Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis

European Journal of Cancer Prevention

Volumn 17, Issue 5, 2008, Pages 446-452

  Sun, Liang ^a   Sun, Ye Huan ^a   Wang, Bo ^a   Cao, Hong Yuan ^a   Yu, Chen ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Meta analysis; Methylenetetrahydrofolate reductase; Polymorphism; Stomach neoplasms

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

CANCER DIAGNOSIS; CANCER LOCALIZATION; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHINESE; CLINICAL TRIAL; FOLIC ACID BLOOD LEVEL; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; META ANALYSIS; PRIORITY JOURNAL; RELIABILITY; REVIEW; SENSITIVITY ANALYSIS; STOMACH CANCER; SYSTEMATIC REVIEW; ARTICLE; CASE CONTROL STUDY; CHINA; COHORT ANALYSIS; GENETIC PREDISPOSITION; GENETICS; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH TUMOR;

CASE-CONTROL STUDIES; CHINA; COHORT STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE; STOMACH NEOPLASMS;

EID: 56149085511     PISSN: 09598278     EISSN: None     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e328305a140     Document Type: Review

References (52)

1. Bi JP, Cai L, Zheng ZL (2005). Study on C667T gene polymorphism and susceptibility to gastric cancer. Chin J Public Health (Chinese) 21:661-663.
2. Boccia S, Gianfagna F, Persiani R, La Greca A, Arzani D, Rausei S, D'ugo D, et al. (2007). Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population. Biomarkers 12:635-644.
3. Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, et al. (2008). Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol 167:505-516.
4. Echem R (2003). Gastric cancer is a major cause of cancer death. Niger J Med 12:175-176.
5. Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. Br Med J 315:629-634.
6. Feng CW, Fan ZM, Gao SS, He X, Guo HQ, Yin LM, et al. (2006). Analysis of methylenetetrahydrofolate reductase and thymidylate synthase gene polymorphisms of esophageal and cardia cancer patients. J Zhengzhou Univ (Chinese) 41:10-14.
7. Friedman G, Goldschmidt N, Friedlander Y, Ben-Yehuda A, Selhub J, Babaey S, et al. (1999). A common mutation A1298C in human methylenetetrahydro- folate reductase gene: association with plasma total homocysteine and folate concentrations. J Nutr 129:1656-1661.
8. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. (1995). A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113.
9. Fu G, Yang YF, Shen KB, Pu YP, Zhang J (2007). Relationship between the methylenetetrahydrofolate reductase A1298C genetic polymorphisms and susceptibiilty to gastric cancer. J Environ Occup Med (Chinese) 24:32-35.
10. Gao C, Wu J, Ding J, Liu Y, Zang Y, Li S, et al. (2002). Polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of stomach cancer. Zhonghua Liu Xing Bing Xue ZaZhi (Chinese) 23:289-292.
11. Gao CM, Wu JZ, Ding JH, Liu YT, Zang Y, Li SP, et al. (2001). MTHFR C677T genotypes, lifestyle and the risk of stomachcancer. Chin J Cancer Prev Treat (Chinese) 8 (4S):187-190.
12. Gao CM, Takezaki T, Wu JZ, Ding JH, Liu YT, Li SP, et al. (2003). Methylenetetrahydrofolate reductase genotypes, dietary habits and susceptibility of stomach cancer. Tumor (Chinese) 23:95-98.
13. Gao CM, Takezaki T, Wu JZ, Liu YT, Ding JH, Li SP, et al. (2004a). Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking. Asian Pac J Cancer Prev 5:133-138.
14. Gao CM, Takezaki T, Wu JZ, Ding JH, Liu YT, Li SP, et al. (2004b). Methylenetetrahydrofolate reductase genotypes, dietary habits and susceptibility to stomach cancer. Chin J Clin Oncol (Chinese) 1:162-166.
