Bioinorganics in bioactive calcium silicate ceramics for bone tissue repair: Bioactivity and biological properties

Journal of Ceramic Science and Technology

Volumn 5, Issue 1, 2014, Pages 1-12

  Mohammadi, H ^a   Hafezi, M ^b   Nezafati, N ^b   Heasarki, S ^b   Nadernezhad, A ^c,d   Ghazanfari, S M H ^b   Sepantafar, M ^e  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b MATERIALS AND ENERGY RESEARCH CENTER   (Iran)

^c AMIRKABIR UNIVERSITY OF TECHNOLOGY   (Iran)

^d Yazd Science and Technology Park   (Iran)

^e SEMNAN UNIVERSITY   (Iran)

Author keywords

Calcium silicate; Chemical stability; Ion doping

Indexed keywords

APATITE FORMATION; BIOLOGICAL PROPERTIES; BONE TISSUE REGENERATION; CHEMICAL COMPOSITIONS; HIGH DISSOLUTION RATE; ION DOPING; IONIC-DISSOLUTION PRODUCTS; SIMULATED BODY FLUIDS;

APATITE; BIOCERAMICS; BIOCOMPATIBILITY; BIOLOGICAL MATERIALS; BONE; CALCIUM SILICATE; CELL PROLIFERATION; CHEMICAL STABILITY; DISSOLUTION; SILICATES; ZINC; ZIRCONIUM;

METAL IONS;

EID: 84897883642     PISSN: 21909385     EISSN: None     Source Type: Journal    
DOI: 10.4416/JCST2013-00027     Document Type: Review

References (188)

