Silica-based bioactive glasses modulate expression of bone morphogenetic protein-2 mRNA in Saos-2 osteoblasts in vitro

Biomaterials

Volumn 22, Issue 12, 2001, Pages 1475-1483

  Gao, Tiejun ^a,b,d   Aro, Hannu T ^b   Ylänen, Heimo ^c   Vuorio, Eero ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Alkaline phosphatase; Bioactive glass; Bone morphogenetic protein 2; Collagen type I; MRNA; Saos 2 cells

Indexed keywords

COLLAGEN; GLASS; MICROSCOPIC EXAMINATION; RNA; SILICA GEL;

BIOACTIVE GLASSES;

BONE;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; CYTOKINE; F ACTIN; FLUORESCEIN ISOTHIOCYANATE; GLASS; MESSENGER RNA; PEPTIDE; SILICON DIOXIDE;

ARTICLE; BIOCOMPATIBILITY; BONE PROSTHESIS; CELL CULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DRUG ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROSCOPY; NORTHERN BLOTTING; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; SURFACE PROPERTY;

ALKALINE PHOSPHATASE; BIOCOMPATIBLE MATERIALS; BONE MORPHOGENETIC PROTEINS; COLLAGEN; GENE EXPRESSION REGULATION; GLASS; HUMANS; KINETICS; OSTEOBLASTS; OSTEOSARCOMA; RNA, MESSENGER; SILICON DIOXIDE; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

MYCOBACTERIUM BOVIS BCG;

EID: 0035876206     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(00)00288-X     Document Type: Article

References (27)

1. Direct chemical bond of bioactive glass-ceramic materials to bone and muscle
2. Surface-active biomaterials
3. Surface chemistry of bioactive glass-ceramics
4. In vitro adsorption and activity of enzymes on reaction layers of bioactive glass substitutes
5. Cellular and molecular biological events at the implant interface
6. Novel regulators of bone formation; molecular clones and activities
7. Bone morphogenetic protein -2
8. Characterization of a human osteoblastic osteosarcoma cell line(Saos-2) with high bone alkaline phosphatase activity
9. Long-term effects of physiological concentrations of dexamethasone on human bone-derived cells
10. Specific hybridization probes for mouse type I, II, III and IX collagen mRNA
11. Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase
12. 2
13. Bioactive ceramics
14. Behavior of bone marrow cells cultured on three different coating of gel-derived bioactive glass ceramics at early stage of cell differentiation
15. Porous bioactive glass and hydroxyapatite ceramic affect bone cell function in vitro along different time lines
16. Better histology and biochemistry for osteoblasts cultured on titanium-doped bioactive glass; bioglass 45S5 compared with iron-, titanium-, fluorine- and boron-containing bioactive glasses
17. Human osteoblast-like cells (MG63) proliferate on a bioactive glass surface
18. The mechanism of bone induction and bone healing by human osteosarcoma cell extracts
19. Expression of bone morphogenetic protein in human osteosarcoma
20. Zeolite A increases proliferation, differentiation, and transforming factor β production in normal adult osteoblast-like cells in vitro
21. In vitro analysis of the stimulation of bone formation by highly bioactive apatite- and wollastonite- containing glass-ceramics; released calcium ions promote osteogenic differentiation in osteoblastic ROS17/2.8 cells
22. Bone morphogenetic protein-2 is a regulator of cell adhesion
23. A bioactive glass template for the in vitro synthesis of bone
24. Histological and biochemical evaluation of osteoblasts cultured on bioactive glass, hydroxylapatite, titanium alloy, and stainless steel
25. Behavior of fetal rat osteoblasts cultured in vitro on bioactive glass, nonreactive
26. Human endothelial cell interactions with surface-coupled adhesion peptides on a non-adhesive glass substrate and two polymeric biomaterials
27. 3