15. Gonzalez CA, Riboli E, Badosa J, Batiste E, Cardona T, Pita S, et al. (1994). Nutritional factors and gastric cancer in Spain. Am J Epidemiol 139: 466-473.
16. Graziano F, Kawakami K, Ruzzo A, Watanabe G, Santini D, Pizzagalli F, et al. (2006). Methylenetetrahydrofolate reductase 677C/T gene polymorphism, gastric cancer susceptibility and genomic DNA hypomethylation in an at-risk Italian population. Int J Cancer 118:628-632.
17. Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539-1558.
18. Inoue M, Tsugane S (2005). Epidemiology of gastric cancer in Japan. Postgrad Med J 81:419-424.
19. Jiang AR, Wu JZ, Gao CM, Ding JH, Liu YT, Cao HX, et al. (2004). Relationship between polymorphisms of methylenetetrahydrofolate reductase A1298C and the susceptibility of gastric cancer. Hebei Med J (Chinese) 26: 851-853.
20. Kim JK, Kim S, Han JH, Kim HJ, Chong SY, Hong SP, et al. (2005). Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of stomach cancer in a Korean population. Anticancer Res 25 (3B): 2249-2252.
21. Kim YI (2000). Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis. Nutr Rev 58:205-209.
22. Lacasan̄; a-Navarro M, Galván-Portillo M, Chen J, López-Cervantes M, López-Carrillo L (2006). Methylenetetrahydrofolate reductase 677C >T polymorphism and gastric cancer susceptibility in Mexico. Eur J Cancer 42:528-533.
23. Larsson SC, Giovannucci E, Wolk A (2006). Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology 131:1271-1283.
24. La Vecchia C, Ferraroni M, D'Avanzo B, Decarli A, Franceschi S (1994). Selected micronutrient intake and the risk of gastric cancer. Cancer Epidemiol Biomarkers Prev 3:393-398.
25. Li S, Ji MJ, Hou P, He NY (2006). Single nucleotide polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase gene and susceptibility to gastric carcinoma. J Southeast Univ (Chinese) 25:321-324.
26. Li S, Ji M, He N, Lu Z (2007). Application of microarray-based method for methylenetetrahydrofolate reductase (MTHFR) polymorphisms in the risk of gastric carcinoma in east China population. J Nanosci Nanotechnol 7:3245-3249.
27. Mayne ST, Risch HA, Dubrow R, Chow WH, Gammon MD, Vaughan TL, et al. (2001). Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 10:1055-1062.
28. Miao X, Xing D, Tan W, Lv WF, Lin DX (2002a). Single nucleotide polymorphisms in methylenetetrahydrofolate reductase gene and susceptibility to cancer of the gastric cardia in Chinese population. Zhonghua Yi Xue Za Zhi (Chinese) 82:669-672.
29. Miao X, Xing D, Tan W, Qi J, Lu W, Lin D (2002b). Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an at-risk Chinese population. Cancer Epidemiol Biomarkers Prev 11:1454-1458.
30. Mu LN, Ding BG, Chen CW, Wei GR, Zhou XF, Wang RH, et al. (2004). A case-control study on the relationship between methyl-tetra-hydrofolic acid reductase 677 gene polymorphism and the risk of stomach cancer. Zhonghua Liu Xing Bing Xue ZaZhi (Chinese) 25:495-498.
31. Mu LN, Cao W, Zhang ZF, Yu SZ, Jiang QW, You NC, et al. (2007). Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer. Biomarkers 12:61-75.
32. Plummer M, Franceschi S, Munoz N (2004). Epidemiology of gastric cancer. IARC Sci Publ 157:311-326.
33. Sarbia M, Geddert H, Kiel S, Kandemin Y, Schulz WA, Vossen S, et al. (2005). Methylenetetrahydrofolate reductase C677T polymorphism and risk of adenocarcinoma of the upper gastrointestinal tract. Scand J Gastroenterol 40:109-111.
