Characterization of creatine guanidinium proton exchange by water-exchange (WEX) spectroscopy for absolute-pH CEST imaging in vitro

NMR in Biomedicine

Volumn 27, Issue 5, 2014, Pages 507-518

  Goerke, Steffen ^a   Zaiss, Moritz ^a   Bachert, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Arrhenius equation; CEST; Chemical exchange; Creatine; PH imaging; WEX

Indexed keywords

CATALYSIS; CHEMICAL DETECTION; MAGNETIC RESONANCE IMAGING; RATE CONSTANTS; TOMOGRAPHY;

ARRHENIUS EQUATION; CEST; CHEMICAL EXCHANGE; CREATINE; PH IMAGING; WEX;

PH;

CREATINE; GUANIDINE; PROTON; SOLUTION AND SOLUBILITY; WATER;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CHEMICAL EXCHANGE SATURATION TRANSFER IMAGING; IMAGING; IN VITRO STUDY; IN VIVO STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; TEMPERATURE DEPENDENCE; WATER EXCHANGE SPECTROSCOPY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PROCEDURES; SOLUTION AND SOLUBILITY; TEMPERATURE;

CREATINE; GUANIDINE; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; PROTONS; SOLUTIONS; TEMPERATURE; WATER;

EID: 84897958011     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.3086     Document Type: Article

References (54)