1. Hench, L.L.: The story of Bioglass®, J. Mater. Sci.: Mater. Med., 17, 967-978, (2006).
2. Liu, Q. et al.: A comparative study of proliferation and osteogenic differentiation of adipose-derived stem cells on akermanite and beta-TCP ceramics, Biomaterials, 29, 4792-4799, doi:10.1016/j.biomaterials.2008.08.039, (2008).
3. Xia, L. et al.: Proliferation and osteogenic differentiation of human periodontal ligament cells on akermanite and beta-TCP bioceramics, Euro. Cells Mater., 22, 68-82, (2011).
4. Wang, G., Lu, Z., Dwarte, D., Zreiqat, H.: Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses, Mater. Sci. Eng.: C, 32, 1818-1826, doi:http://dx.doi.org/10.1016/j.msec.2012.04.068, (2012).
5. Hoppe, A., Guldal, N.S., Boccaccini, A.R.: A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics, Biomaterials, 32, 2757-2774, doi:10.1016/j.biomaterials.2011.01. 004, (2011).
6. Meyer, U., Buchter, A., Wiesmann, H.P., Joos, U., Jones, D.B.: Basic reactions of osteoblasts on structured material surfaces, Euro. Cells Mater., 9, 39-49, (2005).
7. Ramaswamy, Y. et al.: The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic, Biomaterials, 29, 4392-4402, doi:http://dx.doi.org/10.1016/j.biomaterials.2008. 08.006, (2008).
8. 3 ceramics in simulated body fluids with different carbonate concentrations, J. Mater. Sci.: Mater. Med., 16, 73-79, (2005).
9. Wu, C.: Methods of improving mechanical and biomedical properties of Ca-Si-based ceramics and scaffolds, Expert Rev. Med. Devic., 6, 237-241, (2009).
10. De Aza, P.N., Guitan, F., De Aza, S.: Bioactivity of wollastonite ceramics: in vitro evaluation. (Pergamon Press, 1994).
11. 3 powders in simulated body fluid, J. Eur. Ceram. Soc., 22, 511-520, (2002).
12. Hench, L.L.: Biomaterials: a forecast for the future, Biomaterials, 19, 1419-1423, (1998).
13. Wu, C., Chang, J., Wang, J., Ni, S., Zhai, W.: Preparation and characteristics of a calcium magnesium silicate (bredigite) bioactive ceramic, Biomaterials, 26, 2925-2931, doi:10.1016/j.biomaterials.2004.09.019, (2005).
14. 5 ceramic coating on Ti-6Al-4V with excellent bonding strength, stability and cellular bioactivity, J. Roy. Soc. Interface, 6, 159-168, doi:10.1098/rsif.2008.0274, (2009).
15. Wu, C. et al.: The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co- glycolide) films, Biomaterials, 30, 2199-2208, doi:10.1016/j.biomaterials.2009. 01.029, (2009).
16. Xu, S. et al.: Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics, Biomaterials, 29, 2588-2596, doi:10.1016/j.biomaterials.2008.03.013, (2008).
17. Heikkila, J.T. et al.: Bioactive glass granules: a suitable bone substitute material in the operative treatment of depressed lateral tibial plateau fractures: a prospective, randomized 1 year follow-up study, J. Mater. Sci. Mater. M., 22, 1073-1080, doi:10.1007/s10856-011-4272-0, (2011).
18. Hench, L.L.: The story of bioglass, J. Mater. Sci. Mater. M., 17, 967-978, doi:10.1007/s10856-006-0432-z, (2006).
19. Tirapelli, C., Panzeri, H., Soares, R.G., Peitl, O., Zanotto, E.D.: A novel bioactive glass-ceramic for treating dentin hypersensitivity, Braz. Oral Res., 24, 381-387, (2010).
20. Wu, C., Chang, J.: A review of bioactive silicate ceramics, Biomed. Mater., 8, 032001, doi:10.1088/1748-6041/8/3/032001, (2013).
21. Nedelec, J.M. et al.: Materials doping through sol-gel chemistry: a little something can make a big difference, J. Sol-Gel Sci. Technol., 46, 259-271, doi:10.1007/s10971-007-1665-0, (2008).
22. Valerio, P., Pereira, M.M., Goes, A.M., Leite, M.F.: The effect of ionic products from bioactive glass dissolution on osteoblast proliferation and collagen production, Biomaterials, 25, 2941-2948, doi:10.1016/j.biomaterials. 2003.09.086, (2004).
23. Wu, C., Chang, J., Ni, S., Wang, J.: In vitro bioactivity of akermanite ceramics, J. Biomed. Mater. Res.-A, 76, 73-80, doi:10.1002/jbm.a.30496, (2006).
24. Ou, J. et al.: Preparation of merwinite with apatite-formimg ability by sol-gel process, Key Eng. Mat., 330-332, 67-70, (2007).
25. Wu, C., Chang, J.: A novel akermanite bioceramic: preparation and characteristics. J. Biomater. Appl., 21, 119-129, doi:10.1177/0885328206057953, (2006).
26. Porter, A.E., Buckland, T., Hing, K., Best, S.M., Bonfield, W.: The structure of the bond between bone and porous siliconsubstituted hydroxyapatite bioceramic implants, J. Biomed. Mater. Res. A, 78, 25-33, doi:10.1002/jbm.a. 30690, (2006).
27. Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H.: Biological response of human bone cells to zinc-modified ca-si-based ceramics, Acta Biomater., 4, 1487-1497, doi:10.1016/j.actbio.2008.04.014, (2008).
28. Zreiqat, H. et al.: The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts, Biomaterials, 26, 7579-7586, (2005).