34. Shen H, Xu Y, Zheng Y, Qian Y, Yu R, Qin Y, et al. (2001). Polymorphisms of 5,10-methylenetetrahydrofolate reductase and risk of gastric cancer in a Chinese population: a case-control study. Int J Cancer 95:332-336.
35. Shen H, Newmann AS, Hu Z, Zhang Z, Xu Y, Wang L, et al. (2005). Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China. Oncol Rep 13:355-360.
36. Si PR, Fang DC (2003). The relationship between methylenetetrahydrofolate reductase gene polymorphism and helicobacter pylori infection in gastric cancer. Med J Chin PLA (Chinese) 28:978-981.
37. Si PR, Fang DC, Zhang H, Luo YH (2003). The relationship between methylenetetrahydrofolate reductase gene polymorphism and risk of gastric cancer. ChongQing Med J (Chinese) 32:1123-1125.
38. Si PR, Fang DC, Zhang H, Yang LQ, Luo YH, Miao HY (2004). Relationship between polymorphisms in methylenetetrahydrofolate reductase gene 1298AC and H. pylori infection in gastric cancer. Acta academiae medicinae militaris tertiae (Chinese) 26:1201-1204.
39. Si PR, Fang DC, Zhang H, Yang LQ, Luo YH, Liao HY (2005). The relationship between methylenetetrahydrofolate reductase gene polymorphism and microsatellite instability in gastric cancer. Zhonghua Liu Xing Bing Xue ZaZhi (Chinese) 26:794-799.
40. Stolzenberg-Solomon RZ, Qiao YL, Abnet CC, Ratnasinghe DL, Dawsey SM, Dong ZW, et al. (2003). Esophageal and gastric cardia cancer risk and folate-and vitamin B(12)-related polymorphisms in Linxian, China. Cancer Epidemiol Biomarkers Prev 12:1222-1226.
41. Sun X, Mu R, Zhou Y, Dai X, Qiao Y, Zhang S, et al. (2002). 1990-1992 mortality of stomach cancer in China. Zhonghua Zhong Liu Za Zhi (Chinese) 24:4-8.
42. Vollset SE, Igland J, Jenab M, Fredriksen A, Meyer K, Eussen S, et al. (2007). The association of gastric cancer risk with plasma folate, cobalamin, andmethy-lenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 16:2416-2424.
43. Wacholder S, McLaughlin JK, Silverman DT, Mandel JS (1992). Selection of controls in case-control studies: I. Principles. Am J Epidemiol 135: 1019-1028.
44. Wang L, Ke Q, Chen W, Wang J, Tan Y, Zhou Y, et al. (2007). Polymorphisms of MTHFD, plasma homocysteine levels, and risk of gastric cancer in a high-risk Chinese population. Clin Cancer Res 13:2526-2532.
45. Wang LD, Guo RF, Fan ZM, He X, Gao SS, Guo HQ, et al. (2005). Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population. Dis Esophagus 18:177-184.
46. Wang Y, Guo W, He Y, Chen Z, Wen D, Zhang X, et al. (2007). Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China. Cancer Causes Control 18:143-152.
47. Weisberg I, Tran P, Christensen B, Sibani S, Rozen R (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64:169-172.
48. Weng YR, Fang JY, Sun DF, Chen CF, Zhu HY (2006a). Relationship between folate and methylenetetrahydrofolate reductase polymorphisms in human gastric cancer tissues. Chin J Dig (Chinese) 26:26-30.
49. Weng YR, Sun DF, Fang JY, Gu WQ, Zhu HY (2006b). Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis. World J Gastroenterol 12: 7591-7597.
50. Zeybek U, Yaylim I, Yilmaz H, Aǧ açhan B, Ergen A, Arikan S, et al. (2007). Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer. Cell Biochem Funct 25:419-422.
51. Zhang FF, Terry MB, Hou L, Chen J, Lissowska J, Yeager M, et al. (2007). Genetic polymorphisms in folate metabolism and the risk of stomach cancer. Cancer Epidemiol Biomarkers Prev 16:115-121.
52. Zintzaras E (2006). Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis. J Hum Genet 51:618-624.