-
1
-
-
0034680102
-
Molecular portraits of human breast tumours
-
10.1038/35021093, 10963602
-
Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lønning PE, Børresen-Dale AL, Brown PO, Botstein D. Molecular portraits of human breast tumours. Nature 2000, 406:747-752. 10.1038/35021093, 10963602.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sørlie, T.2
Eisen, M.B.3
van de Rijn, M.4
Jeffrey, S.S.5
Rees, C.A.6
Pollack, J.R.7
Ross, D.T.8
Johnsen, H.9
Akslen, L.A.10
Fluge, O.11
Pergamenschikov, A.12
Williams, C.13
Zhu, S.X.14
Lønning, P.E.15
Børresen-Dale, A.L.16
Brown, P.O.17
Botstein, D.18
-
2
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumour subclasses with clinical implications
-
10.1073/pnas.191367098, 58566, 11553815
-
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL. Gene expression patterns of breast carcinomas distinguish tumour subclasses with clinical implications. Proc Natl Acad Sci U S A 2001, 98:10869-10874. 10.1073/pnas.191367098, 58566, 11553815.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10869-10874
-
-
Sørlie, T.1
Perou, C.M.2
Tibshirani, R.3
Aas, T.4
Geisler, S.5
Johnsen, H.6
Hastie, T.7
Eisen, M.B.8
van de Rijn, M.9
Jeffrey, S.S.10
Thorsen, T.11
Quist, H.12
Matese, J.C.13
Brown, P.O.14
Botstein, D.15
Lønning, P.E.16
Børresen-Dale, A.L.17
-
3
-
-
80053406583
-
Heterogeneity in breast cancer
-
10.1172/JCI60534, 3195489, 21965334
-
Polyak K. Heterogeneity in breast cancer. J Clin Invest 2011, 121:3786-3788. 10.1172/JCI60534, 3195489, 21965334.
-
(2011)
J Clin Invest
, vol.121
, pp. 3786-3788
-
-
Polyak, K.1
-
4
-
-
40949121882
-
Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
-
10.1158/1078-0432.CCR-07-1658, 18316557
-
Cheang MC, Voduc D, Bajdik C, Leung S, McKinney S, Chia SK, Perou CM, Nielsen TO. Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res 2008, 14:1368-1376. 10.1158/1078-0432.CCR-07-1658, 18316557.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1368-1376
-
-
Cheang, M.C.1
Voduc, D.2
Bajdik, C.3
Leung, S.4
McKinney, S.5
Chia, S.K.6
Perou, C.M.7
Nielsen, T.O.8
-
5
-
-
65249104546
-
Triple-negative breast cancer: distinguishing between basal and nonbasal sub-types
-
10.1158/1078-0432.CCR-08-2132, 19318481
-
Rakha EA, Elsheikh SE, Aleskandarany MA, Habashi HO, Green AR, Powe DG, El-Sayed ME, Benhasouna A, Brunet JS, Akslen LA, Evans AJ, Blamey R, Reis-Filho JS, Foulkes WD, Ellis IO. Triple-negative breast cancer: distinguishing between basal and nonbasal sub-types. Clin Cancer Res 2009, 15:2302-2310. 10.1158/1078-0432.CCR-08-2132, 19318481.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2302-2310
-
-
Rakha, E.A.1
Elsheikh, S.E.2
Aleskandarany, M.A.3
Habashi, H.O.4
Green, A.R.5
Powe, D.G.6
El-Sayed, M.E.7
Benhasouna, A.8
Brunet, J.S.9
Akslen, L.A.10
Evans, A.J.11
Blamey, R.12
Reis-Filho, J.S.13
Foulkes, W.D.14
Ellis, I.O.15
-
6
-
-
82755194790
-
Focal adhesion kinase and tumour angiogenesis
-
10.1002/path.3018, 21984450
-
Lechertier T, Hodivala-Dilke K. Focal adhesion kinase and tumour angiogenesis. J Pathol 2012, 226:404-412. 10.1002/path.3018, 21984450.