29. Habibovic, P., Barralet, J.E.: Bioinorganics and biomaterials: bone repair, Acta Biomater., 7, 3013-3026, doi:10.1016/j.actbio.2011.03.027, (2011).
30. Wu Cheng-Tie, C.J.: Silicate bioceramics for bone tissue regeneration, J. Inorg. Mater., 28, 29-39, doi:10.3724/sp.j.1077.2013.12241, (2013).
31. Roohani-Esfahani, S. I. et al.: Repairing a critical-sized bone defect with highly porous modified and unmodified baghdadite scaffolds, Acta Biomater., 8, 4162-4172, (2012).
32. Zreiqat, H. et al.: The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering, Biomaterials, 31, 3175-3184, doi:http://dx.doi.org/10.1016/j.biomaterials.2010.01.024, (2010).
33. Wu, C. et al.: The effect of Zn contents on phase composition, chemical stability and cellular bioactivity in Zn-Ca-Si system ceramics. J. Biomed. Mater. Res. B, 87, 346-353, doi:10.1002/jbm.b.31109, (2008).
34. Wu, C., Ramaswamy, Y., Soeparto, A., Zreiqat, H.: Incorporation of titanium into calcium silicate improved their chemical stability and biological properties, J. Biomed. Mater. Res. A, 86, 402-410, doi:10.1002/jbm.a.31623, (2008).
35. Althoff, J., Quint, P., Krefting, E.R., Hohling, H.J.: Morphological studies on the epiphyseal growth plate combined with biochemical and X-ray microprobe analyses, Histochemistry, 74, 541-552, (1982).
36. Hench, L.L.: Bioceramics: from concept to clinic. J. Am. Ceram. Soc., 74, 1487-1510, doi:10.1111/j.1151-2916.1991.tb07132.x, (1991).
37. Zhang, M., Lin, K., Chang, J.: Preparation and characterization of Sr-hardystonite (Sr2ZnSi2O7) for bone repair applications, Mat. Sci. Eng. C, 32, 184-188, doi:http://dx.doi.org/10.1016/j.msec.2011.10.017, (2012).
38. LeGeros, R.Z.: Calcium phosphates in oral biology and medicine, Monographs in Oral Science, 15, 1-201, (1991).
39. Okuma, T.: Magnesium and bone strength, Nutrition, 17, 679-680, (2001).
40. Rude, R.K., Gruber, H.E.: Magnesium deficiency and osteoporosis: animal and human observations, J. Nutr. Biochem., 15, 710-716, doi:10.1016/j.jnutbio. 2004.08.001, (2004).
41. Webster, T.J., Ergun, C., Doremus, R.H., Bizios, R.: Hydroxylapatite with substituted magnesium, zinc, cadmium, and yttrium. II. mechanisms of osteoblast adhesion., J. Biomed. Mater. Res., 59, 312-317, (2002).
42. Wolf, F.I., Cittadini, A.: Magnesium in cell proliferation and differentiation, Front. Biosci., 4, D607-617, (1999).
43. Zreiqat, H. et al.: Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants. J. Biomed. Mater. Res., 62, 175-184, doi:10.1002/jbm.10270, (2002).
44. Moseley, D., Glasser, F.P.: Properties and composition of bredigite-structured phases, J. Mater. Sci., 17, 2736-2740, doi:10.1007/ BF00543911, (1982).
45. Webster, T.J., Ergun, C., Doremus, R.H., Siegel, R.W., Bizios, R.: Enhanced functions of osteoblasts on nanophase ceramics, Biomaterials, 21, 1803-1810, (2000).
46. Sgambato, A., Wolf, F.I., Faraglia, B., Cittadini, A.: Magnesium depletion causes growth inhibition, reduced expression of cyclin D1, and increased expression of P27Kip1 in normal but not in transformed mammary epithelial cells, J. Cell. Physiol., 180, 245-254, doi:10.1002/(sici)1097- 4652(199908)180:2 <245::aid-jcp12>3.0.co;2-r, (1999).
47. Sojka, J.E., Weaver, C.M.: Magnesium supplementation and osteoporosis, Nutr. Rev., 53, 71-74, (1995).
48. Stendig-Lindberg, G., Tepper, R., Leichter, I.: Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis, Magnesium Res., 6, 155-163, (1993).
49. Iwata, N.Y., Lee, G.-H., Tokuoka, Y., Kawashima, N.: Sintering behavior and apatite formation of diopside prepared by coprecipitation process, Colloid Surface B, 34, 239-245, doi:http://dx.doi.org/10.1016/j.colsurfb.2004.01.007, (2004).
50. Wu, C., Chang, J., Zhai, W., Ni, S., Wang, J.: Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies. J. Biomed. Mater. Res. B, 78, 47-55, doi:10.1002/jbm.b.30456, (2006).
51. Sripanyakorn, S. et al.: The silicon content of beer and its bioavailability in healthy volunteers, Brit. J. Nutr., 91, 403-409, doi:10.1079/bjn20031082, (2004).
52. Zhang, E., Yang, L., Xu, J., Chen, H.: Microstructure, mechanical properties and bio-corrosion properties of mg-si(-ca, Zn) alloy for biomedical application, Acta Biomater., 6, 1756-1762, doi:10.1016/j.actbio.2009.11.024, (2010).
53. LeVier, R.R.: Distribution of silicon in the adult rat and rhesus monkey, Bioinorg. Chem., 4, 109-115, doi:http://dx.doi.org/10.1016/S0006-3061(00)81019- 4, (1975).
54. Najda, J., Gminski, J., Drozdz, M, Danch, A.: The action of excessive, inorganic silicon (Si) on the mineral metabolism of calcium (Ca) and magnesium (Mg), Biol. Trace Elem. Res., 37, 107-114, doi:10.1007/bf02783786, (1993).
55. Seaborn, C.D., Nielsen, F.H.: Effects of germanium and silicon on bone mineralization, Biol. Trace Elem. Res., 42, 151-164, doi:10.1007/bf02785386, (1994).
