Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

Genetics and Molecular Research

Volumn 13, Issue 1, 2014, Pages 2060-2068

  Lin, J ^a   Zeng, R M ^a   Li, R N ^a   Cao, W H ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Gastric cancer; Haplotype analysis; Methylenetetrahydrofolate reductase; Susceptibility

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN MLH1; PROTEIN P16;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CHINESE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; MGMT GENE; MLH1 GENE; P16 GENE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK REDUCTION; STOMACH CANCER; VITAMIN SUPPLEMENTATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; ALLELES; CASE-CONTROL STUDIES; CHINA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; NUCLEAR PROTEINS; ODDS RATIO; POLYMORPHISM, GENETIC; RISK FACTORS; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 84897951905     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2014.March.24.10     Document Type: Article

References (30)

1. Bagley PJ and Selhub J (1998). A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc. Natl. Acad. Sci. U. S. A. 95: 13217-13220.
2. Bai XL, Sun LP, Liu J, Chen W, et al. (2008). Correlation of interleukin-10-1082G/a single nucleotide polymorphism to the risk of gastric cancer in north China: a case-control study. Ai Zheng. 27: 35-40.
3. Bastos J, Peleteiro B, Pinto H, Marinho A, et al. (2013). Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen). Dig. Liver Dis. 45: 290-295.
4. Boccia S, Gianfagna F, Persiani R, La Greca A, et al. (2007). Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population. Biomarkers 12: 635-644.
5. Botto LD and Yang Q (2000). 5, 10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am. J. Epidemiol. 151: 862-877.
6. Brattström L, Wilcken DE, Ohrvik J and Brudin L (1998). Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 98: 2520-2526.
7. Brockton NT (2006). Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate? Cancer Causes Control. 17: 1005-1016.
8. Choi SW and Mason JB (2000). Folate and carcinogenesis: an integrated scheme. J. Nutr. 130: 129-132.
9. Cui LH, Shin MH, Kweon SS, Kim HN, et al. (2010). Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population. BMC Cancer 10: 236.
10. Dong X, Wu J, Liang P, Li J, et al. (2010). Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis. Arch. Med. Res. 41: 125-133.
11. Forman D and Burley VJ (2006). Gastric cancer: global pattern of the disease and an overview of environmental risk factors. Best. Pract. Res. Clin. Gastroenterol. 20: 633-649.
12. Frosst P, Blom HJ, Milos R, Goyette P, et al. (1995). A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 10: 111-113.
13. Götze T, Rocken C, Rohl FW, Wex T, et al. (2007). Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer. Cancer Lett. 251: 228-236.
14. Hamajima N, Naito M, Kondo T and Goto Y (2006). Genetic factors involved in the development of Helicobacter pylori-related gastric cancer. Cancer Sci. 97: 1129-1138.
15. Inoue S, Hashiguchi M, Chiyoda T, Sunami Y, et al. (2007). Pharmacogenetic study of methylenetetrahydrofolate reductase and thymidylate synthase in Japanese and assessment of ethnic and gender differences. Pharmacogenomics 8: 41-47.
16. Lao-Sirieix P, Caldas C and Fitzgerald RC (2010). Genetic predisposition to gastro-oesophageal cancer. Curr. Opin. Genet. Dev. 20: 210-217.
17. Miao X, Xing D, Tan W, Qi J, et al. (2002). Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an at-risk Chinese population. Cancer Epidemiol. Biomarkers Prev. 11: 1454-1458.
18. Neves Filho EH, Alves MK, Lima VP and Rabenhorst SH (2010). MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection. Virchows Arch. 457: 627-633.
19. Pan XF, Xie Y, Loh M, Yang SJ, et al. (2012). Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study. Asian Pac. J. Cancer Prev. 13: 5637-5642.
20. Saberi S, Zendehdel K, Jahangiri S, Talebkhan Y, et al. (2012). Impact of methylenetetrahydrofolate reductase C677T polymorphism on the risk of gastric cancer and its interaction with Helicobacter pylori infection. Iran Biomed. J. 16: 179-184.
21. Sun L, Sun YH, Wang B, Cao HY, et al. (2008). Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis. Eur. J. Cancer Prev. 17: 446-452.
22. Tahara T, Shibata T, Nakamura M, Yamashita H, et al. (2009). MTHFR 677T carrier influences the methylation status of H. pylori-infected gastric mucosa in older subjects. Dig. Dis. Sci. 54: 2391-2398.
23. Teng Z, Wang L, Cai S, Yu P, et al. (2013). The 677C>T (rs1801133) polymorphism in the MTHFR gene contributes to colorectal cancer risk: a meta-analysis based on 71 research studies. PLoS One 8: e55332.
24. van Huis-Tanja LH, Gelderblom H, Punt CJ and Guchelaar HJ (2013). MTHFR polymorphisms and capecitabine-induced toxicity in patients with metastatic colorectal cancer. Pharmacogenet. Genomics 23: 208-218.
25. Vollset SE, Igland J, Jenab M, Fredriksen A, et al. (2007). The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol. Biomarkers Prev. 16: 2416-2424.
26. Wang J, Sasco AJ, Fu C, Xue H, et al. (2008). Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev. 17: 118-125.
27. Weng YR, Sun DF, Fang JY, Gu WQ, et al. (2006). Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis. World J. Gastroenterol. 12: 7591-7597.
28. Yoo JY, Kim SY, Hwang JA, Hong SH, et al. (2012). Association study between folate pathway gene single nucleotide polymorphisms and gastric cancer in Koreans. Genomics Inform. 10: 184-193.
29. Yu L, Chang K, Han J, Deng S, et al. (2013). Association between Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to cervical cancer: a meta-analysis. PLoS One 8: e55835.
30. Zhang FF, Terry MB, Hou L, Chen J, et al. (2007). Genetic polymorphisms in folate metabolism and the risk of stomach cancer. Cancer Epidemiol. Biomarkers Prev. 16: 115-121.