-
(2012)
J Pathol
, vol.226
, pp. 404-412
-
-
Lechertier, T.1
Hodivala-Dilke, K.2
-
7
-
-
76849100707
-
Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis
-
10.1016/j.canlet.2009.07.005, 2854647, 19643531
-
Luo M, Guan JL. Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett 2010, 289:127-139. 10.1016/j.canlet.2009.07.005, 2854647, 19643531.
-
(2010)
Cancer Lett
, vol.289
, pp. 127-139
-
-
Luo, M.1
Guan, J.L.2
-
8
-
-
84876343011
-
Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer
-
10.1007/s00432-012-1342-8, 23143646
-
Ji HF, Pang D, Fu SB, Jin Y, Yao L, Qi JP, Bai J. Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer. J Cancer Res Clin Oncol 2013, 139:429-435. 10.1007/s00432-012-1342-8, 23143646.
-
(2013)
J Cancer Res Clin Oncol
, vol.139
, pp. 429-435
-
-
Ji, H.F.1
Pang, D.2
Fu, S.B.3
Jin, Y.4
Yao, L.5
Qi, J.P.6
Bai, J.7
-
9
-
-
9644275426
-
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumourigenesis
-
10.1007/s10549-004-1022-8, 15564794
-
Lightfoot HM, Lark A, Livasy CA, Moore DT, Cowan D, Dressler L, Craven RJ, Cance WG. Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumourigenesis. Breast Cancer Res Treat 2004, 88:109-116. 10.1007/s10549-004-1022-8, 15564794.
-
(2004)
Breast Cancer Res Treat
, vol.88
, pp. 109-116
-
-
Lightfoot, H.M.1
Lark, A.2
Livasy, C.A.3
Moore, D.T.4
Cowan, D.5
Dressler, L.6
Craven, R.J.7
Cance, W.G.8
-
10
-
-
0037343388
-
Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas
-
10.1053/hupa.2003.40, 12673558
-
Oktay MH, Oktay K, Hamele-Bena D, Buyuk A, Koss LG. Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas. Hum Pathol 2003, 34:240-245. 10.1053/hupa.2003.40, 12673558.
-
(2003)
Hum Pathol
, vol.34
, pp. 240-245
-
-
Oktay, M.H.1
Oktay, K.2
Hamele-Bena, D.3
Buyuk, A.4
Koss, L.G.5
-
11
-
-
0029039421
-
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumours
-
Owens LV, Xu L, Craven RJ, Dent GA, Weiner TM, Kornberg L, Liu ET, Cance WG. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumours. Cancer Res 1995, 55:2752-2755.
-
(1995)
Cancer Res
, vol.55
, pp. 2752-2755
-
-
Owens, L.V.1
Xu, L.2
Craven, R.J.3
Dent, G.A.4
Weiner, T.M.5
Kornberg, L.6
Liu, E.T.7
Cance, W.G.8
-
12
-
-
27144539046
-
High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome
-
10.1186/bcr977, 1064131, 15743500
-
Schmitz KJ, Grabellus F, Callies R, Otterbach F, Wohlschlaeger J, Levkau B, Kimmig R, Schmid KW, Baba HA. High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Breast Cancer Res 2005, 7:R194-203. 10.1186/bcr977, 1064131, 15743500.
-
(2005)
Breast Cancer Res
, vol.7
-
-
Schmitz, K.J.1
Grabellus, F.2
Callies, R.3
Otterbach, F.4
Wohlschlaeger, J.5
Levkau, B.6
Kimmig, R.7
Schmid, K.W.8
Baba, H.A.9
-
13
-
-
29044442658
-
Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma
-
10.1016/j.humpath.2005.09.024, 16360410
-
Madan R, Smolkin MB, Cocker R, Fayyad R, Oktay MH. Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma. Hum Pathol 2006, 37:9-15. 10.1016/j.humpath.2005.09.024, 16360410.