56. Seaborn, C.D., Nielsen, F.H.: Dietary silicon and arginine affect mineral element composition of rat femur and vertebra, Biol. Trace Elem. Res., 89, 239-250, (2002).
57. Schwarz, K., Milne, D.B.: Growth-promoting effects of silicon in rats, Nature, 239, 333-334, (1972).
58. Gao, T., Aro, H.T., Ylanen, H., Vuorio, E.: Silica-based bioactive glasses modulate expression of bone morphogenetic protein-2 mRNA in Saos-2 osteoblasts in vitro, Biomaterials, 22, 1475-1483, (2001).
59. Gough, J.E., Jones, J.R., Hench, L.L.: Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold, Biomaterials, 25, 2039-2046, (2004).
60. Hing, K.A., Revell, P.A., Smith, N., Buckland, T.: Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds, Biomaterials, 27, 5014-5026, doi:10.1016/j.biomaterials.2006.05.039, (2006).
61. Xynos, I.D., Edgar, A.J., Buttery, L.D., Hench, L.L., Polak, J.M.: Gene-expression profiling of human osteoblasts following treatment with the ionic products of bioglass 45S5 dissolution, J. Biomed. Mater. Res., 55, 151-157 (2001).
62. 2 hybrids prepared by sol-gel process, Biomaterials, 20, 1127-1132, (1999).
63. 3 ceramics on their physical and biological properties. Biomaterials,. 28, 3171-3181, doi:10.1016/j.biomaterials.2007.04. 002, (2007).
64. Marie, P.J., Ammann, P., Boivin, G., Rey, C.: Mechanisms of action and therapeutic potential of strontium in bone, Calcified Tissue Int., 69, 121-129, (2001).
65. Rokita, E., Mutsaers, P.H.A., Quaedackers, J.A., Tatoń, G., de Voigt, M.J.A.: Bone mineralization after strontium and fluoride treatment in osteoporosis, Nucl. Instrum. Meth. B, 158, 412-417, doi:http://dx.doi.org/10. 1016/S0168-583X(99)00361-4, (1999).
66. Verberckmoes, S.C., De Broe, M.E., D'Haese, P.C.: Dosedependent effects of strontium on osteoblast function and mineralization, Kidney int., 64, 534-543, doi:10.1046/j.1523-1755.2003.00123.x, (2003).
67. Shannon, R.: Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides, Acta Crystallogr. A, 32, 751-767, doi:10.1107/S0567739476001551, (1976).
68. Saint-Jean, S.J., Camire, C.L., Nevsten, P., Hansen, S., Ginebra, M.P.: Study of the reactivity and in vitro bioactivity of Sr-substituted alpha-TCP cements, J. Mater. Sci. Mater. M., 16, 993-1001, doi:10.1007/s10856-005-4754-z, (2005).
69. Li, J., Liao, H., Hermansson, L.: Sintering of partially-stabilized zirconia and partially-stabilized zirconia-hydroxyapatite composites by hot isostatic pressing and pressureless sintering, Biomaterials, 17, 1787-1790, (1996).
70. Daculsi, G., LeGeros, R.Z., Mitre, D.: Crystal dissolution of biological and ceramic apatites, Calcified Tissue Int., 45, 95-103, (1989).
71. 2 ceramics for improved corrosion resistance, J. Mater. Sci. Lett., 16, 1342-1344, doi:10.1023/A:1018568101522, (1997).
72. Porter, A.E. et al.: Ultrastructural comparison of dissolution and apatite precipitation on hydroxyapatite and silicon-substituted hydroxyapatite in vitro and in vivo. J. Biomed. Mater. Res A, 69, 670-679, doi:10.1002/jbm.a. 30035, (2004).
73. Yamaguchi, M., Ehara, Y.: Zinc decrease and bone metabolism in the femoral-metaphyseal tissues of rats with skeletal unloading, Calcified Tissue Int., 57, 218-223, (1995).
74. Yamaguchi, M., Inamoto, K., Suketa, Y.: Effect of essential trace metals on bone metabolism in weanling rats: comparison with zinc and other metals' actions, Res. Exp. Med. Z. Ges. Exp. Med., 186, 337-342 (1986).
75. Yamaguchi, M., Oishi, H., Suketa, Y.: Stimulatory effect of zinc on bone formation in tissue culture, Biochem. Pharmacol., 36, 4007-4012 (1987).
76. Yamaguchi, M., Oishi, H., Suketa, Y.: Zinc stimulation of bone protein synthesis in tissue culture: activation of aminoacyl-tRNA synthetase, Biochem. Pharmacol., 37, 4075-4080, doi:http://dx.doi.org/10.1016/0006-2952(88)90098-6, (1988).
77. Yamaguchi, M., Ozaki, K.: Aging affects cellular zinc and protein synthesis in the femoral diaphysis of rats. Res. Exp. Med. Z. Ges. Exp. Med., 190, 295-300, (1990).
78. Yamaguchi, M., Yamaguchi, R.: Action of zinc on bone metabolism in rats: increases in alkaline phosphatase activity and DNA content, Biochem. Pharmacol., 35, 773-777, doi:http://dx.doi.org/10.1016/0006-2952(86)90245-5, (1986).
79. Gil-Albarova, J. et al.: The in vivo behaviour of a solgel glass and a glass-ceramic during critical diaphyseal bone defects healing, Biomaterials, 26, 4374-4382, doi:10.1016/j.biomaterials.2004.11.006, (2005).
80. Tapiero, H., Tew, K.D.: Trace elements in human physiology and pathology: zinc and metallothioneins, Biomed. Pharmacother., 57, 399-411, (2003).
81. Amro, N.A. et al.: High-resolution atomic force microscopy studies of the escherichia coli outer Membrane: structural basis for permeability, Langmuir, 16, 2789-2796, doi:10.1021/la991013x, (2000).
