Using the water signal to detect invisible exchanging protons in the catalytic triad of a serine protease

Journal of Biomolecular NMR

Volumn 50, Issue 4, 2011, Pages 299-314

  Lauzon, Carolyn B ^a   Van Zijl, Peter ^a,b   Stivers, James T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

Catalytic triad; CEST; Chemical exchange; Chymotrypsinogen; Fast exchange; Saturation transfer; Serine protease

Indexed keywords

AMINO ACID; CHYMOTRYPSINOGEN; IMIDAZOLE; PEPTIDE; PROTON; SERINE PROTEINASE; WATER;

ANALYTIC METHOD; ARTICLE; CATALYSIS; CATTLE; CHEMICAL EXCHANGE SATURATION TRANSFER; CHEMICAL STRUCTURE; ENZYME ACTIVITY; HYDROLYSIS; METHODOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPECTROMETER;

ANIMALS; CATTLE; CHYMOTRYPSINOGEN; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROXIDES; MODELS, CHEMICAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTONS; REPRODUCIBILITY OF RESULTS; SERINE PROTEASES; SOLVENTS; WATER;

BOVINAE;

EID: 80051700610     PISSN: 09252738     EISSN: 15735001     Source Type: Journal    
DOI: 10.1007/s10858-011-9527-z     Document Type: Article

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