-
(2006)
Hum Pathol
, vol.37
, pp. 9-15
-
-
Madan, R.1
Smolkin, M.B.2
Cocker, R.3
Fayyad, R.4
Oktay, M.H.5
-
14
-
-
0037501115
-
Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumours in vivo and promotes capillary tube formation of brain microvascular endothelial cells
-
Haskell H, Natarajan M, Hecker TP, Ding Q, Stewart J, Grammer R, Gladson CL. Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumours in vivo and promotes capillary tube formation of brain microvascular endothelial cells. Clin Cancer Res 2003, 9:2157-2165.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2157-2165
-
-
Haskell, H.1
Natarajan, M.2
Hecker, T.P.3
Ding, Q.4
Stewart, J.5
Grammer, R.6
Gladson, C.L.7
-
15
-
-
10644280092
-
Specific deletion of focal adhesion kinase suppresses tumour formation and blocks malignant progression
-
10.1101/gad.316304, 535910, 15601818
-
McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SG, Frame MC. Specific deletion of focal adhesion kinase suppresses tumour formation and blocks malignant progression. Genes Dev 2004, 18:2998-3003. 10.1101/gad.316304, 535910, 15601818.
-
(2004)
Genes Dev
, vol.18
, pp. 2998-3003
-
-
McLean, G.W.1
Komiyama, N.H.2
Serrels, B.3
Asano, H.4
Reynolds, L.5
Conti, F.6
Hodivala-Dilke, K.7
Metzger, D.8
Chambon, P.9
Grant, S.G.10
Frame, M.C.11
-
16
-
-
84862907457
-
VEGF-induced vascular permeability is mediated by FAK
-
10.1016/j.devcel.2011.11.002, 3266538, 22264731
-
Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD. VEGF-induced vascular permeability is mediated by FAK. Dev Cell 2012, 22:146-157. 10.1016/j.devcel.2011.11.002, 3266538, 22264731.
-
(2012)
Dev Cell
, vol.22
, pp. 146-157
-
-
Chen, X.L.1
Nam, J.O.2
Jean, C.3
Lawson, C.4
Walsh, C.T.5
Goka, E.6
Lim, S.T.7
Tomar, A.8
Tancioni, I.9
Uryu, S.10
Guan, J.L.11
Acevedo, L.M.12
Weis, S.M.13
Cheresh, D.A.14
Schlaepfer, D.D.15
-
17
-
-
78650266014
-
Endothelial FAK is required for tumour angiogenesis
-
10.1002/emmm.201000106, 3377344, 21154724
-
Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V, Hart I, Fruttiger M, Parsons M, Hodivala-Dilke KM. Endothelial FAK is required for tumour angiogenesis. EMBO Mol Med 2010, 2:516-528. 10.1002/emmm.201000106, 3377344, 21154724.
-
(2010)
EMBO Mol Med
, vol.2
, pp. 516-528
-
-
Tavora, B.1
Batista, S.2
Reynolds, L.E.3
Jadeja, S.4
Robinson, S.5
Kostourou, V.6
Hart, I.7
Fruttiger, M.8
Parsons, M.9
Hodivala-Dilke, K.M.10
-
18
-
-
84897965875
-
FAK-heterozygous mice display enhanced tumour angiogenesis
-
Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR, Hodivala-Dilke K. FAK-heterozygous mice display enhanced tumour angiogenesis. Nat Commun 2020, 2013:4.
-
Nat Commun
, vol.2013
, pp. 4
-
-
Kostourou, V.1
Lechertier, T.2
Reynolds, L.E.3
Lees, D.M.4
Baker, M.5
Jones, D.T.6
Tavora, B.7
Ramjaun, A.R.8
Birdsey, G.M.9
Robinson, S.D.10
Parsons, M.11
Randi, A.M.12
Hart, I.R.13
Hodivala-Dilke, K.14
-
19
-
-
80051767224
-
Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase
-
10.2174/187152011796817727, 21787277
-
Schultze A, Fiedler W. Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase. Anticancer Agents Med Chem 2011, 11:593-599. 10.2174/187152011796817727, 21787277.