1. Mori S, Johnson MO, Berg JM, van Zijl PCM. Water exchange filter (WEX filter) for nuclear magnetic resonance studies of macromolecules. J. Am. Chem. Soc. 1994; 116: 11982-11984.
2. Mori S, Abeygunawardana C, van Zijl PC, Berg JM. Water exchange filter with improved sensitivity (WEX II) to study solvent-exchangeable protons. Application to the consensus zinc finger peptide CP-1. J. Magn. Reson. B 1996; 110: 96-101.
3. Sun PZ, Sorensen AG. Imaging pH using the chemical exchange saturation transfer (CEST) MRI: correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH. Magn. Reson. Med. 2008; 60: 390-397.
4. Haris M, Nanga RPR, Singh A, Cai K, Kogan F, Hariharan H, Reddy R. Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI. NMR Biomed. 2012; 25: 1305-1309.
5. Zu Z, Janve VA, Xu J, Does MD, Gore JC, Gochberg DF. A new method for detecting exchanging amide protons using chemical exchange rotation transfer. Magn. Reson. Med. 2013; 69: 637-647.
6. 3+-DOTAM-glycine (Gly)-phenylalanine (Phe). Magn. Reson. Med. 2008; 59: 374-381.
7. Schröder L, Meldrum T, Smith M, Lowery TJ, Wemmer DE, Pines A. Temperature response of 129Xe depolarization transfer and its application for ultrasensitive NMR detection. Phys. Rev. Lett. 2008; 100: 257603.
8. Kogan F, Singh A, Cai K, Haris M, Hariharan H, Reddy R. Investigation of chemical exchange at intermediate exchange rates using a combination of chemical exchange saturation transfer (CEST) and spin-locking methods (CESTrho). Magn. Reson. Med. 2012; 68: 107-119.
9. Jin T, Wang P, Zong X, Kim S-G. Magnetic resonance imaging of the Amine-Proton EXchange (APEX) dependent contrast. Neuroimage 2012; 59: 1218-1227.
10. Kogan F, Haris M, Singh A, Cai K, Debrosse C, Nanga RPR, Hariharan H, Reddy R. Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer. Magn. Reson. Med. 2014; 71: 164-172.
11. Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre JA, Reddy R. Magnetic resonance imaging of glutamate. Nature Med. 2012; 18: 302-306.
12. Haris M, Nath K, Cai K, Singh A, Crescenzi R, Kogan F, Verma G, Reddy S, Hariharan H, Melhem ER, Reddy R. Imaging of glutamate neurotransmitter alterations in Alzheimer's disease. NMR Biomed. 2013; 26: 386-391.
13. Wüthrich K. NMR of Proteins and Nucleic Acids, 1st edn. Wiley: New York, USA, 1986.
14. Proceedings for OctoberCEST, the third international workshop on CEST imaging, 15-17 October 2012. Contrast Media Mol. Imaging 2013; 8: 293-331.
15. McConnell HM. Reaction rates by nuclear magnetic resonance. J. Chem. Phys. 1958; 28: 430-431.
16. Zhou J, Wilson DA, Sun PZ, Klaus JA, van Zijl PCM. Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments. Magn. Reson. Med. 2004; 51: 945-952.
17. Sklenar V, Piotto M, Leppik R, Saudek V. Gradient-tailored water suppression for 1H-15N HSQC experiments optimized to retain full sensitivity. J. Magn. Reson. A 1993; 102: 241-245.
18. Mori S, Abeygunawardana C, Berg JM, van Zijl PCM. NMR study of rapidly exchanging backbone amide protons in staphylococcal nuclease and the correlation with structural and dynamic properties. J. Am. Chem. Soc. 1997; 119: 6844-6852.
19. de Graaf RA. In Vivo NMR Spectroscopy: Principles and Techniques. Wiley: Chichester, England, 2008.
20. Bernstein MA, King KF, Zhou XJ. Handbook of MRI Pulse Sequences. Elsevier: London, England, 2004.
21. Zaiss M, Bachert P. Exchange-dependent relaxation in the rotating frame for slow and intermediate exchange - modeling off-resonant spin-lock and chemical exchange saturation transfer. NMR Biomed. 2013; 26: 507-518.
22. 1ρ relaxation model beyond the fast-exchange limit. Phys. Med. Biol. 2012; 57: 8185-8200.
23. Santyr GE, Fairbanks EJ, Kelcz F, Sorenson JA. Off-resonance spin locking for MR imaging. Magn. Reson. Med. 1994; 32: 43-51.
24. 1-corrected steady-state pulsed CEST-MRI - application to pH-weighted MRI of acute stroke. NMR Biomed.; in press. DOI: 10.1002/nbm.3054.
25. Zhou J, van Zijl PCM. Chemical exchange saturation transfer imaging and spectroscopy. Prog. Nucl. Magn. Reson. Spectrosc. 2006; 48: 109-136.
26. McMahon MT, Gilad AA, Zhou J, Sun PZ, Bulte JWM, van Zijl PCM. Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): pH calibration for poly-L-lysine and a starburst dendrimer. Magn. Reson. Med. 2006; 55: 836-847.
27. Liepinsh E, Otting G. Proton exchange rates from amino acid side chains - implications for image contrast. Magn. Reson. Med. 1996; 35: 30-42.