82. Feng, Q. L. et al.: A mechanistic study of the antibacterial effect of silver ions on escherichia coli and staphylococcus aureus J. Biomed. Mater. Res., 52, 662-668, (2000).
83. Sondi, I., Salopek-Sondi, B.: Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria, J. Colloid Interf. Sci., 275, 177-182, doi:10.1016/j.jcis.2004.02.012, (2004).
84. Maehira, F., Miyagi, I., Eguchi, Y.: Effects of calcium sources and soluble silicate on bone metabolism and the related gene expression in mice, Nutrition, 25, 581-589, doi:10.1016/j.nut.2008.10.023, (2009).
85. Lappalainen, R., Knuuttila, M.: Mg content of healthy and chronically diseased human cancellous bone in relation to age and some physical and chemical factors, Med. Biol., 63, 144-148, (1985).
86. Wood, D.J., Cooper, C., Stevens, J., Edwardson, J.: Bone mass and dementia in hip fracture patients from areas with different aluminium concentrations in water supplies, Age Ageing, 17, 415-419, (1988).
87. Yasui, M., Yase, Y., Ota, K.: Distribution of calcium in central nervous system tissues and bones of rats maintained on calcium-deficient diets, J. Neurolog. Sci., 105, 206-210, (1991).
88. Brown, E.M., MacLeod, R.J.: Extracellular calcium sensing and extracellular calcium signaling, Physiol. Rev., 81, 239-297, (2001).
89. Cifuentes, M., Albala, C., Rojas, C.: Calcium-sensing receptor expression in human adipocytes, Endocrinology, 146, 2176-2179, doi:10.1210/en.2004-1281, (2005).
90. Kifor, O. et al.: Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells, Am. J. Physiol.-Renal, 280, F291-302, (2001).
91. 2+ sensing, J. Clin. Invest., 96, 1582-1590, doi:10.1172/jci118197, (1995).
92. Zayzafoon, M.: Calcium/calmodulin signaling controls osteoblast growth and differentiation, J. Cell. Biochem., 97, 56-70, doi:10.1002/jcb.20675, (2006).
93. Kulakov, O.B., Doktorov, A.A., D'Iakova S.V., Denisov-Nikol'skii Iu, I., Grotz, K.A.: Experimental study of osseointegration of zirconium and titanium dental implants, Morfologiia, 127, 52-55, (2005).
94. Piconi, C., Maccauro, G.: Zirconia as a ceramic biomaterial, Biomaterials, 20, 1-25, (1999).
95. Hench, L.L., Splinter, R.J., Allen, W.C., Greenlee, T.K.: Bonding mechanisms at the interface of ceramic prosthetic materials. J. Biomed. Mat. Res., 5, 117-141, doi:10.1002/jbm.820050611, (1971).
96. Pecheva, E., Petrov, T., Lungu, C., Montgomery, P., Pramatarova, L.: Stimulated in vitro bone-like apatite formation by a novel laser processing technique, Chem. Eng. J., 137, 144-153, doi:http://dx.doi.org/10.1016/j.cej. 2007.07.096, (2008).
97. Hench, L.L., Paschall, H.A.: Histochemical responses at a biomaterial's interface. J. Biomed. Mater. Res., 8, 49-64, doi:10.1002/jbm.820080307, (1974).
98. Merolli, A., Leali, P.T., Guidi, P.L., Gabbi, C.: Comparison in in-vivo response between a bioactive glass and a non-bioactive glass, J. Mater. Sci. Mater. M., 11, 219-222, (2000).
99. Nonami, T., Tsutsumi, S.: Study of diopside ceramics for biomaterials, J. Mater. Sci. Mater. M., 10, 475-479, (1999).
100. Lee, K.Y. et al.: Ceramic bioactivity: progresses, challenges and perspectives, Biomed. Mater., 1, R31-37, doi:10.1088/1748-6041/1/2/r01, (2006).
101. Toquet, J. et al.: Osteogenic potential in vitro of human bone marrow cells cultured on macroporous biphasic calcium phosphate ceramic, J. Biomed. Mater. Res., 44, 98-108, (1999).
102. 2 glasses (M = La, Y; 0 ≤ x ≤ 0.6) in a simulated body fluid, Biomaterials, 16, 1249-1253, doi:http://dx.doi.org/10.1016/0142-9612(95)98132-X, (1995).
103. Kamitakahara, M. et al.: Preparation of porous glass-ceramics containing whitockite and diopside for bone repair, J. Ceram. Soc. Jpn., 114, 82-86, (2006).
104. 5 glasses in a simulated body fluid, J. Non-Cryst. Solids, 143, 84-92, doi:http://dx.doi.org/10.1016/S0022-3093(05) 80556-3, (1992).
105. 3 ceramics, Ceram. Int., 31, 323-326, doi:http://dx.doi.org/10.1016/j.ceramint.2004.05.023, (2005).
106. Arcos, D., Greenspan, D.C., Vallet-Regi, M: A new quantitative method to evaluate the in vitro bioactivity of melt and sol-gel-derived silicate glasses, J. Biomed. Mater. Res. A, 65, 344-351, doi:10.1002/jbm.a.10503, (2003).
107. Ducheyne, P., Radin, S., King, L.: The effect of calcium phosphate ceramic composition and structure on in vitro behavior. I. dissolution, J. Biomed. Mater. Res., 27, 25-34, doi:10.1002/jbm.820270105, (1993).
108. Liu, X., Morra, M., Carpi, A., Li, B.: Bioactive calcium silicate ceramics and coatings, Biomed. Pharma Cother, 62, 526-529, doi:http://dx.doi. org/10.1016/j.biopha.2008.07.051, (2008).
109. Ou, J. et al.: Preparation and in vitro bioactivity of novel merwinite ceramic, Biomed. Mater., 3, 015015, doi:10.1088/1748-6041/3/1/015015, (2008).