-
(2011)
Anticancer Agents Med Chem
, vol.11
, pp. 593-599
-
-
Schultze, A.1
Fiedler, W.2
-
20
-
-
79959303003
-
The changing role of pathology in breast cancer diagnosis and treatment
-
10.1159/000292644, 3128144, 21677473
-
Leong AS, Zhuang Z. The changing role of pathology in breast cancer diagnosis and treatment. Pathobiology 2011, 78:99-114. 10.1159/000292644, 3128144, 21677473.
-
(2011)
Pathobiology
, vol.78
, pp. 99-114
-
-
Leong, A.S.1
Zhuang, Z.2
-
21
-
-
24944452378
-
Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics: REporting recommendations for tumour MARKer prognostic studies (REMARK)
-
10.1038/sj.bjc.6602678, 2361579, 16106245
-
McShane LM1, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM. Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics: REporting recommendations for tumour MARKer prognostic studies (REMARK). Br J Cancer 2005, 93(4):387-391. 10.1038/sj.bjc.6602678, 2361579, 16106245.
-
(2005)
Br J Cancer
, vol.93
, Issue.4
, pp. 387-391
-
-
McShane, L.M.1.1
Altman, D.G.2
Sauerbrei, W.3
Taube, S.E.4
Gion, M.5
Clark, G.M.6
-
22
-
-
29944436856
-
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
-
10.1083/jcb.200506184, 2063542, 16391003
-
Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF, Wang R. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol 2006, 172:151-162. 10.1083/jcb.200506184, 2063542, 16391003.
-
(2006)
J Cell Biol
, vol.172
, pp. 151-162
-
-
Braren, R.1
Hu, H.2
Kim, Y.H.3
Beggs, H.E.4
Reichardt, L.F.5
Wang, R.6
-
23
-
-
0029120440
-
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
-
10.1038/377539a0, 7566154
-
Ilic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 1995, 377:539-544. 10.1038/377539a0, 7566154.
-
(1995)
Nature
, vol.377
, pp. 539-544
-
-
Ilic, D.1
Furuta, Y.2
Kanazawa, S.3
Takeda, N.4
Sobue, K.5
Nakatsuji, N.6
Nomura, S.7
Fujimoto, J.8
Okada, M.9
Yamamoto, T.10
-
24
-
-
22344434300
-
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
-
10.1083/jcb.200411155, 2171636, 15967814
-
Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P, Flavell RA, Gu H, Guan JL. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol 2005, 169:941-952. 10.1083/jcb.200411155, 2171636, 15967814.
-
(2005)
J Cell Biol
, vol.169
, pp. 941-952
-
-
Shen, T.L.1
Park, A.Y.2
Alcaraz, A.3
Peng, X.4
Jang, I.5
Koni, P.6
Flavell, R.A.7
Gu, H.8
Guan, J.L.9
-
25
-
-
24944531575
-
High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype
-
10.1038/modpathol.3800424, 15861214
-
Lark AL, Livasy CA, Dressler L, Moore DT, Millikan RC, Geradts J, Iacocca M, Cowan D, Little D, Craven RJ, Cance W. High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol 2005, 18:1289-1294. 10.1038/modpathol.3800424, 15861214.
