. Wyatt TA, Forget MA, Sisson JH. Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells. Am J Pathol 2003; 163: 1157-1166.
17. Wang Z, Malmberg P, Ek A, Larsson K, Palmberg L. Swine dust induces cytokine secretion from human epithelial cells and alveolar macrophages. Clin Exp Immunol 1999; 115: 6-12.
18. Von Essen SG, O'Neill DP, Olenchok SA, Robbins RA, Rennard SI. Grain dusts and grain plant components vary in their ability to recruit neutrophils. J Toxicol Environ Health 1995; 46: 425-441.
19. Mueller-Anneling LJ, O'Neill ME, Thorne PS. Biomonitoring for assessment of organic dust-induced lung inflammation. Eur Respir J 2006; 27: 1096-1102.
20. Lee SA, Adhikari A, Grinshpun SA, McKay R, Shukla R, Reponen T. Personal exposure to airborne dust and microorganisms in agricultural environments. J Occup Environ Hyg 2006; 3: 118-130.
21. Rojas-Corona RR, Skarnes R, Tamakuma S, Fine J. The Limulus coagulation test for endotoxin. A comparison with other assay methods. Proc Soc Exp Biol Med 1969; 132: 599-601.
22. Sisson JH, Stoner JA, Ammons BA, Wyatt TA. All-digital image capture and whole-field analysis of ciliary beat frequency. J Microsc 2003; 211: 103-111.
23. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 277: 680-685.
24. Kirsten AM, Jorres RA, Kirsten D, Magnussen H. Effect of a nasal challenge with endotoxin-containing swine confinement dust on nasal nitric oxide production. Eur J Med Res 1997; 2: 335-339.
25. Sisson JH, May K, Wyatt TA. Nitric oxide-dependent ethanol stimulation of ciliary motility is linked to cAMP-dependent protein kinase (PKA) activation in bovine bronchial epithelium. Alcohol Clin Exp Res 1999; 23: 1528-1533.
26. Wyatt TA, Spurzem JR, May K, Sisson JH. Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells. Am J Physiol 1998; 275: L827-L835.
27. Poole JA, LeVan TD, Slager RE, et al. Bronchodilator responsiveness in swine veterinarians. J Agromedicine 2007; 12: 49-54.
28. Von Essen SG, Scheppers LA, Robbins RA, Donham KJ. Respiratory tract inflammation in swine confinement workers studied using induced sputum and exhaled nitric oxide. J Toxicol Clin Toxicol 1998; 36: 557-565.
29. Von Essen S, Romberger D. The respiratory inflammatory response to the swine confinement building environment: the adaptation to respiratory exposures in the chronically exposed worker. J Agric Saf Health 2003; 9: 185-196.
30. Fazio F, Lafortuna C. Effect of inhaled salbutamol on mucociliary clearance in patients with chronic bronchitis. Chest 1981; 80: 827-830.
31. Wyatt TA, Schmidt SC, Rennard SI, Sisson JH. Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes. Proc Soc Exp Biol Med 2000; 225: 91-97.