110. Gou, Z., Chang, J.: Synthesis and in vitro bioactivity of dicalcium silicate powders, J. Eur. Ceram. Soc., 24, 93-99, doi:http://dx.doi.org/10.1016/ S0955-2219(03)00320-0, (2004).
111. Silver, I.A., Deas, J., Erecinska, M.: Interactions of bioactive glasses with osteoblasts in vitro: Effects of 45S5 bioglass, and 58S and 77S bioactive glasses on metabolism, intracellular ion concentrations and cell viability, Biomater., 22, 175-185, (2001).
112. el-Ghannam, A., Ducheyne, P., Shapiro, I.M.: Formation of surface reaction products on bioactive glass and their effects on the expression of the osteoblastic phenotype and the deposition of mineralized extracellular matrix, Biomater., 18, 295-303, (1997).
113. Kaunitz, J.D., Yamaguchi, D.T.: TNAP, TrAP, ecto-purinergic signaling, and bone remodeling, J. Cell. Biochem. 105, 655-662, doi:10.1002/jcb.21885, (2008).
114. Pan, H., Zhao, X., Darvell, B.W., Lu, W.W.: Apatite-formation ability-predictor of "bioactivity"?, Acta Biomater., 6, 4181-4188, doi:10.1016/j.actbio.2010.05.013, (2010).
115. 3 bioceramic via tailoring its surface structure and chemical composition, J. Am. Ceram. Soc., 96, 691-696, doi:10.1111/jace.12168, (2013).
116. Lin, K., Zhang, M., Zhai, W., Qu, H., Chang, J.: Fabrication and characterization of Hydroxyapatite/Wollastonite composite bioceramics with controllable properties for hard tissue repair, J. Am. Ceram. Soc., 94, 99-105, doi:10.1111/j.1551-2916.2010.04046.x, (2011).
117. Zhao, L., Wu, C., Lin, K., Chang, J.: The effect of poly(lacticco- glycolic acid), (PLGA) coating on the mechanical, biodegradable, bioactive properties and drug release of porous calcium silicate scaffolds, Bio-med. Mater. Eng., 22, 289-300, doi:10.3233/bme-2012-0719, (2012).
118. Wu, C., Chang, J., Xiao, Y.: Advanced bioactive inorganic materials for bone regeneration and drug delivery. 25-40, CRC Press (2013).
119. Anthony, J.W., Bideaux, R.A., Bladh, K.W., Nichols, M.C.: Handbook of mineralogy, mineral data publishing, (2003).
120. Wu, C., Chang, J. Synthesis and in vitro bioactivity of bredigite powders, J. Biomater. Appl., 21, 251-263, doi:10.1177/0885328206062360, (2007).
121. 16) scaffold with biomimetic apatite layer for bone tissue engineering, J. Mater. Sci. M., 18, 857-864, doi:10.1007/s10856-006-0083-0, (2007).
122. Wu, C., Chang, J.: Degradation, bioactivity, and cytocompatibility of diopside, akermanite, and bredigite ceramics, J. Biomed. Mater. Res. B, 83, 153-160, doi:10.1002/jbm.b.30779, (2007).
123. Huang, X.-H., Chang, J.: Preparation of nanocrystalline bredigite powders with apatite-forming ability by a simple combustion method, Mater. Res. Bull., 43, 1615-1620, doi:http://dx.doi.org/10.1016/j.materresbull.2007.06.033, (2008).
124. Hu, S. et al.: Antibacterial activity of silicate bioceramics, J. Wuhan Univ. Technol., 26, 226-230, doi:10.1007/s11595-011-0202-8, (2011).
125. Zhai, W. et al.: Stimulatory effects of the ionic products from Ca-Mg-Si bioceramics on both osteogenesis and angiogenesis in vitro, Acta biomater., 9, 8004-8014, doi:http://dx.doi.org/10.1016/j.actbio.2013.04.024, (2013).
126. Zhou, Y., Wu, C., Zhang, X., Han, P., Xiao, Y.: The ionic products from bredigite bioceramics induced cementogenic differentiation of periodontal ligament cells via activation of the Wnt/β-catenin signalling pathway, J. Mater. Chem. B, 1, 3380-3389, doi:10.1039/C3TB20445F, (2013).
127. Razavi, M. et al.: Surface modification of magnesium alloy implants by nanostructured bredigite coating, Mater. Lett., doi:http://dx.doi.org/10.1016/j. matlet.2013.09.068.
128. Nakajima, S.: Experimental studies of healing process on reinforcement ceramic implantation in rabbit mandible, Shika gakuho. Dental science reports, 90, 525-553, (1990).
129. Nakajima, S., Harada, Y., Kurihara, Y., Wakatsuki, T., Noma, H.:Physicochemical characteristics of new reinforcement ceramic implant, Shika gakuho. Dental science reports, 89, 1709-1717, (1989).
130. De Aza, P.N., Luklinska, Z.B., Anseau, M.: Bioactivity of diopside ceramic in human parotid saliva, J. Biomed. Mater. Res. B, 73, 54-60, doi:10.1002/jbm.b.30187, (2005).
131. Toya, T., Kameshima, Y., Yasumori, A., Okada, K.: Preparation and properties of glass-ceramics from wastes (Kira) of silica sand and kaolin clay refining, J. Eur. Ceram. Soc., 24, 2367-2372, doi:http://dx.doi.org/10.1016/ S0955-2219(03)00628-9, (2004).
132. 2 or ZnO additives, Ceram. Int., 35, 1083-1093, doi:http://dx.doi.org/10.1016/j.ceramint.2008.04.025, (2009).
133. Iwata, N.Y., Lee, G.-H., Tsunakawa, S., Tokuoka, Y., Kawashima, N.: Preparation of diopside with apatite-forming ability by sol-gel process using metal alkoxide and metal salts, Colloid Surface B, 33, 1-6, doi:http://dx.doi. org/10.1016/j.colsurfb.2003.07.004, (2004).