-
(2005)
Mod Pathol
, vol.18
, pp. 1289-1294
-
-
Lark, A.L.1
Livasy, C.A.2
Dressler, L.3
Moore, D.T.4
Millikan, R.C.5
Geradts, J.6
Iacocca, M.7
Cowan, D.8
Little, D.9
Craven, R.J.10
Cance, W.11
-
26
-
-
68549133222
-
FAK overexpression and p53 mutations are highly correlated in human breast cancer
-
10.1002/ijc.24486, 2773794, 19521985
-
Golubovskaya VM, Conway-Dorsey K, Edmiston SN, Tse CK, Lark AA, Livasy CA, Moore D, Millikan RC, Cance WG. FAK overexpression and p53 mutations are highly correlated in human breast cancer. Int J Cancer 2009, 125:1735-1738. 10.1002/ijc.24486, 2773794, 19521985.
-
(2009)
Int J Cancer
, vol.125
, pp. 1735-1738
-
-
Golubovskaya, V.M.1
Conway-Dorsey, K.2
Edmiston, S.N.3
Tse, C.K.4
Lark, A.A.5
Livasy, C.A.6
Moore, D.7
Millikan, R.C.8
Cance, W.G.9
-
27
-
-
68449086501
-
Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): correlation with clinicopathological parameters and tumour proliferative capacity
-
Theocharis SE, Klijanienko JT, Padoy E, Athanassiou S, Sastre-Garau XX. Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): correlation with clinicopathological parameters and tumour proliferative capacity. Med Sci Monit 2009, 15:BR221-BR226.
-
(2009)
Med Sci Monit
, vol.15
-
-
Theocharis, S.E.1
Klijanienko, J.T.2
Padoy, E.3
Athanassiou, S.4
Sastre-Garau, X.X.5
-
28
-
-
79960842319
-
Clinical significance of high focal adhesion kinase gene copy number and overexpression in invasive breast cancer
-
10.1007/s10549-010-1150-2, 20814816
-
Yom CK, Noh DY, Kim WH, Kim HS. Clinical significance of high focal adhesion kinase gene copy number and overexpression in invasive breast cancer. Breast Cancer Res Treat 2011, 128:647-655. 10.1007/s10549-010-1150-2, 20814816.
-
(2011)
Breast Cancer Res Treat
, vol.128
, pp. 647-655
-
-
Yom, C.K.1
Noh, D.Y.2
Kim, W.H.3
Kim, H.S.4
-
29
-
-
0026072872
-
Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up
-
10.1111/j.1365-2559.1991.tb00229.x, 1757079
-
Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991, 19:403-410. 10.1111/j.1365-2559.1991.tb00229.x, 1757079.
-
(1991)
Histopathology
, vol.19
, pp. 403-410
-
-
Elston, C.W.1
Ellis, I.O.2
-
30
-
-
78649746623
-
Treatment of triple negative breast cancer (TNBC): current options and future perspectives
-
De Laurentiis M, Cianniello D, Caputo R, Stanzione B, Arpino G, Cinieri S, Lorusso V, De Placido S. Treatment of triple negative breast cancer (TNBC): current options and future perspectives. Cancer Treat Rev 2010, 36:S80-S86.
-
(2010)
Cancer Treat Rev
, vol.36
-
-
De Laurentiis, M.1
Cianniello, D.2
Caputo, R.3
Stanzione, B.4
Arpino, G.5
Cinieri, S.6
Lorusso, V.7
De Placido, S.8
-
31
-
-
77950690403
-
Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up
-
10.1007/s10549-010-0758-6, 20135347
-
Rydén L, Jirström K, Haglund M, Stål O, Fernö M. Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up. Breast Cancer Res Treat 2010, 120:491-498. 10.1007/s10549-010-0758-6, 20135347.
-
(2010)
Breast Cancer Res Treat
, vol.120
, pp. 491-498
-
-
Rydén, L.1
Jirström, K.2
Haglund, M.3
Stål, O.4
Fernö, M.5
-
32
-
-
79959520764
-
Molecular stratification of triple-negative breast cancers
-
Perou CM. Molecular stratification of triple-negative breast cancers. Oncologist 2011, 16:61-70.
-
(2011)
Oncologist
, vol.16
, pp. 61-70
-
-
Perou, C.M.1
|