28. Lauzon CB, van Zijl P, Stivers JT. Using the water signal to detect invisible exchanging protons in the catalytic triad of a serine protease. J. Biomol. NMR 2011; 50: 299-314.
29. Bai Y, Milne JS, Mayne L, Englander SW. Primary structure effects on peptide group hydrogen exchange. Proteins: Struct. Funct. Bioinforma. 1993; 17: 75-86.
30. Atkins PW, de Paula J. Atkins' Physical Chemistry, 8th edn. Wiley: Weinheim, Germany, 2006.
31. Gruetter R. Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn. Reson. Med. 1993; 29: 804-811.
32. 1H-NMR method for determining temperature in cell culture perfusion systems. Magn. Reson. Med. 1993; 29: 113-118.
33. Kim M, Gillen J, Landman BA, Zhou J, van Zijl PCM. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn. Reson. Med. 2009; 61: 1441-1450.
34. Englander SW, Downer NW, Teitelbaum H. Hydrogen exchange. Annu. Rev. Biochem. 1972; 41: 903-924.
35. Sun PZ, Benner T, Kumar A, Sorensen AG. Investigation of optimizing and translating pH-sensitive pulsed-chemical exchange saturation transfer (CEST) imaging to a 3T clinical scanner. Magn. Reson. Med. 2008; 60: 834-841.
36. 1 field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging. Magn. Reson. Med. 2007; 58: 1207-1215.
37. ws) with RF saturation time dependent ratiometric analysis (QUESTRA): normalization of relaxation and RF irradiation spillover effects for improved quantitative chemical exchange saturation transfer (CEST) MRI. Magn. Reson. Med. 2012; 67: 936-942.
38. Jin T, Autio J, Obata T, Kim S-G. Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons. Magn. Reson. Med. 2011; 65: 1448-1460.
39. Sun PZ, van Zijl PCM, Zhou J. Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments. J. Magn. Reson. 2005; 175: 193-200.
40. Roeloffs V, Zaiss M, Bachert P. An analytical approach towards pulsed-SL/CEST quantification. Proceedings of the 21st Annual Meeting ISMRM, Salt Lake City, USA, 2013; 2546.
41. Zaiss M, Bachert P. Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods. Phys. Med. Biol. 2013; 58: R221-R269.
42. Neuhaus D, Williamson MP. The Nuclear Overhauser Effect in Structural and Conformational Analysis. Wiley-VCH: New York, USA, 1989.
43. Hwang T-L, Mori S, Shaka AJ, van Zijl PCM. Application of phase-modulated CLEAN chemical exchange spectroscopy (CLEANEX-PM) to detect water-protein proton exchange and intermolecular NOEs. J. Am. Chem. Soc. 1997; 119: 6203-6204.
44. Van Zijl PCM, Zhou J, Mori N, Payen J-F, Wilson D, Mori S. Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids. Magn. Reson. Med. 2003; 49: 440-449.
45. Goerke S, Zaiss M, Bachert P. Water Exchange (WEX) Spectroscopy on creatine model solutions. Proceedings of the 29th Annual Scientific Meeting ESMRMB, Lisbon, Portugal, 2012; 394.
46. Miller RG, Boska MD, Moussavi RS, Carson PJ, Weiner MW. 31P nuclear magnetic resonance studies of high energy phosphates and pH in human muscle fatigue. Comparison of aerobic and anaerobic exercise. J. Clin. Invest. 1988; 81: 1190-1196.
47. Bouissou P, Estrade PY, Goubel F, Guezennec CY, Serrurier B. Surface EMG power spectrum and intramuscular pH in human vastus lateralis muscle during dynamic exercise. J. Appl. Physiol. 1989; 67: 1245-1249.
48. Jasper H, Erickson TC. Cerebral blood flow and pH in excessive cortical discharge induced by metrazol and electrical stimulation. J. Neurophysiol. 1941; 4: 333-347.
49. Op't Eijnde B, Ursø B, Richter EA, Greenhaff PL, Hespel P. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes 2001; 50: 18-23.
50. Robinson TM, Sewell DA, Hultman E, Greenhaff PL. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. J. Appl. Physiol. 1999; 87: 598-604.
51. Steenge GR, Lambourne J, Casey A, Macdonald IA, Greenhaff PL. Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 1998; 275: E974-E979.
52. Barker PB, Soher BJ, Blackband SJ, Chatham JC, Mathews VP, Bryan RN. Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. NMR Biomed. 1993; 6: 89-94.
53. Dechent P, Pouwels PJW, Wilken B, Hanefeld F, Frahm J. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am. J. Physiol. 1999; 277: R698-R704.
54. Lin Y, Zhang YP, Xiao ZW, Li H, Shen ZW, Chen XK, Huang K, Wu RH. Quantification of brain creatine concentration using PRESS sequence and LCModel: comparison with HPLC method. Proceedings of the 28st Annual International Conference of the IEEE EMBS, New York, USA, 2006; 1928-1931.