134. Hsu, F.Y., Chueh, S.C., Wang, Y.J.: Microspheres of hydroxyapatite/ reconstituted collagen as supports for osteoblast cell growth, Biomaterials, 20, 1931-1936, (1999).
135. 6) ceramic microspheres for drug delivery, Acta Biomater., 6, 820-829, doi:http://dx.doi.org/10.1016/j.actbio.2009.09.025, (2010).
136. Wu, C., Ramaswamy, Y., Zreiqat, H.: Porous diopside (CaMgSi(2)O(6)) scaffold: A promising bioactive material for bone tissue engineering, Acta Biomater., 6, 2237-2245, doi:10.1016/j.actbio.2009.12.022, (2010).
137. Chandrasekaran, V., Taggart, R., Polonis, D.H.: The influence of constitution and microstructure on the temperature coefficient of resistivity in Ti-base alloys, J. Mater. Sci., 9, 961-968, doi:10.1007/BF00570390, (1974).
138. Xue, W., Liu, X., Zheng, X., Ding, C.: Plasma-sprayed diopside coatings for biomedical applications, Surf. Coat. Tech., 185, 340-345, doi:http://dx.doi.org/10.1016/j.surfcoat.2003.12.018, (2004).
139. 2 bioceramics: in vitro simulated body fluid test and thermodynamic simulation, Acta Biomater., 6, 2797-2807, doi:10.1016/j.actbio.2010.01.003, (2010).
140. Zhang, M., Liu, C., Sun, J., Zhang, X.: Hydroxyapatite/diopside ceramic composites and their behaviour in simulated body fluid, Ceram. Int., 37, 2025-2029, doi:http://dx.doi.org/10.1016/j.ceramint.2011.01.045, (2011).
141. 3/diopside ceramic composites and their behaviour in simulated body fluid, Ceram. Int., 36, 2505-2509, doi:http://dx.doi.org/10.1016/j.ceramint. 2010.07.004, (2010).
142. 2+-containing silicate materials with stem cells and bacteria, Mater. Lett., 112, 105-108, doi:http://dx.doi.org/10.1016/j.matlet. 2013.08.099, (2013).
143. 6 bioceramic scaffolds, J. Biomed. Mater. Res. A, n/a-n/a, doi:10.1002/jbm.a.34679, (2013).
144. Liu, G. et al.: The effects of bioactive akermanite on physiochemical, drug-delivery, and biological properties of poly(lactide-co-glycolide) beads, J. Biomed. Mater. Res., B, 96, 360-368, doi:10.1002/jbm.b.31779, (2011).
145. Luo, T., Wu, C., Zhang, Y.: The in vivo osteogenesis of mg or Zr-modified silicate-based bioceramic spheres, J. Biomed. Mater. Res. A, 100, 2269-2277, (2012).
146. 2) via sol-gel method, Ceram. Int., 37, 175-180, doi:http://dx.doi.org/10.1016/j.ceramint.2010.08.034, (2011).
147. 8) as a novel bioceramic, J. Ceram. Process. Res., 11, 765-768, (2010).
148. Abbasi-Shahni, M., Hesaraki, S., Behnam-Ghader, A., Hafezi-Ardakani, M.: Mechanical properties and in vitro bioactivity of β-tri calcium phosphate, merwinite nanocomposites, Key Eng. Mat., 493-494, 582-587, (2012).
149. Hafezi, M., Reza Talebi, A., Mohsen Miresmaeili, S., Sadeghian, F., Fesahat, F.: Histological analysis of bone repair in rat femur via nanostructured merwinite granules, Ceram. Int., 39, 4575-4580, doi:http://dx.doi.org/10.1016/j.ceramint.2012.11.054, (2013).
150. Sun, H., Wu, C., Dai, K., Chang, J., Tang, T.: Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics, Biomaterials, 27, 5651-5657, doi:10.1016/j. biomaterials.2006.07.027, (2006).
151. Bhatkar, V.B., Bhatkar, N.V.: Combustion synthesis and photoluminescence characteristics of Akermanite: A novel biomaterial, IJAEST, 5, 184-186.
152. Hou, X. et al.: Effect of akermanite morphology on precipitation of bone-like apatite, Appl. Surf. Sci., 257, 3417-3422, doi:http://dx.doi.org/10. 1016/j.apsusc.2010.11.037, (2011).
153. Huang, Y. et al.: In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration, Biomaterials, 30, 5041-5048, doi:10.1016/j.biomaterials.2009.05.077, (2009).
154. Anselme, K: Osteoblast adhesion on biomaterials, Biomaterials, 21, 667-681, (2000).
155. Gu, H. et al.: The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway, Biomaterials, 32, 7023-7033, doi:10.1016/j. biomaterials.2011.06.003, (2011).
156. Zhai, W. et al.: Silicate bioceramics induce angiogenesis during bone regeneration, Acta Biomater., 8, 341-349, doi:10.1016/j.actbio.2011.09.008, (2012).
157. Wu, C., Chang, J.: Synthesis and apatite-formation ability of akermanite, Mater. Lett., 58, 2415-2417, doi:http://dx.doi.org/10.1016/j.matlet.2004.02. 039, (2004).
158. Goudouri, O. M. et al.: Development of highly porous scaffolds based on bioactive silicates for dental tissue engineering, Mater. Res. Bull., doi:http://dx.doi.org/10.1016/j.materresbull.2013.09.027.
159. Razavi, M. et al.: Controlling the degradation rate of bioactive magnesium implants by electrophoretic deposition of akermanite coating, Ceram. Int, doi:http://dx.doi.org/10.1016/j.ceramint.2013.08.027.
160. 2 system, J. Mater. Sci. Mater. M., 21, 1463-1471, doi:10.1007/s10856-010-4025-5, (2010).
161. Yi, D. et al.: Preparation and in vitro evaluation of plasma-sprayed bioactive akermanite coatings, Biomed. Mater., 7, 065004, (2012).
162. 2 system, J. Mater. Sci. Mater. M., 21, 1463-1471, doi:10.1007/s10856-010-4025-5, (2010).
163. Zhang, M. et al.: Biological responses of human bone marrow mesenchymal stem cells to Sr-M-Si (M = Zn, Mg) silicate bioceramics, J. Biomed. Mater, Res. A, 100, 2979-2990, doi:10.1002/jbm.a.34246, (2012).
164. Chen, X. et al.: Synthesis and characteristics of monticellite bioactive ceramic, J. Mater. Sci. Mater. M, 19, 1257-1263, doi:10.1007/s10856-007-3233-0, (2008).
165. 9 ceramic coating on Ti-6Al-4V, Appl. Surf. Sci., 256, 4677-4681, doi:http://dx.doi.org/ 10.1016/j.apsusc.2010.02.071, (2010).
166. Biagioni, C., Bonaccorsi, E., Perchiazzi, N., Merlino, S.: Single crystal refinement of the structure of baghdadite from fuka (Okayama prefecture, Japan), Period. Mineral, 79, 1-9, (2010).
167. Ramaswamy, Y. et al.: Sphene ceramics for orthopedic coating applications: an in vitro and in vivo study, Acta Biomater., 5, 3192-3204, doi:http://dx.doi.org/10.1016/j.actbio.2009.04.028, (2009).
168. Wang, G. et al.: Nanostructured glass-ceramic coatings for orthopaedic applications. J.R. Soc. Interface, 8, 1192-1203, doi:10.1098/rsif.2010.0680, (2011).
169. Wu, C. et al.: Novel sphene coatings on Ti-6Al-4V for orthopedic implants using sol-gel method, Acta Biomater., 4, 569-576, doi:http://dx.doi.org/10. 1016/j.actbio.2007.11.005, (2008).
170. 5 ceramic coating on Ti-6Al-4V with excellent bonding strength, stability and cellular bioactivity. J. R. Soc. Interface, 6, 159-168, doi:10.1098/rsif.2008.0274, (2009).
171. Ardit, M., Cruciani, G., Dondi, M.: in Z. Kristallogr. Vol. 225 298, (2010).
172. Wu, C., Chang, J., Zhai, W.: A novel hardystonite bioceramic: preparation and characteristics, Ceram. Int., 31, 27-31, doi:http://dx.doi.org/10.1016/j. ceramint.2004.02.008, (2005).
173. Courthéoux, L., Lao, J., Nedelec, J.M., Jallot, E.: Controlled bioactivity in zinc-doped Sol-Gel-derived binary bioactive glasses, J. Phys. Chem. C, 112, 13663-13667, doi:10.1021/jp8044498, (2008).
174. Wu, C., Chang, J., Zhai, W.: A novel hardystonite bioceramic: preparation and characteristics, Ceram. Int., 31, 27-31, doi:http://dx.doi.org/10.1016/j. ceramint.2004.02.008, (2005).
175. 7 coating, J. Mater. Sci. Mater. M., 22, 2781-2789, doi:10.1007/s10856-011-4454-9, (2011).
176. 7 coating against escherichia coli, J. Mater. Sci. Mater. M., 24, 171-178, doi:10.1007/s10856-012- 4788-y, (2013).
177. Yu, J. et al.: In vitro and in vivo evaluation of zinc-modified ca-si-based ceramic coating for bone implants, PloS one, 8, e57564, doi:10.1371/journal.pone.0057564, (2013).
178. Boyd, D. et al.: Preliminary investigation of novel bone graft substitutes based on strontium-calcium-zinc-silicate glasses, J. Mater. Sci. Mater. M., 20, 413-420, doi:10.1007/s10856-008-3569-0, (2009).
179. 7) and beta-TCP ceramics, J. Biomater. Appl., 25, 39-56, doi:10.1177/0885328209342469, (2010).
180. Roohani-Esfahani, S. I. et al.: Unique microstructural design of ceramic scaffolds for bone regeneration under load, Acta Biomater., doi:10.1016/j. actbio.2013.02.039, (2013).
181. Zhang, W. et al.: The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration, Biomaterials, 34, 3184-3195, doi:10.1016/j.biomaterials.2013.01.008, (2013).
182. Jaiswal, A.K. et al.: Hardystonite improves biocompatibility and strength of electrospun polycaprolactone nanofibers over hydroxyapatite: A comparative study. Mater. Sci. Eng. C, 33, 2926-2936, doi:http://dx.doi.org/10.1016/j.msec. 2013.03.020, (2013).
183. Li, K. et al.: Effects of Zn content on crystal structure, cytocompatibility, antibacterial activity, and chemical stability in zn-modified calcium silicate coatings, J. Therm. Spray. Techn., 1-9, doi:10.1007/s11666- 013-9938-3, (2013).
184. Song, W. et al.: Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles, Toxicol. Lett., 199, 389-397, doi:http://dx.doi.org/10.1016/j.toxlet.2010.10.003, (2010).
185. 7 coating against escherichia coli, J. Mater. Sci. Mater. M., 24, 171-178, doi:10.1007/s10856-012- 4788-y, (2013).
186. 7 coating, J. Mater. Sci. Mater. M., 22, 2781-2789, doi:10.1007/s10856-011-4454-9, (2011).
187. Samani, S., Hossainalipour, S. M., Tamizifar, M., Rezaie, H.R.: In vitro antibacterial evaluation of sol-gel-derived Zn-, Ag-, and (Zn + Ag)-doped hydroxyapatite coatings against methicillin-resistant staphylococcus aureus, J. Biomed. Mater. Res. A, 101, 222-230, doi:10.1002/jbm.a.34322, (2013).
188. Roohani - Esfahani, S.-I., Chen, Y., Shi, J., Zreiqat, H.: Fabrication and characterization of a new, strong and bioactive ceramic scaffold for bone regeneration, Mater. Lett., 107, 378-381, doi:http://dx.doi.org/10.1016/j. matlet.2013.06.046, (2013).